LOCUS AF006010 8509 bp mRNA linear HUM 30-JUL-2001
DEFINITION Homo sapiens progestin induced protein (EDD) mRNA, complete cds.
ACCESSION AF006010
VERSION AF006010.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8509)
AUTHORS Callaghan,M.J., Russell,A.J., Woollatt,E., Sutherland,G.R.,
Sutherland,R.L. and Watts,C.K.
TITLE Identification of a human HECT family protein with homology to the
Drosophila tumor suppressor gene hyperplastic discs
JOURNAL Oncogene 17 (26), 3479-3491 (1998)
PUBMED 10030672
REFERENCE 2 (bases 1 to 8509)
AUTHORS Callaghan,M.J., Russell,A.J., Sutherland,R.L. and Watts,C.K.W.
TITLE Direct Submission
JOURNAL Submitted (29-MAY-1997) Cancer Research, Garvan Institute of
Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010,
Australia
REFERENCE 3 (bases 1 to 8509)
AUTHORS Callaghan,M.J., Russell,A.J., Sutherland,R.L. and Watts,C.K.W.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2001) Cancer Research, Garvan Institute of
Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010,
Australia
REMARK Sequence update by submitter
COMMENT On Jul 30, 2001 this sequence version replaced AF006010.1.
FEATURES Location/Qualifiers
source 1..8509
/db_xref="H-InvDB:HIT000061808"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q22"
/cell_line="T-47D"
/tissue_type="breast tumor"
gene 1..8509
/gene="EDD"
/gene_synonym="DD5"
CDS 34..8433
/gene="EDD"
/gene_synonym="DD5"
/note="HECT E3; ubiquitin-protein ligase"
/codon_start=1
/product="progestin induced protein"
/protein_id="AAD01259.2"
/translation="MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLE
QATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTS
RPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRV
IRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNL
AVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDIS
YFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGS
TSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDET
LSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEK
ARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVW
NMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKF
PGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI
PEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERN
VAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPA
NSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISH
RCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSN
GPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDP
PAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFI
LKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISS
SEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLES
LCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTAT
NLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTI
RLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVF
VILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPT
APFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQ
PVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGS
DMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQS
NDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRA
ASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSL
ARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWM
VSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRR
ATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWI
KAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAET
GQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGL
YSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEET
ESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWR
LSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDR
DLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSN
EKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF
RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLE
LSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKR
HGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGL
CLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFS
AMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAM
RKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKR
WFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCIS
RLYVPLYSSKQILKQKLLLAIKTKNFGFV"
BASE COUNT 2502 a 1737 c 2032 g 2238 t
ORIGIN
1 cgccctcgag tggaggacga gaaggaaagc accatgacgt ccatccattt cgtggttcac
61 ccgctgccgg gcaccgagga ccagctcaat gacaggttac gagaagtttc tgagaagctg
121 aacaaatata atttaaacag ccacccccct ttgaatgtat tggaacaggc tactattaaa
181 cagtgtgtgg tgggaccaaa tcatgctgcc tttcttcttg aggatggtag agtttgcagg
241 attggttttt cagtacagcc agacagattg gaattgggta aacctgataa taatgatggg
301 tcaaagttga acagcaactc gggggcaggg aggacgtcaa ggcctggtag gacaagcgac
361 tctccatggt ttctctcagg ttctgagact ctaggcaggc tggcaggcaa caccttagga
421 agccgctgga gttctggagt gggtggaagt ggtggaggat cctctggtag gtcatcagct
481 ggagctcgag attcccgccg gcagactcga gttattcgga caggacggga tcgagggtct
541 gggcttttgg gcagtcagcc ccagccagtt attccagcat ctgtcattcc agaggagctg
601 atttcacagg cccaagttgt tttacaaggc aaatccagaa gtgtcattat tcgagaactt
661 cagagaacaa atcttgatgt gaaccttgct gtaaataatt tacttagccg ggatgatgaa
721 gatggagatg atggggatga tacagccagc gaatcttatt tgcctggaga ggatcttatg
781 tctctccttg atgccgacat tcattctgcc cacccaagtg tcattattga tgcagatgcc
841 atgttttctg aagacattag ctattttggt tacccttctt ttcgtcgttc atcactttcc
901 aggctaggct catctcgagt tctccttctt cccttagaga gagactctga gctgttgcgt
961 gaacgtgaat ccgttttacg tttacgtgaa cgaaggtggc ttgatggagc ctcatttgat
1021 aatgaaaggg gttctaccag caaggaagga gagccaaact tggataagaa gaatacacct
1081 gttcaaagtc cagtatctct aggagaagat ttgcagtggt ggcctgataa ggatggaaca
1141 aaattcatct gtattggggc tctgtattct gaacttctgg ctgtcagcag taaaggagaa
1201 ctttatcagt ggaaatggag tgaatctgag ccttacagaa atgcccagaa tccttcatta
1261 catcatccac gagcaacatt tttggggtta accaatgaaa agatagtcct cctgtctgca
1321 aatagcataa gagcaactgt agctacagaa aataacaagg ttgctacatg ggtggatgaa
1381 actttaagtt ctgtggcttc taaattagag cacactgctc agacttactc tgaacttcaa
1441 ggagagcgga tagtttcttt acattgctgt gccctttaca cctgcgctca gctggaaaac
1501 agtttatatt ggtggggtgt agttcctttt agtcaaagga agaaaatgtt agagaaagct
1561 agagcaaaaa ataaaaagcc taaatccagt gctggtattt cttcaatgcc gaacatcact
1621 gttggtaccc aggtatgctt gagaaataat cctctttatc atgctggagc agttgcattt
1681 tcaattagtg ctgggattcc taaagttggt gtcttaatgg agtcagtttg gaatatgaat
1741 gacagctgta gatttcaact tagatctcct gaaagcttga aaaacatgga aaaagctagc
1801 aaaactactg aagctaagcc tgaaagtaag caggagccag tgaaaacaga aatgggtcct
1861 ccaccatctc cagcatccac gtgtagtgat gcatcctcaa ttgccagcag tgcatcaatg
1921 ccatacaaac gacgacggtc aacccctgca ccaaaagaag aggaaaaggt gaatgaagag
1981 cagtggtctc ttcgggaagt ggtttttgtg gaagatgtca agaatgttcc tgttggcaag
2041 gtgctaaaag tagatggtgc ctatgttgct gtaaaatttc caggaacctc cagtaatact
2101 aactgtcaga acagctctgg tccagatgct gacccttctt ctctcctgca ggattgtagg
2161 ttacttagaa ttgatgaatt gcaggttgtc aaaactggtg gaacaccgaa ggttcccgac
2221 tgtttccaaa ggactcctaa aaagctttgt atacctgaaa aaacagaaat attagcagtg
2281 aatgtagatt ccaaaggtgt tcatgctgtt ctgaagactg gaaattgggt gcgatactgt
2341 atctttgatc ttgctacagg aaaagcagaa caggaaaata attttcctac aagcagcatt
2401 gctttccttg gtcagaatga gaggaatgta gccattttca ctgctggaca ggaatctccc
