LOCUS AF009674 3411 bp mRNA linear HUM 24-JUL-2016
DEFINITION Homo sapiens axin (AXIN) mRNA, partial cds.
ACCESSION AF009674
VERSION AF009674.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3411)
AUTHORS Zeng,L., Fagotto,F., Zhang,T., Hsu,W., Vasicek,T.J., Perry,W.L.
III, Lee,J.J., Tilghman,S.M., Gumbiner,B.M. and Costantini,F.
TITLE The mouse Fused locus encodes Axin, an inhibitor of the Wnt
signaling pathway that regulates embryonic axis formation
JOURNAL Cell 90 (1), 181-192 (1997)
PUBMED 9230313
REFERENCE 2 (bases 1 to 3411)
AUTHORS Vasicek,T.J., Zeng,L., Guan,X.J., Zhang,T., Costantini,F. and
Tilghman,S.M.
TITLE Two dominant mutations in the mouse fused gene are the result of
transposon insertions
JOURNAL Genetics 147 (2), 777-786 (1997)
PUBMED 9335612
REFERENCE 3 (bases 1 to 3411)
AUTHORS Vasicek,T.J., Tilghman,S.M., Costantini,F., Zeng,L., Perry,W.L. III
and Zhang,T.
TITLE Direct Submission
JOURNAL Submitted (22-JUN-1997) Biological Technology, Millennium
Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..3411
/db_xref="H-InvDB:HIT000062053"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
/dev_stage="ubiquitously expressed in development and in
adults"
gene <1..3411
/gene="AXIN"
/note="Fused is the classical dominant mouse tail kink
mutation due to an iap insertion in the Axin gene"
CDS <1..2704
/gene="AXIN"
/function="may inhibit embryonic axis formation"
/note="contains RGS domain and Daughterless similarity;
may inhibit embryonic axis formation"
/codon_start=2
/product="axin"
/protein_id="AAC51624.1"
/translation="GPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQG
FPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSD
LDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTG
FRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM
FDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLP
TLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSW
REPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRRE
MQESAQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERL
KRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRLCWTWACAGLRDAHEENPESI
LDEHVQRVLRTTGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAG
LHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAP
NASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEIS
RHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPN
PLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDME
LSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKG
SYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD"
BASE COUNT 752 a 1010 c 1066 g 582 t
ORIGIN
1 gggcccgggg tcccgccacc accgcgcgcg ggacagattg attcactttg gagctgtaag
61 tactgatgta ttagggtgca gcgctcattg ttcattgacg cagagtccca aaatgaatat
121 ccaagagcag ggtttcccct tggacctcgg agcaagtttc accgaagatg ctccccgacc
181 cccagtgcct ggtgaggagg gagaactggt gtccacagac ccgaggcccg ccagctacag
241 tttctgctcc gggaaaggtg ttggcattaa aggtgagact tcgacggcca ctccgaggcg
301 ctcggatctg gacctggggt atgagcctga gggcagtgcc tcccccaccc caccatactt
361 gaagtgggct gagtcactgc attccctgct ggatgaccaa gatgggataa gcctgttcag
421 gactttcctg aagcaggagg gctgtgccga cttgctggac ttctggtttg cctgcactgg
481 cttcaggaag ctggagccct gtgactcgaa cgaggagaag aggctgaagc tggcgagagc
541 catctaccga aagtacattc ttgataacaa tggcatcgtg tcccggcaga ccaagccagc
