LOCUS AF001362 3500 bp mRNA linear HUM 17-JUN-1998
DEFINITION Homo sapiens Jak2 kinase (JAK2) mRNA, complete cds.
ACCESSION AF001362
VERSION AF001362.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3500)
AUTHORS Dalal,I., Arpaia,E., Dadi,H., Kulkarni,S., Squire,J. and
Roifman,C.M.
TITLE Cloning and characterization of the human homolog of mouse Jak2
JOURNAL Blood 91 (3), 844-851 (1998)
PUBMED 9446644
REFERENCE 2 (bases 1 to 3500)
AUTHORS Roifman,C.M.
TITLE Direct Submission
JOURNAL Submitted (26-APR-1997) Immunology, Hospital for Sick Children, 555
University Ave., Toronto, Ontario M5G 1X8, Canada
FEATURES Location/Qualifiers
source 1..3500
/db_xref="H-InvDB:HIT000061625"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p23-24"
/cell_line="pre-B leukaemia cell line G2"
/cell_type="thymocytes, peripheral blood lymphocytes"
gene 1..3500
/gene="JAK2"
CDS 1..3399
/gene="JAK2"
/codon_start=1
/product="Jak2 kinase"
/protein_id="AAC23653.1"
/translation="MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLY
HSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVF
HIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHD
FVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKI
QDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPG
SGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQE
GSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAV
LENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSN
LLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRRE
VGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL
VQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLI
REEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFG
TTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK
GVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRY
IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRL
PRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQVRDNMAG"
BASE COUNT 1181 a 608 c 740 g 971 t
ORIGIN
1 atggggatgg cttgccttac gatgacagaa atggagggaa catccacctc ttctatatat
61 cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag
121 gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg
181 gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg
241 tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat
301 gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt
361 cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct
421 gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat
481 tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg
541 atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc
601 tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac
661 tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc
721 agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact
781 ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca
841 ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga
901 gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt
961 cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga
1021 gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg
1081 gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat
1141 cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt
1201 catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact
1261 ggactgtatg tactacgatg cagtccgaag gactttaata aatattttct gacctttgct
1321 gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa
1381 gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt
1441 taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc
1501 ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta
1561 ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc
1621 agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt
1681 aaaggcgtac ggagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta
1741 aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg
1801 atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac
1861 gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag
1921 aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc
1981 atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg
2041 cttatcagag aagaagacag gaagacagga aaccctcctt tcatcaaact tagtgatcct
2101 ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca
2161 cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt
2221 acaactctgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa
2281 agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta
2341 gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc
2401 atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac
2461 atgttaccaa atatgaggat aggtgcccta gggttttctg gtgcctttga agaccgggat
2521 cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt
2581 gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct
2641 gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa
2701 atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct
2761 ggtcggcgta atctaaagtt aattatggaa tatttaccat atggaagttt acgagattat
2821 cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata
2881 tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga
2941 aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc
3001 ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg
3061 tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt
3121 ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa
3181 tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa
3241 cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg
3301 atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct
3361 cttcgagtgg atcaagtaag ggataacatg gctggatgaa agaaatgacc ttcattctga
3421 gaccaaagta gatttacaga acaaagtttt atatttcaca ttgctgtgga ctattattac
3481 atatatcatt attatataaa
//