LOCUS AF009039 4805 bp mRNA linear HUM 19-DEC-1997
DEFINITION Homo sapiens synaptojanin mRNA, alternatively spliced, complete
cds.
ACCESSION AF009039
VERSION AF009039.1
KEYWORDS synaptic vesicle; endocytosis.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4805)
AUTHORS Haffner,C., Takei,K., Chen,H., Ringstad,N., Hudson,A., Butler,M.H.,
Salcini,A.E., Di Fiore,P.P. and De Camilli,P.
TITLE Synaptojanin 1: localization on coated endocytic intermediates in
nerve terminals and interaction of its 170 kDa isoform with Eps15
JOURNAL FEBS Lett. 419 (2-3), 175-180 (1997)
PUBMED 9428629
REFERENCE 2 (bases 1 to 4805)
AUTHORS Haffner,C. and DeCamilli,P.
TITLE Direct Submission
JOURNAL Submitted (17-JUN-1997) Dept. of Cell Biology, Howard Hughes
Medical Institute, Yale University School of Medicine, Boyer Center
for Molecular Medicine, 295 Congress Av., New Haven, CT 06510, USA
FEATURES Location/Qualifiers
source 1..4805
/db_xref="H-InvDB:HIT000061946"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 44..3979
/note="isoform p145; inositol 5-phosphatase; presynaptic
protein; contains Sac1 homology domain and proline-rich
SH3 domain-binding region; amphiphysin-binding protein;
alternative splicing generates p170 isoform deposited as
GenBank Accession Number AF009040"
/codon_start=1
/product="synaptojanin"
/protein_id="AAC51921.1"
/translation="MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSA
EKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTE
FISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFW
NQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNV
RGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFE
ANAPAFDRHFRTLKNLYGRQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFD
YHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNS
VQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKA
KLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQT
LQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAP
KLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK
YVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTS
LCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNE
EVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEK
CRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKT
SDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDAL
IDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPD
WIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL
QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDA
QPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIG
APPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGV
ISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQE
PLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG"
BASE COUNT 1371 a 1051 c 1104 g 1279 t
ORIGIN
1 gaggaggagc cggaggaaga gggctgcctc cgaagaaagg agaatggcgt tcagtaaagg
61 attccggatc tatcacaaat tggatccccc acctttcagc ctcatagtgg aaactaggca
121 taaggaagaa tgtctcatgt tcgagtctgg ggctgtcgct gtgctctcat ctgcagaaaa
181 agaggcaatc aagggtacat actccaaagt actggatgca tatggactct taggtgttct
241 gcggttaaat cttggtgata ctatgttaca ttatctggtc ctagtcactg gatgtatgtc
301 tgttggaaaa attcaagaat ctgaagtttt ccgagttact tccactgagt ttatatcact
361 gcgaatcgat tcttcagatg aggatcgcat ttcagaagtg cggaaagttt tgaattcagg
421 aaacttttat tttgcatggt ctgcatctgg catcagttta gatttgagtc ttaatgcgca
481 tcgtagcatg caagaacaga caactgataa tagatttttc tggaatcagt ctttgcattt
541 gcatctcaaa cactatggcg tgaattgtga tgactggtta ttacgtctta tgtgtggagg
601 agtagaaatc agaacaattt atgctgctca taaacaggcg aaggcttgcc tcatttcaag
661 attaagctgt gaacgagctg ggaccaggtt taatgtccgg ggaacaaatg atgatggtca
721 tgttgccaat tttgtagaaa cagaacaggt tgtgtactta gatgactcag tttcttcctt
781 catacaaatc cgaggatctg ttccattgtt ctgggagcaa ccagggttgc aagtgggatc
841 tcatcgtgtc cgtatgtcaa ggggatttga agccaatgca cctgcttttg acaggcattt
901 tagaacactt aagaacttat atggtagaca aataatagta aatttgcttg gatctaagga
961 aggtgaacat atgctaagta aagctttcca gagtcatttg aaagcttctg aacatgctgc
1021 tgatatccag atggtgaatt ttgactatca tcaaatggtt aagggaggaa aggcagaaaa
1081 attacatagt gttcttaaac ctcaagtcca gaagtttcta gattatggat ttttttattt
1141 caatggaagt gaagttcaaa gatgccagag tggtacagtt cgaacaaact gcttggattg
1201 tcttgataga acaaatagtg tgcaggcatt tcttggctta gagatgctag ctaaacagtt
