LOCUS AB085847 1851 bp mRNA linear HUM 26-NOV-2002 DEFINITION Homo sapiens HRD1 mRNA for HRD1, complete cds. ACCESSION AB085847 VERSION AB085847.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1851) AUTHORS Kaneko,M. TITLE Direct Submission JOURNAL Submitted (28-MAY-2002) to the DDBJ/EMBL/GenBank databases. Contact:Masayuki Kaneko Graduate School of Pharmaceutical Sciences, Hokkaido University, Department of Pharmacology; Nishi-6, Kita-12, Kita-ku, Sapporo, Hokkaido 060-0812, Japan URL :http://www.hokudai.ac.jp/pharma/yakuri/e_index.htm REFERENCE 2 AUTHORS Kaneko,M., Ishiguro,M., Niinuma,Y., Uesugi,M. and Nomura,Y. TITLE Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation JOURNAL FEBS Lett. 532, 147-152 (2002) COMMENT FEATURES Location/Qualifiers source 1..1851 /db_xref="H-InvDB:HIT000061441" /db_xref="taxon:9606" /mol_type="mRNA" /organism="Homo sapiens" CDS 1..1851 /codon_start=1 /experiment="experimental evidence, no additional details recorded" /function="ubiquitin-protein ligase for endoplasmic reticulum-associated degradation" /gene="HRD1" /note="Homolog of yeast Hrd1p" /product="HRD1" /protein_id="BAC24801.1" /transl_table=1 /translation="MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMA VLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPR FVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLIFLLGILDFLFVSHAY HSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELF TGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLY PDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVL RASLPAQSPPPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFP PVPPPPSSGEAVAPPSTSAALSRPSGAATTTAAGTSATAASATASGPGSGSAPEAGPA PGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRN IHTLLDAAMLQINQYLTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEATTP TPGASPPAPEMERPPAPESVGTEEMPEDGEPDAAELRRRRLQKLESPVAH" BASE COUNT 328 a 665 c 453 g 405 t ORIGIN 1 atgttccgca cggcagtgat gatggcggcc agcctggcgc tgaccggggc tgtggtggct 61 cacgcctact acctcaaaca ccagttctac cccactgtgg tgtacctgac caagtccagc 121 cccagcatgg cagtcctgta catccaggcc tttgtccttg tcttccttct gggcaaggtg 181 atgggcaagg tgttctttgg gcaactgagg gcagcagaga tggagcacct tctggaacgt 241 tcctggtacg ccgtcacaga gacttgtctg gccttcaccg tttttcggga tgacttcagc 301 ccccgctttg ttgcactctt cactcttctt ctcttcctca aatgtttcca ctggctggct 361 gaggaccgtg tggactttat ggaacgcagc cccaacatct cctggctctt tcactgccgc 421 attgtctctc ttatattcct cctgggcatc ctggacttcc tcttcgtcag ccacgcctat 481 cacagcatcc tgacccgtgg ggcctctgtg cagctggtgt ttggctttga gtatgccatc 541 ctgatgacga tggtgctcac catcttcatc aagtatgtgc tgcactccgt ggacctccag 601 agtgagaacc cctgggacaa caaggctgtg tacatgctct acacagagct gtttacaggc 661 ttcatcaagg ttctgctgta catggccttc atgaccatca tgatcaaggt gcacaccttc 721 ccactctttg ccatccggcc catgtacctg gccatgagac agttcaagaa agctgtgaca 781 gatgccatca tgtctcgccg agccatccgc aacatgaaca ccctgtatcc agatgccacc 841 ccagaggagc tccaggcaat ggacaatgtc tgcatcatct gccgagaaga gatggtgact 901 ggtgccaaga gactgccctg caaccacatt ttccatacca gctgcctgcg ctcctggttc 961 cagcggcagc agacctgccc cacctgccgt atggatgtcc ttcgtgcatc gctgccagcg 1021 cagtcaccac cacccccgga gcctgcggat caggggccac cccctgcccc ccacccccca 1081 ccactcttgc ctcagccccc caacttcccc cagggcctcc tgcctccttt tcctccaggc 1141 atgttcccac tgtggccccc catgggcccc tttccacctg tcccgcctcc ccccagctca 1201 ggagaggctg tggctcctcc atccaccagt gcagcccttt ctcggcccag tggagcagct 1261 acaaccacag ctgctggcac cagtgctact gctgcttctg ccacagcatc tggcccaggc 1321 tctggctctg ccccagaggc tggccctgcc cctggtttcc ccttccctcc tccctggatg 1381 ggtatgcccc tgcctccacc ctttgccttc cccccaatgc ctgtgccccc tgcgggcttt 1441 gctgggctga ccccagagga gctacgagct ctggagggcc atgagcggca gcacctggag 1501 gcccggctgc agagcctgcg taacatccac acactgctgg acgccgccat gctgcagatc 1561 aaccagtacc tcaccgtgct ggcctccttg gggccccccc ggcctgccac ttcagtcaac 1621 tccactgagg agactgccac tacagttgtt gctgctgcct cctccaccag catccctagc 1681 tcagaggcca cgaccccaac cccaggagcc tccccaccag cccctgaaat ggaaaggcct 1741 ccagctcctg agtcagtggg cacagaggag atgcctgagg atggagagcc cgatgcagca 1801 gagctccgcc ggcgccgcct gcagaagctg gagtctcctg ttgcccactg a //