LOCUS AF012272 3633 bp mRNA linear HUM 09-MAR-2000
DEFINITION Homo sapiens Rho GTPase activating protein 6 isoform 3 (ARHGAP6)
mRNA, complete cds.
ACCESSION AF012272
VERSION AF012272.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1367 to 3523)
AUTHORS Schaefer,L., Prakash,S. and Zoghbi,H.Y.
TITLE Cloning and characterization of a novel rho-type GTPase-activating
protein gene (ARHGAP6) from the critical region for microphthalmia
with linear skin defects
JOURNAL Genomics 46 (2), 268-277 (1997)
PUBMED 9417914
REFERENCE 2 (bases 1 to 3633)
AUTHORS Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
TITLE Functional analysis of ARHGAP6, a novel GTPase-activating protein
for RhoA
JOURNAL Hum. Mol. Genet. 9 (4), 477-488 (2000)
PUBMED 10699171
REFERENCE 3 (bases 1367 to 3523)
AUTHORS Schaefer,L., Prakash,S. and Zoghbi,H.Y.
TITLE Direct Submission
JOURNAL Submitted (03-JUL-1997) Howard Hughes Medical Institute, Baylor
College of Medicine, 1 Baylor Plaza, Room T836, Houston, TX 77030,
USA
REFERENCE 4 (bases 1 to 3633)
AUTHORS Prakash,S.
TITLE Direct Submission
JOURNAL Submitted (12-AUG-1999) Molecular and Human Genetics, Baylor
College of Medicine, 1 Baylor Plaza, Room T836, Houston, TX 77401,
USA
REMARK Sequence update by submitter
COMMENT On Aug 12, 1999 this sequence version replaced AF012272.1.
FEATURES Location/Qualifiers
source 1..3633
/db_xref="H-InvDB:HIT000062237"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.3"
gene 1..3633
/gene="ARHGAP6"
CDS 875..3172
/gene="ARHGAP6"
/note="alternatively spliced"
/codon_start=1
/product="Rho GTPase activating protein 6 isoform 3"
/protein_id="AAC98539.2"
/translation="MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIG
GCGSDEAGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSS
FSTPSTPQEKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSG
GGPNGIFASPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQS
LSELERARLQEVPFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFI
PQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSL
SSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSK
KEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR
GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLI
YLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQ
KSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVV
DYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLL
AMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKGNWSLASRRWPKQAT
LLLLHVAWCGALRTFSSSLPYLMFL"
BASE COUNT 819 a 1081 c 1003 g 730 t
ORIGIN
1 ggctgggctg cgaatagcgt gttcctctcc ggcggaacac acacacccgg ccttggggct
61 gtctcctgaa gctccctcct ccacggagag cgctgagcgc cgccgggaat tccatcccac
121 cgtgggcacg cagtctttgg aggtcccggg cgcagcacgc tcggtgtccc cacactgcag
181 caagacagag accccgcggg aaccttgagc ttggaacaac ccttgagcct ctgcagtcgg
241 aagagtgggc gcagcagccc agcggaggcc aggcgcgcaa cctcgggcgc cggggcaagg
301 agagagtgca gggaggcgca gctcaggcgc ccggctcagg agcgggagga agttctcgcg
361 gcgccgggag cgcggtggac gcgccctggg cgcacgccca ggcagccttc tccctggccc
421 tcgggactgt cctcgggcgg caaggaggag cttgctggag tcttagaggc catccagagc
481 cagcgagcag gagcgctgcg tctcccgcct cagctaggaa gggggagtgg cgctggcagg
541 ctggagctgg gaacccagcg agcgcctgac cttcctcctc ctcttcctga ccctcttcgc
601 gtcttgggct ccggaggaag gttctagcgg ctgcaggagg tccccagacc cattttccta
661 gaaggctggt gatggatctg ctgctcctgc cgccgccggg gcacttggag cgcaccggcg
721 gcgcgtgagc tgggctttgc tctccaccgc cctgggcaaa ccccgggcca gccccgcctg
