LOCUS AF009674 3411 bp mRNA linear HUM 24-JUL-2016 DEFINITION Homo sapiens axin (AXIN) mRNA, partial cds. ACCESSION AF009674 VERSION AF009674.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3411) AUTHORS Zeng,L., Fagotto,F., Zhang,T., Hsu,W., Vasicek,T.J., Perry,W.L. III, Lee,J.J., Tilghman,S.M., Gumbiner,B.M. and Costantini,F. TITLE The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation JOURNAL Cell 90 (1), 181-192 (1997) PUBMED 9230313 REFERENCE 2 (bases 1 to 3411) AUTHORS Vasicek,T.J., Zeng,L., Guan,X.J., Zhang,T., Costantini,F. and Tilghman,S.M. TITLE Two dominant mutations in the mouse fused gene are the result of transposon insertions JOURNAL Genetics 147 (2), 777-786 (1997) PUBMED 9335612 REFERENCE 3 (bases 1 to 3411) AUTHORS Vasicek,T.J., Tilghman,S.M., Costantini,F., Zeng,L., Perry,W.L. III and Zhang,T. TITLE Direct Submission JOURNAL Submitted (22-JUN-1997) Biological Technology, Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139, USA FEATURES Location/Qualifiers source 1..3411 /db_xref="H-InvDB:HIT000062053" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16p13.3" /dev_stage="ubiquitously expressed in development and in adults" gene <1..3411 /gene="AXIN" /note="Fused is the classical dominant mouse tail kink mutation due to an iap insertion in the Axin gene" CDS <1..2704 /gene="AXIN" /function="may inhibit embryonic axis formation" /note="contains RGS domain and Daughterless similarity; may inhibit embryonic axis formation" /codon_start=2 /product="axin" /protein_id="AAC51624.1" /translation="GPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQG FPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSD LDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTG FRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM FDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLP TLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSW REPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRRE MQESAQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERL KRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRLCWTWACAGLRDAHEENPESI LDEHVQRVLRTTGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAG LHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAP NASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEIS RHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPN PLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDME LSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKG SYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD" BASE COUNT 752 a 1010 c 1066 g 582 t ORIGIN 1 gggcccgggg tcccgccacc accgcgcgcg ggacagattg attcactttg gagctgtaag 61 tactgatgta ttagggtgca gcgctcattg ttcattgacg cagagtccca aaatgaatat 121 ccaagagcag ggtttcccct tggacctcgg agcaagtttc accgaagatg ctccccgacc 181 cccagtgcct ggtgaggagg gagaactggt gtccacagac ccgaggcccg ccagctacag 241 tttctgctcc gggaaaggtg ttggcattaa aggtgagact tcgacggcca ctccgaggcg 301 ctcggatctg gacctggggt atgagcctga gggcagtgcc tcccccaccc caccatactt 361 gaagtgggct gagtcactgc attccctgct ggatgaccaa gatgggataa gcctgttcag 421 gactttcctg aagcaggagg gctgtgccga cttgctggac ttctggtttg cctgcactgg 481 cttcaggaag ctggagccct gtgactcgaa cgaggagaag aggctgaagc tggcgagagc 541 catctaccga aagtacattc ttgataacaa tggcatcgtg tcccggcaga ccaagccagc 601 caccaagagc ttcataaagg gctgcatcat