LOCUS AF000571 3129 bp mRNA linear HUM 06-OCT-1997
DEFINITION Homo sapiens kidney and cardiac voltage dependent K+ channel
(KvLQT1) mRNA, complete cds.
ACCESSION AF000571
VERSION AF000571.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3129)
AUTHORS Chouabe,C., Neyroud,N., Guicheney,P., Lazdunski,M., Romey,G. and
Barhanin,J.
TITLE Properties of KvLQT1 K+ channel mutations in Romano-Ward and
Jervell and Lange-Nielsen inherited cardiac arrhythmias
JOURNAL EMBO J. 16 (17), 5472-5479 (1997)
PUBMED 9312006
REFERENCE 2 (bases 1 to 3129)
AUTHORS Barhanin,J., Romey,G. and Lazdunski,M.
TITLE Direct Submission
JOURNAL Submitted (21-APR-1997) IPMC, CNRS, route des lucioles,
Sophia-Antipolis, Valbonne 06560, France
FEATURES Location/Qualifiers
source 1..3129
/db_xref="H-InvDB:HIT000061586"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.5"
/tissue_type="kidney"
gene 1..3129
/gene="KvLQT1"
CDS 111..2141
/gene="KvLQT1"
/note="Delayed rectifier IKs alpha subunit"
/codon_start=1
/product="kidney and cardiac voltage dependent K+ channel"
/protein_id="AAC51776.1"
/translation="MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGG
PAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLA
RTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
IVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSK
GQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFS
SYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSV
FAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTW
KIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEE
RRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLRE
HHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQS
IGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGST
PGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS"
BASE COUNT 579 a 1041 c 952 g 557 t
ORIGIN
1 gggcggcggg gctggcagca gtggctgccc gcactgcgcc cgggcgctcg ccttcgctgc
61 agctcccggt gccgccgctc gggccggccc cccggcaggc cctcctcgtt atggccgcgg
121 cctcctcccc gcccagggcc gagaggaagc gctggggttg gggccgcctg ccaggcgccc
181 ggcggggcag cgcgggcctg gccaagaagt gccccttctc gctggagctg gcggagggcg
241 gcccggcggg cggcgcgctc tacgcgccca tcgcgcccgg cgccccaggt cccgcgcccc
301 ctgcgtcccc ggccgcgccc gccgcgcccc cagttgcctc cgaccttggc ccgcggccgc
361 cggtgagcct agacccgcgc gtctccattt acagcacgcg ccgcccggtg ttggcgcgca
421 cccacgtcca gggccgcgtc tacaacttcc tcgagcgtcc caccggctgg aaatgcttcg
481 tttaccactt cgccgtcttc ctcatcgtcc tggtctgcct catcttcagc gtgctgtcca
541 ccatcgagca gtatgccgcc ctggccacgg ggactctctt ctggatggag atcgtgctgg
601 tggtgttctt cgggacggag tacgtggtcc gcctctggtc cgccggctgc cgcagcaagt
661 acgtgggcct ctgggggcgg ctgcgctttg cccggaagcc catttccatc atcgacctca
721 tcgtggtcgt ggcctccatg gtggtcctct gcgtgggctc caaggggcag gtgtttgcca
781 cgtcggccat caggggcatc cgcttcctgc agatcctgag gatgctacac gtcgaccgcc
841 agggaggcac ctggaggctc ctgggctccg tggtcttcat ccaccgccag gagctgataa
901 ccaccctgta catcggcttc ctgggcctca tcttctcctc gtactttgtg tacctggctg
961 agaaggacgc ggtgaacgag tcaggccgcg tggagttcgg cagctacgca gatgcgctgt
1021 ggtggggggt ggtcacagtc accaccatcg gctatgggga caaggtgccc cagacgtggg
1081 tcgggaagac catcgcctcc tgcttctctg tctttgccat ctccttcttt gcgctcccag
1141 cggggattct tggctcgggg tttgccctga aggtgcagca gaagcagagg cagaagcact
1201 tcaaccggca gatcccggcg gcagcctcac tcattcagac cgcatggagg tgctatgctg
1261 ccgagaaccc cgactcctcc acctggaaga tctacatccg gaaggccccc cggagccaca
1321 ctctgctgtc acccagcccc aaacccaaga agtctgtggt ggtaaagaaa aaaaagttca
1381 agctggacaa agacaatggg gtgactcctg gagagaagat gctcacagtc ccccatatca
1441 cgtgcgaccc cccagaagag cggcggctgg accacttctc tgtcgacggc tatgacagtt
1501 ctgtaaggaa gagcccaaca ctgctggaag tgagcatgcc ccatttcatg agaaccaaca
1561 gcttcgccga ggacctggac ctggaagggg agactctgct gacacccatc acccacatct
1621 cacagctgcg ggaacaccat cgggccacca ttaaggtcat tcgacgcatg cagtactttg
1681 tggccaagaa gaaattccag caagcgcgga agccttacga tgtgcgggac gtcattgagc
1741 agtactcgca gggccacctc aacctcatgg tgcgcatcaa ggagctgcag aggaggctgg
1801 accagtccat tgggaagccc tcactgttca tctccgtctc agaaaagagc aaggatcgcg
1861 gcagcaacac gatcggcgcc cgcctgaacc gagtagaaga caaggtgacg cagctggacc
1921 agaggctggc actcatcacc gacatgcttc accagctgct ctccttgcac ggtggcagca
1981 cccccggcag cggcggcccc cccagagagg gcggggccca catcacccag ccctgcggca
2041 gtggcggctc cgtcgaccct gagctcttcc tgcccagcaa caccctgccc acctacgagc
2101 agctgaccgt gcccaggagg ggccccgatg aggggtcctg aggaggggat ggggctgggg
2161 gatgggcctg agtgagaggg gaggccaaga gtggccccac ctggccctct ctgaaggagg
2221 ccacctccta aaaggcccag agagaagagc cccactctca gaggccccaa taccccatgg
2281 accatgctgt ctggcacagc ctgcacttgg gggctcagca aggccacctc ttcctggccg
2341 gtgtgggggc cccgtctcag gtctgagttg ttaccccaag cgccctggcc cccacatggt
2401 gatgttgaca tcactggcat ggtggttggg acccagtggc agggcacagg gcctggccca
2461 tgtatggcca ggaagtagca caggctgagt gcaggcccac cctgcttggc ccagggggct
2521 tcctgagggg agacagagca acccctggac cccagcctca aatccaggac cctgccaggc
2581 acaggcaggg caggaccagc ccacgctgac tacagggcca ccggcaataa aagcccagga
2641 gcccatttgg agggcctggg cctggctccc tcactctcag gaaatgctga cccatgggca
2701 ggagactgtg gagactgctc ctgagccccc agcttccagc aggagggaca gtctcaccat
2761 ttccccaggg cacgtggttg agtgggggga acgcccactt ccctgggtta gactgccagc
2821 tcttcctagc tggagaggag ccctgcctct ccgcccctga gcccactgtg cgtggggctc
2881 ccgcctccaa cccctcgccc agtcccagca gccagccaaa cacacagaag gggactgcca
2941 cctccccttg ccagctgctg agccgcagag aagtgacggt tcctacacag gacaggggtt
3001 ccttctgggc attacatcgc atagaaatca ataatttgtg gtgatttgga tctgtgtttt
3061 aatgagtttc acagtgtgat tttgattatt aattgtgcaa gcttttccta ataaacgtgg
3121 agaatcaca
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