LOCUS       AB045829                 991 bp    mRNA    linear   HUM 19-JUL-2000
DEFINITION  Homo sapiens mRNA for 3alpha-hydroxysteroid dehydrogenase variant,
            complete cds.
ACCESSION   AB045829
VERSION     AB045829.1
KEYWORDS    DD4; AKR1C4; 3alph-hydroxysteroid dehydrogenase type 1;
            chlordecone reductase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Hara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUL-2000) to the DDBJ/EMBL/GenBank databases.
            Contact:Akira Hara
            Gifu Pharmaceutical University, Labratory of Biochemistry;
            Mitahora-higashi, Gifu, Gifu 502-8585, Japan
REFERENCE   2
  AUTHORS   Kume,T., Iwasa,H., Shiraishi,H., Yokoi,T., Nagashima,K.,
            Otsuka,M., Terada,T., Takagi,T., Hara,A. and Kamataki,T.
  TITLE     Characterization of a novel variant (S145C/L311V) of
            3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver
  JOURNAL   Pharmacogenetics 9, 763-771 (1999)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..991
                     /db_xref="H-InvDB:HIT000059449"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /tissue_lib="liver"
                     /tissue_type="liver"
     CDS             1..972
                     /codon_start=1
                     /EC_number="1.1.1.213"
                     /note="The product shows three- to five-fold decreases in
                     catalytic efficiency for xenobiotic and steroidal
                     substrates compared to AKR1C4. The frequency of the
                     variant gene by a genomic DNA analysis is about 20"
                     /product="3alpha-hydroxysteroid dehydrogenase variant"
                     /protein_id="BAA99542.1"
                     /standard_name="dihydrodiol dehydrogenase 4"
                     /transl_table=1
                     /translation="MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEA
                     GFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESS
                     LKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLCATWEVMEKCKDAGLA
                     KSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSA
                     LGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR
                     IRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFVMDHPDYPFSDEY"
BASE COUNT          288 a          223 c          234 g          246 t
ORIGIN      
        1 atggatccca aatatcagcg tgtagagcta aatgatggtc atttcatgcc cgtattggga
       61 tttggcacct atgcacctcc agaggttccg aggaacagag ctgtagaggt caccaaatta
      121 gcaatagaag ctggcttccg ccatattgat tctgcttatt tatacaataa tgaggagcag
      181 gttggactgg ccatccgaag caagattgca gatggcagtg tgaagagaga agacatattc
      241 tacacttcaa agctttggtg cactttcttt caaccacaga tggtccaacc agccttggaa
      301 agctcactga aaaaacttca actggactat gttgacctct atcttcttca tttcccaatg
      361 gctctcaagc caggtgagac gccactacca aaagatgaaa atggaaaagt aatattcgac
      421 acagtggatc tctgtgccac atgggaggtc atggagaagt gtaaggatgc aggattggcc
      481 aagtccatcg gggtgtcaaa cttcaactgc aggcagctgg agatgatcct caacaagcca
      541 ggactcaagt acaagcctgt ctgcaaccag gtagaatgtc atccttacct caaccagagc
      601 aaactgctgg atttctgcaa gtcaaaagac attgttctgg ttgcccacag tgctctggga
      661 acccaacgac ataaactatg ggtggaccca aactccccag ttcttttgga ggacccagtt
      721 ctttgtgcct tagcaaagaa acacaaacga accccagccc tgattgccct gcgctaccag
      781 ctgcagcgtg gggttgtggt cctggccaag agctacaatg agcagcggat cagagagaac
      841 atccaggttt ttgaattcca gttgacatca gaggatatga aagttctaga tggtctaaac
      901 agaaattatc gatatgttgt catggatttt gttatggacc atcctgatta tccattttca
      961 gatgaatatt agcatagagg gtgttgcacg a
//