LOCUS AB056663 2869 bp mRNA linear HUM 05-OCT-2006
DEFINITION Homo sapiens Itch mRNA for ubiquitin protein ligase Itch, complete
cds.
ACCESSION AB056663
VERSION AB056663.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2869)
AUTHORS Nakagawara,A., Miyazaki,K., Okamoto,Y. and Sakamoto,M.
TITLE Direct Submission
JOURNAL Submitted (05-MAR-2001) to the DDBJ/EMBL/GenBank databases.
Contact:Akira Nakagawara
Chiba Cancer Center Research Institute, Division of Biochemistry;
666-2 Nitona Chuoh-ku, Chiba, Chiba 260-8717, Japan
REFERENCE 2
AUTHORS Miyazaki,K., Okamoto,Y., Sakamoto,M. and Nakagawara,A.
TITLE Homo sapiens mRNA for ubiquitin protein ligase Itch, complete cds
JOURNAL Unpublished (2001)
REFERENCE 3
AUTHORS Qiu,L., Joazeiro,C., Fang,N., Wang,H.Y., Elly,C., Altman,Y.,
Fang,D., Hunter,T. and Liu,Y.C.
TITLE Recognition and ubiquitination of Notch by Itch, a hect-type E3
ubiquitin ligase
JOURNAL J. Biol. Chem. 275, 35734-35737 (2000)
REFERENCE 4
AUTHORS Perry,W.L., Hustad,C.M., Swing,D.A., O'Sullivan,T.N., Jenkins,N.A.
and Copeland,N.G.
TITLE The itchy locus encodes a novel ubiquitin protein ligase that is
disrupted in a18H mice
JOURNAL Nat. Genet. 18, 143-146 (1998)
REFERENCE 5
AUTHORS Winberg,G., Matskova,L., Chen,F., Plant,P., Rotin,D., Gish,G.,
Ingham,R., Ernberg,I. and Pawson,T.
TITLE Latent membrane protein 2A of Epstein-Barr virus binds WW domain
E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine
kinases
JOURNAL Mol. Cell. Biol. 20, 8526-8535 (2000)
REFERENCE 6
AUTHORS Wood,J.D., Yuan,J., Margolis,R.L., Colomer,V., Duan,K., Kushi,J.,
Kaminsky,Z., Kleiderlein,J.J., Sharp,A.H. and Ross,C.A.
TITLE Atrophin-1, the DRPLA gene product, interacts with two families of
WW domain-containing proteins
JOURNAL Mol. Cell. Neurosci. 11, 149-160 (1998)
COMMENT
FEATURES Location/Qualifiers
source 1..2869
/chromosome="20"
/db_xref="H-InvDB:HIT000059771"
/db_xref="taxon:9606"
/map="20q"
/mol_type="mRNA"
/note="Human AIP4( partial sequence /ACCESSION :
AF038564) is identical to a part of CDS and 3'-UTR of
this gene(493-2869)"
/organism="Homo sapiens"
/tissue_lib="human primary neuroblastoma"
5'UTR 1..123
CDS 124..2712
/codon_start=1
/gene="Itch"
/product="ubiquitin protein ligase Itch"
/protein_id="BAB39389.1"
/transl_table=1
/translation="MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVE
VTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDI
YETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESA
SQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRP
PPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGP
RPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIY
YVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKE
FDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVD
GIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIK
ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP
MYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYK
RILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN
GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPV
GGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET
EGFGQE"
3'UTR 2713..2869
BASE COUNT 919 a 562 c 643 g 745 t
ORIGIN
1 ggagtcgccg ccgccccgag ttccggtacc atgcatttca cggtggcctt gtggagacaa
61 cgccttaacc caaggaagtg actcaaactg tgagaactcc aggttttcca acctattggt
