LOCUS       AF007567                3939 bp    mRNA    linear   HUM 10-SEP-1997
DEFINITION  Homo sapiens insulin receptor substrate 4 mRNA, complete cds.
ACCESSION   AF007567
VERSION     AF007567.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3939)
  AUTHORS   Lavan,B.E., Fantin,V.R., Chang,E.T., Lane,W.S., Keller,S.R. and
            Lienhard,G.E.
  TITLE     A novel 160-kDa phosphotyrosine protein in insulin-treated
            embryonic kidney cells is a new member of the insulin receptor
            substrate family
  JOURNAL   J. Biol. Chem. 272 (34), 21403-21407 (1997)
   PUBMED   9261155
REFERENCE   2  (bases 1 to 3939)
  AUTHORS   Lavan,B.E., Fantin,V.R., Chang,E.T., Lane,W.S., Keller,S.R. and
            Lienhard,G.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-1997) Biochemistry, Dartmouth Medical School,
            Hanover, NH 03755, USA
FEATURES             Location/Qualifiers
     source          1..3939
                     /db_xref="H-InvDB:HIT000061907"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="293"
                     /tissue_type="kidney"
                     /dev_stage="embryo"
     CDS             79..3852
                     /function="tyrosine kinase substrate"
                     /codon_start=1
                     /product="insulin receptor substrate 4"
                     /protein_id="AAC51738.1"
                     /translation="MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALI
                     GTGSSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLET
                     ADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRA
                     DARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPA
                     ALAAAAAAEPPFYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVV
                     VQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCAD
                     EYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDE
                     MLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAPSPARPRHPAEAP
                     NNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSN
                     GQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGG
                     GHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQ
                     QQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGA
                     ARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPMAPQNVSASKKRHSRSPFEDS
                     RGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYMFMAPGAGAIPKNPRNPQG
                     GSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAAS
                     KPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHEQRE
                     ADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYVNVEFGVPFPNPA
                     NDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMA
                     LADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSR
                     SQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGI
                     GAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAG
                     GAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR"
BASE COUNT          950 a         1102 c         1103 g          784 t
ORIGIN      
        1 ggtcagggta gttccccaac cctccctttc gtgaattccc cctcgtcctc gctcacctta
       61 aaaccatcgt gcatcaccat ggcgagttgc tccttcactc gcgaccaagc gacaagaaga
      121 ctaagaggtg cagcagcggc ggcagcggca gctctagcag cagtggtgac caccccgctt
      181 ctttcctcgg gaaccccgac cgcactcatt gggaccgggt cgtcttgtcc gggagccatg
      241 tggctctcca cggccactgg ctcccggtca gactccgagt ccgaagagga ggacctgccc
      301 gtcggggagg aagtctgcaa acgcggctac ctgcggaaac agaagcatgg gcacaggcgc
      361 tacttcgtgc tcaaactcga gactgctgac gccccagctc ggctggaata ctacgaaaat
      421 gccaggaagt tccggcacag tgtccgcgcc gcggcggctg cagcagcggc ggccgcctct
      481 ggcgccgcga tccccccgct cattccaccg cggcgcgtga tcaccctata ccagtgcttt
      541 tccgtgagcc agcgagcaga tgcaaggtac cgacacctca ttgctctttt cacccaagac
      601 gaatacttcg cgatggtggc cgagaacgag tcggagcagg aaagctggta cttgctgctc
