LOCUS AF005216 4161 bp mRNA linear HUM 30-OCT-1997
DEFINITION Homo sapiens receptor-associated tyrosine kinase (JAK2) mRNA,
complete cds.
ACCESSION AF005216
VERSION AF005216.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4161)
AUTHORS Peeters,P., Raynaud,S.D., Cools,J., Wlodarska,I., Grosgeorge,J.,
Philip,P., Monpoux,F., Van Rompaey,L., Baens,M., Van den Berghe,H.
and Marynen,P.
TITLE Fusion of TEL, the ETS-variant gene 6 (ETV6), to the
receptor-associated kinase JAK2 as a result of t(9;12) in a
lymphoid and t(9;15;12) in a myeloid leukemia
JOURNAL Blood 90 (7), 2535-2540 (1997)
PUBMED 9326218
REFERENCE 2 (bases 1 to 4161)
AUTHORS Peeters,P., Cools,J. and Marynen,P.
TITLE Direct Submission
JOURNAL Submitted (23-MAY-1997) Human Genome laboratory, Center for Human
Genetics, Herestraat 49, Leuven B-3000, Belgium
COMMENT On Oct 30, 1997 this sequence version replaced gi:2565219.
FEATURES Location/Qualifiers
source 1..4161
/db_xref="H-InvDB:HIT000061792"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p24"
gene 1..4161
/gene="JAK2"
CDS 495..3893
/gene="JAK2"
/note="Janus kinase 2"
/codon_start=1
/product="receptor-associated tyrosine kinase"
/protein_id="AAB82092.1"
/translation="MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLY
HSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVF
HIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHD
FVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKI
QDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPG
SGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQE
GSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAV
LENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSN
LLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRRE
VGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL
VQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLI
REEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFG
TTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK
GVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRY
IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRL
PRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG"
BASE COUNT 1314 a 792 c 946 g 1109 t
ORIGIN
1 ctgcaggaag gagagaggaa gaggagcaga agggggcagc agcggacgcc gctaacggcc
61 tccctcggcg ctgacaggct gggccggcgc ccggctcgct tgggtgttcg cgtcgccact
121 tcggcttctc ggccggtcgg gcccctcggc ccgggcttgc ggcgcgcgtc ggggctgagg
181 gctgctgcgg cgcagggaga ggcctggtcc tcgctgccga gggatgtgag tgggagctga
241 gcccacactg gagggccccc gagggcccag cctggaggtc gttcagagcc gtgcccgccc
301 cggggcttcg cagaccttga cccgccgggt aggagccgcc cctgcgggct cgagggcgcg
361 ctctggtcgc ccgatctgtg tagccggttt cagaagcagg caacaggaac aagatgtgaa
421 ctgtttctct tctgcagaaa aagaggctct tcctcctcct cccgcgacgg caaatgttct
481 gaaaaagact ctgcatggga atggcctgcc ttacgatgac agaaatggag ggaacatcca
541 cctcttctat atatcagaat ggtgatattt ctggaaatgc caattctatg aagcaaatag
601 atccagttct tcaggtgtat ctttaccatt cccttgggaa atctgaggca gattatctga
661 cctttccatc tggggagtat gttgcagaag aaatctgtat tgctgcttct aaagcttgtg
721 gtatcacacc tgtgtatcat aatatgtttg ctttaatgag tgaaacagaa aggatctggt
781 atccacccaa ccatgtcttc catatagatg agtcaaccag gcataatgta ctctacagaa
841 taagatttta ctttcctcgt tggtattgca gtggcagcaa cagagcctat cggcatggaa
901 tatctcgagg tgctgaagct cctcttcttg atgactttgt catgtcttac ctctttgctc
961 agtggcggca tgattttgtg cacggatgga taaaagtacc tgtgactcat gaaacacagg
1021 aagaatgtct tgggatggca gtgttagata tgatgagaat agccaaagaa aacgatcaaa
1081 ccccactggc catctataac tctatcagct acaagacatt cttaccaaaa tgtattcgag
1141 caaagatcca agactatcat attttgacaa ggaagcgaat aaggtacaga tttcgcagat
