LOCUS       AF007216                7586 bp    mRNA    linear   HUM 26-JUL-1997
DEFINITION  Homo sapiens sodium bicarbonate cotransporter (HNBC1) mRNA,
            complete cds.
ACCESSION   AF007216
VERSION     AF007216.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7586)
  AUTHORS   Burnham,C.E., Amlal,H., Wang,Z., Shull,G.E. and Soleimani,M.
  TITLE     Cloning and functional expression of a human kidney Na+:HCO3-
            cotransporter
  JOURNAL   J. Biol. Chem. 272 (31), 19111-19114 (1997)
   PUBMED   9235899
REFERENCE   2  (bases 1 to 7586)
  AUTHORS   Burnham,C.E., Amlal,H., Wang,Z., Shull,G.E. and Soleimani,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-1997) Nephrology, University of Cincinnati, 231
            Bethesda Avenue, Cincinnati, OH 45267-0585, USA
FEATURES             Location/Qualifiers
     source          1..7586
                     /db_xref="H-InvDB:HIT000061900"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /sex="male"
                     /tissue_type="kidney"
                     /dev_stage="38 year old"
                     /note="Caucasian"
     gene            1..7586
                     /gene="HNBC1"
     CDS             150..3257
                     /gene="HNBC1"
                     /note="Na+:HCO3- cotransporter"
                     /codon_start=1
                     /product="sodium bicarbonate cotransporter"
                     /protein_id="AAC51645.1"
                     /translation="MSTENVEGKPSNLGERGRARSSTFLRVVQPMFNHSIFTSAVSPA
                     AERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWS
                     KPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKV
                     TYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDIS
                     DKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVP
                     TRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVI
                     VLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEEL
                     QRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDA
                     TDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLE
                     FRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADY
                     YPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAF
                     LSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKL
                     ISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAA
                     AIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYV
                     AATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFI
                     PMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQV
                     LCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKED
                     EKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLE
                     RHTSC"
BASE COUNT         2211 a         1473 c         1501 g         2401 t
ORIGIN      
        1 gttctttgtg acacatcaca cagaattgga gtgctgtcct tctggagagt ggtggagaac
       61 caagatacag ttcagaacca aaggaataga gaagggcttt gatttctttt tggctttaga
