LOCUS AF008915 7383 bp mRNA linear HUM 28-NOV-2001
DEFINITION Homo sapiens EVI5 homolog mRNA, complete cds.
ACCESSION AF008915
VERSION AF008915.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7383)
AUTHORS Roberts,T.P. and Cowell,J.C.
TITLE Human EVI5 gene complete cDNA sequence
JOURNAL Hum. Mol. Genet. (1998) In press
REFERENCE 2 (bases 1 to 7383)
AUTHORS Roberts,T., Chernova,O. and Cowell,J.K.
TITLE NB4S, a member of the TBC1 domain family of genes, is truncated as
a result of a constitutional t(1;10)(p22;q21) chromosome
translocation in a patient with stage 4S neuroblastoma
JOURNAL Hum. Mol. Genet. 7 (7), 1169-1178 (1998)
PUBMED 9618176
REFERENCE 3 (bases 1 to 7383)
AUTHORS Roberts,T.P. and Cowell,J.C.
TITLE Direct Submission
JOURNAL Submitted (17-JUN-1997) Neurosciences NC3-150, Cleveland Clinic
Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
FEATURES Location/Qualifiers
source 1..7383
/db_xref="H-InvDB:HIT000061936"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p22"
/tissue_type="brain;liver"
CDS 12..2444
/function="cell cycle regulator"
/note="similar to tre-2 oncogene and TBC1"
/codon_start=1
/product="EVI-5 homolog"
/protein_id="AAC16031.1"
/translation="MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQ
MASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDVLELLAKLEEQNILLETDSKS
LRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELV
HKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKE
KDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRL
RELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPL
PVATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPD
KLIQAAYQVQYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHK
CSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQ
EELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDEL
MTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEKVQYLSAQNKG
LLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQKEEGKLQG
QLNKSDSNQYIGELKDQIAELNHELRCLKGQKGFSGQPPFDGIHIVNHLIGDDESFHS
SDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQKER
PPRRRESYSTTV"
BASE COUNT 2330 a 1296 c 1448 g 2309 t
ORIGIN
1 ttctgcttat catggttacc aacaaaatga ctgctgcctt tagaaaccct agtgggaaac
61 aggtggcgac agacaaagtt gcagaaaagc tgagctctac tctctcatgg gtgaagaaca
121 cagtatcgca tacagtcagt cagatggcca gtcaggtggc aagtccatct acttcattac
181 ataccacatc ctcatctacc acactatcaa caccagccct ttcaccatct tccccatcac
241 agttgagtcc agacgtctta gaactcctgg ctaaactgga agaacagaat atattgttag
301 aaacggatag taagtcttta agatctgtaa atgggtcaag aagaaacagt ggctcttctc
361 ttgtgtcgag ttcatcagcc tctagcaacc tcagtcacct tgaagaagat tcttggattc
421 tttggggaag aattgttaat gaatgggaag atgtacgcaa aaagaaggaa aagcaagtta
