LOCUS       AF005058                5161 bp    DNA     linear   HUM 21-SEP-2000
DEFINITION  Homo sapiens chemokine receptor (CXCR-4) gene, complete cds.
ACCESSION   AF005058
VERSION     AF005058.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5161)
  AUTHORS   Wegner,S.A., Ehrenberg,P.K., Chang,G., Dayhoff,D.E., Sleeker,A.L.
            and Michael,N.L.
  TITLE     Genomic organization and functional characterization of the
            chemokine receptor CXCR4, a major entry co-receptor for human
            immunodeficiency virus type 1
  JOURNAL   J. Biol. Chem. 273 (8), 4754-4760 (1998)
   PUBMED   9468539
REFERENCE   2  (bases 1 to 5161)
  AUTHORS   Wegner,S.A., Ehrenberg,P.K., Chang,G., Dayhoff,D.E. and
            Michael,N.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-1997) Division of Retrovirology, Walter Reed Army
            Institute of Research, 13 Taft Court, Suite 200, Rockville, MD
            20850, USA
FEATURES             Location/Qualifiers
     source          1..5161
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
     gene            2..5161
                     /gene="CXCR-4"
     regulatory      919..923
                     /regulatory_class="TATA_box"
                     /gene="CXCR-4"
     mRNA            join(950..1052,3185..4760)
                     /gene="CXCR-4"
                     /product="chemokine receptor"
     exon            950..1052
                     /gene="CXCR-4"
                     /number=1
     5'UTR           950..1037
                     /gene="CXCR-4"
     CDS             join(1038..1052,3185..4228)
                     /gene="CXCR-4"
                     /note="seven-transmembrane G-coupled receptor for the CXC
                     chemokine SDF-1; entry co-receptor for HIV-1 strains with
                     the syncytium-inducing phenotype"
                     /codon_start=1
                     /product="chemokine receptor"
                     /protein_id="AAB93982.1"
                     /translation="MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTI
                     YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
                     YFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV
                     WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSC
                     YCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEF
                     ENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKR
                     GGHSSVSTESESSSFHSS"
     intron          1053..3184
                     /gene="CXCR-4"
                     /number=1
     exon            3185..4760
                     /gene="CXCR-4"
                     /number=2
     3'UTR           4229..4760
                     /gene="CXCR-4"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR-4"
BASE COUNT         1160 a         1338 c         1287 g         1376 t
ORIGIN      
        1 tttcatctct ccgggcttat ttgctggttt ctccgaatgc gggccttgtc tggttcacgc
       61 tggatcccca acgcctagaa cagtgcgtgg cacgcagttc gtccttctat aaatatcgga
      121 ctaaatgcat ctctgtgatg gtaataccca cacggtgttg tgagaatgaa tgagtgattc