2461 attattcttc gagatggaaa tggtaccatc tacccaatgg ccaaagattg catgggagga
2521 ataagggatc ccgattggct ggatcttcca cctattagta gtcttggaat gggtgtgcat
2581 tctttaataa atcttcctgc caattcaaca atcaaaaaga aagctgctgt tatcatcatg
2641 gctgtagaga aacaaacctt aatgcaacac attctgcgct gtgactatga ggcctgtcga
2701 caatatctaa tgaatcttga gcaagcggtt gttttagagc agaatctaca gatgctgcag
2761 acattcatca gccacagatg tgatggaaat cgaaatattt tgcatgcttg tgtatcagtt
2821 tgctttccaa ccagcaataa agaaactaaa gaagaagagg aagcggagcg ttctgaaaga
2881 aatacatttg cagaaaggct ttctgctgtt gaggccattg caaatgcaat atcagttgtt
2941 tcaagtaatg gcccaggtaa tcgggctgga tcatcaagta gccgaagttt gagattacgg
3001 gaaatgatga gacgttcgtt gagagcagct ggtttgggta gacatgaagc tggagcttca
3061 tccagtgacc accaggatcc agtttcaccc cccatagctc cccctagttg ggttcctgac
3121 cctcctgcga tggatcctga tggtgacatt gattttatcc tggcccccgc tgtgggatct
3181 cttaccacag cagcaaccgg tactggtcaa ggaccaagca cctccactat tccaggtcct
3241 tccacagagc catctgtagt agaatccaag gatcgaaagg cgaatgctca ttttatattg
3301 aaattgttat gtgacagtgt ggttctccag ccctatctac gagaacttct ttctgccaag
3361 gatgcaagag ggatgacccc atttatgtca gctgtaagtg gccgagctta tcctgctgca
3421 attaccatct tagaaactgc tcagaaaatt gcaaaagctg aaatatcctc aagtgaaaaa
3481 gaggaagatg tattcatggg aatggtttgc ccatcaggta ccaaccctga tgactctcct
3541 ttatatgttt tatgttgtaa tgacacttgc agttttacat ggactggagc agagcacatt
3601 aaccaggata tttttgagtg tcgaacttgt ggcttgctgg agtcactgtg ttgttgtacg
3661 gaatgtgcaa gggtttgtca taaaggtcat gattgcaaac tcaaacggac atcaccaaca
3721 gcctactgtg attgttggga gaaatgtaaa tgtaaaactc ttattgctgg acagaaatct
3781 gctcgtcttg atctacttta tcgcctgctc actgctacta atctggttac tctgccaaac
3841 agcaggggag agcacctctt actattctta gtacagacag tcgcaaggca gacggtggag
3901 cattgtcaat acaggccacc tcgaatcagg gaagatcgta accgaaaaac agccagtcct
3961 gaagattcag atatgccaga tcatgattta gagcctccaa gatttgccca gcttgcattg
4021 gagcgtgttc tacaggactg gaatgccttg aaatctatga ttatgtttgg gtcgcaggag
4081 aataaagacc ctcttagtgc cagcagtaga ataggccatc ttttgccaga agagcaagta
4141 tacctcaatc agcaaagtgg cacaattcgg ctggactgtt tcactcattg ccttatagtt
4201 aagtgtacag cagatatttt gcttttagat actctactag gtacactagt gaaagaactc
4261 caaaacaaat atacacctgg acgtagagaa gaagctattg ctgtgacaat gaggtttcta
4321 cgttcagtgg caagagtttt tgttattctg agtgtggaaa tggcttcatc caaaaagaaa
4381 aacaacttta ttccacagcc aattggaaaa tgcaagcgtg tattccaagc attgctacct
4441 tacgctgtgg aagaattgtg caacgtagca gagtcactga ttgttcctgt cagaatgggg
4501 attgctcgtc caactgcacc atttaccctg gctagtacta gcatagatgc catgcagggc
4561 agtgaagaat tattttcagt ggaaccacta ccaccacgac catcatctga tcagtctagc
4621 agctccagtc agtctcagtc atcctacatc atcaggaatc cacagcagag gcgcatcagc
4681 cagtcacagc ccgttcgggg cagagatgaa gaacaggatg atattgtttc agcagatgtg
4741 gaagaggttg aggtggtgga gggtgtggct ggagaagagg atcatcatga tgaacaggaa
4801 gaacacgggg aagaaaatgc tgaggcagag ggacaacatg atgagcatga tgaagacggg
4861 agtgatatgg agctggactt gttagcagca gctgaaacag aaagtgatag tgaaagtaac
4921 cacagcaacc aagataatgc tagtgggcgc agaagcgttg tcactgcagc aactgctggt
4981 tcagaagcag gagcaagcag tgttcctgcc ttcttttctg aagatgattc tcaatcgaat
5041 gactcaagtg attctgatag cagtagtagt cagagtgacg acatagaaca ggagaccttt
5101 atgcttgatg agccattaga aagaaccaca aatagctccc atgccaatgg tgctgcccaa
5161 gctccccgtt caatgcagtg ggctgtccgc aacacccagc atcagcgagc agccagtaca
5221 gccccttcca gtacatctac accagcagca agttcagcgg gtttgattta tattgatcct
5281 tcaaacttac gccggagtgg taccatcagt acaagtgctg cagctgcagc agctgctttg
5341 gaagctagca acgccagcag ttacctaaca tctgcaagca gtttagccag ggcttacagc
5401 attgtcatta gacaaatctc ggacttgatg ggccttattc ctaagtataa tcacctagta
5461 tactctcaga ttccagcagc tgtgaaattg acttaccaag atgcagtaaa cttacagaac
