LOCUS       AB054881                4474 bp    mRNA    linear   HUM 05-APR-2001
DEFINITION  Homo sapiens FZD4 mRNA for Soluble-type polypeptide FZD4S,
            complete cds.
ACCESSION   AB054881
VERSION     AB054881.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Katoh,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JAN-2001) to the DDBJ/EMBL/GenBank databases.
            Contact:Masaru Katoh
            National Cancer Center Research Institute, Genetics and Cell
            Biology Section, Genetics Division; Tsukiji 5-chome, Chuo-ku,
            Tokyo 104-0045, Japan
REFERENCE   2
  AUTHORS   Sagara,N., Kirikoshi,H., Terasaki,H., Yasuhiko,Y., Toda,G.,
            Shiokawa,K. and Katoh,M.
  TITLE     FZD4S, a splicing variant of Frizzled-4, encodes a soluble-type
            positive regulator of the WNT signaling pathway
  JOURNAL   Biochem. Biophys. Res. Commun. 282, 750-756 (2001)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..4474
                     /chromosome="11"
                     /clone_lib="lambda gt10 human fetal lung cDNA (Clontech
                     Laboratories)"
                     /db_xref="H-InvDB:HIT000059707"
                     /db_xref="taxon:9606"
                     /map="11q14-q21"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
     CDS             165..542
                     /codon_start=1
                     /function="positive regulator of the WNT signaling
                     pathway"
                     /gene="FZD4"
                     /product="Soluble-type polypeptide FZD4S"
                     /protein_id="BAB40811.1"
                     /transl_table=1
                     /translation="MLAMAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEE
                     ERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQVGAP
                     TPTPGGTPWGGTLQTNFAEPMPS"
BASE COUNT         1155 a          989 c         1117 g         1213 t
ORIGIN      
        1 atcccacaca gtcgcgcgca gctgctggag agccggccgc tgccccctcg tcgccgcatc
       61 acactcccgt cccgggagct gggagcagcg cgggcagccg gcgcccccgt gcaaactggg
      121 ggtgtctgcc agagcagccc cagccgctgc cgctgctacc cccgatgctg gccatggcct
      181 ggcggggcgc agggccgagc gtcccggggg cgcccggggg cgtcggtctc agtctggggt
      241 tgctcctgca gttgctgctg ctcctggggc cggcgcgggg cttcggggac gaggaagagc
      301 ggcgctgcga ccccatccgc atctccatgt gccagaacct cggctacaac gtgaccaaga
      361 tgcccaacct ggttgggcac gagctgcaga cggacgccga gctgcagctg acaactttca
      421 caccgctcat ccagtacggc tgctccagcc agctgcaggt gggcgccccc acccccaccc
      481 ctggcgggac cccttgggga gggacgctcc aaactaactt tgcagagccc atgccaagtt
      541 gatcatccta gcccgaagga gacagctctc ctggaaaagt gatttccatc cccaccccca
      601 ctttctcagg gactggaagc caaaacgttg tgtaagtcat ctggcctggg aaagaaccca
      661 ctcttacacc ccgcccttcc gtttttctct cttgcccacc catgtctggc ccagacccct
      721 aaccccagtg gagctgaggg ttatctctgc caaggattct ggccgccact gctcggtggg
      781 cgagtgggag ggagccagct gcagctaaga cttggaggga gtgataagga gaccatcctt
      841 caccgaactt ccttctcccc actatttttg gggtgttatt aaatgaaaca ctactgcacc
      901 tttttctgct gaatagcccc ttctcacgac gtcccgcagc gttttagagg tcatgcatga
      961 aggagtggtt gggttggctt gagttctttc ttatcctcac agttgaaggc acgtttaatg
     1021 cttggagggt gagaagaagc tgcaggaagg tggttggtat attggaagaa atttttttgc
     1081 agtcattaaa aaatgtaaag catatctaat gatagagaaa atgtttattc cacagtaata
     1141 agaatttgca tatacagggt gattataatc ctgcaaaata aaaaatttat tgggataata
     1201 aaagactgac aggaaaattt ttaaagtgtt aacattggtt atgtttgggt tggtgaggct
     1261 gggtgatttt tagaaattta gaaaagagag aagttgtggg aaaaagtaga cgttagttgt
     1321 ccaggcttca gaaatctggt ttctggccgg gcgcagtggc tcacgcctgt aatcccagca
     1381 ctttgggagg ccgaggcagg tggctcacga ggttaggagt tcgagaccag cctgaccaac