gaagcagctg atcgatcctg ccatgtttga 661 ccaggcccag accgaaatcc aggccactat ggaggaaaac acctatccct ccttccttaa 721 gtctgatatt tatttggaat atacgaggac aggctcggag agccccaaag tctgtagtga 781 ccagagctct gggtcaggga cagggaaggg catatctgga tacctgccga ccttaaatga 841 agatgaggaa tggaagtgtg accaggacat ggacgaggac gatggcagag acgctgctcc 901 ccccggaaga ctccctcaga agctgctcct ggagacagct gccccgaggg tctcctccag 961 tagacggtac agcgaaggca gagagttcag gtatggatcc tggcgggagc cagtcaaccc 1021 ctattatgtc aatgccggct atgccctggc cccagccacc agtgccaacg acagcgagca 1081 gcagagcctg tccagcgatg cagacaccct gtccctcacg gacagcagcg tggatgggat 1141 ccccccatac aggatccgta agcagcaccg cagggagatg caggagagcg cgcaggtcaa 1201 tgggcgggtg cccctacctc acattccccg cacgtaccgg gtgccgaagg aggtccgcgt 1261 ggagcctcag aagttcgcgg aggagctcat ccaccgcctg gaggctgtgc agcgcacgcg 1321 ggaggccgag gagaagctgg aggagcggct gaagcgcgtg cgcatggagg aggaaggtga 1381 ggacggcgat ccatcgtcag ggcccccagg gccgtgtcac aagctgcctc ccgcccccgc 1441 ttggcaccac ttcccgcccc gcttgtgttg gacatgggct tgtgccgggc tccgggatgc 1501 acacgaggag aaccctgaga gcatcctgga cgagcacgta cagcgtgtgc tgaggacaac 1561 tggccgccag tcgcctgggc ctggccatcg ctccccggac agtgggcacg tggccaagat 1621 gccagtggca ctggggggtg ccgcctcggg gcacgggaag cacgtaccca agtcaggggc 1681 gaagctggac gcggccggcc tgcaccacca ccgacacgtc caccaccacg tccaccacag 1741 cacagcccgg cccaaggagc aggtggaggc cgaggccacc cgcagggccc agagcagctt 1801 cgcctggggc ctggaaccac acagccatgg ggcaaggtcc cgaggctact cagagagtgt 1861 tggcgctgcc cccaacgcca gtgatggcct cgcccacagt gggaaggtgg gcgttgcgtg 1921 caaaagaaat gccaagaagg ctgagtcggg gaagagcgcc agcaccgagg tgccaggtgc 1981 ctcggaggat gcggagaaga accagaaaat catgcagtgg atcattgagg gggaaaagga 2041 gatcagcagg caccgcagga ccggccacgg gtcttcgggg acgaggaagc cacagcccca 2101 tgagaactcc agaccyttgt cccttgagca cccctgggcc ggccctcagc tccggacctc 2161 cgtgcagccc tcccacctct tcatccaaga ccccaccatg ccaccccacc cagctcccaa 2221 ccccctaacc cagctggagg aggcgcgccg acgtctggag gaggaagaaa agagagccag 2281 ccgagcaccc tccaagcaga ggtatgtgca ggaggttatg cggcggggac gcgcctgcgt 2341 caggccagcg tgcgcgccgg tgctgcacgt ggtaccagcc gtgtcggaca tggagctctc 2401 cgagacagag acaagatcgc agaggaaggt gggcggcggg agtgcccagc cgtgtgacag 2461 catcgttgtg gcgtactact tctgcgggga acccatcccc taccgcaccc tggtgagggg 2521 ccgcgctgtc accctgggcc agttcaagga gctgctgacc aaaaagggca gctacagata 2581 ctacttcaag aaagtgagcg acgagtttga ctgtggggtg gtgtttgagg aggttcgaga 2641 ggacgaggcc gtcctgcccg tctttgagga gaagatcatc ggcaaagtgg agaaggtgga 2701 ctgataggct ggtgggctgg ccgctgtgcc aggcgaggcc cttggcgggc acgggtgtca 2761 cggccaggca gatgacctcg tactcaggag cccgatgggg aacagtgttg ggtgtaccac 2821 ccatccctgt ggtctacccg tgtctagagg caggtagggg gtccctccaa gtggtccaca 2881 agcttctgtc ctgcccccaa ggaggcagcc tggaccactc ctcatagcaa tacttggagg 2941 gcccagccca agtgaggcag ccgaggtccc tgctgccagc ttcaggtgac ccccccccat 3001 cccccggcac ctcccttggg cacgtgtgct gggatctact ttccctctgg gatttgccca 3061 cgtacccagg tctggctggg gcccaggccc ggatgcagag gcctgcaggg cctctgtcaa 3121 ttgtacgcgc caccaagtgc cttcaacaca gcttgtctct tgcctgccac tgtgtgaatc 3181 ggcgacggag cactgcacct gcctccagcc gccggctgtg cagtcctggg tcctcctttc 3241 tgagggcccg tgtaaatatg tacatttctc aggctagggc cagcaggggc tgcccgagtc 3301 tgtttttcat gcgatgacac ttgtacaatt atcttttcaa aggtacttgg ataataatga 3361 aataaaactg tttttgaacc tgaataaaaa aaaaaaaaaa aaaaaaaaaa a //