      181 tgtgcaagtt cctagtgatc tgttacaaaa agtactggtc gctaaattac tcttataata
      241 aagcatactt ttaggataat aaagcactat tcgcgaattg gttaccgcta ttatgaaatt
      301 actgagcaat acatatctac atctgatcag tctccagaat tatgccaaat cctaccttct
      361 tctgaaagta tctcctaatt atctgcacct gaccctagtg atgctgtgaa tgtgcaagta
      421 tagctacatc ctccgaagga aggatcttta ctccttttac ctcctgaatg ggctgcgtct
      481 gctgaaagcg cgggggaatg ggcggttgga agcttggccc tacttccagc attgccgcct
      541 actggttggg ttactccagc aagtcactcc ccttccctgg gcctcagtgt ctctactgta
      601 gcattcccag gtctggaatt ccatccactt tagcaaggat ggacgcgcca cagagagacg
      661 cgttcctagc ccgcgcttcc cacctgtctt caggcgcatc ccgcttccct caaacttagg
      721 aaatgcctct gggaggtcct gtccggctcc ggactcacta ccgaccaccc gcaaacagca
      781 gggtcccctg ggcttcccaa gccgcgcacc tctccgcccc gcccctgcgc cctccttcct
      841 cgcgtctgcc cctctccccc accccgcctt ctccctcccc gccccagcgg cgcatgcgcc
      901 gcgctcggag cgtgttttta taaaagtccg gccgcggcca gaaacttcag tttgttggct
      961 gcggcagcag gtagcaaagt gacgccgagg gcctgagtgc tccagtagcc accgcatctg
     1021 gagaaccagc ggttaccatg gaggggatca gtgtaagtcc agtttcaacc tgctttgtca
     1081 taaatgtaca aacgtttgaa cttagagcgc agcccctctc cgagcgggca gaagcggcca
     1141 ggacattgga ggtacccgta ctccaaaaaa gggtcaccga aaggagtttt cttgaccatg
     1201 cctatatagt gcgggtgggt ggggggggag caggattgga atctttttct ctgtgagtcg
     1261 aggagaaacg actggaaaga gcgttccagt ggctgcatgt gtctccccct tgagtcccgc
     1321 cgcgcgcggc ggcttgcacg ctgtttgcaa acgtaagaac attctgtgca caagtgcaga
     1381 gaaggcgtgc gcgctgcctc gggactcaga ccaccggtct cttccttggg gaagcgggga
     1441 tgtcttggag cgagttacat tgtctgaatt tagaggcgga gggcggcgtg cctgggctga
     1501 cttcccagga ggagattgcg cccgctttaa cttcggggtt aagcgcctgg tgactgttct
     1561 tgacactggg tgcgtgtttg ttaaactctg tgcggccgac ggagctgtgc cagtctccca
     1621 gcacagtagg cagagggcgg gagaggcggg tggacccacc gcgccgatcc tctgagggga
     1681 tcgagtggtg gcagcagcta ggagttgatc cgcccgcgcg ctttgggttt gagggggaaa
     1741 ccttcccgcc gtccgaagcg cgcctcttcc ccacggccgc gagtgggtcc tgcagttcga
     1801 gagtttgggg tcgtgcagag gtcagcggag tggtttgacc tcccctttga caccgcgcag
     1861 ctgccagccc tgagatttgc gctccgggga taggagcggg tacggggtga ggggcggggg
     1921 cggttaagac cgcacctggg ctgccaggtc gccgccgcga agactggcag gtgcaagtgg
     1981 ggaaaccgtt tggctctctc cgagtccagt tgtgatgttt aaccgtcggt ggtttccaga
     2041 aaccttttga aaccctcttg ctagggagtt tttggtttcc tgcagcggcg cgcaattcaa
     2101 agacgctcgc ggcggagccg cccagtcgct ccccagcacc ctgtgggaca gagcctggcg
     2161 tgtcgcccag cggagcccct gcagcgctgc ttgcgggcgg ttggcgtggg tgtagtgggc
     2221 agccgcggcg gcccggggct ggacgacccg gccccccgcg tgcccaccgc ctggaggctt
     2281 ccagctgccc acctccggcc gggttaactg gatcagtggc ggggtaatgg gaagccaccc
     2341 gggagagtga ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct
     2401 ccacccagga aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg
     2461 atggcaagag acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc
     2521 attttctgac actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg
     2581 cattctcttt acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg
     2641 tgggaaaatt aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc
     2701 cccgtgatcc tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt
     2761 aatcactgcc cctcctagca gcacccaccc caccccccac gccgcctggg agtggcctct
     2821 ttgtgtgtat tttttttttc ctcctaagga aggttttttt tcttccctct agtgggcggg
     2881 gcagaggagt tagccaagat gtgactttga aaccctcagc gtctcagtgc ccttttgttc
     2941 taaacaaaga attttgtaat tggttctacc aaagaaggat ataatgaagt cactatggga
     3001 aaagatgggg aggagagttg taggattcta cattaattct cttgtgccct tagcccacta
     3061 cttcagaatt tcctgaagaa agcaagcctg aattggtttt ttaaattgct ttaaaaattt
     3121 tttttaactg ggttaatgct tgctgaattg gaagtgaatg tccattcctt tgcctctttt
     3181 gcagatatac acttcagata actacaccga ggaaatgggc tcaggggact atgactccat
     3241 gaaggaaccc tgtttccgtg aagaaaatgc taatttcaat aaaatcttcc tgcccaccat
     3301 ctactccatc atcttcttaa ctggcattgt gggcaatgga ttggtcatcc tggtcatggg
     3361 ttaccagaag aaactgagaa gcatgacgga caagtacagg ctgcacctgt cagtggccga
     3421 cctcctcttt gtcatcacgc ttcccttctg ggcagttgat gccgtggcaa actggtactt
     3481 tgggaacttc ctatgcaagg cagtccatgt catctacaca gtcaacctct acagcagtgt
     3541 cctcatcctg gccttcatca gtctggaccg ctacctggcc atcgtccacg ccaccaacag
     3601 tcagaggcca aggaagctgt tggctgaaaa ggtggtctat gttggcgtct ggatccctgc
     3661 cctcctgctg actattcccg acttcatctt tgccaacgtc agtgaggcag atgacagata
     3721 tatctgtgac cgcttctacc ccaatgactt gtgggtggtt gtgttccagt ttcagcacat
     3781 catggttggc cttatcctgc ctggtattgt catcctgtcc tgctattgca ttatcatctc
     3841 caagctgtca cactccaagg gccaccagaa gcgcaaggcc ctcaagacca cagtcatcct
     3901 catcctggct ttcttcgcct gttggctgcc ttactacatt gggatcagca tcgactcctt
     3961 catcctcctg gaaatcatca agcaagggtg tgagtttgag aacactgtgc acaagtggat
     4021 ttccatcacc gaggccctag ctttcttcca ctgttgtctg aaccccatcc tctatgcttt
     4081 ccttggagcc aaatttaaaa cctctgccca gcacgcactc acctctgtga gcagagggtc
     4141 cagcctcaag atcctctcca aaggaaagcg aggtggacat tcatctgttt ccactgagtc
     4201 tgagtcttca agttttcact ccagctaaca cagatgtaaa agactttttt ttatacgata
     4261 aataactttt ttttaagtta cacatttttc agatataaaa gactgaccaa tattgtacag
     4321 tttttattgc ttgttggatt tttgtcttgt gtttctttag tttttgtgaa gtttaattga
     4381 cttatttata taaatttttt ttgtttcata ttgatgtgtg tctaggcagg acctgtggcc
     4441 aagttcttag ttgctgtatg tctcgtggta ggactgtaga aaagggaact gaacattcca
     4501 gagcgtgtag tgaatcacgt aaagctagaa atgatcccca gctgtttatg catagataat
     4561 ctctccattc ccgtggaacg tttttcctgt tcttaagacg tgattttgct gtagaagatg
     4621 gcacttataa ccaaagccca aagtggtata gaaatgctgg tttttcagtt ttcaggagtg
     4681 ggttgatttc agcacctaca gtgtacagtc ttgtattaag ttgttaataa aagtacatgt
     4741 taaacttact tagtgttatg ttctgatttc tgttgacatt cttttggcta gtagaagaca
     4801 aaagtaatac atttatggta tgcaaagcac tatcctaggt atttcattgt aatattttac
     4861 ttacccctta tcacaactct gatagattct gcttctgtta ctaattacat tttatagaag
     4921 aggaaacgga ggcacagaaa gcctaagtaa cttggttaaa ggcatgtagt aagtatcaaa
     4981 tcctgtattt taaaccaggt aacatgactt aacgaatctg aagccttcac cactttaaat
     5041 tcaaatggaa gtttagaaat ggccagccag cacctatttg tatgaaaggt catctttcag
     5101 aggataagca tgtataaaga agaaaaggta tgcagtcgtg tttggatttt actccaccat
     5161 c
//