LOCUS       AB019397                5255 bp    mRNA    linear   HUM 06-NOV-1998
DEFINITION  Homo sapiens TopBP1 mRNA for DNA topoisomerase II binding protein,
            complete cds.
ACCESSION   AB019397
VERSION     AB019397.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5255)
  AUTHORS   Yamane,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-1998) to the DDBJ/EMBL/GenBank databases.
            Contact:Kazuhiko Yamane
            Japanese Foundation for Cancer Research, Cancer Chemotherapy
            Center; 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan
REFERENCE   2
  AUTHORS   Yamane,K., Kawabata,M. and Tsuruo,T.
  TITLE     A DNA topoisomerase II binding protein with eight repeating
            regions similar to DNA repair enzymes and to a cell cycle regulator
  JOURNAL   Eur. J. Biochem. 250, 794-799 (1998)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..5255
                     /cell_line="HeLa"
                     /db_xref="H-InvDB:HIT000058583"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
     CDS             341..4648
                     /codon_start=1
                     /gene="TopBP1"
                     /product="DNA topoisomerase II binding protein"
                     /protein_id="BAA34202.1"
                     /transl_table=1
                     /translation="MHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMM
                     GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTD
                     INMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPK
                     GQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINT
                     IDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCR
                     IYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHV
                     VGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAP
                     SEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV
                     SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAV
                     VPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISF
                     SQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKW
                     NLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTR
                     LQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFL
                     SKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVAL
                     SASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVT
                     HFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDI
                     SAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKG
                     VLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRS
                     RVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQV
                     DIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQ
                     APSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLG
                     GLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDY
                     EWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSR
                     EAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLR
                     TEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH"
     regulatory      5222..5227
                     /regulatory_class="polyA_signal_sequence"
