LOCUS       AF004327                2269 bp    mRNA    linear   HUM 16-JUL-1997
DEFINITION  Homo sapiens angiopoietin-2 mRNA, complete cds.
ACCESSION   AF004327
VERSION     AF004327.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., Aldrich,T.H.,
            Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and
            Yancopoulos,G.D.
  TITLE     Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo
            angiogenesis
  JOURNAL   Science 277 (5322), 55-60 (1997)
   PUBMED   9204896
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., Aldrich,T.H.,
            Papdopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and Yancopoulos,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-1997) Discovery, Regeneron Pharmaceuticals, 777
            Old Saw Mill River Rd., Tarrytown, NY 10591, USA
FEATURES             Location/Qualifiers
     source          1..2269
                     /db_xref="H-InvDB:HIT000061744"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="lung"
                     /clone_lib="human fetal lung cDNA library (Clontech)"
                     /dev_stage="fetal"
     CDS             350..1840
                     /note="Ligand for Tie2/Tek receptor tyrosine kinase;
                     Method: conceptual translation with partial peptide
                     sequencing"
                     /codon_start=1
                     /product="angiopoietin-2"
                     /protein_id="AAB63190.1"
                     /translation="MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYT
                     FLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQ
                     DNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQL
                     LEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQV
                     LVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKE
                     EQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVD
                     FQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYL
                     SSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDAC
                     GPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF"
BASE COUNT          742 a          495 c          518 g          514 t
ORIGIN      
        1 tgggttggtg tttatctcct cccagccttg agggagggaa caacactgta ggatctgggg
       61 agagaggaac aaaggaccgt gaaagctgct ctgtaaaagc tgacacagcc ctcccaagtg
      121 agcaggactg ttcttcccac tgcaatctga cagtttactg catgcctgga gagaacacag
      181 cagtaaaaac caggtttgct actggaaaaa gaggaaagag aagactttca ttgacggacc
      241 cagccatggc agcgtagcag ccctgcgttt cagacggcag cagctcggga ctctggacgt
      301 gtgtttgccc tcaagtttgc taagctgctg gtttattact gaagaaagaa tgtggcagat
      361 tgttttcttt actctgagct gtgatcttgt cttggccgca gcctataaca actttcggaa
      421 gagcatggac agcataggaa agaagcaata tcaggtccag catgggtcct gcagctacac
      481 tttcctcctg ccagagatgg acaactgccg ctcttcctcc agcccctacg tgtccaatgc
      541 tgtgcagagg gacgcgccgc tcgaatacga tgactcggtg cagaggctgc aagtgctgga
      601 gaacatcatg gaaaacaaca ctcagtggct aatgaagctt gagaattata tccaggacaa
      661 catgaagaaa gaaatggtag agatacagca gaatgcagta cagaaccaga cggctgtgat
      721 gatagaaata gggacaaacc tgttgaacca aacagctgag caaacgcgga agttaactga
      781 tgtggaagcc caagtattaa atcagaccac gagacttgaa cttcagctct tggaacactc
      841 cctctcgaca aacaaattgg aaaaacagat tttggaccag accagtgaaa taaacaaatt
      901 gcaagataag aacagtttcc tagaaaagaa ggtgctagct atggaagaca agcacatcat
      961 ccaactacag tcaataaaag aagagaaaga tcagctacag gtgttagtat ccaagcaaaa
     1021 ttccatcatt gaagaactag aaaaaaaaat agtgactgcc acggtgaata attcagttct
     1081 tcaaaagcag caacatgatc tcatggagac agttaataac ttactgacta tgatgtccac
     1141 atcaaactca gctaaggacc ccactgttgc taaagaagaa caaatcagct tcagagactg
     1201 tgctgaagta ttcaaatcag gacacaccac aaatggcatc tacacgttaa cattccctaa
     1261 ttctacagaa gagatcaagg cctactgtga catggaagct ggaggaggcg ggtggacaat
     1321 tattcagcga cgtgaggatg gcagcgttga ttttcagagg acttggaaag aatataaagt
     1381 gggatttggt aacccttcag gagaatattg gctgggaaat gagtttgttt cgcaactgac
     1441 taatcagcaa cgctatgtgc ttaaaataca ccttaaagac tgggaaggga atgaggctta
     1501 ctcattgtat gaacatttct atctctcaag tgaagaactc aattatagga ttcaccttaa
     1561 aggacttaca gggacagccg gcaaaataag cagcatcagc caaccaggaa atgattttag
     1621 cacaaaggat ggagacaacg acaaatgtat ttgcaaatgt tcacaaatgc taacaggagg
     1681 ctggtggttt gatgcatgtg gtccttccaa cttgaacgga atgtactatc cacagaggca
     1741 gaacacaaat aagttcaacg gcattaaatg gtactactgg aaaggctcag gctattcgct
     1801 caaggccaca accatgatga tccgaccagc agatttctaa acatcccagt ccacctgagg
     1861 aactgtctcg aactattttc aaagacttaa gcccagtgca ctgaaagtca cggctgcgca
     1921 ctgtgtcctc ttccaccaca gagggcgtgt gctcggtgct gacgggaccc acatgctcca
     1981 gattagagcc tgtaaacttt atcacttaaa cttgcatcac ttaacggacc aaagcaagac
     2041 cctaaacatc cataattgtg attagacaga acacctatgc aaagatgaac ccgaggctga
     2101 gaatcagact gacagtttac agacgctgct gtcacaacca agaatgttat gtgcaagttt
     2161 atcagtaaat aactggaaaa cagaacactt atgttataca atacagatca tcttggaact
     2221 gcattcttct gagcactgtt tatacactgt gtaaataccc atatgtcct
//