LOCUS AF004709 1838 bp mRNA linear HUM 02-JUL-1997
DEFINITION Homo sapiens stress-activated protein kinase 4 mRNA, complete cds.
ACCESSION AF004709
VERSION AF004709.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1838)
AUTHORS Kumar,S., McDonnell,P.C., Gum,R.J., Hand,A.T., Lee,J.C. and
Young,P.R.
TITLE Novel homologues of CSBP/p38 MAP kinase: activation, substrate
specificity and sensitivity to inhibition by pyridinyl imidazoles
JOURNAL Biochem. Biophys. Res. Commun. 235 (3), 533-538 (1997)
PUBMED 9207191
REFERENCE 2 (bases 1 to 1838)
AUTHORS McDonnell,P.C. and Young,P.R.
TITLE Direct Submission
JOURNAL Submitted (19-MAY-1997) Molecular Immunology, SmithKline Beecham,
709 Swedeland Road, King of Prussia, PA 19406-0939, USA
FEATURES Location/Qualifiers
source 1..1838
/db_xref="H-InvDB:HIT000061756"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="activated T cell"
CDS 49..1146
/function="serine/threonine protein kinase"
/note="SAPK4; similar to CSBP/p38 MAP kinase"
/codon_start=1
/product="stress-activated protein kinase 4"
/protein_id="AAC51374.1"
/translation="MSLIRKKGFYKQELNKTAWELPKTYVSPTHVGSGAYGSWCSAID
KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYD
FYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE
DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT
GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR
ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLT
VDEWKQHIYKEIVNFSPIARKDSRRRSGMKL"
BASE COUNT 418 a 498 c 523 g 396 t
ORIGIN
1 gcacgagcgc agccgccacg ccggggccgc cgagatcggg tgcccgggat gagcctcatc
61 cggaaaaagg gcttctacaa gcaggagctc aacaagaccg cctgggagct gcccaagacc
121 tacgtctccc cgacgcacgt cggcagcggg gcctatggct cctggtgctc ggccatcgac
181 aagcggtcag gggagaaggt ggccatcaag aagctgagcc gaccctttca gtccgagatt
241 ttcgccaagc gcgcctaccg ggagctgctg ctgctgaagc acatgcagca tgagaacgtc
301 attgggctcc tggatgtttt caccccagcc tcctccctgc gcaacttcta tgacttctac
361 ctggtgatgc ccttcatgca gacggatctg cagaagatca tggggatgga gttcagtgag
421 gagaagatcc agtacctggt gtatcagatg ctcaaaggcc ttaagtacat ccactctgct
481 ggggtcgtgc acagggacct gaagccaggc aacctggctg tgaatgagga ctgtgaactg
541 aagattctgg attttgggct ggcgcgacat gcagacgccg agatgactgg ctacgtggtg
601 acccgctggt accgagcccc cgaggtgatc ctcagctgga tgcactacaa ccagacagtg
661 gacatctggt ctgtgggctg tatcatggca gagatgctga cagggaaaac tctgttcaag
721 gggaaagatt acctggacca gctgacccag atcctgaaag tgaccggggt gcctggcacg
781 gagtttgtgc agaagctgaa cgacaaagcg gccaaatcct acatccagtc cctgccacag
841 acccccagga aggatttcac tcagctgttc ccacgggcca gcccccaggc tgcggacctg
901 ctggagaaga tgctggagct agacgtggac aagcgcctga cggccgcgca ggccctcacc
961 catcccttct ttgaaccctt ccgggaccct gaggaagaga cggaggccca gcagccgttt
1021 gatgattcct tagaacacga gaaactcaca gtggatgaat ggaagcagca catctacaag
1081 gagattgtga acttcagccc cattgcccgg aaggactcac ggcgccggag tggcatgaag
1141 ctgtagggac tcatcttgca tggcaccgcc ggccagacac tgcccaagga ccagtatttg
1201 tcactaccaa actcagccct tcttggaata cagcctttca agcagaggac agaagggtcc
1261 ttctccttat gtgggaaatg ggcctagtag atgcagaatt caaagatgtc ggttgggaga
1321 aactagctct gatcctaaca ggccacgtta aactgcccat ctggagaatc gcctgcaggt
1381 ggggcccttt ccttcccgcc agagtggggc tgagtgggcg ctgagccagg ccgggggcct
1441 atggcagtga tgctgtgttg gtttcctagg gatgctctaa cgaattacca caaacctggt
1501 ggattgaaac agcagaactt gattccctta cagttctgga ggctggaaat ytgggatgga
1561 ggtgttggca gggctgtggt ccctttgaag gctctgggga agaatccttc cttggctctt
1621 tttagcttgt ggcggcagtg ggcagtccgt ggcattcccc agcttattgc tgcatcactc
1681 cagtctctgt ctcttctgtt ctctcctctt ttaacaacag tcattggatt tagggcccac
1741 cctaatcctg tgtgatytta tyttgatcct tattaattaa acctgcaaat actctagttc
1801 caaataaagt cacattctca ggttccaggt ggacatga
//