LOCUS AF001691 6227 bp mRNA linear HUM 29-MAY-1998
DEFINITION Homo sapiens 195 kDa cornified envelope precursor mRNA, complete
cds.
ACCESSION AF001691
VERSION AF001691.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6227)
AUTHORS Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
TITLE Periplakin, a novel component of cornified envelopes and desmosomes
that belongs to the plakin family and forms complexes with
envoplakin
JOURNAL J. Cell Biol. 139 (7), 1835-1849 (1997)
PUBMED 9412476
REFERENCE 2 (bases 1 to 6227)
AUTHORS Ruhrberg,C. and Watt,F.M.
TITLE Direct Submission
JOURNAL Submitted (30-APR-1997) Keratinocyte Lab, ICRF, 44 Lincoln's Inn
Fields, London WC2A 3PX, United Kingdom
FEATURES Location/Qualifiers
source 1..6227
/db_xref="H-InvDB:HIT000061654"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="primary epidermal keratinocyte"
CDS 91..5361
/codon_start=1
/product="195 kDa cornified envelope precursor"
/protein_id="AAC17738.1"
/translation="MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKN
IVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDM
IAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPL
VDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDY
MQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSE
GDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQE
LLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLK
YRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCF
VIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLL
AGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRS
TAEGEAFIQALPGSGTTPLLRTQVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQS
WELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQC
SSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD
HVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAV
KDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR
LQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK
STQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE
ALQLQLRALEQETRDGGQEYVFKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAE
VLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQE
EELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARA
SQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRG
AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLI
ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVE
LRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAE
AREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE
VKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNS
KSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDS
RLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHLDTGRE
LSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQ
SGRLTPAQYDRYVNKDMSIQELAVLVSGQK"
polyA_site 6227
/note="22 A nucleotides"
BASE COUNT 1596 a 1677 c 2025 g 929 t
ORIGIN
1 cgcgccgccg ctcgctcacc tgcgctcccg cccgcccctc ggtgcgcgcc cggcccgcca
61 gccgccgccg cccgcacccc gagcgccacc atgaactcgc tcttcaggaa gagaaacaaa
121 ggcaaataca gccccactgt gcagacccgg agcatctcta acaaggagct ctcggagctg
181 atcgagcagc tgcagaagaa tgccgaccag gtggagaaga acatcgtgga cacagaggcc
241 aagatgcaga gtgacctggc tcggctgcag gagggtcggc agcctgagca ccgggacgtg
301 accctgcaga aggtgttgga ctctgagaag ctgctctatg tgctagaggc ggatgcggcc
361 attgccaagc acatgaagca cccacagggg gacatgatcg ccgaggatat ccgccagctg
421 aaggagcgtg tgaccaacct gcgcgggaaa cacaagcaga tctacaggct ggcggtgaag
