LOCUS AB040430 11204 bp DNA linear HUM 03-OCT-2000
DEFINITION Homo sapiens AID gene for activation-induced cytidine deaminase,
complete cds.
ACCESSION AB040430
VERSION AB040430.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 11204)
AUTHORS Muto,T., Muramatsu,M., Taniwaki,M., Kinoshita,K. and Honjo,T.
TITLE Direct Submission
JOURNAL Submitted (18-MAR-2000) to the DDBJ/EMBL/GenBank databases.
Contact:Tasuku Honjo
Kyoto University, Department of Medical Chemistry, Faculty of
Medicine; Yoshida, Sakyo-ku, Kyoto, Kyoto 606-8501, Japan
REFERENCE 2
AUTHORS Muto,T., Muramatsu,M., Taniwaki,M., Kinoshita,K. and Honjo,T.
TITLE Isolation, tissue distribution and chromosomal localization of the
human activation-induced cytidine deaminase (hAID) gene
JOURNAL Genomics 68, 85-88 (2000)
REFERENCE 3
AUTHORS Revy,P., Muto,T., Levy,Y., Geissmann,F., Plebani,A., Sanal,O.,
Catalan,N., Forveille,M., Dufourcq-Lagelouse,R., Gennery,A.,
Tezcan,I., Ersoy,F., Kayserili,H., Ugazio,A.G., Brousse,N.,
Muramatsu,M., Notarangelo,L.D., Kinoshita,K., Honjo,T., Fischer,A.
and Durandy,A.
TITLE Activation-induced cytidine deaminase (AID) deficiency causes the
autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
JOURNAL Cell 102, 565-575 (2000)
COMMENT
FEATURES Location/Qualifiers
source 1..11204
/db_xref="taxon:9606"
/mol_type="genomic DNA"
/organism="Homo sapiens"
CDS join(521..528,6280..6427,7807..8077,8371..8486,8956..9009)
/codon_start=1
/gene="AID"
/product="activation-induced cytidine deaminase"
/protein_id="BAB12720.1"
/transl_table=1
/translation="MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSL
DFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNP
NLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFK
AWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL"
BASE COUNT 3305 a 2273 c 2373 g 3253 t
ORIGIN
1 aggttcagag agactgtggg aatatggggg aattagaggc tatctgaggc tcttcaacac
61 aataacccaa gaagctattt aaatgctctt taaggtattt acataaatat tactattctc
121 attgtgcttt tattttgtgt tatcatgatt ataattgaag tgtctactgt tactgcctcc
181 tgatctttgc tagctatgga gcatggactg ggcttttaga gcagcagccc caaaggaacc
241 taaacattaa agcagagctg ccctcaatgg tttaacctgt gtgactctgc ctatgacagc
301 cccacccacc catcttcact ggatccaaat caggagcaag gccgttgggg tacctggtgg
361 gggtgatgct gtcaggggag gagcccaaaa gggcaagctc aaatttgaat gtgaagggcc
421 aatgcactgt cagactgaga cagagaacca tcattaattg aagtgagatt tttctggcct
481 gagacttgca gggaggcaag aagacactct ggacaccact atggacaggt aaagaggcag
541 tcttctcgtg ggtgattgca ctggccttcc tctcagagca aatctgagta atgagactgg
601 tagctatccc tttctctcat gtaactgtct gactgataag atcagcttga tcaatatgca
661 tatatatttt ttgatctgtc tccttttctt ctattcagat cttatacgct gtcagcccaa
721 ttctttctgt ttcagacttc tcttgatttc cctctttttc atgtggcaaa agaagtagtg
781 cgtacaatgt actgattcgt cctgagattt gtaccatggt tgaaactaat ttatggtaat
841 aatattaaca tagcaaatct ttagagactc aaatcatgaa aaggtaatag cagtactgta
901 ctaaaaacgg tagtgctaat tttcgtaata attttgtaaa tattcaacag taaaacaact
961 tgaagacaca ctttcctagg gaggcgttac tgaaataatt tagctatagt aagaaaattt
