LOCUS AB038158 2554 bp mRNA linear HUM 17-JAN-2001
DEFINITION Homo sapiens TMPRSS3b mRNA for serine protease, complete cds.
ACCESSION AB038158
VERSION AB038158.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2554)
AUTHORS Shimizu,N., Kudoh,J. and Shibuya,K.
TITLE Direct Submission
JOURNAL Submitted (10-FEB-2000) to the DDBJ/EMBL/GenBank databases.
Contact:Nobuyoshi Shimizu
Keio University, School of Medicine, Molecular Biology; 35
Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
REFERENCE 2
AUTHORS Scott,H.S., Kudoh,J., Wattenhofer,M., Shibuya,K., Berry,A.,
Chrast,R., Guipponi,M., Wang,J., Kawasaki,K., Asakawa,S.,
Minoshima,S., Younus,F., Mehdi,S.Q., Radhakrishna,U.,
Papasavvas,M.P., Gehrig,C., Rossier,C., Korostishevsky,M., Gal,A.,
Shimizu,N., Bonne-Tamir,B. and Antonarakis,S.E.
TITLE Insertion of beta-satellite repeats identifies a transmembrane
protease causing both congenital and childhood onset autosomal
recessive deafness
JOURNAL Nat. Genet. 27, 59-63 (2001)
COMMENT
FEATURES Location/Qualifiers
source 1..2554
/chromosome="21"
/db_xref="H-InvDB:HIT000059223"
/db_xref="taxon:9606"
/map="21q22.3"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="liver and thymus"
CDS 669..1652
/codon_start=1
/gene="TMPRSS3b"
/note="transmembrane protease, serine 3"
/product="serine protease"
/protein_id="BAB20078.1"
/translation="MCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVS
IDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWP
WQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLV
EKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGA
TEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGG
PLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT"
BASE COUNT 590 a 679 c 662 g 623 t
ORIGIN
1 gccacgttgg attagggccc accctaatga ctcattttaa ctagatgact ctgtaaagac
61 tctccaggcc atctccaaat aagatgccat tctgaggtac taagagttaa gacctcaacg
121 tgtctttctg ggggatacta ttcaacccat agcacatccc ctcatccccc atggaataac
181 cgggtcagag gtggagcagg taggactgaa ctagagaatg tgccccttgg tgggtggccc
241 tttccctaat taaggcacct ttctttgggc tgagacttct ctgcaaagag gggaggggga
301 aaggatagtt aaatttgtaa gtttcatggc actccaagtc aggttctggg gctttctgct
361 cttccttttt ctggttatca gatgcagatg ctgttgctgc acagatcctg tcactgctgc
421 cattgaagtt ttttccaatc atcgtcattg ggatcattgc attgatatta gcactggcca
481 ttggtctggg catccacttc gactgctcag ggaagtacag atgtcgctca tcctttaagt
541 gtatcgagct gatagctcga tgtgacggag tctcggattg caaagacggg gaggacgagt
601 accgctgtgt ccgggtgggt ggtcagaatg ccgtgctcca ggtgttcaca gctgcttcgt
661 ggaagaccat gtgctccgat gactggaagg gtcactacgc aaatgttgcc tgtgcccaac
721 tgggtttccc aagctatgtg agttcagata acctcagagt gagctcgctg gaggggcagt
781 tccgggagga gtttgtgtcc atcgatcacc tcttgccaga tgacaaggtg actgcattac
841 accactcagt atatgtgagg gagggatgtg cctctggcca cgtggttacc ttgcagtgca
901 cagcctgtgg tcatagaagg ggctacagct cacgcatcgt gggtggaaac atgtccttgc
961 tctcgcagtg gccctggcag gccagccttc agttccaggg ctaccacctg tgcgggggct
1021 ctgtcatcac gcccctgtgg atcatcactg ctgcacactg tgtttatgac ttgtacctcc
1081 ccaagtcatg gaccatccag gtgggtctag tttccctgtt ggacaatcca gccccatccc
1141 acttggtgga gaagattgtc taccacagca agtacaagcc aaagaggctg ggcaatgaca
1201 tcgcccttat gaagctggcc gggccactca cgttcaatga aatgatccag cctgtgtgcc
1261 tgcccaactc tgaagagaac ttccccgatg gaaaagtgtg ctggacgtca ggatgggggg
1321 ccacagagga tggagcaggt gacgcctccc ctgtcctgaa ccacgcggcc gtccctttga
1381 tttccaacaa gatctgcaac cacagggacg tgtacggtgg catcatctcc ccctccatgc
1441 tctgcgcggg ctacctgacg ggtggcgtgg acagctgcca gggggacagc ggggggcccc
1501 tggtgtgtca agagaggagg ctgtggaagt tagtgggagc gaccagcttt ggcatcggct
1561 gcgcagaggt gaacaagcct ggggtgtaca cccgtgtcac ctccttcctg gactggatcc
1621 acgagcagat ggagagagac ctaaaaacct gaagaggaag gggacaagta gccacctgag
1681 ttcctgaggt gatgaagaca gcccgatcct cccctggact cccgtgtagg aacctgcaca
1741 cgagcagaca cccttggagc tctgagttcc ggcaccagta gcaggcccga aagaggcacc
1801 cttccatctg attccagcac aaccttcaag ctgctttttg ttttttgttt ttttgaggtg
1861 gagtctcgct ctgttgccca ggctggagtg cagtggcgaa atccctgctc actgcagcct
1921 ccgcttccct ggttcaagcg attctcttgc ctcagcttcc ccagtagctg ggaccacagg
1981 tgcccgccac cacacccaac taatttttgt atttttagta gagacagggt ttcaccatgt
2041 tggccaggct gctctcaaac ccctgacctc aaatgatgtg cctgcttcag cctcccacag
2101 tgctgggatt acaggcatgg gccaccacgc ctagcctcac gctcctttct gatcttcact
2161 aagaacaaaa gaagcagcaa cttgcaaggg cggcctttcc cactggtcca tctggttttc
2221 tctccagggg tcttgcaaaa ttcctgacga gataagcagt tatgtgacct cacgtgcaaa
2281 gccaccaaca gccactcaga aaagacgcac cagcccagaa gtgcagaact gcagtcactg
2341 cacgttttca tctctaggga ccagaaccaa acccaccctt tctacttcca agacttattt
2401 tcacatgtgg ggaggttaat ctaggaatga ctcgtttaag gcctattttc atgatttctt
2461 tgtagcattt ggtgcttgac gtattattgt cctttgattc caaataatat gtttccttcc
2521 ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
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