     1441 atggcgaaat cctgtctcta ctaaaagtac aaaaattagc cgggcgtggt ggcgtgcgcc
     1501 tgtaatccca gctactcagg aggctgaggc aggagaatcg cttgaaccca ggaggcagag
     1561 gttgcagtga gcggggattg caccattgca ctctagcctg ggccacagga gcgaaactcc
     1621 gtatcaaaaa aaaaaagaaa agaaaagaaa tctgtggttc tggctgtaac ttctgagaga
     1681 taataaacag acatacagct tacttactag gtgcatgttt ttacataggt cattttaaaa
     1741 cttggtttgt ggttttggaa agatggtggg gattagacct gttgctgcta aaatatccct
     1801 ttggaagttt cagaacttta gaactaggtt ataaaagctt aagaaatgat cctccagctc
     1861 tcagtttgga aacagcacat atcctgacat cagtggcaat ttgttggaga aacagctttt
     1921 gcagggatat atatttttaa ttacatgtat cctggggaaa gcggccaagc tgttttgaag
     1981 gacaagactg gatcccttta catgctggaa aatagttact tgtaactcta gacttcatag
     2041 acaacatctg taaggagcca agcagactgt ttatcaatgc tggaggaatt gaggacagca
     2101 actggactct cccctgctgg tactgcagtt tcagcgactt aacatttaca ttttcctatt
     2161 gtgcttcatt attattcatt gaggaaacct ggccaaacaa atccctagtg accagagacc
     2221 tcaatctgca tcccatcctt gagtctaaca gtgtctcatt tgggccattt tttgtttcag
     2281 tatgggacta gtttaaacaa atttttaagg gataaattag ggagaagaga atactaacag
     2341 gatctacatt tttttttaac ttttattttt aaaatgataa agaaacgggg ataaaaataa
     2401 accacctaaa tgagtcatat tagtttcttt agctttttca aatagtttct aaaatggaag
     2461 gagattgaaa gccagttttt taagatttat ttcaagtgtt gtgcaaagag ggcttatgca
     2521 attcttcaga ccctatttat tttatttatt tatttatgta cattcttctg gaaaggatta
     2581 ctaaagccaa actaagaaaa gtatgtaagt gatggattat caggcgccct tgtttgaggt
     2641 cagagtaaac agacagactc ccgataggtt ggtttaaaag tagataccta gattgcctgg
     2701 aagcattcaa ctcagctttg tgggagcatt tggtcaaact tccaagtcat tgtttttttt
     2761 gtgtgtgttc attttgttac ttttccagtt cttcctttgt tctgtttatg tgccaatgtg
     2821 cacagagaag atcaacatcc ccattggccc atgcggcggc atgtgtcttt cagtcaagag
     2881 acgctgtgaa cccgtcctga aggaatttgg atttgcctgg ccagagagtc tgaactgcag
     2941 caaattccca ccacagaacg accacaacca catgtgcatg gaagggccag gtgatgaaga
     3001 ggtgccctta cctcacaaaa cccccatcca gcctggggaa gagtgtcact ctgtgggaac
     3061 caattctgat cagtacatct gggtgaaaag gagcctgaac tgtgtgctca agtgtggcta
     3121 tgatgctggc ttatacagcc gctcagccaa ggagttcact gatatctgga tggctgtgtg
     3181 ggccagcctg tgtttcatct ccactgcctt cacagtactg accttcctga tcgattcttc
     3241 taggttttcc taccctgagc gccccatcat atttctcagt atgtgctata atatttatag
     3301 cattgcttat attgtcaggc tgactgtagg ccgggaaagg atatcctgtg attttgaaga
     3361 ggcagcagaa cctgttctca tccaagaagg acttaagaac acaggatgtg caataatttt
     3421 cttgctgatg tacttttttg gaatggccag ctccatttgg tgggttattc tgacactcac
     3481 ttggtttttg gcagcaggac tcaaatgggg tcatgaagcc attgaaatgc acagctctta
     3541 tttccacatt gcagcctggg ccatccccgc agtgaaaacc attgtcatct tgattatgag
     3601 actggtggat gcagatgaac tgactggctt gtgctatgtt ggaaaccaaa atctcgatgc
     3661 cctcaccggg ttcgtggtgg ctcccctctt tacttatttg gtcattggaa ctttgttcat
     3721 tgctgcaggt ttggtggcct tgttcaaaat tcggtcaaat cttcaaaagg atgggacaaa
     3781 gacagacaag ttagaaagac tgatggtcaa gattggggtg ttctcagtac tgtacacagt
     3841 tcctgcaacg tgtgtgattg cctgttattt ttatgaaatc tccaactggg cactttttcg
     3901 gtattctgca gatgattcca acatggctgt tgaaatgttg aaaattttta tgtctttgtt
     3961 ggtgggcatc acttcaggca tgtggatttg gtctgccaaa actcttcaca cgtggcagaa
     4021 gtgttccaac agattggtga attctggaaa ggtaaagaga gagaagagag gaaatggttg
     4081 ggtgaagcct ggaaaaggca gtgagactgt ggtataaggc tagtcagcct ccatgctttc
     4141 ttcattttga aggggggaat gccagcattt tggaggaaat tctactaaaa gttttatgca
     4201 gtgaatctca gtttgaacaa actagcaaca attaagtgac ccccgtcaac ccactgcctc
     4261 ccaccccgac cccagcatca aaaaaccaat gattttgctg cagactttgg aatgatccaa
     4321 aatggaaaag ccagttagag gctttcaaag ctgtgaaaaa tcaaaacgtt gatcacttta
     4381 gcaggttgca gcttggagcg tggaggtcct gcctagattc caggaagtcc agggcgatac
     4441 tgttttcccc tgcagggtgg gatttgagct gtga
//