LOCUS AB019397 5255 bp mRNA linear HUM 06-NOV-1998 DEFINITION Homo sapiens TopBP1 mRNA for DNA topoisomerase II binding protein, complete cds. ACCESSION AB019397 VERSION AB019397.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5255) AUTHORS Yamane,K. TITLE Direct Submission JOURNAL Submitted (31-OCT-1998) to the DDBJ/EMBL/GenBank databases. Contact:Kazuhiko Yamane Japanese Foundation for Cancer Research, Cancer Chemotherapy Center; 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan REFERENCE 2 AUTHORS Yamane,K., Kawabata,M. and Tsuruo,T. TITLE A DNA topoisomerase II binding protein with eight repeating regions similar to DNA repair enzymes and to a cell cycle regulator JOURNAL Eur. J. Biochem. 250, 794-799 (1998) COMMENT FEATURES Location/Qualifiers source 1..5255 /cell_line="HeLa" /db_xref="H-InvDB:HIT000058583" /db_xref="taxon:9606" /mol_type="mRNA" /organism="Homo sapiens" CDS 341..4648 /codon_start=1 /gene="TopBP1" /product="DNA topoisomerase II binding protein" /protein_id="BAA34202.1" /transl_table=1 /translation="MHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMM GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTD INMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPK GQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINT IDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCR IYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHV VGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAP SEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAV VPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISF SQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKW NLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTR LQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFL SKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVAL SASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVT HFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDI SAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKG VLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRS RVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQV DIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQ APSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLG GLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDY EWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSR EAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLR TEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH" regulatory 5222..5227 /regulatory_class="polyA_signal_sequence" regulatory 5229..5234 /regulatory_class="polyA_signal_sequence" BASE COUNT 1699 a 1046 c 1107 g 1403 t ORIGIN 1 cgaccccagc caccgccctg cggccagcgc gtcccccgac tcgccgcccg gagaccccga 61 ggctccaacg agttcagaaa tgtccagaaa tgacaaagaa ccgttttttg tgaagttttt 121 aaagtcttca gacaattcca aatgtttttt taaagctctc gagtccataa aagaattcca 181 atcagaagaa tatcttcaga ttattacaga agaagaggca ttgaagataa aggagaatga 241 tagatcactt tatatctgcg acccttttag tggcgttgtc tttgatcacc tcaaaaagct 301 tggctgcaga attgttggtc ctcaagtagt catattttgt atgcaccacc agcgatgtgt 361 cccaagagcc gaacatccag tttataatat ggttatgtct gatgtaacca tatcttgtac 421 aagtctggaa aaagaaaaaa gggaagaagt tcataaatat gtacaaatga tgggcggacg 481 agtatacaga gaccttaatg tatcagtaac tcaccttatt gcaggagaag ttggtagcaa 541 aaaatattta gttgctgcaa acctgaagaa acctattttg cttccctctt ggataaaaac 601 actttgggag aagtcacaag agaaaaaaat aactagatat actgatataa acatggaaga 661 tttcaagtgt cctatttttc ttggttgcat aatctgtgtg actggcttat gtggcttaga 721 caggaaagaa gttcagcaac tcacagttaa gcatggaggt caatacatgg gacaattgaa 781 aatgaatgaa tgtacacacc tcattgtgca agaaccaaaa ggtcagaagt atgagtgtgc 841 caagagatgg aatgtacact gtgtgaccac acagtggttt tttgacagta ttgagaaagg 901 tttttgtcag gatgaatcca tatacaagac agaacctaga ccagaagcaa agactatgcc 961 caattcttca actcctacca gccagatcaa cacaattgat agtcgtactc tttcagatgt 1021 cagcaatatt tccaacataa atgcaagttg cgtaagtgaa tcaatatgta attcacttaa 1081 cagcaaactg gagcctacac ttgaaaatct agaaaatctg gatgtcagtg catttcaagc 1141 acctgaagat ttattagatg gttgtcggat atatctttgc ggttttagtg gcagaaagct 1201 agataaactg agaagactta ttaacagtgg aggtggagtt cgttttaacc agctaaatga 1261 agatgtaact catgttattg tgggagatta tgatgatgaa ttgaagcagt tttggaataa 1321 atcagcccac aggcctcatg tagtgggagc aaagtggttg ctagagtgtt tcagtaaagg 1381 ttatatgctt tctgaagaac catatatcca tgctaattac cagccagtgg aaattccagt 1441 ttcacatcag cctgaaagta aagcagctct tttaaaaaag aagaacagca gcttctctaa 1501 gaaagacttt gctcctagtg aaaagcatga