481 aggaacttgt tcataaaggg ataccccatc actttagagc aatagtttgg caacttttat
541 gcagtgcaca aagtatgcca attaaggatc agtattcaga actcctgaaa atgacctcgc
601 cttgtgaaaa attgatccga agggacattg ctagaactta ccctgaacac aactttttta
661 aggaaaaaga tagccttgga caggaggttt tatttaatgt aatgaaggct tactctttag
721 tagatcgtga ggttggttac tgtcaaggaa gtgcttttat agttggattg ttgcttatgc
781 agatgccaga agaagaagct ttctgtgtat ttgttaaatt aatgcaagat tatagacttc
841 gtgaactttt taaaccaagt atggcagaat tgggcctttg tatgtaccag tttgaatgta
901 tgatacagga gcatcttcca gagctctttg tacattttca atctcagagt tttcatacct
961 caatgtatgc atcatcctgg tttctgacta tctttcttac aacttttcca ctaccagttg
1021 caacaaggat atttgatatc tttatgtctg agggtttaga aatagtgttt cgtgtaggat
1081 tagcacttct tcagatgaat caggcagaac tgatgcaact tgacatggaa gggatgttac
1141 agcactttca aaaggtcatt ccacatcagt ttgatggtgt cccagacaag ctaatccaag
1201 cagcttacca agtccaatac aattcaaaaa aaatgaaaaa gcttgaaaag gaatacacta
1261 caataaaaac gaaagaaatg gaagagcaag ttgaaattaa aaggttacgc acagaaaata
1321 gacttttaaa acagcgcatc gagacattag aaaaacataa atgcagttcc aactacaacg
1381 aagattttgt gctacagcta gagaaggaat tggtccaagc ccgactgagt gaagctgagt
1441 ctcagtgtgc attaaaagag atgcaggata aagtcttgga tatagagaag aggaataact
1501 cccttcctga tgagaataat attgcaaggc ttcaggaaga actcattgct gtgaaactta
1561 gagaagcaga agccattatg ggtttgaaag aacttagaca gcaagtcaag gatttagagg
1621 aacactggca gcgccactta gctcgtacta ctgggagatg gaaagaccca cccaagaaaa
1681 atgctatgaa tgagttacag gatgaactga tgaccattcg acttagagaa gctgaaacac
1741 aagcagaaat aagagaaata aaacaaagga tgatggaaat ggaaacacag aaccagatca
1801 atagtaacca tcttcgaaga gcagaacaag aggtgattag cctacaggag aaagtgcagt
1861 atctttctgc acagaacaaa ggactcctta ctcaattaag tgaagcaaag cgtaaacaag
1921 cagagattga atgcaagaat aaggaagaag tgatggctgt gaggcttcgg gaagcagata
1981 gcatagctgc tgtggctgaa ctacgacaac acattgctga gcttgaaatc cagaaagaag
2041 aaggaaagct tcaaggacag cttaacaagt ctgattctaa ccagtatatt ggggaactga
2101 aagatcagat agcagagctg aatcatgagc tcaggtgcct aaaaggccag aagggcttct
2161 caggccaacc tccttttgat ggaatccaca ttgtcaacca tttaatagga gatgatgaat
2221 cattccattc ctccgatgaa gattttatag ataattcctt acaggaaact ggtgttggtt
2281 ttcctttgca cggaaaatct ggctcgatgt ctttggaccc cgcagtggca gatggtagtg
2341 agagcgaaac agaagacagt gtgctggaga ccagagagag caaccaagtg gttcaaaagg
2401 agcggccccc gagaagaaga gagtcgtatt caaccactgt ctgaccatca ctgtgaccta
2461 gactatggat ttatttaagg gatcagttat catatgatta gggctttttg gaaataattt
2521 gttttcatat gtatatatat atatatatat atatatttta cagtcttatc tgccttttta
2581 tctttgccaa atctttacca ctgatttacc attgccataa agtagactgg tatatggtta
2641 atgtgtaaaa caaggttcta acagtattac tgaatattaa tgtttcttgt ttagaaaatg
2701 caactatatc tatatgtggg aaccatttct gaagttcaaa actatggaaa attgaatttt
2761 cttcaaacaa aactgctctt gtgcaatatt ttatgctcag tgagcaaatt gtgtatttat
