LOCUS AB020593 4576 bp mRNA linear HUM 30-JUN-1999
DEFINITION Homo sapiens mRNA for 3',5'-Cyclic nucleotide phosphodiesterase,
complete cds.
ACCESSION AB020593
VERSION AB020593.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4576)
AUTHORS Omori,K.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-1998) to the DDBJ/EMBL/GenBank databases.
Contact:Kenji Omori
Tanabe Seiyaku Co. Ltd., Discovery Research Laboratory; Toda,
Saitama 335-8505, Japan
REFERENCE 2
AUTHORS Fujishige,K., Kotera,J., Michibata,H., Yuasa,K., Takebayashi,S.,
Okumura,K. and Omori,K.
TITLE Cloning and characterization of a novel human phosphodiesterase
that hydrolyzes both cAMP and cGMP (PDE10A)
JOURNAL J. Biol. Chem. 274, 18438-18445 (1999)
COMMENT
FEATURES Location/Qualifiers
source 1..4576
/clone="HSPDE10-1"
/clone_lib="Lambda gt11 library (Clontech, USA)"
/db_xref="H-InvDB:HIT000058637_02"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="fetal lung"
CDS 251..2590
/product="3',5'-Cyclic nucleotide phosphodiesterase"
/protein_id="BAA78034.1"
/translation="MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVE
KWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSI
IKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRK
TLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLS
HQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMI
YAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQV
ARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSA
FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM
QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKN
YRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQ
KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDI
YAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEP
LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED"
regulatory 2730..2735
/regulatory_class="polyA_signal_sequence"
regulatory 3239..3244
/regulatory_class="polyA_signal_sequence"
regulatory 3304..3309
/regulatory_class="polyA_signal_sequence"
regulatory 3408..3413
/regulatory_class="polyA_signal_sequence"
regulatory 4079..4084
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1378 a 955 c 978 g 1265 t
ORIGIN
1 gaattccggg cggcggcggc caaactccgc ggcgtcccca gggcgccacg ttcgccctcg
61 ccgccgcggc cgcgctgctc ttcggctccg acatggaaga tggaccttct aataatgcga
121 gctgcttccg aaggctgacc gagtgcttcc tgagccccaa agctaatggt atagatatag
181 aagtcatcca cagagatgtt acagttgaag agatgggggt agagaagact ttgaaggaaa
241 agaatgtaga atgaggatag aagagaggaa atcccaacat ttaacaggtt tgacagatga
301 aaaagtgaag gcatatcttt ctcttcaccc ccaggtatta gatgaatttg tatctgaaag
361 tgttagtgca gagacagtag agaaatggct gaagaggaag aacaacaaat cagaagatga
421 atcagctcct aaggaagtca gcaggtacca agatacgaat atgcagggag ttgtatatga
481 actaaacagc tatatagaac aacggttgga cacaggagga gacaaccagc tactcctcta
541 tgaactgagc agcatcatta aaatagccac aaaagccgat ggatttgcac tgtatttcct
601 tggagagtgc aataatagcc tgtgtatatt cacgccacct gggataaagg aaggaaaacc
661 ccgcctcatc cctgctgggc ccatcactca gggcaccacc gtctctgctt atgtggccaa
721 gtccaggaaa acactgctag tagaagacat ccttggagat gaacgatttc caagaggtac
781 tggactggaa tcagggactc gtatccagtc tgttctttgc ttaccaattg tcactgcaat
841 tggtgacttg attggtattc tcgagctgta tcggcactgg ggcaaagaag ccttctgtct
901 tagtcaccag gaggttgcaa cagcaaatct tgcctgggct tcagtagcaa tacatcaggt
961 gcaggtatgc agaggccttg ccaaacagac agaattgaat gacttcctac tcgacgtatc
1021 aaaaacatat tttgataaca tagttgcaat agattctcta cttgaacaca taatgatata
1081 tgcaaaaaac ctggtgaatg ccgatcgttg tgcgcttttc caggtggacc ataagaacaa
1141 ggagttatat tcagaccttt ttgatattgg agaggaaaag gaaggaaaac ctgtcttcaa
1201 gaagaccaaa gagataagat tttcaattga gaaaggaatt gctggccaag tagcaagaac
1261 aggggaagtc ctgaacattc cagatgccta tgcagaccca cgctttaaca gagaagtaga
1321 cttgtacaca ggctacacca cgcggaacat cctgtgcatg cccatcgtca gccgaggcag
