LOCUS AB586699 4343 bp mRNA linear HUM 17-SEP-2010
DEFINITION Homo sapiens IREB2 variant mRNA for iron-responsive element
binding protein 2 variant, complete cds.
ACCESSION AB586699
VERSION AB586699.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4343)
AUTHORS Takei,M., Ishiwata,T., Nishi,T. and Sawada,S.
TITLE Direct Submission
JOURNAL Submitted (07-SEP-2010) to the DDBJ/EMBL/GenBank databases.
Contact:Masami Takei
Nihon University School of Medicine, Division of hematology and
Rheumatology, Department of Medicine; 30-1 Oyaguchi, Itabashi-ku,
Tokyo 173-8610, Japan
REFERENCE 2
AUTHORS Takei,M., Ishiwata,T., Mitamura,K., Fujiwara,S., Sasaki,K.,
Nishi,T., Kuga,T., Ookubo,T., Horie,T., Ryu,J., Ohi,H. and
Sawada,S.
TITLE Decreased expression of signaling lymphocytic-activation
molecule-associated protein (SAP) transcripts in T cells from
patients with rheumatoid arthritis
JOURNAL Int. Immunol. 13, 559-565 (2001)
REFERENCE 3
AUTHORS Sawada,S. and Takei,M.
TITLE Possible involvement of Epstein-Barr virus and its regulatory gene
in rheumatoid synovitis
JOURNAL Autoimmun Rev (Suppl 1), S69-S71 (2004)
REFERENCE 4
AUTHORS Sawada,S. and Takei,M.
TITLE Epstein-Barr virus etiology in rheumatoid synovitis
JOURNAL Autoimmun Rev 4, 106-110 (2005)
REFERENCE 5
AUTHORS Sawada,S., Takei,M., Inomata,H., Nozaki,T. and Shiraiwa,H.
TITLE What is after cytokine-blocking therapy, a novel therapeutic
target--synovial Epstein-Barr virus for rheumatoid arthritis
JOURNAL Autoimmun Rev 6, 126-130 (2007)
REFERENCE 6
AUTHORS Sawada,S., Takei,M. and Ishiwata,T.
TITLE SAP discovery: the sword edges-beneficial and harmful
JOURNAL Autoimmun Rev 6, 444-449 (2007)
REFERENCE 7
AUTHORS Sawada,S., Takei,M., Ishiwata,T., Shiraiwa,H., Inomata,H. and
Nozaki,T.
TITLE SLAM-associated protein solves a mystery of autoimmunity
JOURNAL Ann. N. Y. Acad. Sci. 1109, 19-30 (2007)
REFERENCE 8
AUTHORS Takei,M., Kitamura,N., Shiraiwa,H., Inomata,H., Nozaki,T.,
Kuwata,Y., Shiozaki,M., Sawada,S. and Ishiwata,T.
TITLE The possible curative therapy for rheumatoid arthritis-EBV
infection control gene SAP and its application
JOURNAL Nihon Rinsho Meneki Gakkai Kaishi 31, 141-151 (2008)
REFERENCE 9
AUTHORS Ishiwata,T., Sakurada,M., Nishimura,A., Nakagawa,S., Nishi,T.,
Kuga,T., Sawada,S., Takei,M., Shibata,K. and Furuya,A.
TITLE IgA nephropathy-related gene
JOURNAL Patent: WO 98/24899 11-JUN-1998
REFERENCE 10
AUTHORS Ishiwata,T., Sakurada,M., Kawabata,A., Nakagawa,S., Nishi,T.,
Kuga,T., Sawada,S., Takei,M., Shibata,K. and Furuya,A.
TITLE IgA nephropathy-related DNA
JOURNAL Patent: CA 2329683 09-DEC-1999
REFERENCE 11
AUTHORS Ishiwata,T., Sakurada,M., Nishimura,A., Nakagawa,S., Nishi,T.,
Kuga,T., Sawada,S. and Takei,M.
TITLE IgA nephropathy-related gene
JOURNAL Patent: US 6828428-B2 07-DEC-2004
REFERENCE 12
AUTHORS Ishiwata,T., Sakurada,M., Kawabata,A., Nakagawa,S., Nishi,T.,
Kuga,T., Sawada,S., Takei,M., Shibata,K. and Furuya,A.
