LOCUS       AF000145                4380 bp    mRNA    linear   HUM 16-JUL-1999
DEFINITION  Homo sapiens germinal center kinase related protein kinase mRNA,
            complete cds.
ACCESSION   AF000145
VERSION     AF000145.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4380)
  AUTHORS   Diener,K., Wang,X.S., Chen,C., Meyer,C.F., Keesler,G., Zukowski,M.,
            Tan,T.H. and Yao,Z.
  TITLE     Activation of the c-Jun N-terminal kinase pathway by a novel
            protein kinase related to human germinal center kinase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (18), 9687-9692 (1997)
   PUBMED   9275185
REFERENCE   2  (bases 1 to 4380)
  AUTHORS   Katrina,D., Wang,X.S., Chen,C., Zukowski,M., Tan,T.-H. and Yao,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-1997) 261, Amgen, Inc., 3200 Walnut St., Boulder,
            CO 80301, USA
FEATURES             Location/Qualifiers
     source          1..4380
                     /db_xref="H-InvDB:HIT000061559"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="macrophage"
     CDS             361..3015
                     /note="GLK; germinal center kinase-like kinase"
                     /codon_start=1
                     /product="germinal center kinase related protein kinase"
                     /protein_id="AAC15472.1"
                     /translation="MAQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED
                     FAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQ
                     IAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKS
                     FIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTK
                     SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELL
                     DKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRK
                     ETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGADKSLLKSVEEE
                     LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIK
                     RCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGT
                     NLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLI
                     FGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFD
                     YARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGAL
                     QTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQ
                     VVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSR
                     KLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDR
                     VVVLESRPTDNPTANSNLYILAGHENSY"
BASE COUNT         1509 a          745 c          835 g         1291 t
ORIGIN      
        1 gaagaagaga ttttaaacaa aaaacgatct aaaaaaattc agaagaaata tgatgaaagg
       61 aaaaagaatg ccaaaatcag cagtctcctg gaggagcagt tccagcaggg caagcttctt
      121 gcgtgcatcg cttcaaggcc gggacagtgt ggccgagcag atggctatgt tgctagaggg
      181 caaagagttg gagttctatc ttaggaaaat caaggccgca aaggcaaata aatccttgtt
      241 ttgtcttcac ccatgtaata aaggtgttta ttgttttgtt cccaccaaaa aaaaaaaaaa
      301 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaacc
      361 atggcgcagg aggacttcga gctgattcag cgcatcggca gcggcaccta cggcgacgtc
      421 tacaaggcac ggaatgttaa cactggtgaa ttagcagcaa ttaaagtaat aaaattggaa
      481 ccaggagaag actttgcagt tgtgcagcaa gaaattatta tgatgaaaga ctgtaaacac
      541 ccaaatattg ttgcttattt tggaagctat ctcaggcgag ataagctttg gatttgcatg
      601 gagttttgtg gaggtggttc tttacaggat atttatcacg taactggacc tctgtcagaa
      661 ctgcaaattg catatgttag cagagaaaca ctgcagggat tatattatct tcacagtaaa
      721 ggaaaaatgc acagagatat aaagggagct aacattctat taacggataa tggtcatgtg
      781 aaattggctg attttggagt atctgcacag ataacagcta caattgccaa acggaagtct
      841 ttcattggca caccatattg gatggctcca gaagttgcag ctgttgagag gaaggggggt
      901 tacaatcaac tctgtgatct ctgggcagtg ggaatcactg ccatagaact tgcagagctt
      961 cagcctccta tgtttgactt acacccaatg agagcattat ttctaatgac aaaaagcaat
     1021 tttcagcctc ctaaactaaa ggataaaatg aaatggtcaa atagttttca tcactttgtg
     1081 aaaatggcac ttaccaaaaa tccgaaaaaa agacctactg ctgaaaaatt attacagcat
