LOCUS AF003521 4702 bp mRNA linear HUM 24-APR-2000
DEFINITION Homo sapiens Jagged 2 mRNA, complete cds.
ACCESSION AF003521
VERSION AF003521.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4702)
AUTHORS Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
Artavanis-Tsakonas,S.
TITLE Human ligands of the Notch receptor
JOURNAL Am. J. Pathol. 154 (3), 785-794 (1999)
PUBMED 10079256
REFERENCE 2 (bases 1 to 4702)
AUTHORS Mann,R.S., Gray,G.E., Henrique,D., Ish-Horowicz,D. and
Artavanis-Tsakonas,S.
TITLE Direct Submission
JOURNAL Submitted (09-MAY-1997) Howard Hughes Medical Institute, Yale
University, 295 Congress Ave, New Haven, CT 06510, USA
FEATURES Location/Qualifiers
source 1..4702
/db_xref="H-InvDB:HIT000061715"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 33..3749
/note="ligand for Notch receptor; Contains EGF repeats and
DSL domain"
/codon_start=1
/product="Jagged 2"
/protein_id="AAB61285.1"
/translation="MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGEL
LSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNS
FYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEE
LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFF
GHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC
VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCT
CPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN
PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCI
PGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDKCASSPCH
SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF
GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC
DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP
CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP
GWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC
YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLA
GQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCAR
LTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSF
SPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLC
GAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKD
VLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKD
PGRSPGRPAHWASGPKVDNRAVRSINEARYVGKE"
BASE COUNT 805 a 1472 c 1557 g 868 t
ORIGIN
1 ggccggggcc gggcgggcgg gtcgcggggg caatgcgggc gcagggccgg gggcgccttc
61 cccggcggct gctgctgctg ctggcgctct gggtgcaggc ggcgcggccc atgggctatt
121 tcgagctgca gctgagcgcg ctgcggaacg tgaacgggga gctgctgagc ggcgcctgct
181 gtgacggcga cggccggaca acgcgcgcgg ggggctgcgg ccacgacgag tgcgacacgt
241 acgtgcgcgt gtgccttaag gagtaccagg ccaaggtgac gcccacgggg ccctgcagct
301 acggccacgg cgccacgccc gtgctgggcg gcaactcctt ctacctgccg ccggcgggcg
361 ctgcggggga ccgagcgcgg gcgcgggccc gggccggcgg cgaccaggac ccgggcctcg
421 tcgtcatccc cttccagttc gcctggccgc gctcctttac cctcatcgtg gaggcctggg
481 actgggacaa cgataccacc ccgaatgagg agctgctgat cgagcgagtg tcgcatgccg
541 gcatgatcaa cccggaggac cgctggaaga gcctgcactt cagcggccac gtggcgcacc
601 tggagctgca gatccgcgtg cgctgcgacg agaactacta cagcgccact tgcaacaagt
661 tctgccggcc ccgcaatgac tttttcggcc actacacctg cgaccagtac ggcaacaagg
721 cctgcatgga cggctggatg ggcaaggagt gcaaggaagc tgtgtgtaaa caagggtgta
781 atttgctcca cgggggatgc accgtgcctg gggagtgcag gtgcagctac ggctggcaag
841 ggaggttctg cgatgagtgt gtcccctacc ccggctgcgt gcatggcagt tgtgtggagc
901 cctggcagtg caactgtgag accaactggg gcggcctgct ctgtgacaaa gacctgaact
961 actgtggcag ccaccacccc tgcaccaacg gaggcacgtg catcaacgcc gagcctgacc
1021 agtaccgctg cacctgccct gacggctact cgggcaggaa ctgtgagaag gctgagcacg
1081 cctgcacctc caacccgtgt gccaacgggg gctcttgcca tgaggtgccg tccggcttcg
1141 aatgccactg cccatcgggc tggagcgggc ccacctgtgc ccttgacatc gatgagtgtg
1201 cttcgaaccc gtgtgcggcc ggtggcacct gtgtggacca ggtggacggc tttgagtgca
1261 tctgccccga gcagtgggtg ggggccacct gccagctgga cgccaatgag tgtgaaggga
1321 agccatgcct taacgctttt tcttgcaaaa acctgattgg cggctattac tgtgattgca
1381 tcccgggctg gaagggcatc aactgccata tcaacgtcaa cgactgtcgc gggcagtgtc