      121 ttggggattt gggaggctta gcaggaaaga tgtccactga aaatgtggaa gggaagccca
      181 gtaaccttgg ggagagagga agagcccgga gctccacttt cctcagggtt gtccagccaa
      241 tgtttaacca cagtattttc acttctgcag tctctcctgc tgcagaacgc atccgattca
      301 tcttgggaga ggaggatgac agcccagctc cccctcagct cttcacggaa ctggatgagc
      361 tgctggccgt ggatgggcag gagatggagt ggaaggaaac agccaggtgg atcaagtttg
      421 aagaaaaagt ggaacagggt ggggaaagat ggagcaagcc ccatgtggcc acattgtccc
      481 ttcatagttt atttgagctg aggacatgta tggagaaagg atccatcatg cttgatcggg
      541 aggcttcttc tctcccacag ttggtggaga tgattgttga ccatcagatt gagacaggcc
      601 tattgaaacc tgaacttaag gataaggtga cctatacttt gctccggaag caccggcatc
      661 aaaccaagaa atccaacctt cggtccctgg ctgacattgg gaagacagtc tccagtgcaa
      721 gtaggatgtt taccaaccct gataatggta gcccagccat gacccatagg aatctgactt
      781 cctccagtct gaatgacatt tctgataaac cggagaagga ccagctgaag aataagttca
      841 tgaaaaaatt gccacgtgat gcagaagctt ccaacgtgct tgttggggag gttgactttt
      901 tggatactcc tttcattgcc tttgttaggc tacagcaggc tgtcatgctg ggtgccctga
      961 ctgaagttcc tgtgcccaca aggttcttgt tcattctctt aggtcctaag gggaaagcca
     1021 agtcctacca cgagattggc agagccattg ccaccctgat gtctgatgag gtgttccatg
     1081 acattgctta taaagcaaaa gacaggcacg acctgattgc tggtattgat gagttcctag
     1141 atgaagtcat cgtccttcca cctggggaat gggatccagc aattaggata gagcctccta
     1201 agagtcttcc atcctctgac aaaagaaaga atatgtactc aggtggagag aatgttcaga
     1261 tgaatgggga tacgccccat gatggaggtc acggaggagg aggacatggg gattgtgaag
     1321 aattgcagcg aactggacgg ttctgtggtg gactaattaa agacataaag aggaaagcgc
     1381 cattttttgc cagtgatttt tatgatgctt taaatattca agctctttcg gcaattctct
     1441 tcatttatct ggcaactgta actaatgcta tcacttttgg aggactgctt ggggatgcca
     1501 ctgacaacat gcagggcgtg ttggagagtt tcctgggcac tgctgtctct ggagccatct
     1561 tttgcctttt tgctggtcaa ccactcacta ttctgagcag caccggacct gtcctagttt
     1621 ttgagaggct tctatttaat ttcagcaagg acaataattt tgactatttg gagtttcgcc
     1681 tttggattgg cctgtggtcc gccttcctat gtctcatttt ggtagccact gatgccagct
     1741 tcttggttca atacttcaca cgtttcacgg aggagggctt ttcctctctg attagcttca
     1801 tctttatcta tgatgctttc aagaagatga tcaagcttgc agattactac cccatcaact
     1861 ccaacttcaa agtgggctac aacactctct tttcctgtac ctgtgtgcca cctgacccag
     1921 ctaatatctc aatatctaat gacaccacac tggccccaga gtatttgcca actatgtctt
     1981 ctactgacat gtaccataat actacctttg actgggcatt tttgtcgaag aaggagtgtt
     2041 caaaatacgg aggaaacctt gtcgggaaca actgtaattt tgttcctgat atcacactca
     2101 tgtcttttat cctcttcttg ggaacctaca cctcttccat ggctctgaaa aaattcaaaa
     2161 ctagtcctta ttttccaacc acagcaagaa aactgatcag tgattttgcc attatcttgt
     2221 ccattctcat cttttgtgta atagatgccc tagtaggcgt ggacacccca aaactaattg
     2281 tgccaagtga gttcaagcca acaagtccaa accgaggttg gttcgttcca ccgtttggag
     2341 aaaacccctg gtgggtgtgc cttgctgctg ctatcccggc tttgttggtc actatactga
     2401 ttttcatgga ccaacaaatt acagctgtga ttgtaaacag gaaagaacat aaactcaaga
     2461 aaggagcagg gtatcacttg gatctctttt gggtggccat cctcatggtt atatgctccc
     2521 tcatggctct tccgtggtat gtagctgcta cggtcatctc cattgctcac atcgacagtt
     2581 tgaagatgga gacagagact tctgcacctg gagaacaacc aaagtttcta ggagtgaggg
