LOCUS AF004813 2182 bp mRNA linear HUM 26-JUL-2016
DEFINITION Homo sapiens electrogenic Na+ bicarbonate cotransporter (NBC) mRNA,
partial cds.
ACCESSION AF004813
VERSION AF004813.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2182)
AUTHORS Romero,M.F., Hediger,M.A. and Boron,W.F.
TITLE Cloning of the human renal electrogenic Na/HCO3 cotransporter, hNBC
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2182)
AUTHORS Romero,M.F., Hediger,M.A. and Boron,W.F.
TITLE Direct Submission
JOURNAL Submitted (19-MAY-1997) Cellular & Molecular Physiology, Yale
Univ., School of Medicine, 333 Cedar St, New Haven, CT 06510, USA
COMMENT NBC mediates the transport of one Na+ with multiple HCO3- ions. a)
electrogenic, b) activity NOT effected by absence of Cl-, c)
activity blocked by stilbene compounds, e.g. DIDS and SITS. NOTE:
Stoichiometry is thought to be 1 Na+ : 3 HCO3-; however, exact
stoichiometry remains to be determined.
FEATURES Location/Qualifiers
source 1..2182
/db_xref="H-InvDB:HIT000061760"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="whole kidney"
gene <1..2182
/gene="NBC"
CDS <1..2013
/gene="NBC"
/codon_start=1
/product="electrogenic Na+ bicarbonate cotransporter"
/protein_id="AAD31379.1"
/translation="EXVEGHHTIYIGVHVPKXYRRRRRHKRKTGHKEKKEKERISENY
SDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQE
MEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLP
QLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMF
TNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLD
TPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFH
DIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGEN
VQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQAL
SAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSS
TGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEE
GFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPGEGITLCVYA
RFVFGGRCRLHACKFSTCCHGPQELVLFFSLKNSATEFDVSLPEVF"
BASE COUNT 584 a 462 c 534 g 600 t
ORIGIN
1 gaagnagtag aaggccacca taccatttac atcggagtcc atgtgccgaa gngttacagg
61 agaaggagac gtcacaagag aaagacaggg cacaaagaaa agaaggaaaa ggagagaatc
121 tctgagaact actctgacaa atcagatatt gaaaatgctg atgaatccag cagcagcatc
181 ctaaaacctc tcatctctcc tgctgcagaa cgcatccgat tcatcttggg agaggaggat
241 gacagcccag ctccccctca gctcttcacg gaactggatg agctgctggc cgtggatggg
301 caggagatgg agtggaagga aacagccagg tggatcaagt ttgaagaaaa agtggaacag
361 ggtggggaaa gatggagcaa gccccatgtg gccacattgt cccttcatag tttatttgag
421 ctgaggacat gtatggagaa aggatccatc atgcttgatc gggaggcttc ttctctccca
481 cagttggtgg agatgattgt tgaccatcag attgagacag gcctattgaa acctgaactt
541 aaggataagg tgacctatac tttgctccgg aagcaccggc atcaaaccaa gaaatccaac
601 cttcggtccc tggctgacat tgggaagaca gtctccagtg caagtaggat gtttaccaac
661 cctgataatg gtagcccagc catgacccat aggaatctga cttcctccag tctgaatgac
721 atttctgata aaccggagaa ggaccagctg aagaataagt tcatgaaaaa attgccacgt
781 gatgcagaag cttccaacgt gcttgttggg gaggttgact ttttggatac tcctttcatt
841 gcctttgtta ggctacagca ggctgtcatg ctgggtgccc tgactgaagt tcctgtgccc
901 acaaggttct tgttcattct cttaggtcct aaggggaaag ccaagtccta ccacgagatt
961 ggcagagcca ttgccaccct gatgtctgat gaggtgttcc atgacattgc ttataaagca
1021 aaagacaggc acgacctgat tgctggtatt gatgagttcc tagatgaagt catcgtcctt
1081 ccacctgggg aatgggatcc agcaattagg atagagcctc ctaagagtct tccatcctct
1141 gacaaaagaa agaatatgta ctcaggtgga gagaatgttc agatgaatgg ggatacgccc
1201 catgatggag gtcacggagg aggaggacat ggggattgtg aagaattgca gcgaactgga
1261 cggttctgtg gtggactaat taaagacata aagaggaaag cgccattttt tgccagtgat
1321 ttttatgatg ctttaaatat tcaagctctt tcggcaattc tcttcattta tctggcaact
1381 gtaactaatg ctatcacttt tggaggactg cttggggatg ccactgacaa catgcagggc
1441 gtgttggaga gtttcctggg cactgctgtc tctggagcca tcttttgcct ttttgctggt
1501 caaccactca ctattctgag cagcaccgga cctgtcctag tttttgagag gcttctattt
1561 aatttcagca aggacaataa ttttgactat ttggagtttc gcctttggat tggcctgtgg
1621 tccgccttcc tatgtctcat tttggtagcc actgatgcca gcttcttggt tcaatacttc
1681 acacgtttca cggaggaggg cttttcctct ctgattagct tcatctttat ctatgatgct
1741 ttcaagaaga tgatcaagct tgcagattac taccccatca actccaactt caaagtgggc
1801 tacaacactc tcttttcctg tacctgtgtg ccacctgacc caggtgaggg cattacgctt
1861 tgtgtttatg ctcgctttgt atttggagga aggtgtaggc tccatgcttg caaattttca
1921 acatgctgtc atggtcctca ggaattagtc ttgttttttt ctctgaaaaa ctctgctact
1981 gaatttgatg tctcattgcc tgaggtattt tagctgtatg attcaaccag gaaggagacc
2041 aggagctctg gaatgtgaac ataaccaact caatattttg aaattaactc aaactgtggg
2101 atttgcaagg aattcatgtg tacattattc ttgattttat aagtggggaa acctggatac
2161 atgtattaac agatataaat cg
//