gcaagctgat gaagatctgc tctctcaata 1561 tgaaaatggt agctccacag tagttgaggc taagacgtct gaagccaggc cctttaatga 1621 ttctactcat gctgagccct tgaatgattc tactcacatt tctttgcaag aagaaaacca 1681 gtcttctgtc agtcattgtg tccctgatgt ttctacaatt actgaagaag gcttatttag 1741 ccaaaagagt ttccttgttt tgggttttag taatgaaaat gaatctaaca tcgcaaacat 1801 cataaaagaa aatgctggga aaatcatgtc ccttctgagc agaactgttg cggattatgc 1861 tgtggttcct ctgctggggt gtgaagtgga agccactgtg ggagaagttg ttacaaatac 1921 atggctggtt acttgcatag actatcagac tttgtttgat ccaaagtcga atcctctctt 1981 cacaccagtt ccagtaatga caggaatgac tcctttagag gattgtgtta tttcatttag 2041 ccagtgtgct ggagcagaaa aagagtcttt aacattccta gcaaacctcc ttggagcaag 2101 tgttcaagaa tactttgttc gcaaatccaa tgcaaagaaa ggcatgtttg ccagtactca 2161 tcttatactg aaagaacgtg gtggctctaa atatgaagct gcaaagaagt ggaatttacc 2221 tgccgttact atagcttggc tgttggagac tgctagaacg ggaaagagag cagacgaaag 2281 ccattttctg attgaaaatt caactaaaga agaacgaagt ttggaaacag aaataacaaa 2341 tggaatcaat ctaaattcag atactgcaga gcatcctggc acacgcctgc aaactcacag 2401 aaaaaccgtc gttacacctt tagatatgaa ccgctttcag agtaaagctt tccgtgctgt 2461 ggtctcacaa catgccagac aggtcgcagc ctccccagca gtaggacaac cacttcagaa 2521 ggagccctcg ttacacctgg atacaccatc aaaattcctg tccaaggaca aactcttcaa 2581 gccttccttt gatgtgaagg atgcacttgc agccttggaa actccaggac gtcccagcca 2641 acagaaaagg aaaccgagta cgccactctc agaagttatt gtcaaaaact tgcaacttgc 2701 tttggcaaat agctctcgaa atgctgtcgc tctttctgcc agccctcaac tgaaagaggc 2761 ccagtcagag aaggaagaag ccccaaagcc acttcacaaa gtagtggtat gtgttagtaa 2821 aaaactcagt aagaagcaga gtgaactaaa tgggatcgca gcctctctag gagcagatta 2881 caggtggagt tttgatgaaa cagtgactca tttcatctat caagggcggc caaatgacac 2941 taatcgggag tataaatctg taaaagaaag aggagtacac attgtttccg agcactggct 3001 tttagattgt gcccaagagt gtaaacatct tcctgaatct ctttatccac atacttataa 3061 tcccaaaatg agcttggata tcagcgcagt gcaagatggc cggctctgta atagtcgact 3121 actctcagct gtgtcttcaa caaaggatga tgagccagat cctttgattt tagaagaaaa 3181 tgatgtagac aatatggcca ccaataataa agagtcagca ccatcaaatg gaagtggaaa 3241 gaatgactct aaaggagttc tgacacagac cttagagatg agagagaact ttcagaagca 3301 gttacaggag ataatgtctg caacatcaat agtgaaaccc caagggcaga ggacttccct 3361 ttcaagaagt ggttgtaaca gcgcatcttc aacccctgac agcactcgct ctgctcgcag 3421 tggacgaagt agagtcctag aggcactgag gcagtctcgt cagacagtac ctgatgtcaa 3481 cacagagcct tcccaaaatg aacagatcat ttgggatgac cctacagcaa gggaggagag 3541 agcaaggctt gccagcaatt tgcagtggcc tagttgtccc acacaatact ctgagcttca 3601 ggttgacatt caaaacttgg aggattctcc ttttcaaaag cctttacatg attcagaaat 3661 tgctaaacag gctgtctgtg atcctggaaa catacgtgtg actgaagctc ccaaacaccc 3721 aatctctgaa gaactggaaa ctcccataaa agacagccac ctgatcccta cgcctcaagc 3781 ccccagtatt gcctttccac tcgccaaccc ccctgtggct ccgcacccta gagaaaagat 3841 tataacgata gaggagactc atgaagaatt aaaaaaacag tacatatttc agttatcatc 3901 tctgaatcct caagaacgta ttgactattg tcatctgatt gagaaactag gtggattggt 3961 gatagaaaag cagtgctttg atcccacctg tacacacatt gttgtgggac atccacttcg 4021 aaacgagaag tatttagcct cagtggcagc tgggaagtgg gtgcttcatc gctcctacct 4081 tgaagcctgc aggactgctg gacacttcgt gcaggaagaa gactatgaat ggggaagtag 4141 ttccatactt gatgttttga ctggaatcaa tgtacagcaa cgaagactag cacttgcagc 4201 aatgagatgg agaaaaaaaa tccagcaaag acaagaatct ggcattgttg agggagcatt 4261 tagtgggtgg aaggttattt tacatgtgga tcagtctcga gaagcaggct tcaaacgcct 4321 tcttcagtca ggaggagcaa aggtgctacc tggtcattct gtacctttat ttaaagaggc 4381 cacacatctt ttttctgact tgaataaact gaaaccagat gactcgggag ttaatatagc 4441 agaagctgct gcccagaacg tgtactgctt gagaacagaa tacattgctg attatctcat 4501 gcaggaatca cctcctcatg tagaaaatta ctgtctacca gaagctattt catttattca 4561 gaataataag gaacttggga ctggattatc acaaaagagg aaagctccta cagaaaaaaa 4621 taaaatcaaa cgacctagag tacactaatc gcatctaccc tttagttacc aaacattaaa 4681 tgtttttaaa aattgaaagc ctgaatgtga ctgtgataga tttgggtagt aatttaaaga 4741 tgagtacctg aagaattctg cttcagagta taatgatgac ccttcttgag ttttgaacac 4801 ctgaaattgt aatcactgaa atattaactg tttcttaata aaaagttacc tgaaataaca 4861 acaaaataca actcctcagc tagcttgctg ttaaaccaca ttgaagtctg ttaaaagata 4921 tttatttttc ttgtaaatat ctgaagctgt agcttagtgg aaattttagc aaggtaatgg 4981 attttgcttt aaaatgtctg ccttacaaat tcataacaac aagatttgtc agtcagcatt 5041 tattcatgtt ttccctgatt tttatcttct caccatttta cctcttttaa caggagcctg 5101 agcacaaggt ttaatgagga agctggggct ataaatatgt gtgtatatat gtatatgtat 5161 gtttgtacaa atctccatga tgtttgccaa gtttgaatgc gcaaaacttg gaaaatgtga 5221 caataaagaa taaaagtagt aactcaaatt agtat //