481 gaagtggatc cacaggtcaa ctgggcggca ctggtggagg agaagctgga caagctgaac
541 aaccagagct ttgggactga cctgccgctg gtggaccacc aagtggagga gcataacatc
601 ttccacaatg aggtcaaggc catcgggccc cacctggcca aggacgggga caaggagcag
661 aacagcgaac tccgggccaa gtaccagaaa ctgctggcag catcacaggc ccggcagcag
721 cacctgagtt cgctgcagga ctacatgcag cgctgcacca atgagctgta ctggctggac
781 cagcaggcca agggccgcat gcagtacgac tggagtgacc gcaacctcga ctaccccagc
841 cgccggcgcc agtatgagaa tttcatcaac cggaacctgg aggccaaaga ggagagaatc
901 aacaaactgc acagcgaggg cgaccagctg ctggcggccg agcaccccgg gaggaactcc
961 attgaggcgc acatggaggc tgtgcacgca gactggaagg agtacctgaa cctgctcatc
1021 tgcgaggaga gccacctcaa gtacatggag gactaccacc agtttcacga agacgtgaag
1081 gacgctcagg agctgctgcg caaggtggac tcggacctga accagaagta tggccctgac
1141 ttcaaggacc ggtaccagat tgagctgctg ctgcgggagc tggatgacca ggagaaggtg
1201 ctggacaagt atgaggacgt ggtgcagggg ctgcagaagc gaggccagca ggtggtgccc
1261 ctcaagtacc gccgggagac tccgctcaag cccatccccg tggaggcact ctgtgacttt
1321 gagggggagc agggcctgat ctcgcggggc tacagctaca ccctgcagaa gaacaacggg
1381 gagagctggg agctcatgga cagcgctggg aacaagctga ttgctccggc cgtctgtttt
1441 gtgatccccc ccacagaccc tgaggccctg gctctggctg acagcctggg cagccagtac
1501 cggagcgtgc ggcagaaggc agctgggagc aaacgcacgc tgcagcagcg gtatgaggtg
1561 ctgaagaccg agaatcccgg agatgcctct gacctacagg ggcggcagct gctggctggc
1621 ttggacaagg tggccagcga cctggaccgg caggagaagg ccatcacagg gatcctgcgg
1681 ccaccactgg agcaaggccg ggctgtgcag gacagtgccg agcgggccaa ggacctcaag
1741 aacatcacca acgagctact gcggattgaa cctgagaaga cgcggagcac ggctgagggc
1801 gaagccttca tccaggccct cccaggcagt ggcaccacac ccctgctgag gacccaggtg
1861 gaggacacca accggaaata cgagcacctc ctgcagctgc tggacttggc ccaggagaag
1921 gttgatgtgg ccaaccgcct ggagaagagc ctgcagcaga gctgggagtt gctggccaca
1981 cacgagaacc atctgaatca ggatgacaca gtgcctgaga gcagccgtgt cctggacagc
2041 aaggggcagg agctggcggc catggcctgt gagttacagg cccagaagtc cctcctgggt
2101 gaggtggagc agaacttgca ggcggccaag cagtgctcga gcacactggc cagccgcttc
2161 caggagcact gcccggacct ggagcgccag gaggccgagg tgcacaagct gggccagcgt
2221 ttcaacaacc tgcgccagca ggtggaacgc agggcgcaga gcctacagag cgccaaggca
2281 gcctacgagc acttccaccg cggccatgac cacgtgctgc agttcctagt cagcatcccc
2341 agttacgagc cccaggagac agacagcctc agccagatgg agaccaagct gaagaaccag
2401 aagaacctgc tagatgagat agcaagtagg gagcaggaag tacagaagat ctgtgccaat
2461 tcccagcagt accagcaagc tgtaaaggac tatgagttag aagcagaaaa actaaggtct
2521 cttctcgact tggagaatgg aaggagcagc cacgtgagca agagagccag gctccaatct
2581 cctgccacca aagtgaagga agaggaagca gcacttgccg ccaagttcac tgaagtttat
2641 gccatcaaca gacagaggct gcagaatctg gagtttgctc tgaatctcct cagacagcag
2701 ccggaagtag aagtgaccca tgagaccctg caaaggaata ggccggactc tggagtggag
2761 gaggcgtgga agatcaggaa ggaactggat gaggagactg agcggaggcg gcagctggag
2821 aacgaggtca agagcaccca ggaagaaatc tggaccttga ggaatcaggg gcctcaggaa
2881 tcggtggtga ggaaggaggt gctcaagaag gtgccggatc ccgtgctgga ggagagcttc
2941 cagcagctgc agcggacgct ggcagaggag cagcacaaga accagctgct gcaggaggag
3001 ctggaggcac tgcagctgca gctgcgtgcc ctggagcagg agaccagaga cggggggcag
3061 gagtacgtgt tcaaggaggt cctgcgcatc gagcctgaca gggcccaggc ggatgaggtc
3121 ttgcagctgc gggaggagct ggaggcactg aggcggcaga agggcgcccg ggaggcagag
3181 gtgctcctcc tgcagcagcg tgtggccgcc ctggctgaag agaagagccg ggcgcaggag
3241 aaggtcacag agaaagaggt ggtgaaactg cagaatgacc cccagctgga ggcagagtac
3301 cagcagctgc aggaggacca ccagcgccag gaccagctca gggagaagca ggaggaggag