1021 gtaattttag aaatgccaag cattctaaat taattgcttg aaagtcacta tgattgtgtc
1081 cattataagg agacaaattc attcaagcaa gttatttaat gttaaaggcc caattgttag
1141 gcagttaatg gcacttttac tattaactaa tctttccatt tgttcagacg tagcttaact
1201 tacctcttag gtgtgaattt ggttaaggtc ctcataatgt ctttatgtgc agtttttgat
1261 aggttattgt catagaactt attctattcc tacatttatg attactatgg atgtatgaga
1321 ataacaccta atccttatac tttacctcaa tttaactcct ttataaagaa cttacattac
1381 agaataaaga ttttttaaaa atatattttt ttgtagagac agggtcttag cccagccgag
1441 gctggtctct aagtcctggc ccaagcgatc ctcctgcctg ggcctcctaa agtgctggaa
1501 ttatagacat gagccatcac atccaatata cagaataaag atttttaatg gaggatttaa
1561 tgttcttcag aaaattttct tgaggtcaga caatgtcaaa tgtctcctca gtttacactg
1621 agattttgaa aacaagtctg agctataggt ccttgtgaag ggtccattgg aaatacttgt
1681 tcaaagtaaa atggaaagca aaggtaaaat cagcagttga aattcagaga aagacagaaa
1741 aggagaaaag atgaaattca acaggacaga agggaaatat attatcatta aggaggacag
1801 tatctgtaga gctcattagt gatggcaaaa tgacttggtc aggattattt ttaacccgct
1861 tgtttctggt ttgcacggct ggggatgcag ctagggttct gcctcaggga gcacagctgt
1921 ccagagcagc tgtcagcctg caagcctgaa acactccctc ggtaaagtcc ttcctactca
1981 ggacagaaat gacgagaaca gggagctgga aacaggcccc taaccagaga agggaagtaa
2041 tggatcaaca aagttaacta gcaggtcagg atcacgcaat tcatttcact ctgactggta
2101 acatgtgaca gaaacagtgt aggcttattg tattttcatg tagagtagga cccaaaaatc
2161 cacccaaagt cctttatcta tgccacatcc ttcttatcta tacttccagg acactttttc
2221 ttccttatga taaggctctc tctctctcca cacacacaca cacacacaca cacacacaca
2281 cacacacaca cacaaacaca caccccgcca accaaggtgc atgtaaaaag atgtagattc
2341 ctctgccttt ctcatctaca cagcccagga gggtaagtta atataagagg gatttattgg
2401 taagagatga tgcttaatct gtttaacact gggcctcaaa gagagaattt cttttcttct
2461 gtacttatta agcacctatt atgtgttgag cttatatata caaagggtta ttatatgcta
2521 atatagtaat agtaatggtg gttggtacta tggtaattac cataaaaatt attatccttt
2581 taaaataaag ctaattatta ttggatcttt tttagtattc attttatgtt ttttatgttt
2641 ttgatttttt aaaagacaat ctcaccctgt tacccaggct ggagtgcagt ggtgcaatca
2701 tagctttctg cagtcttgaa ctcctgggct caagcaatcc tcctgccttg gcctcccaaa
2761 gtgttgggat acagtcatga gccactgcat ctggcctagg atccatttag attaaaatat
2821 gcattttaaa ttttaaaata atatggctaa tttttacctt atgtaatgtg tatactggta
2881 ataaatctag tttgctgcct aaagtttaaa gtgctttcca ataagcttca tgtacgtgag
2941 gggagacatt taaagtgaaa cagacagcca ggtgtggtgg ctcacgcctg taatcccagc
3001 actctgggag gctgaggtgg gtggatcgct tgagccctgg agttcaagac cagcctgagc
3061 aacatggcaa aaccctgttt ctataacaaa aattagccgg gcatggtggc atgtgcctgt
3121 ggtcccagct actagggggc tgaggcagga gaatctttgg agcccaggag gtcaaggctg
3181 cactgagcag tgcttgcgcc actgcactcc agcctgggtg acaggaccag accttgcctc
3241 aaaaaaataa gaagaaaaat taaaaataaa tggaaacaac tacaaagagc tgttgtccta
3301 gatgagctac ttagttaggc tgatattttg gtatttaact tttaaagtca gggtctgtca
3361 cctgcactac attattaaaa tatcaattct caatgtatat ccacacaaag actggtacgt
3421 gaatgttcat agtaccttta ttcacaaaac cccaaagtag agactatcca aatatccatc
3481 aacaagtgaa caaataaaca aaatgtgcta tatccatgca atggaatacc accctgcagt
3541 acaaaggaag aagctacttg gggatgaatc ccaaagtcat gacgctaaat gaaagagtca