1261 ggaagctctt ggtttagctg aaaagcctca gttggtgact cgctttcaag aagtttttcg
1321 gtcaatgtgg tccgtgaatg gtgattcaat cagtaagata tatgcaggaa ctggagctct
1381 tgaagggaaa gcgaagttaa aagatggtgc tcgctctgtt acccgaacaa ttcagaataa
1441 cttctttgac agctccaagc aagaggccat tgatgttttg ctactgggaa atactctgaa
1501 tagtgattta gctgacaaag ctcgagcact tttaactact ggaagtttgc gtgtttctga
1561 gcagacatta cagtcagcat cttctaaagt actaaagagc atgtgtgaga atttctacaa
1621 atattcaaag cctaagaaaa ttcgagtatg tgtcggaacc tggaatgtga atggtgggaa
1681 gcaatttcgc agcatagctt ttaagaatca gacactcact gactggcttc ttgatgcacc
1741 caagttagct ggcatccagg agtttcaaga taaaagaagt aagccaactg atatatttgc
1801 aattggtttt gaagaaatgg tagaattgaa tgctggaaac attgtgagtg caagcacaac
1861 aaatcagaag ctctgggctg tagaacttca gaagacaatc tccagagaca acaagtatgt
1921 gctgctggct tctgaacagt tggtgggcgt ctgtttgttt gtttttatca gaccacagca
1981 tgctcctttt atcagggatg ttgcagttga tactgtgaag actggaatgg gaggtgcaac
2041 tggaaataag ggagcagttg caatccgaat gctcttccat acaaccagcc tttgcttcgt
2101 ctgtagccac tttgctgcag ggcagtcaca agtcaaagaa agaaatgaag attttataga
2161 aatagcacga aaattgagtt ttcctatggg aaggatgcta ttttcccatg actatgtatt
2221 ttggtgtggt gatttcaact atcgaatcga tctccctaac gaagaagtta aagagctcat
2281 aagacagcaa aattgggatt ctcttatagc aggagatcaa cttatcaatc agaaaaatgc
2341 tggacaggtt tttagaggat ttttagaagg aaaggtaacc tttgctccga catataagta
2401 tgacttgttt tctgacgact atgacaccag tgaaaagtgc cgcacccctg cctggacaga
2461 ccgtgtcctt tggagaagga ggaaatggcc ttttgataga tcagctgaag atctagatct
2521 tctaaatgct agttttcaag atgaaagcaa aattctgtac acgtggactc caggcacttt
2581 gctgcactat ggaagagctg agctgaagac ttctgaccac aggcctgtcg ttgccctgat
2641 tgatatagat atatttgaag ttgaagctga agagaggcaa aacatttata aagaagtaat
2701 tgcagttcag ggtccaccag atggtacagt attggtctca atcaaaagtt ctttaccaga
2761 aaataatttt tttgatgatg ccttgattga tgagcttctg cagcagtttg caagttttgg
2821 tgaagttata cttataagat ttgtagaaga taaaatgtgg gttacatttt tggagggaag
2881 ctctgccttg aatgttctga gcctaaatgg taaagagtta ttgaatcgga ctataactat
2941 tgctttaaaa agtccagact ggatcaaaaa tttggaagaa gaaatgagtt tagagaaaat
3001 tagcattgca ttgccatcat caacaagctc taccctgctt ggtgaagatg cagaggttgc
3061 agcagatttt gatatggaag gtgatgttga tgactatagt gctgaagtgg aggaacttct
3121 tcctcagcat ctccagccat cttcaagttc cggccttggt acttccccca gctcttcacc
3181 ccgaactagt ccctgccagt cacctacaat atcagagggt cctgtacctt cccttcccat
3241 cagaccaagc cgagcaccgt caagaactcc tgggcctccc agtgcacaga gttctcctat
3301 tgacgcgcag ccagcaacgc cgctgccgca gaaagacccc gcccagccct tggagcccaa
3361 gcggccgccg ccgccccgcc cggtcgcccc tcccacacgc ccggctcccc cacagagacc
3421 tcctccgcct tcaggggcta ggagtcctgc acccactaga aaggaatttg gaggtattgg
3481 agcccctccc agtcctgggg tagctaggag agagatggaa gcacccaaaa gccctggaac
3541 aacaaggaaa gataatatag gacgcagtca gccttcacct caagcaggac ttgcaggccc
3601 aggacctgct ggatacagta cagccagacc gacgattcct cctcgtgctg gagttatcag
3661 tgccccacag agccacgcgc gggcatctgc tggaagactg actcctgaaa gccaaagcaa
3721 aacatcagaa acgtcgaaag gttcaacttt ccttcctgaa ccactgaagc ctcaggctgc
3781 ttttcctccg cagtcttctt tgcccccgcc tgctcaaagg ttgcaagagc ctcttgtccc
3841 tgtggcagca cctatgcctc agtctggccc ccagccaaat ttggaaaccc caccacaacc
3901 accacctcga agcaggtcat cccatagctt gccttcagaa gcttcctcac aaccgcaaca
3961 ggagcaacca tcagggtaac aggtaaaaac aaatggaatc tctgatggca aaagagaatc
4021 accattaaag attgacccat ttgaagatct gtcatttaat ctgcttgctg tatcaaaggc
4081 tcagctatct gttcaaacgt cacctgttcc caccccagac ccaaagaggt tgattcagtt
4141 gccttctgca acgcaaagta atgttaatac tttgagttct gtaagttgca tgccaacaat
4201 gcctccaatt ccagctcgga gtcaatccca ggaaaatatg cgaagttctc caaacccatt
4261 tattactggc ttgaccagga caaatccttt cagtgacagg actgctgctc ctggaaaccc
4321 atttagagcc aagtctgaag aatcagaggc aacttcatgg ttctccaaag aagagcccgt
4381 tactatcagt cctttccctt ctctgcagcc tcttggtcat aacaaaagca gggcttcatc
4441 ttcacttgat ggctttaagg acagttttga tctacagggc cagtctacat taaaaattag
4501 caacccgaaa ggatgggtaa ccttcgagga agaagaggat tttggtgtga aagggaagtc
4561 aaagtcagct tgttcagact tactgggtaa tcagccaagt tcattttctg gctccaacct
4621 gacattgaat gatgactgga ataaagggac aaatgtctcc ttctgtgtgt tgccgtcaag
4681 aagacctcct ccacctcctg tccctctgct cccgcccggc accagccctc cagtagatcc
4741 tttcacgacc ttggcctcta aggcttcacc cacactggac tttacagaaa gataacgcca
4801 gcccg
//