3361 ctgagcttcc tccaggacaa gctcaagagg ctagagaagg agcgggccat ggccgagggc
3421 aagatcaccg tcaaggaggt gctcaaggtg gagaaggacg cggccaccga gagggaggtc
3481 agcgatctca cccgccaata tgaggacgag gctgccaagg ctcgcgctag ccagagggag
3541 aagacggagc tgctccgaaa gatatgggcc ttggaggagg agaacgccaa agtggtggtg
3601 caggagaagg tgcgggagat cgtgcggcca gaccccaagg cggaaagtga agtggcgaac
3661 ctccgcctgg agcttgtgga gcaggagcga aagtaccggg gtgccgagga gcagctccgg
3721 agctaccaga gtgagctgga ggccctcagg aggcgaggcc cccaggtgga agtcaaagag
3781 gtgactaagg aagtcattaa gtacaagact gaccctgaga tggagaagga gcttcagcgg
3841 ctcagggagg agatcgtgga caagaccaga ctgatcgaaa ggtgtgattt agagatctac
3901 cagctgaaaa aggaaatcca ggccctgaaa gacaccaaac cccaggtcca gaccaaagag
3961 gtggtccagg agatcctcca attccaagaa gaccctcaaa ccaaggagga ggtggcgtct
4021 ctgagggcaa agctctcaga ggagcagaag aaacaagtgg atctggagag ggaaagagct
4081 tcccaggaag agcagatcgc ccggaaagag gaggagctct cgcgggtgaa ggaaagggtg
4141 gtgcagcagg aggtggtcag gtatgaggag gagccaggcc tccgggccga ggcgagtgcc
4201 tttgccgaga gcatcgatgt ggagctgcgg cagattgaca agctgcgggc agagctgcgg
4261 cggctgcagc gccggcgcac cgagcttgag cggcagctgg aggagctaga gcgcgagcgg
4321 caggcccgca gggaggccga gcgcgaggta cagcggttgc agcagcggct ggcagcgctg
4381 gagcaggaag aagctgaggc ccgtgagaag gtaacccata cgcagaaggt ggtgctgcag
4441 caggacccgc agcaggcgcg agagcatgcc ctgctccgac tccagctgga agaagagcag
4501 caccggcggc agctcctgga gggggagctc gagaccctcc ggaggaaact ggctgcactg
4561 gagaaggcgg aggtcaagga gaaggtggtg ctctccgaga gtgtccaggt ggagaagggc
4621 gacaccgagc aagagatcca gaggctcaag agcagcctgg aggaggagag ccgcagcaag
4681 cgcgagctgg acgtcgaggt gagccggctg gaagccaggc tttcggagct ggaattccat
4741 aactccaagt catccaagga actagacttt ctgagggaag agaaccacaa attacagctg
4801 gagaggcaaa acctgcagct ggagacccga aggctccaat cggaaatcaa catggcagcg
4861 acggaaacac gagacctgcg gaacatgacc gtggcggact ctgggaccaa ccatgactcc
4921 agactgtggt ccctggagag ggaactggat gacctcaaga ggctctccaa ggacaaagac
4981 ctcgagatcg acgagctgca gaagcgcctg ggctccgtgg ccgtcaagcg ggagcagcgg
5041 gagaaccacc tgcggcgctc catcgtagtc atccaccttg acacaggccg cgagctgtcc
5101 ccggaggaag cccaccgtgc cgggctcatt gactggaaca tgttcgtgaa actcagaagc
5161 caggagtgcg actgggagga gatctcagtg aagggtccca atggggagtc ctcagtgata
5221 cacgacagga agtctggcaa gaagttctcc atcgaagagg ccctgcagag tggcaggctg
5281 acccctgctc agtatgaccg ctatgtcaac aaggatatgt ccatccagga gctggcggtc
5341 ttggtatctg ggcagaagta ggcacagctc ttgcaactct tcgtaacggc agacgctggc
5401 cctctcctac gacgcagtga cctccttggt gtcgtcctct ccctagccct ggtgcaggcc
5461 aagcatttta tacataccct cgctgccagg ctgctcagag tcccgcccac atatgagaca
5521 ggcactggct gaagacaggc aactctcgtc ccaaccatca ttcaccctga gtgacgtact
5581 tcatcctcca atgactggac aactgcgatg ccttttcctc ccttttcctg tacactccca
5641 gcaacaaact cctcatgata actgcacaca atctgaaaac cactgaagga caagccaacc
5701 acagcagcca agcccactcc ttgcagcatg ggtactggtg gcacaccaga cagtgacact
5761 gccccacaaa ggcctgggcc cgtgggggct gctgcctggc atgacatctc tccagatttc
5821 tggcttaaaa caactttcca tccgagaagc ctcctcagta gttactctgc tcatgagaca
5881 gatctgggct ccaagccagg aaaggtgaac agaaaccaca agtgtccagc cctcggtgct
5941 ggagtggacg ttaattgtca gccaccagac tgtcccggca cctacagaga atgtttcaca
6001 gttctggcat ttaaatcctt tgatagtgga ttgtgctgct gttagcctta gtttcagtgc
6061 tttacaagtc tcgcttatta tctcattggt atttaggtat acaaaacagt tgattattca
6121 ccacgccaat atctgggtct ctgtatctca tgtagaacat aagaaaatgg gaactaatag
6181 ggaactttat ttatagcatg aaaataaacc tggtggctgg agtctga
//