3601 gacatgaagg aggagataat gtatgccata cgaaattcta gaaaatgaaa gtaacttata
3661 gttacagaaa gcaaatcagg gcaggcatag aggctcacac ctgtaatccc agcactttga
3721 gaggccacgt gggaagattg ctagaactca ggagttcaag accagcctgg gcaacacagt
3781 gaaactccat tctccacaaa aatgggaaaa aaagaaagca aatcagtggt tgtcctgtgg
3841 ggaggggaag gactgcaaag agggaagaag ctctggtggg gtgagggtgg tgattcaggt
3901 tctgtatcct gactgtggta gcagtttggg gtgtttacat ccaaaaatat tcgtagaatt
3961 atgcatctta aatgggtgga gtttactgta tgtaaattat acctcaatgt aagaaaaaat
4021 aatgtgtaag aaaagtttca attctcttgc cagcaaacgt tattcaaatt cctgagccct
4081 ttacttcgca aattctctgc acttctgccc cgtaccatta ggtgacagca ctagctccac
4141 aaattggata aatgcatttc tggaaaagac tagggacaaa atccaggcat cacttgtgct
4201 ttcatatcaa ccacgctgta cagcttgtgt tgctgtctgc agctgcaatg gggactcttg
4261 atttctttaa ggaaacttgg gttaccagag tatttccaca aatgctattc aaattagtgc
4321 ttatgatatg caagacactg tgctaggagc cagaaaacaa agaggaggag aaatcagtca
4381 ttatgtggga acaacatagc aagatattta gatcattttg actagttaaa aaagcagcag
4441 agtacaaaat cacacatgca atcagtataa tccaaatcat gtaaatatgt gcctgtagaa
4501 agactagagg aataaacaca agaatcttaa cagtcattgt cattagacac taagtctaat
4561 tattattatt agacactatg atatttgaga tttaaaaaat ctttaatatt ttaaaattta
4621 gagctcttct atttttccat agtattcaag tttgacaatg atcaagtatt actctttctt
4681 tttttttttt tttttttttt tttgagatgg agttttggtc ttgttgccca tgctggagtg
4741 gaatggcatg accatagctc actgcaacct ccacctcctg ggttcaagca aagctgtcgc
4801 ctcagcctcc cgggtagatg ggattacagg cgcccaccac cacactcggc taatgtttgt
4861 atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaac tcctgacctc
4921 agaggatcca cctgcctcag cctcccaaag tgctgggatt acagatgtag gccactgcgc
4981 ccggccaagt attgctctta tacattaaaa aacaggtgtg agccactgcg cccagccagg
5041 tattgctctt atacattaaa aaataggccg gtgcagtggc tcacgcctgt aatcccagca
5101 ctttgggaag ccaaggcggg cagaacaccc gaggtcagga gtccaaggcc agcctggcca
5161 agatggtgaa accccgtctc tattaaaaat acaaacatta cctgggcatg atggtgggcg
5221 cctgtaatcc cagctactca ggaggctgag gcaggaggat ccgcggagcc tggcagatct
5281 gcctgagcct gggaggttga ggctacagta agccaagatc atgccagtat acttcagcct
5341 gggcgacaaa gtgagaccgt aacaaaaaaa aaaaaattta aaaaaagaaa tttagatcaa
5401 gatccaactg taaaaagtgg cctaaacacc acattaaaga gtttggagtt tattctgcag
5461 gcagaagaga accatcaggg ggtcttcagc atgggaatgg catggtgcac ctggtttttg
5521 tgagatcatg gtggtgacag tgtggggaat gttattttgg agggactgga ggcagacaga
5581 ccggttaaaa ggccagcaca acagataagg aggaagaaga tgagggcttg gaccgaagca
5641 gagaagagca aacagggaag gtacaaattc aagaaatatt ggggggtttg aatcaacaca
5701 tttagatgat taattaaata tgaggactga ggaataagaa atgagtcaag gatggttcca
5761 ggctgctagg ctgcttacct gaggtggcaa agtcgggagg agtggcagtt taggacaggg
5821 ggcagttgag gaatattgtt ttgatcattt tgagtttgag gtacaagttg gacacttagg
5881 taaagactgg aggggaaatc tgaatataca attatgggac tgaggaacaa gtttatttta
5941 ttttttgttt cgttttcttg ttgaagaaca aatttaattg taatcccaag tcatcagcat
6001 ctagaagaca gtggcaggag gtgactgtct tgtgggtaag ggtttggggt ccttgatgag
6061 tatctctcaa ttggccttaa atataagcag gaaaaggagt ttatgatgga ttccaggctc