     regulatory      5229..5234
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT         1699 a         1046 c         1107 g         1403 t
ORIGIN      
        1 cgaccccagc caccgccctg cggccagcgc gtcccccgac tcgccgcccg gagaccccga
       61 ggctccaacg agttcagaaa tgtccagaaa tgacaaagaa ccgttttttg tgaagttttt
      121 aaagtcttca gacaattcca aatgtttttt taaagctctc gagtccataa aagaattcca
      181 atcagaagaa tatcttcaga ttattacaga agaagaggca ttgaagataa aggagaatga
      241 tagatcactt tatatctgcg acccttttag tggcgttgtc tttgatcacc tcaaaaagct
      301 tggctgcaga attgttggtc ctcaagtagt catattttgt atgcaccacc agcgatgtgt
      361 cccaagagcc gaacatccag tttataatat ggttatgtct gatgtaacca tatcttgtac
      421 aagtctggaa aaagaaaaaa gggaagaagt tcataaatat gtacaaatga tgggcggacg
      481 agtatacaga gaccttaatg tatcagtaac tcaccttatt gcaggagaag ttggtagcaa
      541 aaaatattta gttgctgcaa acctgaagaa acctattttg cttccctctt ggataaaaac
      601 actttgggag aagtcacaag agaaaaaaat aactagatat actgatataa acatggaaga
      661 tttcaagtgt cctatttttc ttggttgcat aatctgtgtg actggcttat gtggcttaga
      721 caggaaagaa gttcagcaac tcacagttaa gcatggaggt caatacatgg gacaattgaa
      781 aatgaatgaa tgtacacacc tcattgtgca agaaccaaaa ggtcagaagt atgagtgtgc
      841 caagagatgg aatgtacact gtgtgaccac acagtggttt tttgacagta ttgagaaagg
      901 tttttgtcag gatgaatcca tatacaagac agaacctaga ccagaagcaa agactatgcc
      961 caattcttca actcctacca gccagatcaa cacaattgat agtcgtactc tttcagatgt
     1021 cagcaatatt tccaacataa atgcaagttg cgtaagtgaa tcaatatgta attcacttaa
     1081 cagcaaactg gagcctacac ttgaaaatct agaaaatctg gatgtcagtg catttcaagc
     1141 acctgaagat ttattagatg gttgtcggat atatctttgc ggttttagtg gcagaaagct
     1201 agataaactg agaagactta ttaacagtgg aggtggagtt cgttttaacc agctaaatga
     1261 agatgtaact catgttattg tgggagatta tgatgatgaa ttgaagcagt tttggaataa
     1321 atcagcccac aggcctcatg tagtgggagc aaagtggttg ctagagtgtt tcagtaaagg
     1381 ttatatgctt tctgaagaac catatatcca tgctaattac cagccagtgg aaattccagt
     1441 ttcacatcag cctgaaagta aagcagctct tttaaaaaag aagaacagca gcttctctaa
     1501 gaaagacttt gctcctagtg aaaagcatga gcaagctgat gaagatctgc tctctcaata
     1561 tgaaaatggt agctccacag tagttgaggc taagacgtct gaagccaggc cctttaatga
     1621 ttctactcat gctgagccct tgaatgattc tactcacatt tctttgcaag aagaaaacca
     1681 gtcttctgtc agtcattgtg tccctgatgt ttctacaatt actgaagaag gcttatttag
     1741 ccaaaagagt ttccttgttt tgggttttag taatgaaaat gaatctaaca tcgcaaacat
     1801 cataaaagaa aatgctggga aaatcatgtc ccttctgagc agaactgttg cggattatgc
     1861 tgtggttcct ctgctggggt gtgaagtgga agccactgtg ggagaagttg ttacaaatac
     1921 atggctggtt acttgcatag actatcagac tttgtttgat ccaaagtcga atcctctctt
     1981 cacaccagtt ccagtaatga caggaatgac tcctttagag gattgtgtta tttcatttag
     2041 ccagtgtgct ggagcagaaa aagagtcttt aacattccta gcaaacctcc ttggagcaag
     2101 tgttcaagaa tactttgttc gcaaatccaa tgcaaagaaa ggcatgtttg ccagtactca
     2161 tcttatactg aaagaacgtg gtggctctaa atatgaagct gcaaagaagt ggaatttacc
     2221 tgccgttact atagcttggc tgttggagac tgctagaacg ggaaagagag cagacgaaag
     2281 ccattttctg attgaaaatt caactaaaga agaacgaagt ttggaaacag aaataacaaa
     2341 tggaatcaat ctaaattcag atactgcaga gcatcctggc acacgcctgc aaactcacag
     2401 aaaaaccgtc gttacacctt tagatatgaa ccgctttcag agtaaagctt tccgtgctgt
     2461 ggtctcacaa catgccagac aggtcgcagc ctccccagca gtaggacaac cacttcagaa
     2521 ggagccctcg ttacacctgg atacaccatc aaaattcctg tccaaggaca aactcttcaa