1381 cgtgataggt gtggtgcaga tggtcaacaa aatcagtggc agtgccttct ctaaaacaga
1441 tgaaaacaac ttcaaaatgt ttgccgtctt ttgtgcttta gccttacact gtgctaatat
1501 gtatcataga attcgccact cagagtgcat ttaccgggta acgatggaaa agctgtccta
1561 ccatagcatt tgtacttcag aagagtggca aggtctcatg caattcaccc ttcccgtgcg
1621 tctctgcaaa gaaattgaat tattccactt tgacattggt ccttttgaaa acatgtggcc
1681 tggaattttt gtctacatgg ttcatcggtc ctgtgggaca tcctgctttg agcttgaaaa
1741 gttgtgtcgt tttattatgt ctgtgaagaa gaactatcgg cgggttcctt atcacaactg
1801 gaagcatgcg gtcactgtag cacactgcat gtatgccata cttcagaaca atcacacgct
1861 tttcacagac cttgagcgca aaggactgct gattgcgtgt ctgtgtcatg acctggacca
1921 caggggcttc agtaacagct acctgcagaa gttcgaccac cctctggccg ctctctactc
1981 cacttccacc atggagcagc accacttctc ccagactgtg tccatccttc agttggaagg
2041 gcacaatatc ttctccactc tgagctccag tgaatatgag caggtgcttg agatcatccg
2101 caaagccatc attgccacag accttgcttt atactttgga aacaggaagc agttggaaga
2161 gatgtaccag accggatcac taaaccttaa taatcaatca catagagacc gtgtaattgg
2221 tttgatgatg actgcctgtg acctttgttc tgtgacaaaa ctgtggcccg ttacaaaatt
2281 gacggcaaat gatatatatg cagaattctg ggctgagggt gatgaaatga agaaattggg
2341 aatacagcct attcctatga tggacagaga caagaaggat gaagtccccc aaggccagct
2401 tgggttctac aatgccgtgg ccattccctg ctatacaacc cttacccaga tcctccctcc
2461 cacggagcct cttctgaaag catgcaggga taatctcagt cagtgggaga aggtgattcg
2521 aggggaggag actgcaacct ggatttcatc cccatccgtg gctcagaagg cagctgcatc
2581 tgaagattga gcactggtca ccctgacacg ctgtcccacc tacagatcct catcttgctt
2641 ctttgacatt cttttccttt ttttgggggg ggtgggggga acctgcacct ggtaactggg
2701 gtgcaaacct cttcaagaag gtaacatcaa ataaataagt caagcagagg acttcctgcc
2761 aatctcttct gtgaggcatc atagacactg agcaaccagg accaccccca cgttcagaaa
2821 tcagctggcc aagtgactcc atttgacttg caaaccagcc ttttctaata ggctaatatt
2881 gctgaggcct taaaggaaat ggacaaaaat tatccagaag gggtactttt ccattgtatc
2941 tttctaataa gggtttaaaa tggtactatt atggtattgt acttgggctt taacatcaat
3001 gttgctttga tgttgttgga tataaatagg aattttacac attactattg tgaatggtga
3061 atgttcatgt atgacctact tgtaattaac ttgagttgta gtccacagcc tcaggacaaa
3121 tgtcgttgag gttacagagt aagaaatgat ggcaaaacgt caaactctta tttcagagct
3181 tcatgaattt agttagacta aacataattc tttaagttca acctaaaggg ctgagatcaa
3241 taaatttaac actagacgaa gtagacttcc tgtctttttg agaagagatg aggtatatgt
3301 tacaataaat ctcagaactt caagtagcag ttcaaaagat gtcagttttt aaaattgttt
3361 ttgttgttgt cttggcagtt ttactgaacc ctttgcataa agaacaaaat aaaagctcgg
3421 cattgtaatt tttttaatgg acaagtctta tggatacgag gggtacattt ttcataatga
3481 ttcctttata ttttcacttt gtgtcatatg cagaatttta gactctcatt cacaatgaaa
3541 agtttatttt aaacattgtt taattaaaat accatacagt tctcttttaa acatcaaacc
3601 ataaaaagtg tattttgtaa ttttactctg acctgccgca gtcacctctc acttatctct
3661 tccacgtact gcacggtcgt atttcatgag ctttctgtcc atagcacaga aacagagcag
3721 aaagtagtac aatcatgttg gaccttcttt ctgttctctt tactcttctc acagatcaga
3781 tcactccata gaagcctgtg ggtttcgatg gtttcttcta tacacctttt tggttgacca
3841 gtattactat acaatgtaag tgttttaaaa aatacgaaag taatactctg caccccttcc
3901 tacaaagatg ataaagcagt cacttctggc gcattttaat aatttaaaga tttttagtgc
3961 aatggcacgg taacctccaa acctgaatta gacagagact cactcaggaa gtgacaggcc
4021 catcatatca aataacttat tcacttttca tgtggcagga aactggaata tcgcttttaa
4081 taaaatggaa aaatatgctt ctacatattt accaccatag gcgttttgtt catatgagcc
4141 tggtttgtgc aaaattaaat cagaggcttc tacaacatgg tttatttatg ttgtagcaaa
4201 gttggctcta cataaacatt gttcttattt taaaattaac actatgtgtt cagttttctt
4261 gtgggcttct gaaagttgcc atcttccctc cgtggagctc catttgctat tttcattata
4321 cactatgagg taaaatgtaa taacaaaaga gagagaagta ccactgtggc tagatatata
4381 cacacacata tatatatgga tggatgtaat atatgtagca cacacacata gatgtatata
4441 ggatacacac tcatgtatgt aaacgtatac atatgtgtat atatgataca tacacataca
4501 cacacacgag agacagaagg aaagagagga agagagaagc aaacatgtag gaaaaaatat
4561 aaatcagccg gaattc
//