      661 agccgcctca tcctcgagag caagcgccgc cgctgcggca cgctcggcgc gcagccggac
      721 ggagagccgg ccgcgctggc ggcggcagcg gcggcggagc cacccttcta taaagatgtg
      781 tggcaggtaa tagtcaaacc cagggggctg gggcacagaa aagagctgag cggcgtgttc
      841 cggctgtgtc taaccgacga ggaggtcgtg tttgtgaggc tgaacaccga agtggccagc
      901 gtggtcgtcc agctcctgag catccgtcgc tgtggacact cggagcagta tttcttcttg
      961 gaagtaggca ggtccactgt catcggtccg ggagagctct ggatgcaggt cgatgactgt
     1021 gtggttgccc aaaacatgca tgagctgttt ttggagaaga tgagagcctt gtgtgcagac
     1081 gaatacagag cccgctgccg cagctacagc atcagcatcg gcgcccacct gttaaccctg
     1141 ctgtccgcta ggaggcacct gggcttggtg ccgctcgagc cgggaggctg gctcagaagg
     1201 tcccgctttg agcagttttg ccacctcagg gccatcggcg acggggaaga cgagatgctt
     1261 ttcaccaggc gcttcgtaac acccagcgag cctgtggccc actccaggcg aggaagactg
     1321 cacctgccca gagggcgcag gtcaaggaga gcggtttcag tgccggccag cttttttcgc
     1381 cgcttagcac ccagcccagc acgtccccgg caccctgcag aagccccgaa caatggagct
     1441 cgcctgtctt ctgaagtgtc tggttctggc tctggcaact ttggggagga aggcaatccc
     1501 cagggcaaag aagatcagga aggaagcgga ggtgactaca tgcctatgaa caattggggc
     1561 tcaggaaatg gccggggctc aggaggtggc cagggctcaa atggccaagg ctccagtagc
     1621 catagctcgg gaggaaacca gtgttcaggc gagggacagg gatcccgagg tggtcagggc
     1681 tcaaatggcc agggctcagg aggaaaccag tgctctagag atggccaggg caccgcaggt
     1741 gggcacggtt caggtggtgg ccagagacct ggaggtgggc atggctcagg tggtggccag
     1801 ggacctggag atggccatgg ctcaggtggt ggcaagaact ctgggggggg caaaggctca
     1861 ggaagtggga aaggatccga tggtgatggt gaacgtggaa aatctctgaa gaaaagatcc
     1921 tattttggca aattaactca aagcaagcaa cagcaaatgc caccacctcc accacctcct
     1981 cctccacccc caccagctgg aggaactggt ggaaaaggga agtctggggg aagattcaga
     2041 ctttattttt gtgttgacag aggagccacg aaagaatgca aagaagccaa agaagtgaaa
     2101 gatgcagaga tcccagaagg tgcagctcga ggtccccaca gagccagagc ttttgatgaa
     2161 gatgaggatg acccatacgt gccaatgagg ccaggggtgg ccacccctct tgtaagctcc
     2221 agtgattata tgccaatggc tcctcaaaat gtctctgctt caaaaaagcg ccactctcga
     2281 tccccttttg aagattcaag agggtacatg atgatgtttc ccagagtgag cccaccacct
     2341 gctccgagtc ctccaaaagc acctgatact aataaagagg atgactcaaa ggacaatgac
     2401 agtgagagtg actacatgtt tatggctcct ggagccggtg caattccaaa aaaccccaga
     2461 aatcctcagg gtggctcttc ctccaaaagt tggagctcct acttctctct accaaaccct
     2521 tttcggagct cacctttggg acagaatgac aacagtgagt atgtgccaat gttacctgga
     2581 aagttcctgg ggaggggcct agacaaagaa gtctcctata actgggaccc caaagatgca
     2641 gcttcaaagc cttcaggtga gggatcattc tcaaagcctg gagatggggg atcaccttca
     2701 aagccttcag atcatgagcc cccaaagaat aaagctaaga gacctaaccg actttctttt
     2761 attacaaaag gatataaaat caagccaaaa ccacaaaagc ccacacatga gcagagagaa
     2821 gctgacagct ctagtgacta cgtcaacatg gacttcacta aaagagagag caatacacca
     2881 gctccctcta ctcaaggact accagattcg tggggcataa ttgctgaacc cagacagtca
     2941 gccttttcta attatgtgaa tgttgagttt ggagtgccat ttccaaatcc agcaaacgac
     3001 ctctcagatc ttttaagagc tataccacgt gccaacccct tatctctgga cagtgctagg
     3061 tggccacttc ctccccttcc cctcagtgct acaggtagca atgctattga ggaagagggt
     3121 gactacattg aagtaatttt caactcagca atgacaccag ccatggctct tgctgacagt
     3181 gccattcgct atgatgctga aacaggtcga atctatgtgg tcgacccatt ttctgagtgc
     3241 tgtatggata tttctctctc ccccagccga tgttctgaac caccacctgt agctaggctg
     3301 ctgcaggaag aagagcagga gagaagacgc ccacaaagcc gttctcaaag tttctttgca
     3361 gcagccagag ccgctgtctc tgcttttcca acagacagcc tcgagagaga cctttcccca
     3421 tcctcagccc cggctgtcgc ttcggctgca gagccgactt tagccctcag ccaagttgta
     3481 gctgcggcct ccgcgctcgc cgcagccccg ggcatcggcg cagcagccgc agctgctgga
     3541 tttgactccg cctctgcccg ctggtttcaa cctgttgcta atgctgctga tgccgaagca
     3601 gtaaggggag cccaagacgt tgccggtggc tcgaaccctg gagcccacaa cccatctgca
     3661 aaccttgcca gaggtgataa ccaggctggc ggggctgccg ctgcagctgc cgctccggaa
     3721 ccaccacctc gcagtcgccg ggtgccaaga cccccggaga gagaagattc tgacaacgac
     3781 gacgacactc acgtgagaat ggattttgcc agacgtgata atcagttcga ctctcccaaa
     3841 agaggtcggt aattttagaa ttaatttccc taaagtgaat ggtcattgtc taatgattcg
     3901 atgcgctaca gtctacagtg ttagggtata tttcattaa
//