LOCUS AB006683 1545 bp mRNA linear HUM 13-DEC-1997
DEFINITION Homo sapiens APECED mRNA for AIRE-2, complete cds.
ACCESSION AB006683
VERSION AB006683.1
KEYWORDS autoimmune regulator-2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1545)
AUTHORS Shimizu,N.
TITLE Direct Submission
JOURNAL Submitted (16-AUG-1997) to the DDBJ/EMBL/GenBank databases.
Contact:Nobuyoshi Shimizu
Keio University School of Medicine, Department of Molecular
Biology; 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
REFERENCE 2
AUTHORS Nagamine,K., Peterson,P., Scott,H.S., Kudoh,J., Minoshima,S.,
Heino,M., Krohn,K.J.E., Lalioti,M.D., Mullis,P.E.,
Antonarakis,S.E., Kawasaki,K., Asakawa,S., Ito,F. and Shimizu,N.
TITLE Positional cloning of the APECED gene
JOURNAL Nat. Genet. 17, 393-398 (1997)
COMMENT
FEATURES Location/Qualifiers
source 1..1545
/chromosome="21"
/db_xref="H-InvDB:HIT000058085"
/db_xref="taxon:9606"
/dev_stage="3-yr-old"
/isolate="Caucasian"
/map="21q22.3"
/mol_type="mRNA"
/organism="Homo sapiens"
/sex="male"
/tissue_type="thymus"
CDS 237..1283
/gene="APECED"
/note="autoimmune regulator-2"
/product="AIRE-2"
/protein_id="BAA23989.1"
/translation="MWLVYSSGAPGTQQPARNRVFFPIGMAPGGVCWRPDGWGTGGQG
RISGPGSMGAGQRLGSSGTQRCCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDEC
AVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRP
QEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALH
PLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCR
SCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQW
AIQSMARPAAPFPS"
regulatory 1531..1536
/regulatory_class="polyA_signal_sequence"
BASE COUNT 261 a 485 c 508 g 291 t
ORIGIN
1 agagaaagtg aggtcttctc aggctcttaa gagcatggcg tttggtccag gctgtacccg
61 ctgctctcag ctgggcccgt gggtgggccg ggcgcccctg ctatagccag gaggtcaagg
121 atccactggg aatgccatgc tcatctttcg tccccagcat ggtttcttaa tggggtagaa
181 gcaggtcggg agagacctcc ctgggcctgg ccccactgcc ctgtgaggaa gggttcatgt
241 ggttggtgta cagttccggg gcccctggaa cgcagcagcc tgcaagaaac cgggttttct
301 tcccaatagg gatggccccg gggggtgtct gttggagacc agatggatgg ggaacaggtg
361 gtcagggcag aatttcaggc cctggcagca tgggagcagg gcagagactg gggagttcag
421 gtacccagag atgctgctgg gggagctgtt ttgggaagga ggtggctctc aggagggtgc
481 tgcaccccag cccagtctgc atgggcgtct cttgcctgtg ccagaagaat gaggacgagt
541 gtgccgtgtg tcgggacggc ggggagctca tctgctgtga cggctgccct cgggccttcc
601 acctggcctg cctgtcccct ccgctccggg agatccccag tgggacctgg aggtgctcca
661 gctgcctgca ggcaacagtc caggaggtgc agccccgggc agaggagccc cggccccagg
721 agccacccgt ggagaccccg ctccccccgg ggcttaggtc ggcgggagag gaggtaagag
781 gtccacctgg ggaaccccta gccggcatgg acacgactct tgtctacaag cacctgccgg
841 ctccgccttc tgcagccccg ctgccagggc tggactcctc ggccctgcac cccctactgt
901 gtgtgggtcc tgagggtcag cagaacctgg ctcctggtgc gcgttgcggg gtgtgcggag
961 atggtacgga cgtgctgcgg tgtactcact gcgccgctgc cttccactgg cgctgccact
1021 tcccagccgg cacctcccgg cccgggacgg gcctgcgctg cagatcctgc tcaggagacg
1081 tgaccccagc ccctgtggag ggggtgctgg cccccagccc cgcccgcctg gcccctgggc
1141 ctgccaagga tgacactgcc agtcacgagc ccgctctgca cagggatgac ctggagtccc
1201 ttctgagcga gcacaccttc gatggcatcc tgcagtgggc catccagagc atggcccgtc
1261 cggcggcccc cttcccctcc tgaccccaga tggccgggac atgcagctct gatgagagag
1321 tgctgagaag gacacctcct tcctcagtcc tggaagccgg ccggctggga tcaagaaggg
1381 gacagcgcca cctcttgtca gtgctcggct gtaaacagct ctgtgtttct ggggacacca
1441 gccatcatgt gcctggaaat taaaccctgc cccacttctc tactctggaa gtccccggga
1501 gcctctcctt gcctggtgac ctactaaaaa tataaaaatt agctg
//