6121 agcagggctc aggagggctc aggcagccag cagaggaagt cagagcatct tctttggttt
6181 agcccaagta atgacttcct taaaaagctg aaggaaaatc cagagtgacc agattataaa
6241 ctgtactctt gcattttctc tccctcctct cacccacagc ctcttgatga accggaggaa
6301 gtttctttac caattcaaaa atgtccgctg ggctaagggt cggcgtgaga cctacctgtg
6361 ctacgtagtg aagaggcgtg acagtgctac atccttttca ctggactttg gttatcttcg
6421 caataaggta tcaattaaag tcagctttgc aagcagttta atggtcaact gtgagtgctt
6481 ttagagccac ctgctgatgg tattacttcc atcctttttt ggcatttgtg tctctatcac
6541 attcctcaaa tccttttttt tatttctttt tccatgtcca tgcacccata ttagacatgg
6601 cccaaaatat gtgatttaat tcctccccag taatgctggg caccctaata ccactccttc
6661 cttcagtgcc aagaacaact gctcccaaac tgtttaccag ctttcctcag catctgaatt
6721 gcctttgaga ttaattaagc taaaagcatt tttatatggg agaatattat cagcttgtcc
6781 aagcaaaaat tttaaatgtg aaaaacaaat tgtgtcttaa gcatttttga aaattaagga
6841 agaagaattt gggaaaaaat taacggtggt tcaattctgt tttccaaatg atttcttttc
6901 cctcctactc acatgggtcg taggccagtg aatacattca acatggtgat ccccagaaaa
6961 ctcagagaag cctcggctga tgattaatta aattgatctt tcggctaccc gagagaatta
7021 catttccaag agacttcttc accaaaatcc agatgggttt acataaactt ctgcccatgg
7081 gtatctcctc tctcctaaca cgctgtgacg tctgggcttg gtggaatctc agggaagcat
7141 ccgtggggtg gaaggtcatc gtctggctcg ttgtttgatg gttatattac catgcaattt
7201 tctttgccta catttgtatt gaatacatcc caatctcctt cctattcggt gacatgacac
7261 attctatttc agaaggcttt gattttatca agcactttca tttacttctc atggcagtgc
7321 ctattacttc tcttacaata cccatctgtc tgctttacca aaatctattt ccccttttca
7381 gatcctccca aatggtcctc ataaactgtc ctgcctccac ctagtggtcc aggtatattt
7441 ccacaatgtt acatcaacag gcacttctag ccattttcct tctcaaaagg tgcaaaaagc
7501 aacttcataa acacaaatta aatcttcggt gaggtagtgt gatgctgctt cctcccaact
7561 cagcgcactt cgtcttcctc attccacaaa aacccatagc cttccttcac tctgcaggac
7621 tagtgctgcc aagggttcag ctctacctac tggtgtgctc ttttgagcaa gttgcttagc
7681 ctctctgtaa cacaaggaca atagctgcaa gcatccccaa agatcattgc aggagacaat
7741 gactaaggct accagagccg caataaaagt cagtgaattt tagcgtggtc ctctctgtct
7801 ctccagaacg gctgccacgt ggaattgctc ttcctccgct acatctcgga ctgggaccta
7861 gaccctggcc gctgctaccg cgtcacctgg ttcacctcct ggagcccctg ctacgactgt
7921 gcccgacatg tggccgactt tctgcgaggg aaccccaacc tcagtctgag gatcttcacc
7981 gcgcgcctct acttctgtga ggaccgcaag gctgagcccg aggggctgcg gcggctgcac
8041 cgcgccgggg tgcaaatagc catcatgacc ttcaaaggtg cgaaagggcc ttccgcgcag
8101 gcgcagtgca gcagcccgca ttcgggattg cgatgcggaa tgaatgagtt agtggggaag
8161 ctcgagggga agaagtgggc ggggattctg gttcacctct ggagccgaaa ttaaagatta
8221 gaagcagaga aaagagtgaa tggctcagag acaaggcccc gaggaaatga gaaaatgggg
8281 ccagggttgc ttctttcccc tcgatttgga acctgaactg tcttctaccc ccatatcccc
8341 gccttttttt cctttttttt ttttttgaag attattttta ctgctggaat acttttgtag
8401 aaaaccacga aagaactttc aaagcctggg aagggctgca tgaaaattca gttcgtctct
8461 ccagacagct tcggcgcatc cttttggtaa ggggcttcct cgctttttaa attttctttc
8521 tttctctaca gtcttttttg gagtttcgta tatttcttat attttcttat tgttcaatca
8581 ctctcagttt tcatctgatg aaaactttat ttctcctcca catcagcttt ttcttctgct
8641 gtttcaccat tcagagccct ctgctaaggt tccttttccc tcccttttct ttcttttgtt
