LOCUS AB054881 4474 bp mRNA linear HUM 05-APR-2001 DEFINITION Homo sapiens FZD4 mRNA for Soluble-type polypeptide FZD4S, complete cds. ACCESSION AB054881 VERSION AB054881.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4474) AUTHORS Katoh,M. TITLE Direct Submission JOURNAL Submitted (22-JAN-2001) to the DDBJ/EMBL/GenBank databases. Contact:Masaru Katoh National Cancer Center Research Institute, Genetics and Cell Biology Section, Genetics Division; Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan REFERENCE 2 AUTHORS Sagara,N., Kirikoshi,H., Terasaki,H., Yasuhiko,Y., Toda,G., Shiokawa,K. and Katoh,M. TITLE FZD4S, a splicing variant of Frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway JOURNAL Biochem. Biophys. Res. Commun. 282, 750-756 (2001) COMMENT FEATURES Location/Qualifiers source 1..4474 /chromosome="11" /clone_lib="lambda gt10 human fetal lung cDNA (Clontech Laboratories)" /db_xref="H-InvDB:HIT000059707" /db_xref="taxon:9606" /map="11q14-q21" /mol_type="mRNA" /organism="Homo sapiens" CDS 165..542 /codon_start=1 /function="positive regulator of the WNT signaling pathway" /gene="FZD4" /product="Soluble-type polypeptide FZD4S" /protein_id="BAB40811.1" /transl_table=1 /translation="MLAMAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEE ERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQVGAP TPTPGGTPWGGTLQTNFAEPMPS" BASE COUNT 1155 a 989 c 1117 g 1213 t ORIGIN 1 atcccacaca gtcgcgcgca gctgctggag agccggccgc tgccccctcg tcgccgcatc 61 acactcccgt cccgggagct gggagcagcg cgggcagccg gcgcccccgt gcaaactggg 121 ggtgtctgcc agagcagccc cagccgctgc cgctgctacc cccgatgctg gccatggcct 181 ggcggggcgc agggccgagc gtcccggggg cgcccggggg cgtcggtctc agtctggggt 241 tgctcctgca gttgctgctg ctcctggggc cggcgcgggg cttcggggac gaggaagagc 301 ggcgctgcga ccccatccgc atctccatgt gccagaacct cggctacaac gtgaccaaga 361 tgcccaacct ggttgggcac gagctgcaga cggacgccga gctgcagctg acaactttca 421 caccgctcat ccagtacggc tgctccagcc agctgcaggt gggcgccccc acccccaccc 481 ctggcgggac cccttgggga gggacgctcc aaactaactt tgcagagccc atgccaagtt 541 gatcatccta gcccgaagga gacagctctc ctggaaaagt gatttccatc cccaccccca 601 ctttctcagg gactggaagc caaaacgttg tgtaagtcat ctggcctggg aaagaaccca 661 ctcttacacc ccgcccttcc gtttttctct cttgcccacc catgtctggc ccagacccct 721 aaccccagtg gagctgaggg ttatctctgc caaggattct ggccgccact gctcggtggg 781 cgagtgggag ggagccagct gcagctaaga cttggaggga gtgataagga gaccatcctt 841 caccgaactt ccttctcccc actatttttg gggtgttatt aaatgaaaca ctactgcacc 901 tttttctgct gaatagcccc ttctcacgac gtcccgcagc gttttagagg tcatgcatga 961 aggagtggtt gggttggctt gagttctttc ttatcctcac agttgaaggc acgtttaatg 1021 cttggagggt gagaagaagc tgcaggaagg tggttggtat attggaagaa atttttttgc 1081 agtcattaaa aaatgtaaag catatctaat gatagagaaa atgtttattc cacagtaata 1141 agaatttgca tatacagggt gattataatc ctgcaaaata aaaaatttat tgggataata 1201 aaagactgac aggaaaattt ttaaagtgtt aacattggtt atgtttgggt tggtgaggct 1261 gggtgatttt tagaaattta gaaaagagag aagttgtggg aaaaagtaga cgttagttgt 1321 ccaggcttca gaaatctggt ttctggccgg gcgcagtggc tcacgcctgt aatcccagca 1381 ctttgggagg ccgaggcagg tggctcacga ggttaggagt tcgagaccag cctgaccaac 1441 atggcgaaat cctgtctcta ctaaaagtac aaaaattagc cgggcgtggt ggcgtgcgcc 1501 tgtaatccca gctactcagg aggctgaggc aggagaatcg cttgaaccca ggaggcagag 1561 gttgcagtga gcggggattg caccattgca ctctagcctg ggccacagga gcgaaactcc 1621 gtatcaaaaa aaaaaagaaa agaaaagaaa