LOCUS AB040450 1290 bp mRNA linear HUM 15-SEP-2000
DEFINITION Homo sapiens tok-1 mRNA for TOK-1alpha, complete cds.
ACCESSION AB040450
VERSION AB040450.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1290)
AUTHORS Ariga,H.
TITLE Direct Submission
JOURNAL Submitted (22-MAR-2000) to the DDBJ/EMBL/GenBank databases.
Contact:Hiroyoshi Ariga
Graduate School of Pharmaceutical Sciences, Hokkaido University,
Molecular Biology; Kita 12, Nishi 6, Kita-ku, Sapporo, Hokkaido
060-0812, Japan
REFERENCE 2
AUTHORS Ono,T., Kitaura,H., Ugai,H., Murata,T., Yokoyama,K.K.,
Iguchi-Ariga,S.M.M. and Ariga,H.
TITLE TOK-1, a novel p21Cip1-binding protein that cooperatively enhances
p21- dependent inhibitory activity toward CDK2 kinase
JOURNAL J. Biol. Chem. 275, 31145-31154 (2000)
COMMENT
FEATURES Location/Qualifiers
source 1..1290
/db_xref="H-InvDB:HIT000059278"
/db_xref="taxon:9606"
/mol_type="mRNA"
/note="vector:pACT2"
/organism="Homo sapiens"
/tissue_lib="Matchmaker (CLONTECH)"
/tissue_type="brain"
CDS 13..981
/codon_start=1
/gene="tok-1"
/note="cdk inhibitor p21 binding protein"
/product="TOK-1alpha"
/protein_id="BAA92927.1"
/transl_table=1
/translation="MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDK
EKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHI
GSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKS
MVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYF
YLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLE
PVPIQHNGGSRGQVTALVSLKAGLIQSRSTLSDFQGTFMTVGIALS"
regulatory 1173..1178
/regulatory_class="polyA_signal_sequence"
BASE COUNT 435 a 207 c 306 g 337 t
ORIGIN
1 gtgagcggca acatggcgtc caggtctaag cggcgtgccg tggaaagtgg ggttccgcag
61 ccgccggatc ccccagtcca gcgcgacgag gaagaggaaa aagaagtcga aaatgaggat
121 gaagacgatg atgacagtga caaggaaaag gatgaagagg acgaggtcat tgacgaggaa
181 gtgaatattg aatttgaagc ttattcccta tcagataatg attatgacgg aattaagaaa
241 ttactgcagc agctttttct aaaggctcct gtgaacactg cagaactaac agatctctta
301 attcaacaga accatattgg gagtgtgatt aagcaaacgg atgtttcaga agacagcaat
361 gatgatatgg atgaagatga ggtttttggt ttcataagcc ttttaaattt aactgaaaga
421 aagggtaccc agtgtgttga acaaattcaa gagttggttc tacgcttctg tgagaagaac
481 tgtgaaaaga gcatggttga acagctggac aagtttttaa atgacaccac caagcctgtg
541 ggccttctcc taagtgaaag attcattaat gtccctccac agatcgctct gcccatgtac
601 cagcagcttc agaaagaact ggcgggggca cacagaacca ataagccatg tgggaagtgc
661 tacttttacc ttctgattag taagacattt gtggaagcag gaaaaaacaa ttccaaaaag
721 aaacctagca acaaaaagaa agctgcgtta atgtttgcaa atgcagagga agaatttttc
781 tatgaggagc agggaaaacc tgaggtgctt ggaggtccag acacaagaag aggattggaa
841 ccagttccga tacagcacaa tggtggttca cgggggcaag tgacagccct ggtttctctg
901 aaggctggac taattcaatc aagatcaact ctaagtgatt tccagggaac cttcatgact
961 gttggaattg ctctgtcata ataagtcagg gatatttagg gggctcatag tntcctggag
1021 ggataaaaca tttcggcacc tagtaatggt aaattagtca atatttgtta gtttcgtttg
1081 agatntcaaa tgttaggatt ttntgaagtt tcagtgtctt tcagagtttg agataccttg
1141 ttttcatttt ttntaatttt taatttaaaa gtaataaagg atattttgta atgattagga
1201 tgaaaatttt atngtcaatt ataagcccaa atttgctaaa attaaagtca gtatacttgg
1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//