8701 gtttcacatc tttaaatttc tgtctctccc cagggttgcg tttccttcct ggtcagaatt
8761 cttttctcct tttttttttt tttttttttt ttttttaaac aaacaaacaa aaaacccaaa
8821 aaaactcttt cccaatttac tttcttccaa catgttacaa agccatccac tcagtttaga
8881 agactctccg gccccaccga cccccaacct cgttttgaag ccattcactc aatttgcttc
8941 tctctttctc tacagcccct gtatgaggtt gatgacttac gagacgcatt tcgtactttg
9001 ggactttgat agcaacttcc aggaatgtca cacacgatga aatatctctg ctgaagacag
9061 tggataaaaa acagtccttc aagtcttctc tgtttttatt cttcaactct cactttctta
9121 gagtttacag aaaaaatatt tatatacgac tctttaaaaa gatctatgtc ttgaaaatag
9181 agaaggaaca caggtctggc cagggacgtg ctgcaattgg tgcagttttg aatgcaacat
9241 tgtcccctac tgggaataac agaactgcag gacctgggag catcctaaag tgtcaacgtt
9301 tttctatgac ttttaggtag gatgagagca gaaggtagat cctaaaaagc atggtgagag
9361 gatcaaatgt ttttatatca acatccttta ttatttgatt catttgagtt aacagtggtg
9421 ttagtgatag atttttctat tcttttccct tgacgtttac tttcaagtaa cacaaactct
9481 tccatcaggc catgatctat aggacctcct aatgagagta tctgggtgat tgtgacccca
9541 aaccatctct ccaaagcatt aatatccaat catgcgctgt atgttttaat cagcagaagc
9601 atgtttttat gtttgtacaa aagaagattg ttatgggtgg ggatggaggt atagaccatg
9661 catggtcacc ttcaagctac tttaataaag gatcttaaaa tgggcaggag gactgtgaac
9721 aagacaccct aataatgggt tgatgtctga agtagcaaat cttctggaaa cgcaaactct
9781 tttaaggaag tccctaattt agaaacaccc acaaacttca catatcataa ttagcaaaca
9841 attggaagga agttgcttga atgttgggga gaggaaaatc tattggctct cgtgggtctc
9901 ttcatctcag aaatgccaat caggtcaagg tttgctacat tttgtatgtg tgtgatgctt
9961 ctcccaaagg tatattaact atataagaga gttgtgacaa aacagaatga taaagctgcg
10021 aaccgtggca cacgctcata gttctagctg cttgggaggt tgaggaggga ggatggcttg
10081 aacacaggtg ttcaaggcca gcctgggcaa cataacaaga tcctgtctct caaaaaaaaa
10141 aaaaaaaaaa agaaagagag agggccgggc gtggtggctc acgcctgtaa tcccagcact
10201 ttgggaggcc gagccgggcg gatcacctgt ggtcaggagt ttgagaccag cctggccaac
10261 atggcaaaac cccgtctgta ctcaaaatgc aaaaattagc caggcgtggt agcaggcacc
10321 tgtaatccca gctacttggg aggctgaggc aggagaatcg cttgaaccca ggaggtggag
10381 gttgcagtaa gctgagatcg tgccgttgca ctccagcctg ggcgacaaga gcaagactct
10441 gtctcagaaa aaaaaaaaaa aaagagagag agagagaaag agaacaatat ttgggagaga
10501 aggatgggga agcattgcaa ggaaattgtg ctttatccaa caaaatgtaa ggagccaata
10561 agggatccct atttgtctct tttggtgtct atttgtccct aacaactgtc tttgacagtg
10621 agaaaaatat tcagaataac catatccctg tgccgttatt acctagcaac ccttgcaatg
10681 aagatgagca gatccacagg aaaacttgaa tgcacaactg tcttatttta atcttattgt
10741 acataagttt gtaaaagagt taaaaattgt tacttcatgt attcatttat attttatatt
10801 attttgcgtc taatgatttt ttattaacat gatttccttt tctgatatat tgaaatggag
10861 tctcaaagct tcataaattt ataactttag aaatgattct aataacaacg tatgtaattg
10921 taacattgca gtaatggtgc tacgaagcca tttctcttga tttttagtaa acttttatga
10981 cagcaaattt gcttctggct cactttcaat cagttaaata aatgataaat aattttggaa
11041 gctgtgaaga taaaatacca aataaaataa tataaaagtg atttatatga agttaaaata
11101 aaaaatcagt atgatggaat aaacttgaga gtccagaagt tatcccatac atctgtaatc
11161 aactaatttc tcacaagggt gtaaggacca ttcaatggag aaaa
//