601 caccaagagc ttcataaagg gctgcatcat gaagcagctg atcgatcctg ccatgtttga
661 ccaggcccag accgaaatcc aggccactat ggaggaaaac acctatccct ccttccttaa
721 gtctgatatt tatttggaat atacgaggac aggctcggag agccccaaag tctgtagtga
781 ccagagctct gggtcaggga cagggaaggg catatctgga tacctgccga ccttaaatga
841 agatgaggaa tggaagtgtg accaggacat ggacgaggac gatggcagag acgctgctcc
901 ccccggaaga ctccctcaga agctgctcct ggagacagct gccccgaggg tctcctccag
961 tagacggtac agcgaaggca gagagttcag gtatggatcc tggcgggagc cagtcaaccc
1021 ctattatgtc aatgccggct atgccctggc cccagccacc agtgccaacg acagcgagca
1081 gcagagcctg tccagcgatg cagacaccct gtccctcacg gacagcagcg tggatgggat
1141 ccccccatac aggatccgta agcagcaccg cagggagatg caggagagcg cgcaggtcaa
1201 tgggcgggtg cccctacctc acattccccg cacgtaccgg gtgccgaagg aggtccgcgt
1261 ggagcctcag aagttcgcgg aggagctcat ccaccgcctg gaggctgtgc agcgcacgcg
1321 ggaggccgag gagaagctgg aggagcggct gaagcgcgtg cgcatggagg aggaaggtga
1381 ggacggcgat ccatcgtcag ggcccccagg gccgtgtcac aagctgcctc ccgcccccgc
1441 ttggcaccac ttcccgcccc gcttgtgttg gacatgggct tgtgccgggc tccgggatgc
1501 acacgaggag aaccctgaga gcatcctgga cgagcacgta cagcgtgtgc tgaggacaac
1561 tggccgccag tcgcctgggc ctggccatcg ctccccggac agtgggcacg tggccaagat
1621 gccagtggca ctggggggtg ccgcctcggg gcacgggaag cacgtaccca agtcaggggc
1681 gaagctggac gcggccggcc tgcaccacca ccgacacgtc caccaccacg tccaccacag
1741 cacagcccgg cccaaggagc aggtggaggc cgaggccacc cgcagggccc agagcagctt
1801 cgcctggggc ctggaaccac acagccatgg ggcaaggtcc cgaggctact cagagagtgt
1861 tggcgctgcc cccaacgcca gtgatggcct cgcccacagt gggaaggtgg gcgttgcgtg
1921 caaaagaaat gccaagaagg ctgagtcggg gaagagcgcc agcaccgagg tgccaggtgc
1981 ctcggaggat gcggagaaga accagaaaat catgcagtgg atcattgagg gggaaaagga
2041 gatcagcagg caccgcagga ccggccacgg gtcttcgggg acgaggaagc cacagcccca
2101 tgagaactcc agaccyttgt cccttgagca cccctgggcc ggccctcagc tccggacctc
2161 cgtgcagccc tcccacctct tcatccaaga ccccaccatg ccaccccacc cagctcccaa
2221 ccccctaacc cagctggagg aggcgcgccg acgtctggag gaggaagaaa agagagccag
2281 ccgagcaccc tccaagcaga ggtatgtgca ggaggttatg cggcggggac gcgcctgcgt
2341 caggccagcg tgcgcgccgg tgctgcacgt ggtaccagcc gtgtcggaca tggagctctc
2401 cgagacagag acaagatcgc agaggaaggt gggcggcggg agtgcccagc cgtgtgacag
2461 catcgttgtg gcgtactact tctgcgggga acccatcccc taccgcaccc tggtgagggg
2521 ccgcgctgtc accctgggcc agttcaagga gctgctgacc aaaaagggca gctacagata
2581 ctacttcaag aaagtgagcg acgagtttga ctgtggggtg gtgtttgagg aggttcgaga
2641 ggacgaggcc gtcctgcccg tctttgagga gaagatcatc ggcaaagtgg agaaggtgga
2701 ctgataggct ggtgggctgg ccgctgtgcc aggcgaggcc cttggcgggc acgggtgtca
2761 cggccaggca gatgacctcg tactcaggag cccgatgggg aacagtgttg ggtgtaccac
2821 ccatccctgt ggtctacccg tgtctagagg caggtagggg gtccctccaa gtggtccaca
2881 agcttctgtc ctgcccccaa ggaggcagcc tggaccactc ctcatagcaa tacttggagg
2941 gcccagccca agtgaggcag ccgaggtccc tgctgccagc ttcaggtgac ccccccccat
3001 cccccggcac ctcccttggg cacgtgtgct gggatctact ttccctctgg gatttgccca
3061 cgtacccagg tctggctggg gcccaggccc ggatgcagag gcctgcaggg cctctgtcaa
3121 ttgtacgcgc caccaagtgc cttcaacaca gcttgtctct tgcctgccac tgtgtgaatc
3181 ggcgacggag cactgcacct gcctccagcc gccggctgtg cagtcctggg tcctcctttc
3241 tgagggcccg tgtaaatatg tacatttctc aggctagggc cagcaggggc tgcccgagtc
3301 tgtttttcat gcgatgacac ttgtacaatt atcttttcaa aggtacttgg ataataatga
3361 aataaaactg tttttgaacc tgaataaaaa aaaaaaaaaa aaaaaaaaaa a
//