tctgtggttc tggctgtaac ttctgagaga 1681 taataaacag acatacagct tacttactag gtgcatgttt ttacataggt cattttaaaa 1741 cttggtttgt ggttttggaa agatggtggg gattagacct gttgctgcta aaatatccct 1801 ttggaagttt cagaacttta gaactaggtt ataaaagctt aagaaatgat cctccagctc 1861 tcagtttgga aacagcacat atcctgacat cagtggcaat ttgttggaga aacagctttt 1921 gcagggatat atatttttaa ttacatgtat cctggggaaa gcggccaagc tgttttgaag 1981 gacaagactg gatcccttta catgctggaa aatagttact tgtaactcta gacttcatag 2041 acaacatctg taaggagcca agcagactgt ttatcaatgc tggaggaatt gaggacagca 2101 actggactct cccctgctgg tactgcagtt tcagcgactt aacatttaca ttttcctatt 2161 gtgcttcatt attattcatt gaggaaacct ggccaaacaa atccctagtg accagagacc 2221 tcaatctgca tcccatcctt gagtctaaca gtgtctcatt tgggccattt tttgtttcag 2281 tatgggacta gtttaaacaa atttttaagg gataaattag ggagaagaga atactaacag 2341 gatctacatt tttttttaac ttttattttt aaaatgataa agaaacgggg ataaaaataa 2401 accacctaaa tgagtcatat tagtttcttt agctttttca aatagtttct aaaatggaag 2461 gagattgaaa gccagttttt taagatttat ttcaagtgtt gtgcaaagag ggcttatgca 2521 attcttcaga ccctatttat tttatttatt tatttatgta cattcttctg gaaaggatta 2581 ctaaagccaa actaagaaaa gtatgtaagt gatggattat caggcgccct tgtttgaggt 2641 cagagtaaac agacagactc ccgataggtt ggtttaaaag tagataccta gattgcctgg 2701 aagcattcaa ctcagctttg tgggagcatt tggtcaaact tccaagtcat tgtttttttt 2761 gtgtgtgttc attttgttac ttttccagtt cttcctttgt tctgtttatg tgccaatgtg 2821 cacagagaag atcaacatcc ccattggccc atgcggcggc atgtgtcttt cagtcaagag 2881 acgctgtgaa cccgtcctga aggaatttgg atttgcctgg ccagagagtc tgaactgcag 2941 caaattccca ccacagaacg accacaacca catgtgcatg gaagggccag gtgatgaaga 3001 ggtgccctta cctcacaaaa cccccatcca gcctggggaa gagtgtcact ctgtgggaac 3061 caattctgat cagtacatct gggtgaaaag gagcctgaac tgtgtgctca agtgtggcta 3121 tgatgctggc ttatacagcc gctcagccaa ggagttcact gatatctgga tggctgtgtg 3181 ggccagcctg tgtttcatct ccactgcctt cacagtactg accttcctga tcgattcttc 3241 taggttttcc taccctgagc gccccatcat atttctcagt atgtgctata atatttatag 3301 cattgcttat attgtcaggc tgactgtagg ccgggaaagg atatcctgtg attttgaaga 3361 ggcagcagaa cctgttctca tccaagaagg acttaagaac acaggatgtg caataatttt 3421 cttgctgatg tacttttttg gaatggccag ctccatttgg tgggttattc tgacactcac 3481 ttggtttttg gcagcaggac tcaaatgggg tcatgaagcc attgaaatgc acagctctta 3541 tttccacatt gcagcctggg ccatccccgc agtgaaaacc attgtcatct tgattatgag 3601 actggtggat gcagatgaac tgactggctt gtgctatgtt ggaaaccaaa atctcgatgc 3661 cctcaccggg ttcgtggtgg ctcccctctt tacttatttg gtcattggaa ctttgttcat 3721 tgctgcaggt ttggtggcct tgttcaaaat tcggtcaaat cttcaaaagg atgggacaaa 3781 gacagacaag ttagaaagac tgatggtcaa gattggggtg ttctcagtac tgtacacagt 3841 tcctgcaacg tgtgtgattg cctgttattt ttatgaaatc tccaactggg cactttttcg 3901 gtattctgca gatgattcca acatggctgt tgaaatgttg aaaattttta tgtctttgtt 3961 ggtgggcatc acttcaggca tgtggatttg gtctgccaaa actcttcaca cgtggcagaa 4021 gtgttccaac agattggtga attctggaaa ggtaaagaga gagaagagag gaaatggttg 4081 ggtgaagcct ggaaaaggca gtgagactgt ggtataaggc tagtcagcct ccatgctttc 4141 ttcattttga aggggggaat gccagcattt tggaggaaat tctactaaaa gttttatgca 4201 gtgaatctca gtttgaacaa actagcaaca attaagtgac ccccgtcaac ccactgcctc 4261 ccaccccgac cccagcatca aaaaaccaat gattttgctg cagactttgg aatgatccaa 4321 aatggaaaag ccagttagag gctttcaaag ctgtgaaaaa tcaaaacgtt gatcacttta 4381 gcaggttgca gcttggagcg tggaggtcct gcctagattc caggaagtcc agggcgatac 4441 tgttttcccc tgcagggtgg gatttgagct gtga //