     1141 ccttttgtaa cacaacattt gacacggtct ttggcaatcg agctgttgga taaagtaaat
     1201 aatccagatc attccactta ccatgatttc gatgatgatg atcctgagcc tcttgttgct
     1261 gtaccacata gaattcactc aacaagtaga aacgtgagag aagaaaaaac acgctcagag
     1321 ataacctttg gccaagtgaa atttgatcca cccttaagaa aggagacaga accacatcat
     1381 gaacttcccg acagtgatgg ttttttggac agttcagaag aaatatacta cactgcaaga
     1441 tctaatctgg atctgcaact ggaatatgga caaggacacc aaggtggtta ctttttaggt
     1501 gcagacaaga gtcttctcaa gtctgttgaa gaagaattgc atcagcgagg acacgtcgca
     1561 catttagaag atgatgaagg agatgatgat gaatctaaac actcaactct gaaagcaaaa
     1621 attccacctc ctttgccacc aaagcctaag tctatcttca taccacagga aatgcattct
     1681 actgaggatg aaaatcaagg aacaatcaag agatgtccca tgtcagggag cccagcaaag
     1741 ccatcccaag ttccacctag accaccacct cccagattac ccccacacaa acctgttgcc
     1801 ttaggaaatg gaatgagctc cttccagtta aatggtgaac gagatggctc attatgtcaa
     1861 caacagaatg aacatagagg cacaaacctt tcaagaaaag aaaagaaaga tgtaccaaag
     1921 cctattagta atggtcttcc tccaacacct aaagtgcata tgggtgcatg tttttcaaaa
     1981 gtttttaatg ggtgtccctt gaaaattcac tgtgcatcat catggataaa cccagataca
     2041 agagatcagt acttgatatt tggtgccgaa gaagggattt ataccctcaa tcttaatgaa
     2101 cttcatgaaa catcaatgga acagctattc cctcgaaggt gtacatggtt gtatgtaatg
     2161 aacaattgct tgctatcaat atctggtaaa gcttctcagc tttattccca taatttacca
     2221 gggctttttg attatgcaag acaaatgcaa aagttacctg ttgctattcc agcacacaaa
     2281 ctccctgaca gaatactgcc aaggaaattt tctgtatcag caaaaatccc tgaaaccaaa
     2341 tggtgccaga agtgttgtgt tgtaagaaat ccttacacgg gccataaata cctatgtgga
     2401 gcacttcaga ctagcattgt tctattagaa tgggttgaac caatgcagaa atttatgtta
     2461 attaagcaca tagattttcc tataccatgt ccacttagaa tgtttgaaat gctggtagtt
     2521 cctgaacagg agtacccttt agtttgtgtt ggtgtcagta gaggtagaga cttcaaccaa
     2581 gtggttcgat ttgagacggt caatccaaat tctacctctt catggtttac agaatcagat
     2641 accccacaga caaatgttac tcatgtaacc caactggaga gagataccat ccttgtatgc
     2701 ttggactgtt gtataaaaat agtaaatctc caaggaagat taaaatctag caggaaattg
     2761 tcatcagaac tcacctttga tttccagatt gaatcaatag tgtgcctaca agacagtgtg
     2821 ctagctttct ggaaacatgg aatgcaaggt agaagtttta gatctaatga ggtaacacaa
     2881 gaaatttcag atagcacaag aattttcagg ctgcttggat ctgacagggt cgtggttttg
     2941 gaaagtaggc caactgataa ccccacagca aatagcaatt tgtacatcct ggcgggtcat
     3001 gaaaacagtt actgagaatt gttgtgcttt gacagttaac tctagaaaga aagaacacta
     3061 ccactgcaac attaatggat gcttgaagct gtacaaaagc tgcagtaacc tgtcttcagt
     3121 tactttgtaa tttattgtgg catgagataa gatggggaaa attttgtttt atgtggtatg
     3181 gatatattta gcatattgaa ccacacaagt gcttaattca ttgttatgta atctttgtac
     3241 atataggcag tattttttct gtgaaacttc atattgctga agacatacac taagaattta
     3301 tgtagataat gtacttttat gagatgtaca agtaagtgtc ttatctgtac agatgtaaat
     3361 gttgatgaaa atgcaattgg ggttaatatt ttaagaattc tttagtatat tcttgggtgt
     3421 ggctatatta caaaatggga tgctggcaat gaaacaatac atttaacact attgtatttt
     3481 tattatatgt aatttagtaa tatgaatata aatcttgtaa cttttaaaat tgtaatggag
     3541 gctgtaatca ttttataatc tttttaattt taatgcaagt acactggtgt ttatatttgc
     3601 acaaagtatt gatatgtgat gtattaagtc acaaaagtaa gctgtgacat tgtctataag
     3661 catttggctc cacaaatgta tttggattgt tttctatgtg aagcaaacca attataatta
     3721 accacatgtt gtagtaactg gtctttttat atttaagcag aatcctgtaa gattgcttgt
     3781 ctttgcttaa aaacaatacc tttgaacatt tttgaatcac agaatagcgg taccatgata
     3841 gaatactgca attgtggtca gaattacagt atgcacaaag aattaattag cattattaaa
     3901 gagtcctcac taaacatttc atatgatcac actgaagaac tgtaacattc catagagtga
     3961 agtggttcaa atttctcttg gaatttttac ttttgttggc cttattttat gatccttttc
     4021 atatttcttt tgacttagag tattaataca tggccaaaat aatttagtta ctacctcata
     4081 caaacaatat aatggttact acacatcaca ggaacttagt tttggtttaa gtcatttttg
     4141 attgcttttt tccaatggaa tatgtatata ccaggtttta gcaaaatgca cacttttggc
     4201 tctttttggt atatgttctt tatattttaa tgtgagtata tacactaaga acaaactaaa
     4261 ttgtgattta tgatcttcat ttattttaat gataatggtt ttaaaatatg ttcctgattg
     4321 tacatattgt aaaataaaca tgttttttaa caaaaaaaaa aaagaaaaaa aaaaaaaaaa
//