TITLE IgA nephropathy-related DNA
JOURNAL Patent: US 6962984-B2 08-NOV-2005
REFERENCE 13
AUTHORS Furuya,A., Ishiwata,T., Kawabata,A., Kuga,T., Nakagawa,S.,
Nishi,T., Sakurada,M., Sawada,S., Shibata,K. and Takei,M.
TITLE IgA nephropathy-related DNA
JOURNAL Patent: EP 2077275-A2 08-JUL-2009
COMMENT
FEATURES Location/Qualifiers
source 1..4343
/db_xref="H-InvDB:HIT000563806"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
CDS 1..1032
/codon_start=1
/gene="IREB2 variant"
/product="iron-responsive element binding protein 2
variant"
/protein_id="BAJ19024.1"
/transl_table=1
/translation="MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRV
LLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAM
REAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLK
VQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQ
EVEFGRNRERLQFFKWSSRVLKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSV
VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSID
VVLGITKVS"
BASE COUNT 1321 a 795 c 865 g 1359 t
ORIGIN
1 atggacgccc caaaagcagg atacgccttt gagtacctta ttgaaacatt aaatgacagt
61 tcacataaga agttcttcga tgtatctaaa cttggcacca agtatgatgt tctgccttac
121 tcaatacggg tcttgttgga agctgctgta cgaaattgtg atggcttttt aatgaagaag
181 gaagatgtta tgaacatttt agactggaaa accaaacaaa gcaatgttga agtgcccttt
241 ttccctgccc gtgttcttct tcaagatttt actggaatac cagcaatggt ggattttgct
301 gctatgaggg aggcagtgaa aactcttgga ggtgatcctg agaaagtcca tcctgcttgt
361 ccgacagatc ttacagttga ccattcttta caaattgact tcagtaaatg tgcaatacag
421 aatgcaccaa atcctggagg tggtgacctg cagaaagcag gaaagctctc tccacttaaa
481 gtgcagccta agaagcttcc ctgcagaggc cagactacct gccgaggatc ttgtgattct
541 ggagaactag gccgaaactc aggaacattt tcttcgcaga ttgagaatac acccatcctg
601 tgtccttttc atttgcaacc agtgcctgaa cctgaaacag tgttaaaaaa tcaagaagta
661 gaattcggca gaaatcgaga gaggcttcag ttttttaagt ggagttcaag agttttaaag
721 aatgtggcag tgatccctcc tggaactgga atggctcatc aaataaactt agaatatttg
781 tcaagagtgg tttttgaaga aaaagacctc ctcttcccag acagtgtagt cggcacagat
841 tcacacataa cgatggtgaa tggtttaggg attctggggt ggggggttgg aggcattgaa
901 acagaagcag ttatgcttgg tctgccagtt tctcttactt taccagaggt ggttggatgt
961 gagttaactg ggtcatcaaa cccttttgtt acatccatag atgttgttct tggtattaca
1021 aaggtaagtt aaagttgtgg tagctctatg acttactgaa cattattttt ataaaaattg
1081 aagagctcta tgagagcagg gatttgggtt cattactgca tcctcaggtc tcttgacgtt
1141 agccacatca tcatagttat catagtaata acaacaaaca gagcatttag tttgtactaa
1201 taaatacaaa gaaatttgtt gtgttcactt atgttagctc atttagtcct tataacaagc
1261 ctgtgagatg gatactatta ctattctcat tgtaactctg agaaaactaa ggtacagtag
1321 ggtttagtga cttaccaaag ggtcgaaggc ctgagtataa ggggtagagc aaagattcca
1381 ggcagtcaga ttcttgagtc atgtctaacc attatgcctt attagtgcct tgttgcctta
1441 ataaacactt gctggactac atattttttt tctctttttt aacttgaatt aaaaaaaaat
1501 gtttagcaaa agttgawtgt gtcgtcttta attaaattat ttgcccgtta gaaactgttg
1561 ctctactaag taatgctttc aaaaacatgg actgtagaaa tgtgatatat catttttctg
1621 ttgccgtttt aacatttctc tggattatta tgtaaaaatc ttctctctga atttttaaaa
1681 tactggcttc agaacttcaa tacatacact gagcttgtta agcatattaa tacacaggct