1201 ttattcagca attcagccaa tgcaaagcca ctgccagaaa cttgaaactt aagtatctta
1261 taaatctgga aactctgcag tctgccttct acacagagaa atttgaagta aaagaacctg
1321 gaagtggtcc ttcaggtgag gagatttttg caaccattat aataactgga aacggtggaa
1381 ttcagtggtc aagagggaaa cataaagaaa gtgagacact gacagaacag gatttacagt
1441 tatattgcga ttttcctaat attattgatg tcagtattaa gcaagcaaac caagagggtt
1501 caaatgaaag ccgagttgta actatccata agcaagatgg taaaaatctg gaaattgaac
1561 ttagctcatt aagggaagct ttgtctttcg tgtcattaat tgatggatat tatagattaa
1621 ctgcagatgc acatcattac ctctgtaaag aagtagcacc tccagccgtg cttgaaaata
1681 tacaaagcaa ctgtcatggc ccaatttcga tggattttgc cattagtaaa ctgaagaaag
1741 caggtaatca gactggactg tatgtacttc gatgcagtcc taaggacttt aataaatatt
1801 ttttgacttt tgctgtcgag cgagaaaatg tcattgaata taaacactgt ttgattacaa
1861 aaaatgagaa tgaagagtac aacctcagtg ggacaaagaa gaacttcagc agtcttaaag
1921 atcttttgaa ttgttaccag atggaaactg ttcgctcaga caatataatt ttccagttta
1981 ctaaatgctg tcccccaaag ccaaaagata aatcaaacct tctagtcttc agaacgaatg
2041 gtgtttctga tgtaccaacc tcaccaacat tacagaggcc tactcatatg aaccaaatgg
2101 tgtttcacaa aatcagaaat gaagatttga tatttaatga aagccttggc caaggcactt
2161 ttacaaagat ttttaaaggc gtacgaagag aagtaggaga ctacggtcaa ctgcatgaaa
2221 cagaagttct tttaaaagtt ctggataaag cacacagaaa ctattcagag tctttctttg
2281 aagcagcaag tatgatgagc aagctttctc acaagcattt ggttttaaat tatggagtat
2341 gtgtctgtgg agacgagaat attctggttc aggagtttgt aaaatttgga tcactagata
2401 catatctgaa aaagaataaa aattgtataa atatattatg gaaacttgaa gttgctaaac
2461 agttggcatg ggccatgcat tttctagaag aaaacaccct tattcatggg aatgtatgtg
2521 ccaaaaatat tctgcttatc agagaagaag acaggaagac aggaaatcct cctttcatca
2581 aacttagtga tcctggcatt agtattacag ttttgccaaa ggacattctt caggagagaa
2641 taccatgggt accacctgaa tgcattgaaa atcctaaaaa tttaaatttg gcaacagaca
2701 aatggagttt tggtaccact ttgtgggaaa tctgcagtgg aggagataaa cctctaagtg
2761 ctctggattc tcaaagaaag ctacaatttt atgaagatag gcatcagctt cctgcaccaa
2821 agtgggcaga attagcaaac cttataaata attgtatgga ttatgaacca gatttcaggc
2881 cttctttcag agccatcata cgagatctta acagtttgtt tactccagat tatgaactat
2941 taacagaaaa tgacatgtta ccaaatatga ggataggtgc cctagggttt tctggtgcct
3001 ttgaagaccg ggatcctaca cagtttgaag agagacattt gaaatttcta cagcaacttg
3061 gcaagggtaa ttttgggagt gtggagatgt gccggtatga ccctctacag gacaacactg
3121 gggaggtggt cgctgtaaaa aagcttcagc atagtactga agagcaccta agagactttg
3181 aaagggaaat tgaaatcctg aaatccctac agcatgacaa cattgtaaag tacaagggag
3241 tgtgctacag tgctggtcgg cgtaatctaa aattaattat ggaatattta ccatatggaa
3301 gtttacgaga ctatcttcaa aaacataaag aacggataga tcacataaaa cttctgcagt
3361 acacatctca gatatgcaag ggtatggagt atcttggtac aaaaaggtat atccacaggg
3421 atctggcaac gagaaatata ttggtggaga acgagaacag agttaaaatt ggagattttg
3481 ggttaaccaa agtcttgcca caagacaaag aatactataa agtaaaagaa cctggtgaaa
3541 gtcccatatt ctggtatgct ccagaatcac tgacagagag caagttttct gtggcctcag
3601 atgtttggag ctttggagtg gttctgtatg aacttttcac atacattgag aagagtaaaa
3661 gtccaccagc ggaatttatg cgtatgattg gcaatgacaa acaaggacag atgatcgtgt
3721 tccatttgat agaacttttg aagaataatg gaagattacc aagaccagat ggatgcccag
3781 atgagatcta tatgatcatg acagaatgct ggaacaataa tgtaaatcaa cgcccctcct
3841 ttagggatct agctcttcga gtggatcaaa taagggataa catggctgga tgaaagaaat
3901 gaccttcatt ctgagaccaa agtagattta cagaacaaag ttttatattt cacattgctg
3961 tggactatta ttacatatat cattattata taaatcatga tgctagccag caaagatgtg
4021 aaaatatctg ctcaaaactt tcaaagttta gtaagttttt cttcatgagg ccaccagtaa
4081 aagacattaa tgagaattcc ttagcaagga ttttgtaaga agtttcttaa acattgtctg
4141 ttaacatcac tcttgtctgg c
//