     2641 aacaaagagt cactggaacc cttgtgttta ttctgactgg tctgtcagtc tttatggctc
     2701 ccatcttgaa gtttataccc atgcctgtac tctatggtgt gttcctgtat atgggagtag
     2761 catcccttaa tggtgtgcag ttcatggatc gtctgaagct gcttctgatg cctctgaagc
     2821 atcagcctga cttcatctac ctgcgtcatg ttcctctgcg cagagtccac ctgttcactt
     2881 tcctgcaggt gttgtgtctg gccctgcttt ggatcctcaa gtcaacggtg gctgctatca
     2941 tttttccagt aatgatcttg gcacttgtag ctgtcagaaa aggcatggac tacctcttct
     3001 cccagcatga cctcagcttc ctggatgatg tcattccaga aaaggacaag aaaaagaagg
     3061 aggatgagaa gaaaaagaaa aagaagaagg gaagtctgga cagtgacaat gatgattctg
     3121 actgcccata ctcagaaaaa gttccaagta ttaaaattcc aatggacatc atggaacagc
     3181 aacctttcct aagcgatagc aaaccttctg acagagaaag atcaccaaca ttccttgaac
     3241 gccacacatc atgctgataa aattcctttc cttcagtcac tcggtatgcc aagtcctcct
     3301 agaactccag taaaagttgc ctcaaattag actagaactt gaacctgaag acaatgatta
     3361 tttctggagg agcaagggaa cagaaactac attgtaacct gtttgtcttt cttaaaactg
     3421 acatttgttg ttaatgtcat ttgtttttgt ttggctgttt gtttattttt taacttttat
     3481 ttcgtctcag tttttggtca caggccaaat aatacagcgc tctctctgct tctctcttgc
     3541 atagatacaa tcaagacaat agtgcaccgt tccttaaaaa cagcatctga ggaatccccc
     3601 ttttgttctt aaactttcag atgtgtcctt tgataaccaa attctgtcac tcaagacaca
     3661 gacacccaca gaccctgtcc tttgcctcta ttaagcagag gatggaagta ttaaggattt
     3721 tgtaacacct tttatgaaaa tgttgaagga acttaaaact ttagctttgg agctgtgctt
     3781 actggcttgt ctttgtctgg tagaacaaac cttgacctcc agacagagtc ccttctcact
     3841 tatagagctc tccaggactg gaaaaagtgc tgctatttta acttgctctt gcttgtaaat
     3901 cctaatctta gagttatcaa aagaagaaaa aactgaaggt actttactcc ctatagagaa
     3961 accattgcca tcattgtagc aagtgctgga atgtcccttt tttcctatgc aactttttta
     4021 taacccttta atgaacttat ctgtggagta cattgaagaa tatttttctt cctagatttt
     4081 gttgtttaaa ttatggggcc taacctgcca cttatttttt gtcaattttt aaaacttttt
     4141 tttaattact gtaaagaaaa tgaatttttt cctgcagcag gaaacatagt tttcagtagt
     4201 tctacctctt atttgtagct gccaggcttt ctgtaaaaat tgtattgtat ataatgtgat
     4261 ttttacacat acatacacac acaaatacac aatctctagg gtaagccaga aggcaagatc
     4321 agattaaaaa caccatgttt ctaagcatcc atttttccct ttctttaaaa gaaacttaac
     4381 tgttctatga aggagattga gggagaagag acaaactcct atgtcatgag aataaccgat
     4441 gttctgataa tagtagcatc taggtacaga tgctggttgt attaccacgt caatgtccta
     4501 tgcagtattg ttagacattt tctcattttg aaatatttgt gtgtttgtgt atgtgctctg
     4561 tgccatggct ggtgtatata tgtgcaatgt tagaaggcaa aagagtgatg gtaggcagag
     4621 ggcaaagtca ttgaatctct tatgccagtt ttcataaaac ccaaaccaca tatgaaaaaa
     4681 tccattaagg gtccaagaag tctgtccata tgaaaatgag ggtaaatata gtttatttcc
     4741 caggtatcag tcattataat tgatataata gctctaacat gcaatataaa attcatagga
     4801 gtattaatag cccatttaca catctataaa atgtaatggg attgcagagc tgcagagtac
     4861 agtgtaacag tactctcatg caattttttt caggatgcaa aggcaattat tctttgtaag
     4921 cgggacattt agatatattt gtgtacatat tatatgtatg tatatttcaa agtaccacac
     4981 tgaaaattag acatttatta accaaattta acgtggtatt taaaggtaat atttttaata
     5041 tgatacatta catattgtga atgtatacta aaaaaacatt ttaaatgtta aaattataat
