LOCUS AF004327 2269 bp mRNA linear HUM 16-JUL-1997 DEFINITION Homo sapiens angiopoietin-2 mRNA, complete cds. ACCESSION AF004327 VERSION AF004327.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2269) AUTHORS Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S., Wiegand,S.J., Radziejewski,C., Compton,D., Aldrich,T.H., Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and Yancopoulos,G.D. TITLE Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis JOURNAL Science 277 (5322), 55-60 (1997) PUBMED 9204896 REFERENCE 2 (bases 1 to 2269) AUTHORS Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S., Wiegand,S.J., Radziejewski,C., Compton,D., Aldrich,T.H., Papdopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and Yancopoulos,G.D. TITLE Direct Submission JOURNAL Submitted (16-MAY-1997) Discovery, Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA FEATURES Location/Qualifiers source 1..2269 /db_xref="H-InvDB:HIT000061744" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="lung" /clone_lib="human fetal lung cDNA library (Clontech)" /dev_stage="fetal" CDS 350..1840 /note="Ligand for Tie2/Tek receptor tyrosine kinase; Method: conceptual translation with partial peptide sequencing" /codon_start=1 /product="angiopoietin-2" /protein_id="AAB63190.1" /translation="MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYT FLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQ DNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQL LEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQV LVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKE EQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVD FQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYL SSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDAC GPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF" BASE COUNT 742 a 495 c 518 g 514 t ORIGIN 1 tgggttggtg tttatctcct cccagccttg agggagggaa caacactgta ggatctgggg 61 agagaggaac aaaggaccgt gaaagctgct ctgtaaaagc tgacacagcc ctcccaagtg 121 agcaggactg ttcttcccac tgcaatctga cagtttactg catgcctgga gagaacacag 181 cagtaaaaac caggtttgct actggaaaaa gaggaaagag aagactttca ttgacggacc 241 cagccatggc agcgtagcag ccctgcgttt cagacggcag cagctcggga ctctggacgt 301 gtgtttgccc tcaagtttgc taagctgctg gtttattact gaagaaagaa tgtggcagat 361 tgttttcttt actctgagct gtgatcttgt cttggccgca gcctataaca actttcggaa 421 gagcatggac agcataggaa agaagcaata tcaggtccag catgggtcct gcagctacac 481 tttcctcctg ccagagatgg acaactgccg ctcttcctcc agcccctacg tgtccaatgc 541 tgtgcagagg gacgcgccgc tcgaatacga tgactcggtg cagaggctgc aagtgctgga 601 gaacatcatg gaaaacaaca ctcagtggct aatgaagctt gagaattata tccaggacaa 661 catgaagaaa gaaatggtag agatacagca gaatgcagta cagaaccaga cggctgtgat 721 gatagaaata gggacaaacc tgttgaacca aacagctgag caaacgcgga agttaactga 781 tgtggaagcc caagtattaa atcagaccac gagacttgaa cttcagctct tggaacactc 841 cctctcgaca aacaaattgg aaaaacagat tttggaccag accagtgaaa taaacaaatt 901 gcaagataag aacagtttcc tagaaaagaa ggtgctagct atggaagaca agcacatcat 961 ccaactacag tcaataaaag aagagaaaga tcagctacag gtgttagtat ccaagcaaaa 1021 ttccatcatt gaagaactag aaaaaaaaat agtgactgcc acggtgaata attcagttct 1081 tcaaaagcag caacatgatc tcatggagac agttaataac ttactgacta tgatgtccac 1141 atcaaactca gctaaggacc ccactgttgc taaagaagaa caaatcagct tcagagactg 1201 tgctgaagta ttcaaatcag gacacaccac aaatggcatc tacacgttaa cattccctaa 1261 ttctacagaa gagatcaagg cctactgtga catggaagct ggaggaggcg ggtggacaat 1321 tattcagcga cgtgaggatg gcagcgttga ttttcagagg acttggaaag aatataaagt 1381 gggatttggt aacccttcag gagaatattg gctgggaaat gagtttgttt cgcaactgac 1441 taatcagcaa cgctatgtgc ttaaaataca ccttaaagac tgggaaggga atgaggctta 1501 ctcattgtat gaacatttct atctctcaag tgaagaactc aattatagga ttcaccttaa 1561 aggacttaca gggacagccg gcaaaataag cagcatcagc caaccaggaa atgattttag 1621 cacaaaggat ggagacaacg acaaatgtat ttgcaaatgt tcacaaatgc taacaggagg 1681 ctggtggttt gatgcatgtg gtccttccaa cttgaacgga atgtactatc cacagaggca 1741 gaacacaaat aagttcaacg gcattaaatg gtactactgg aaaggctcag gctattcgct 1801 caaggccaca accatgatga tccgaccagc agatttctaa acatcccagt ccacctgagg 1861 aactgtctcg aactattttc aaagacttaa gcccagtgca ctgaaagtca cggctgcgca 1921 ctgtgtcctc ttccaccaca gagggcgtgt gctcggtgct gacgggaccc acatgctcca 1981 gattagagcc tgtaaacttt atcacttaaa cttgcatcac ttaacggacc aaagcaagac 2041 cctaaacatc cataattgtg attagacaga acacctatgc aaagatgaac ccgaggctga 2101 gaatcagact gacagtttac agacgctgct gtcacaacca agaatgttat gtgcaagttt 2161 atcagtaaat aactggaaaa cagaacactt atgttataca atacagatca tcttggaact 2221 gcattcttct gagcactgtt tatacactgt gtaaataccc atatgtcct //