2821 gtttatcaat ttgttcccca ggtggctgtc tacaaacatt tgaccaaaac atacatttga
2881 attaccttgg gttttttttt attggtgttt tttttttaag acagagattc agtttgtcac
2941 ccaggctgga gtgctgtggt gtgattttag ttcactgcaa cttccgcttc ccaggttcaa
3001 gcaattttcc tgcttcagct tcccgagtac ctgggactat atgtgcgcac caccacgcct
3061 ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggctg ggctggtctc
3121 gaactcctaa cctcaagtga tccacccgcc tcagcctccc aaagtgctgg gattacaggt
3181 gtgagccact gcacccagcc taccttgtct gtttgtgtct gggaggtttt ttttttctat
3241 ttttattttt tcatgaaaat tattggtggg ccactgaaag tccccacaca caaagccttt
3301 attctatata attttataaa cacaaattca tgattatctg ttttgagagt tttaagtttt
3361 gttttaatgt ttaactttta tgtgcatatg atgctttcca tgtgttggtt actagagtag
3421 taggttaact acagacatac tgttttgttt gtacatattt ataaatctgt accacctaac
3481 attgaacatc attttatatg aagaacatac atgttgcaaa atgactgctt tcagcatcta
3541 acaggacttc tgtaaataat aggttaaaag ttaaaaataa aacactaatg ttttaagagc
3601 tttagtattt tgcttagcat tcaatactag cagattcata actgatgcct gttcaaaaac
3661 actgttggtg gaatctttta tttcatgtgt atgtaactac taaatttttc atgactgaag
3721 aggttatagc acatattagt tagtgctaat attctactga atataattta agcaatgggc
3781 taaggtccaa gaaacatagc aattatatct acaaataatc tattaacatg atcttcagaa
3841 tctctagttt ttgttctata gataaagcca taagaatcct ttcctaccag tttttcctat
3901 atcatttaga tattatttcc tagaaaacag gatgcctgtc actgataagt tagagaaaac
3961 acccaaatta tacttgcact atggaaagac gacatggatt tgttgtctgg gtactttcta
4021 ctctcatttt tgttagccta tgaaaaaaaa aaacattttg ttaacctatg gaaaaagcct
4081 tggaagagaa aagtagaatt cagtatgtat ggaggcacag ttttgcacag tatgttgcat
4141 gcggcaaaaa aaaaaatatg aaatagagta gaagagataa aagtagtttt ctgtcaaaaa
4201 ctaggagtta agccttcagg tacgttgtgg actaggcttt ccagcaaggt ttttgtagct
4261 atttgcttgc ctgagaaatg aaattgaaaa catacccctg cgtgtctgtc cttaacacca
4321 ggctaaattc tggtggttaa ataacttacc tgtggttaca agctagtaag tagcagagcc
4381 aagatttttt ttaatataga gacaggtgtc tcactgtgtt gtccaggctg gtcttgaact
4441 cctggcctca agtggtcctc ctgcctcagc ctcccaaagt gtggggatta caggtgcgag
4501 ctactgctcc cagcaagagc caagatttta acctagatct ccctaacacc aaagcttttg
4561 aaagggtttc agctgaagaa tttcttcaat tcttctgttt tgtttttatt tttgtttttt
4621 gagatgaagt ctcactgcac tcaggctgga gtgcagtggt acgatcttgg ctcactgcaa
4681 cttccacttc ccgggttcaa gcgattctcc tgcctcagct cccaagtagc tgggactaca
4741 ggtgcacgcc accacaactg gctaattttt gtatttttag tagagatggg gtttcgctat
4801 gttggccagg ctgatctcaa acttctgacc tcaggtgatc cacccacttt gacctcccaa
4861 agtgctggga ttactagacg taagccacca cacctggcaa ttccctgctt ttttgacaac
4921 ataatttaaa tgaatttgat ttaaatgttt cctgaatata tatacagata gatagatgag
4981 tatcaacact tacaagctct acacagtctg tgagtgtaga tactacttac ttgtaggatt
5041 gtcttgtgct ttggggattt ttgttcggag ttctatacta tcagcccaga aagctatcaa