1741 cacggatttc ctagtgaaca ataatttgta actcttcttc ctaaatgtct ggcctttgct
1801 aactttattt taatgattaa atcctatttt gttaaatgaa tgtacctgga aaatgttcca
1861 catataattc caatttgagt cccaatctca gcatttttgg ttagattatt ggtacgaagg
1921 ctttctggat actccagtgt aaggaaatga taatgcctcc ctctcagcat ttggtattga
1981 tccttcttcc ctaattagaa aagaatttgg catcttagag aaattattga ttcaacgtat
2041 gataccaaaa gatcaagtag taaattggga attgcaggat tattcctaga ggaaaaggag
2101 tatcccatta tgtttttaca gaaatcaatt ctttacttta gacatcctga aaactaacgc
2161 tgctttttag ccttctctag ctgttttttc ctgacaatat tactgtgtgt tttttgacat
2221 tttagtttaa tgttaaaaaa ttaatctatt atatatgttt acatttattg aatatattga
2281 ttacttcttt tttgagatcc tgttccattt gtgatcctta taggaataat cctgtattgt
2341 ttttttgatg agagcagcat ttggtttgta atatctaatc tgtgtttctt tcatcctaaa
2401 aaataaaacc ataggccggg cgcggtggct cacgcctgta atcccagcac tttgggaggc
2461 cgaggcgggt ggatcatgag gtcaggagat cgagaccatc ctggctaaca aggtgaaacc
2521 ccgtctctac taaaaataca aaaaattagc cgggcgcggt ggcgggcgcc tgtagtccca
2581 gcttctcggg aggctgaggc aggagaatgg cgtgaacccg ggaggcggag cttgcagtga
2641 gccaagattg cgccactgca gtccgcagtc cggcctgggc gacagagcga gactctgtyt
2701 caaaaaaaaa aaaaaaaaaa aaaaaaccat aaatgaggaa acgcatcttt acacttaggg
2761 tttgagtttc tgtatctata aaaaagggtt tggattaagt gatccctggc acttataaaa
2821 tgttagggct taatattatt catagatcga ggatagtttc attcttagtc gcctccttag
2881 tcactcttcc tataccaatc tgagaccatt ttacaattta gaaaagacaa ataactggtt
2941 gggttacttg atagtataat aaccaagaaa aataatttta gaaggaatta agtttgaaac
3001 cacatgttaa caaattctac caaagtggga tttgcctgtg attaaagatg ctgtaaacat
3061 ttgggccagt agttataatt tgaaaaatgt ttatagccaa tatataattt tttatttaaa
3121 tatacagttt catcagtcta ttagtatttc attaagtcta agatgccatc agtggttagc
3181 aaacaccact gttttatgca ctgctaagaa agaataaagg gctgtgtgca gtggctcaca
3241 cctgtgggac gccaaggcag gagcatcact tgaggccaga agttcaagac caacctggtc
3301 aacattgtaa gaccctgtct ctacaaaaaa aaaaaagtta aaaattagct gggtgcggtg
3361 gcacatgcct gtagttccag ctactctgga ggctaaggtg ggaggattgc tagagccacg
3421 gtgttggaag ctgcaatgag ctgtgaccac accactgcgc tccagcgtgg gcaacagagt
3481 gagaccctgt ttctaaaaga aagaaagaaa aaagggctgc cacctaaaca gacacactat
3541 tgagttgagg taccctgatt tcaaagacat gaaaatgtta attatagcca ccttgaagct
3601 ttcaggsccc tttctaccct gaattaacag tgacattgga ccagtcttct ctttacttct
3661 tatcttaaaa tacccccaaa accagaatga gttgattcat aaggacaatg aaggatctca
3721 ttccttcacc atcactagta ttggttaaaa attttatttt atagttttca gacaatcgtt
3781 gctaatctta tctttgcaat tttgtatgtg tttctgtgta ttccttatat agcacctcag
3841 gcaagtagga gtggctggaa agtttgttga gttttttgga agtggagttt cacaattatc
3901 tatagttgat cgaactacaa tagcaaacat gtgtccggaa tatggtgcta tcctcagctt
3961 tttccctgtt gacaatgtga cattaaaaca tttagaacat acaggtaaga agataaaaga
4021 tcactagaat aaacatgtta catttccaat gtgtttgata atattttata aattactacc
4081 ttatccatgt tatttactac tcacaaaatt acattatgtt gaaacaacaa ctttcaagca
4141 aacatcagat gtctttaaag agtgttgtgt cctcaaaccc tagttccctg tgacacattg
4201 aaagcaattt aaaggaatta ttcaaaccat tgatcctgac ttgactgttt cccataatga
4261 tggatacctc cccctctact taggggtcat aggtgcaatt taatggagtc agcccttaaa
4321 catattcaca gcagtcccct tct
//