781 gcacctttgc ctgagtccct ttcggttccc gacccaaagc caccagcgtc cagggaggga
841 ggaggaggtg gtcctcaggt gcagccccgc cgagatgtcc gcgcagagcc tgctccacag
901 cgtcttctcc tgttcctcgc ccgcttcaag tagcgcggcc tcggccaagg gcttctccaa
961 gaggaagctg cgccagaccc gcagcctgga cccggccctg atcggcggct gcgggagcga
1021 cgaggcgggc gcggagggca gtgcgcgggg agccacggcg ggccgcctct actccccatc
1081 actcccagcc gagagtctcg gccctcgctt ggcgtcctct tcccggggtc cgccccccag
1141 ggccaccagg ctaccgcctc ctggacctct ttgctcgtcc ttctccacac ccagcacccc
1201 gcaggagaag tcaccatccg gcagctttca ctttgactat gaggttcccc tgggtcgcgg
1261 cggcctcaag aagagcatgg cctgggacct gccttctgtc ctggccgggc cagccagtag
1321 ccgaagcgct tccagcatcc tctgttcatc cgggggaggc cccaatggca tcttcgcttc
1381 tcctaggagg tggctccagc agaggaagtt ccagtcccca cccgacagtc gcgggcaccc
1441 ctacgtcgtg tggaaatccg agggtgattt cacctggaac agcatgtcag gccgcagtgt
1501 gcggctgagg tcagtcccca tccagagtct ctcagagctg gagagggccc ggctgcagga
1561 agtgcctttt tatcagttgc aacaggactg tgacctgagc tgtcagatca ccattcccaa
1621 agatggacaa aagagaaaga aatctttaag aaagaaactg gattcactag gaaaggagaa
1681 aaacaaagac aaagaattca tcccacaggc atttggaatg cccttatccc aagtcattgc
1741 gaatgacagg gcctataaac tcaagcagga cttgcagagg gacgagcaga aagatgcatc
1801 tgactttgtg gcttccctcc tcccatttgg aaataaaaga caaaacaaag aactctcaag
1861 cagtaactca tctctcagct caacctcaga aacaccgaat gagtcaacgt ccccaaacac
1921 cccggaaccg gctcctcggg ctaggaggag gggtgccatg tcagtggatt ctatcaccga
1981 tcttgatgac aatcagtctc gactactaga agctttacaa ctttccttgc ctgctgaggc
2041 tcaaagtaaa aaggaaaaag ccagagataa gaaactcagt ctgaatccta tttacagaca
2101 ggtccctagg ctggtggaca gctgctgtca gcacctagaa aaacatggcc tccagacagt
2161 ggggatattc cgagttggaa gctcaaaaaa gagagtgaga caattacgtg aggaatttga
2221 ccgtgggatt gatgtctctc tggaggagga gcacagtgtt catgatgtgg cagccttgct
2281 gaaagagttc ctgagggaca tgccagaccc ccttctcacc agggagctgt acacagcttt
2341 catcaacact ctcttgttgg agccggagga acagctgggc accttgcagc tcctcatata
2401 ccttctacct ccctgcaact gcgacaccct ccaccgcctg ctacagttcc tctccatcgt
2461 ggccaggcat gccgatgaca acatcagcaa agatgggcaa gaggtcactg ggaataaaat
2521 gacatctcta aacttagcca ccatatttgg acccaacctg ctgcacaagc agaagtcatc
2581 agacaaagaa ttctcagttc agagttcagc ccgggctgag gagagcacgg ccatcatcgc
2641 tgttgtgcaa aagatgattg aaaattatga agccctgttc atggttcccc cagatctcca
2701 gaacgaagtg ctgatcagcc tgttagagac cgatcctgat gtcgtggact atttactcag
2761 aagaaaggct tcccaatcat caagccctga catgctgcag tcggaagttt ccttttccgt
2821 gggagggagg cattcatcta cagactccaa caaggcctcc agcggagaca tctcccctta
2881 tgacaacaac tccccagtgc tgtctgagcg ctccctgctg gctatgcaag aggacgcggc
2941 cccggggggc tcggagaagc tttacagagt gccagggcag tttatgctgg tgggccactt
3001 gtcgtcgtca aagtcaaggg aaagttctcc tggaccaagg cttgggaaag gtaactggag
3061 cctggccagc aggcgctggc caaaacaagc gaccctcctc ttgttgcatg tggcatggtg
3121 tggggctctt cggaccttct cttcgtctct cccttatttg atgtttctgt aattcaacct
3181 gcatttaccg agtacctgct gaacgcctac tctaggaaga ggaaggtatg gcgagcccag
3241 tcgttggctg ggagggtccc tgcaggccac actccaagtc tcagatatct gggaaataaa
3301 cgcatgccca gaggagccac tcctattccc agctgattct ttttccctcc agcatcctag
3361 gaactttatg tatactggat ttgggttgca tatttgctag tctgaggtgc cacccaatta
3421 ctgctgttac atttctaaag aaaacaagct gaacctacta tatgtatgaa gacaaccttc
3481 cagaaccaaa tagtgttagt atccaatgac aagagagcac tatactggga gtcacaaacc
3541 tgctctgcca ctttcaacct gcaggatctc cagtgagcga ttgagcttcc cagagtccca
3601 tttcctcctg ctgtgaaaac tcagaatgat aac
//