LOCUS       AB006682                2027 bp    mRNA    linear   HUM 13-DEC-1997
DEFINITION  Homo sapiens APECED mRNA for AIRE-1, complete cds.
ACCESSION   AB006682
VERSION     AB006682.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2027)
  AUTHORS   Shimizu,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-AUG-1997) to the DDBJ/EMBL/GenBank databases.
            Contact:Nobuyoshi Shimizu
            Keio University School of Medicine, Department of Molecular
            Biology; 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
REFERENCE   2
  AUTHORS   Nagamine,K., Peterson,P., Scott,H.S., Kudoh,J., Minoshima,S.,
            Heino,M., Krohn,K.J.E., Lalioti,M.D., Mullis,P.E.,
            Antonarakis,S.E., Kawasaki,K., Asakawa,S., Ito,F. and Shimizu,N.
  TITLE     Positional cloning of the APECED gene
  JOURNAL   Nat. Genet. 17, 393-398 (1997)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..2027
                     /chromosome="21"
                     /db_xref="H-InvDB:HIT000058084"
                     /db_xref="taxon:9606"
                     /dev_stage="3-yr-old"
                     /isolate="Caucasian"
                     /map="21q22.3"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /sex="male"
                     /tissue_type="thymus"
     CDS             128..1765
                     /gene="APECED"
                     /note="autoimmune regulator-1"
                     /product="AIRE-1"
                     /protein_id="BAA23988.1"
                     /translation="MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQ
                     ETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPK
                     DVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKA
                     KPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESG
                     GSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQ
                     GSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGT
                     WRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTL
                     VYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCA
                     AAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHE
                     PALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          357 a          716 c          644 g          310 t
ORIGIN      
        1 agacgggcgg gcgcacagcc ggcgcggagg ccccacagcc ccgccgggac ccgaggccaa
       61 gcgaggggct gccagtgtcc cgggacccac cgcgtccgcc ccagccccgg gtccccgcgc
      121 ccaccccatg gcgacggacg cggcgctacg ccggcttctg aggctgcacc gcacggagat
      181 cgcggtggcc gtggacagcg ccttcccact gctgcacgcg ctggctgacc acgacgtggt
      241 ccccgaggac aagtttcagg agacgcttca tctgaaggaa aaggagggct gcccccaggc
      301 cttccacgcc ctcctgtcct ggctgctgac ccaggactcc acagccatcc tggacttctg
      361 gagggtgctg ttcaaggact acaacctgga gcgctatggc cggctgcagc ccatcctgga
      421 cagcttcccc aaagatgtgg acctcagcca gccccggaag gggaggaagc ccccggccgt
      481 ccccaaggct ttggtaccgc cacccagact ccccaccaag aggaaggcct cagaagaggc
      541 tcgagctgcc gcgccagcag ccctgactcc aaggggcacc gccagcccag gctctcaact
      601 gaaggccaag ccccccaaga agccggagag cagcgcagag cagcagcgcc ttccactcgg
      661 gaacgggatt cagaccatgt cagcttcagt ccagagagct gtggccatgt cctccgggga
      721 cgtcccggga gcccgagggg ccgtggaggg gatcctcatc cagcaggtgt ttgagtcagg
      781 cggctccaag aagtgcatcc aggttggcgg ggagttctac actcccagca agttcgaaga
      841 ctccggcagt gggaagaaca aggcccgcag cagcagtggc ccgaagcctc tggttcgagc
      901 caagggagcc cagggcgctg cccccggtgg aggtgaggct aggctgggcc agcagggcag
      961 cgttcccgcc cctctggccc tccccagtga cccccagctc caccagaaga atgaggacga
     1021 gtgtgccgtg tgtcgggacg gcggggagct catctgctgt gacggctgcc ctcgggcctt
     1081 ccacctggcc tgcctgtccc ctccgctccg ggagatcccc agtgggacct ggaggtgctc
     1141 cagctgcctg caggcaacag tccaggaggt gcagccccgg gcagaggagc cccggcccca
     1201 ggagccaccc gtggagaccc cgctcccccc ggggcttagg tcggcgggag aggaggtaag
     1261 aggtccacct ggggaacccc tagccggcat ggacacgact cttgtctaca agcacctgcc
     1321 ggctccgcct tctgcagccc cgctgccagg gctggactcc tcggccctgc accccctact
     1381 gtgtgtgggt cctgagggtc agcagaacct ggctcctggt gcgcgttgcg gggtgtgcgg
     1441 agatggtacg gacgtgctgc ggtgtactca ctgcgccgct gccttccact ggcgctgcca
     1501 cttcccagcc ggcacctccc ggcccgggac gggcctgcgc tgcagatcct gctcaggaga
     1561 cgtgacccca gcccctgtgg agggggtgct ggcccccagc cccgcccgcc tggcccctgg
     1621 gcctgccaag gatgacactg ccagtcacga gcccgctctg cacagggatg acctggagtc
     1681 ccttctgagc gagcacacct tcgatggcat cctgcagtgg gccatccaga gcatggcccg
     1741 tccggcggcc cccttcccct cctgacccca gatggccggg acatgcagct ctgatgagag
     1801 agtgctgaga aggacacctc cttcctcagt cctggaagcc ggccggctgg gatcaagaag
     1861 gggacagcgc cacctcttgt cagtgctcgg ctgtaaacag ctctgtgttt ctggggacac
     1921 cagccatcat gtgcctggaa attaaaccct gccccacttc tctactctgg aagtccccgg
     1981 gagcctctcc ttgcctggtg acctactaaa aatataaaaa ttagctg
//