     2581 gccttccttt gatgtgaagg atgcacttgc agccttggaa actccaggac gtcccagcca
     2641 acagaaaagg aaaccgagta cgccactctc agaagttatt gtcaaaaact tgcaacttgc
     2701 tttggcaaat agctctcgaa atgctgtcgc tctttctgcc agccctcaac tgaaagaggc
     2761 ccagtcagag aaggaagaag ccccaaagcc acttcacaaa gtagtggtat gtgttagtaa
     2821 aaaactcagt aagaagcaga gtgaactaaa tgggatcgca gcctctctag gagcagatta
     2881 caggtggagt tttgatgaaa cagtgactca tttcatctat caagggcggc caaatgacac
     2941 taatcgggag tataaatctg taaaagaaag aggagtacac attgtttccg agcactggct
     3001 tttagattgt gcccaagagt gtaaacatct tcctgaatct ctttatccac atacttataa
     3061 tcccaaaatg agcttggata tcagcgcagt gcaagatggc cggctctgta atagtcgact
     3121 actctcagct gtgtcttcaa caaaggatga tgagccagat cctttgattt tagaagaaaa
     3181 tgatgtagac aatatggcca ccaataataa agagtcagca ccatcaaatg gaagtggaaa
     3241 gaatgactct aaaggagttc tgacacagac cttagagatg agagagaact ttcagaagca
     3301 gttacaggag ataatgtctg caacatcaat agtgaaaccc caagggcaga ggacttccct
     3361 ttcaagaagt ggttgtaaca gcgcatcttc aacccctgac agcactcgct ctgctcgcag
     3421 tggacgaagt agagtcctag aggcactgag gcagtctcgt cagacagtac ctgatgtcaa
     3481 cacagagcct tcccaaaatg aacagatcat ttgggatgac cctacagcaa gggaggagag
     3541 agcaaggctt gccagcaatt tgcagtggcc tagttgtccc acacaatact ctgagcttca
     3601 ggttgacatt caaaacttgg aggattctcc ttttcaaaag cctttacatg attcagaaat
     3661 tgctaaacag gctgtctgtg atcctggaaa catacgtgtg actgaagctc ccaaacaccc
     3721 aatctctgaa gaactggaaa ctcccataaa agacagccac ctgatcccta cgcctcaagc
     3781 ccccagtatt gcctttccac tcgccaaccc ccctgtggct ccgcacccta gagaaaagat
     3841 tataacgata gaggagactc atgaagaatt aaaaaaacag tacatatttc agttatcatc
     3901 tctgaatcct caagaacgta ttgactattg tcatctgatt gagaaactag gtggattggt
     3961 gatagaaaag cagtgctttg atcccacctg tacacacatt gttgtgggac atccacttcg
     4021 aaacgagaag tatttagcct cagtggcagc tgggaagtgg gtgcttcatc gctcctacct
     4081 tgaagcctgc aggactgctg gacacttcgt gcaggaagaa gactatgaat ggggaagtag
     4141 ttccatactt gatgttttga ctggaatcaa tgtacagcaa cgaagactag cacttgcagc
     4201 aatgagatgg agaaaaaaaa tccagcaaag acaagaatct ggcattgttg agggagcatt
     4261 tagtgggtgg aaggttattt tacatgtgga tcagtctcga gaagcaggct tcaaacgcct
     4321 tcttcagtca ggaggagcaa aggtgctacc tggtcattct gtacctttat ttaaagaggc
     4381 cacacatctt ttttctgact tgaataaact gaaaccagat gactcgggag ttaatatagc
     4441 agaagctgct gcccagaacg tgtactgctt gagaacagaa tacattgctg attatctcat
     4501 gcaggaatca cctcctcatg tagaaaatta ctgtctacca gaagctattt catttattca
     4561 gaataataag gaacttggga ctggattatc acaaaagagg aaagctccta cagaaaaaaa
     4621 taaaatcaaa cgacctagag tacactaatc gcatctaccc tttagttacc aaacattaaa
     4681 tgtttttaaa aattgaaagc ctgaatgtga ctgtgataga tttgggtagt aatttaaaga
     4741 tgagtacctg aagaattctg cttcagagta taatgatgac ccttcttgag ttttgaacac
     4801 ctgaaattgt aatcactgaa atattaactg tttcttaata aaaagttacc tgaaataaca
     4861 acaaaataca actcctcagc tagcttgctg ttaaaccaca ttgaagtctg ttaaaagata
     4921 tttatttttc ttgtaaatat ctgaagctgt agcttagtgg aaattttagc aaggtaatgg
     4981 attttgcttt aaaatgtctg ccttacaaat tcataacaac aagatttgtc agtcagcatt
     5041 tattcatgtt ttccctgatt tttatcttct caccatttta cctcttttaa caggagcctg
     5101 agcacaaggt ttaatgagga agctggggct ataaatatgt gtgtatatat gtatatgtat
     5161 gtttgtacaa atctccatga tgtttgccaa gtttgaatgc gcaaaacttg gaaaatgtga
     5221 caataaagaa taaaagtagt aactcaaatt agtat
//