5521 tatgtagaag aaaagcttat tcccacttgg aactggatgg tcagtattat ggattctact
5581 gaagctcaat tacgttatgg ttctgcatta gcatctgctg gtgatcctgg acatccaaat
5641 catcctcttc acgcttctca gaattcagcg agaagagaga ggatgactgc gcgagaagaa
5701 gctagcttac gaacacttga aggcagacga cgtgccacct tgcttagcgc ccgtcaagga
5761 atgatgtctg cacgaggaga cttcctaaat tatgctctgt ctctaatgcg gtctcataat
5821 gatgagcatt ctgatgttct tccagttttg gatgtttgct cattgaagca tgtggcatat
5881 gtttttcaag cacttatata ctggattaag gcaatgaatc agcagacaac attggataca
5941 cctcaactag aacgcaaaag gacgcgagaa ctcttggaac tgggtattga taatgaagat
6001 tcagaacatg aaaatgatga tgacaccaat caaagtgcta ctttgaatga taaggatgat
6061 gactctcttc ctgcagaaac tggccaaaac catccatttt tccgacgttc agactccatg
6121 acattccttg ggtgtatacc cccaaatcca tttgaagtgc ctctggctga agccatcccc
6181 ttggctgatc agccacatct gttgcagcca aatgctagaa aggaggatct ttttggccgt
6241 ccaagtcagg gtctttattc ttcatctgcc agtagtggga aatgtttaat ggaggttaca
6301 gtggatagaa actgcctaga ggttcttcca acaaaaatgt cttatgctgc caatctgaaa
6361 aatgtaatga acatgcaaaa ccggcaaaaa aaagaagggg aagaacagcc cgtgctgcca
6421 gaagaaactg agagttcaaa accagggcca tctgctcatg atcttgctgc acaattaaaa
6481 agtagcttac tagcagaaat aggacttact gaaagtgaag ggccacctct cacatctttc
6541 aggccacagt gtagctttat gggaatggtt atttcccatg atatgctgct aggacgttgg
6601 cgcctttctt tagaactgtt cggcagggta ttcatggaag atgttggagc agaacctgga
6661 tcaatcctaa ctgaattggg tggttttgag gtaaaagaat caaaattccg cagagaaatg
6721 gaaaaactga gaaaccagca gtcaagagat ttgtcactag aggttgatcg ggatcgagat
6781 cttctcattc agcagactat gaggcagctt aacaatcact ttggtcgaag atgtgctact
6841 acaccaatgg ctgtacacag agtaaaagtc acatttaagg atgagccagg agagggcagt
6901 ggtgtagcac gaagttttta tacagccatt gcacaagcat ttttatcaaa tgaaaaattg
6961 ccaaatctag agtgtatcca aaatgccaac aaaggcaccc acacaagttt aatgcagaga
7021 ttaaggaacc gaggagagag agaccgggaa agggagagag aaagggaaat gaggaggagt
7081 agtggtttgc gagcaggttc tcggagggac cgggatagag actttagaag acagctttcc
7141 atcgacacta ggccctttag accagcctct gaagggaatc ctagcgatga tcctgagcct
7201 ttgccagcac atcggcaggc acttggagag aggctttatc ctcgtgtaca agcaatgcaa
7261 ccagcatttg caagtaaaat cactggcatg ttgttggaat tatccccagc tcagctgctt
7321 ctccttctag caagtgagga ttctctgaga gcaagagtgg atgaggccat ggaactcatt
7381 attgcacatg gacgggaaaa tggagctgat agtatcctgg atcttggatt agtagactcc
7441 tcagaaaagg tacagcagga aaaccgaaag cgccatggct ctagtcgaag tgtagtagat
7501 atggatttag atgatacaga tgatggtgat gacaatgccc ctttgtttta ccaacctggg
7561 aaaagaggat tttatactcc aaggcctggc aagaacacag aagcaaggtt gaattgtttc
7621 agaaacattg gcaggattct tggactatgt ctgttacaga atgaactctg tcctatcaca
7681 ttgaatagac atgtaattaa agtattgctt ggtagaaaag tcaattggca tgattttgct
7741 ttttttgatc ctgtaatgta tgagagtttg cggcaactaa tcctcgcgtc tcagagttca
7801 gatgctgatg ctgttttctc agcaatggat ttggcatttg caattgacct gtgtaaagaa
7861 gaaggtggag gacaggttga actcattcct aatggtgtaa atataccagt cactccacag
7921 aatgtatatg agtatgtgcg gaaatacgca gaacacagaa tgttggtagt tgcagaacag
7981 cccttacatg caatgaggaa aggtctacta gatgtgcttc caaaaaattc attagaagat
8041 ttaacggcag aagattttag gcttttggta aatggctgcg gtgaagtcaa tgtgcaaatg
8101 ctgatcagtt ttacctcttt caatgatgaa tcaggagaaa atgctgagaa gcttctgcag
8161 ttcaagcgtt ggttctggtc aatagtagag aagatgagca tgacagaacg acaagatctt
8221 gtttactttt ggacatcaag cccatcactg ccagccagtg aagaaggatt ccagcctatg
8281 ccctcaatca caataagacc accagatgac caacatcttc ctactgcaaa tacttgcatt
8341 tctcgacttt acgtcccact ctattcctct aaacagattc tcaaacagaa attgttactc
8401 gccattaaga ccaagaattt tggttttgtg tagagtataa aaagtgtgta ttgctgtgta
8461 atattactag caaattttgt agattttttt ccatttgtct ataaaagtt
//