     5101 ttcagattca tataaccaca actgtgatat atcctaacta taaccagttg ttgaggggta
     5161 tactagaagc agaatgaaac cacatttttt ggtttgataa tatgcactta ttgactccca
     5221 ctcattgtta tgttaattaa gttattattc tgtctccttg taattttgat tacaaaaatt
     5281 ttattatcct gagttagctg ttacttttac agtacctgat actcctaaaa cttttaactt
     5341 atacaaatta gtcaataatg accccaattt tttcattaaa ataatagtgg tgaattatat
     5401 gttattgtgt taaaacctca cttgccaaat tctggcttca catttgtatt tagggctatc
     5461 cttaaaatga tgagtctata ttatctagct ttctattacc ctaatataaa ctggtataag
     5521 aagactttcc ttttttcttt atgcatggaa gcatcaataa attgtttaaa aaccatgtat
     5581 agtaaattca gcttaacccg tgatcttctt aagttaaagg tacttttgtt ttataaaagc
     5641 tctagataaa actttctttt ctgatcatga atcaagtatc tgtggtttca tgcccctctc
     5701 tatacctttc aaagaactcc tgaagcaact taactcatca tttcagcctc tgagtagagg
     5761 taaaacctat gtgtacttct gtttatgatc catattgata tttatgacat gaacacagaa
     5821 tagtacctta catttgctaa acagacagtt aatatcaaat cctttcaata ttctgggaac
     5881 ccagggaagt ttttaaaaat gtcattactt tcaaaggaac agaagtagtt aaccaaacta
     5941 acaagcaaaa cctgaggttt acctagtgac accaaattat cggtatttta actgaattta
     6001 cccattgact aagaatgaac cggatttggt ggtggttttg tttctatgca aactggacac
     6061 aaattacaac agtaaatttt tttataagtg cttctccctt ctccatgatg tgacttccgg
     6121 agataaagga ttcaaaagat aaagacaaag tacgctcaga gttgttaacc agaaagtcct
     6181 ggctgtggtt gcagaaacac tgttggaaga aaagagatga ctaagtcaag tgtctgcctt
     6241 atcaaaagag caaaaatgcc tctggttttg tgtttgggag aaaaatatct tggacgcact
     6301 gttttccttg ataaaagtca tcttctctac tgtgtgaaat gaatacttgg aattctaatt
     6361 gttttgtgtg ccaggggcag taatgtccct gcctcttctc ccaatcaagg ttgaggagtg
     6421 gggctgggga gaggacttaa ctgacttaag aagtaggaaa acaaaaacct ctctcctcag
     6481 ccttccacct ccaagagagg aggaaaaaca gttgtctgct gtctgtaatt cagtttgcgt
     6541 gtattttatg ctcatgcacc aacccataca gagtaaatct tttatcaact atatactggt
     6601 gtttaataga gaatgattgt cttccgagtt ttttggttcc ttttttaact gtgttaaagt
     6661 acttgaaatg tattgactgc tgactatatt ttaaaaacaa aatgaaataa tttgagttgt
     6721 attacagagg ttgacattgt tcagggatgg gacaaagcct tcttcaatcc ttttcatact
     6781 acttaatgat tttggtgcag gaacctgaga ttttctgatt tatatttcat gatatttcac
     6841 atttgctctt cacagcatga gcatgaagcc cagtggcacc aaatggctgg gtacaatcaa
     6901 gtgatatttt gtagcacctc actatctgaa aggccatgag ttttcagatg atttcattga
     6961 gcttcattgc agcctgaaat tttaaaaaag ttgtgtaata cgccaaccag tcaagttgtg
     7021 ttttggccag agatttagat atgtccaatt tcctggctca tttcattgtg ctctatgggt
     7081 acgtataaaa agcaagaatt ctgtttccta ggcaaacatt gcaactcagg gctaaagtca
     7141 tccagtgaaa cttttagagc cagaagtaac tttgtcccag tcctacaatg tgaaaagagt
     7201 gaatagttgc ctctttttag ccattttcat ggctggtaca tattcgtacg cattactttt
     7261 cagaatcaat acgcactttc agatattctt atttttattc tcttaagtct ttattaactt
     7321 tggagagaga aatgatgcat ctttttattt taaatgaagt agatcaacat ggtggaacaa
     7381 aatgataaag aacagaaaac atttcaatat attactaata actttttcca atataaatcc
     7441 taaaattcct ataacatagt attttacagt tttatgaagc tttctattgt gacttttatg
     7501 gaattaagag atgaagaaga tgagatattt tagcatttat atttttcaaa attatatgta
     7561 tacttaaaaa taaagtaact ttatgc
//