121 ggtatgtctg acagtggatc acaacttggt tcaatgggta gcctcaccat gaaatcacag
181 cttcagatca ctgtcatctc agcaaaactt aaggaaaata agaagaattg gtttggacca
241 agtccttacg tagaggtcac agtagatgga cagtcaaaga agacagaaaa atgcaacaac
301 acaaacagtc ccaagtggaa gcaacccctt acagttatcg ttacccctgt gagtaaatta
361 cattttcgtg tgtggagtca ccagacactg aaatctgatg ttttgttggg aactgctgca
421 ttagatattt atgaaacatt aaagtcaaac aatatgaaac ttgaagaagt agttgtgact
481 ttgcagcttg gaggtgacaa agagccaaca gagacaatag gagacttgtc aatttgtctt
541 gatgggctac agttagagtc tgaagttgtt accaatggtg aaactacatg ttcagaaagt
601 gcttctcaga atgatgatgg ctccagatcc aaggatgaaa caagagtgag cacaaatgga
661 tcagatgacc ctgaagatgc aggagctggt gaaaatagga gagtcagtgg gaataattct
721 ccatcactct caaatggtgg ttttaaacct tctagacctc caagaccttc acgaccacca
781 ccacccaccc cacgtagacc agcatctgtc aatggttcac catctgccac ttctgaaagt
841 gatgggtcta gtacaggctc tctgccgccg acaaatacaa atacaaatac atctgaagga
901 gcaacatctg gattaataat tcctcttact atatctggag gctcaggccc taggccatta
961 aatcctgtaa ctcaagctcc cttgccacct ggttgggagc agagagtgga ccagcacggg
1021 cgagtttact atgtagatca tgttgagaaa agaacaacat gggatagacc agaacctcta
1081 cctcctggct gggaacggcg ggttgacaac atgggacgta tttattatgt tgaccatttc
1141 acaagaacaa caacgtggca gaggccaaca ctggaatccg tccggaacta tgaacaatgg
1201 cagctacagc gtagtcagct tcaaggagca atgcagcagt ttaaccagag attcatttat
1261 gggaatcaag atttatttgc tacatcacaa agtaaagaat ttgatcctct tggtccattg
1321 ccacctggat gggagaagag aacagacagc aatggcagag tatatttcgt caaccacaac
1381 acacgaatta cacaatggga agaccccaga agtcaaggtc aattaaatga aaagccctta
1441 cctgaaggtt gggaaatgag attcacagtg gatggaattc catattttgt ggaccacaat
1501 agaagaacta ccacctatat agatccccgc acaggaaaat ctgccctaga caatggacct
1561 cagatagcct atgttcggga cttcaaagca aaggttcagt atttccggtt ctggtgtcag
1621 caactggcca tgccacagca cataaagatt acagtgacaa gaaaaacatt gtttgaggat
1681 tcctttcaac agataatgag cttcagtccc caagatctgc gaagacgttt gtgggtgatt
1741 tttccaggag aagaaggttt agattatgga ggtgtagcaa gagaatggtt ctttcttttg
1801 tcacatgaag tgttgaaccc aatgtattgc ctgtttgaat atgcagggaa ggataactac
1861 tgcttgcaga taaaccccgc ttcttacatc aatccagatc acctgaaata ttttcgtttt
1921 attggcagat ttattgccat ggctctgttc catgggaaat tcatagacac gggtttttct
1981 ttaccattct ataagcgtat cttgaacaaa ccagttggac tcaaggattt agaatctatt
2041 gatccagaat tttacaattc tctcatctgg gttaaggaaa acaatattga ggaatgtgat
2101 ttggaaatgt acttctccgt tgacaaagaa attctaggtg aaattaagag tcatgatctg
2161 aaacctaatg gtggcaatat tcttgtaaca gaagaaaata aagaggaata catcagaatg
2221 gtagctgagt ggaggttgtc tcgaggtgtt gaagaacaga cacaagcttt ctttgaaggc
2281 tttaatgaaa ttcttcccca gcaatatttg caatactttg atgcaaagga attagaggtc
2341 cttttatgtg gaatgcaaga gattgatttg aatgactggc aaagacatgc catctaccgt
2401 cattatgcaa ggaccagcaa acaaatcatg tggttttggc agtttgttaa agaaattgat
2461 aatgagaaga gaatgagact tctgcagttt gttactggaa cctgccgatt gccagtagga
2521 ggatttgctg atctcatggg gagcaatgga ccacagaaat tctgcattga aaaagttggg
2581 aaagaaaatt ggctacccag aagtcatacc tgttttaatc gcctggacct gccaccatac
2641 aagagctatg agcaactgaa ggaaaagctg ttgtttgcca tagaagaaac agaaggattt
2701 ggacaagagt aacttctgag aacttgcacc atgaatgggc aagaacttat ttgcaatgtt
2761 tgtccttctc tgcctgttgc acatcttgta aaattggaca atggctcttt agagagttat
2821 ctgagtgtaa gtaaattaat gttctcattt aaaaaaaaaa aaaaaaaaa
//