1441 agcatggggg cacctgcaag gacctggtga acgggtacca gtgtgtgtgc ccacggggct
1501 tcggaggccg gcattgcgag ctggaacgag acaagtgtgc cagcagcccc tgccacagcg
1561 gcggcctctg cgaggacctg gccgacggct tccactgcca ctgcccccag ggcttctccg
1621 ggcctctctg tgaggtggat gtcgaccttt gtgagccaag cccctgccgg aacggcgctc
1681 gctgctataa cctggagggt gactattact gcgcctgccc tgatgacttt ggtggcaaga
1741 actgctccgt gccccgcgag ccgtgccctg gcggggcctg cagagtgatc gatggctgcg
1801 ggtcagacgc ggggcctggg atgcctggca cagcagcctc cggcgtgtgt ggcccccatg
1861 gacgctgcgt cagccagcca gggggcaact tttcctgcat ctgtgacagt ggctttactg
1921 gcacctactg ccatgagaac attgacgact gcctgggcca gccctgccgc aatgggggca
1981 catgcatcga tgaggtggac gccttccgct gcttctgccc cagcggttgg gagggcgagc
2041 tctgcgacac caatcccaac gactgccttc ccgatccctg ccacagccgc ggccgctgct
2101 acgacctggt caatgacttc tactgtgcgt gcgacgacgg ctggaagggc aagacctgcc
2161 actcacgcga gttccagtgc gatgcctaca cctgcagcaa cggtggcacc tgctacgaca
2221 gcggcgacac cttccgctgc gcctgccccc ccggctggaa gggcagcacc tgcgccgtcg
2281 ccaagaacag cagctgcctg cccaacccct gtgtgaatgg tggcacctgc gtgggcagcg
2341 gggcctcctt ctcctgcatc tgccgggacg gctgggaggg tcgtacttgc actcacaata
2401 ccaacgactg caaccctctg ccttgctaca atggtggcat ctgtgttgac ggcgtcaact
2461 ggttccgctg cgagtgtgca cctggcttcg cggggcctga ctgccgcatc aacatcgacg
2521 agtgccagtc ctcgccctgt gcctacgggg ccacgtgtgt ggatgagatc aacgggtatc
2581 gctgtagctg cccacccggc cgagccggcc cccggtgcca ggaagtgatc gggttcggga
2641 gatcctgctg gtcccggggc actccgttcc cacacggaag ctcctgggtg gaagactgca
2701 acagctgccg ctgcctggat ggccgccgtg actgcagcaa ggtgtggtgc ggatggaagc
2761 cttgtctgct ggccggccag cccgaggccc tgagcgccca gtgcccactg gggcaaaggt
2821 gcctggagaa ggccccaggc cagtgtctgc gaccaccctg tgaggcctgg ggggagtgcg
2881 gcgcagaaga gccaccgagc accccctgcc tgccacgctc cggccacctg gacaataact
2941 gtgcccgcct caccttgcat ttcaaccgtg accacgtgcc ccagggcacc acggtgggcg
3001 ccatttgctc cgggatccgc tccctgccag ccacaagggc tgtggcacgg gaccgcctgc
3061 tggtgttgct ttgcgaccgg gcgtcctcgg gggccagtgc tgtggaggtg gccgtgtcct
3121 tcagccctgc cagggacctg cctgacagca gcctgatcca gggcgcggcc cacgccatcg
3181 tggccgccat cacccagcgg gggaacagct cactgctcct ggctgtcacc gaggtcaagg
3241 tggagacggt tgttacgggc ggctcttcca caggtctgct ggtgcctgtg ctgtgtggtg
3301 ccttcagcgt gctgtggctg gcgtgcgtgg tcctgtgcgt gtggtggaca cgcaagcgca
3361 ggaaagagcg ggagaggagc cggctgccgc gggaggagag cgccaacaac cagtgggccc
3421 cgctcaaccc catccgcaac cccattgagc ggccgggggg gcacaaggac gtgctctacc
3481 agtgcaagaa cttcacgccg ccgccgcgca gggcggacga ggcgctgccc gggccggccg
3541 gccacgcggc cgtcagggag gatgaggagg acgaggatct tggccgcggt gaggaggact
3601 ccctggaggc ggagaagttc ctctcacaca aattcaccaa agatcctggc cgctcgccgg
3661 ggaggccggc ccactgggcc tcaggcccca aagtggacaa ccgcgcggtc aggagcatca
3721 atgaggcccg ctacgtcggc aaggaatagg gcggctgcag ctgggccggg acccagggcc
3781 ctcggtggga gccatgccgt ctgccggacc cggaggccga ggccatgtgc atagtttctt
3841 tattttgtgt aaaaaaacca ccaaaaacaa aaaccaaatg tttattttct acgtttcttt
3901 aaccttgtat aaattattca gtaactgtca ggctgaaaac aatggagtat tctcggatag
3961 ttgctatttt tgtaaagtag ccgtgcgtgg cactcgctgt atgaaaggag agagcaaagg
4021 gtgtctgcgt cgtcaccaaa tcgtcgcgtt tgttaccaga ggttgtgcac tgtttacaga
4081 atcttccttt tattcctcac tcgggtttct ctgtgctcca ggccaaagtg ccggtgagac
4141 ccatggctgt gttggtgtgg cccatggctg ttggtgggac ccgtggctga tggtgtggcc
4201 tgtggctgtc ggtgggactc gtggctgtca atgggacctg tggctgtcgg tgggacctac
4261 ggtggtcggt gggaccctgg ttattgatgt ggccctggct gccggcacgg cccgtggctg
4321 ttgacgcacc tgtggttgtt agtggggcct gaggtcatcg gcgtggccca aggccggcag
4381 gtcaacctcg cgcttgctgg ccagtccacc ctgcctgccg tctgtgcttc ctcctgccca
4441 gaacgcccgc tccagcgatc tctccactgt gctttcagaa gtgcccttcc tgctgcgcag
4501 ttctcccatc ctgggacggc ggcagtattg aagctcgtga caagtgcctt cacacagacc
4561 cctcgcaact gtccacgcgt gccgtggcac caggcgctgc ccacctgccg gccccggccg
4621 cccctcctcg tgaaagtgca tttttgtaaa tgtgtacata ttaaaggaag cactctgtat
4681 aaaaaaaaaa aaccggaatt cc
//