5101 tgtccaagtg aagtgagatg atgcatgcca cattattgct ttgaccttca catcaagaaa
5161 tctgaatgat ctggaccagg gtcagcaaag tgcagcctac aagttattgc agtcagctgc
5221 cagtttttac ttttttaaat agttgggaaa aaaattccaa agactgatat tttgtgtcac
5281 atgaaaatta tatgaaattc aaattgcagt gtccataagt aaagttttat tggggcacac
5341 ccatgctcac ccttttaaat attgtgtatg gccgctttgt gctacagtag cagagttgag
5401 tcattgcaag ggagaccata tggcccaggt agcctaaata tttatctgat cctttacaga
5461 aaaagtttgc taacccttga taacagatac tctaaaatgc aggtttttct tcttcagttt
5521 agctcagtgg taggtcaatt gtttgctttt gctattaagc ttatgatttg gaaacgtaaa
5581 attttcatgg tggatcttat aatcagaact attcaaaagg gaaaacatgc cagccatttt
5641 atatgatgaa gtctcttatt ccatagaaaa ctgtagaaag gtatctgtat ctttggagaa
5701 ggagaaagaa aggaaagaac tccagaatcc catcactgtt ctttaaagca tgcatcacag
5761 acctttaaga gtatgcttta ttgagtaaag gttatagttt gactttaaga taagaaattt
5821 tctagaatca tgtttgaatt ctaaacgttg atattcttaa gtaccatttc tgattaggaa
5881 ttaggtgtta aaagaatcat ggtaaggaaa ccttaatccg ttgaaactct tgtaatttgg
5941 acaacaaaaa actagaaata acactctttt ctttgaagat ctgattcaaa tacaccttag
6001 aagagtttaa aatctcccag gcctttagga tgcaatagga tattatgcct tggtttgact
6061 ccttttcatt caaattaatg taagtatgtt gttcaagact ttgaagcatt gaacaatgtt
6121 ctcgacgaat tttatttaat tactgacatt ttgtgatatt tgaatgttat taagttaaac
6181 acttagagtt gagtatattc aggggagaaa agtgaatgaa atgactcata ataagaaagc
6241 ttgctccctt gggacagtta ccttcctggt gtcattgcca tcctgggttg acaagctgag
6301 agtagaggat acaagtgatg tgaataaaat ggaaattgca ttgagttaat gaaacataca
6361 cttttagatc aagataacat tcaacagcct ttttagaaat tgcacactcc tatagtccca
6421 cttactcaag gaggtggggg cagggaggat cactggagta caggagtttg gggctgtagt
6481 gtgtaatgat caacacctgt gaaagaataa ccactgcact ccaacctggg caacatggca
6541 agaccctgtc tctttaaaaa aaaaaaaaaa tcctgggaaa agaagtcaaa gatgtaattt
6601 tacacaattt ctgcccccac cgtctttttt gtttgtttgt ttgtttgttt gttttttggc
6661 tagatactag gtattcagtg tttgctgaga tgacaggttt ctactaatca gccagttatt
6721 tgggaaggag aaaaactttt tctcaattct gaacatgatg cagcttgtta actctccaga
6781 tagtgccttt gattgaaaat aaggtctaca cctttttaag tatattattt ctgacatcgt
6841 aagaaataat ttagttcctt attctcattt atcttttata taatgtactg taatattcag
6901 gtttaaagta aaataagtat atggaattat attttggtaa aactgtttca tgaccagctt
6961 gattaatgta tattaacata ccagacattg acagcgaaca tttcatgaaa tcagttattt
7021 acttactaaa acaatgagtt ttagcttgaa agttactgct gctctattat taacaaaact
7081 aagttttaaa aattaatttt aattctactg aagtttaatt tctggttaaa ggtatagtgg
7141 atgctattta tgatccaagt ttttacatca catccattga tctgcctatc ccttcttttt
7201 actccaaaga ggagatgata gaataataca ttcagtatac taccaagaag caaagttata
7261 atgtgtttca ttttgctatt ggaatttttt attgtaacat tgtatgataa cctgaaatgt
7321 ttacttgtgc cttttcttta aacaattaaa gttttccatt ttataagaaa caaaaaaaaa
7381 aaa
//