LOCUS AB005142 5003 bp mRNA linear HUM 30-SEP-1998
DEFINITION Homo sapiens klotho mRNA, complete cds.
ACCESSION AB005142
VERSION AB005142.1
KEYWORDS Klotho.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5003)
AUTHORS Kuro-o,M.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-1997) to the DDBJ/EMBL/GenBank databases.
Contact:Makoto Kuro-o
National Institute of Neuroscience, NCNP, Division of Molecular
Genetics; 4-1-1 Ogawahigashi, Kodaira, Tokyo 187, Japan
REFERENCE 2
AUTHORS Kuro-o,M., Matsumura,Y., Aizawa,H., Kawaguchi,H., Suga,T.,
Utsugi,T., Ohyama,Y., Kurabayashi,M., Kamane,T., Kume,E.,
Iwasaki,H., Iida,A., Shiraki-Iida,T., Nishikawa,S., Nagai,R. and
Nabeshima,Y.
TITLE Mutation of the mouse klotho gene leads to a syndrome resembling
ageing
JOURNAL Nature 390, 45-51 (1997)
COMMENT
FEATURES Location/Qualifiers
source 1..5003
/db_xref="H-InvDB:HIT000058047"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="kidney"
CDS 9..3047
/codon_start=1
/gene="klotho"
/protein_id="BAA23382.1"
/transl_table=1
/translation="MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWAR
VSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPG
DSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNG
SAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRD
YAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHA
KVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFID
GDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESP
NLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGV
DVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPP
LPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTK
KRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMAS
ELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVK
LWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACP
FSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQ
GTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVL
NWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFA
YSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFCPEEFTVCTE
CSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK"
polyA_site 5003
/note="39 A nucleotides"
BASE COUNT 1311 a 1172 c 1110 g 1410 t
ORIGIN
1 cgcgcagcat gcccgccagc gccccgccgc gccgcccgcg gccgccgccg ccgtcgctgt
61 cgctgctgct ggtgctgctg ggcctgggcg gccgccgcct gcgtgcggag ccgggcgacg
121 gcgcgcagac ctgggcccgt gtctcgcggc ctcctgcccc cgaggccgcg ggcctcttcc
181 agggcacctt ccccgacggc ttcctctggg ccgtgggcag cgccgcctac cagaccgagg
241 gcggctggca gcagcacggc aagggtgcgt ccatctggga cacgttcacc caccaccccc
301 tggcaccccc gggagactcc cggaacgcca gtctgccgtt gggcgccccg tcgccgctgc
361 agcccgccac cggggacgta gccagcgaca gctacaacaa cgtcttccgc gacacggagg
421 cgctgcgcga gctcggggtc actcactacc gcttctccat ctcgtgggcg cgagtgctcc
481 ccaatggcag cgcgggcgtc cccaaccgcg aggggctgcg ctactaccgg cgcctgctgg
541 agcggctgcg ggagctgggc gtgcagcccg tggtcaccct gtaccactgg gacctgcccc
601 agcgcctgca ggacgcctac ggcggctggg ccaaccgcgc cctggccgac cacttcaggg
661 attacgcgga gctctgcttc cgccacttcg gcggtcaggt caagtactgg atcaccatcg
721 acaaccccta cgtggtggcc tggcacggct acgccaccgg gcgcctggcc cccggcatcc
781 ggggcagccc gcggctcggg tacctggtgg cgcacaacct cctcctggct catgccaaag
841 tctggcatct ctacaatact tctttccgtc ccactcaggg aggtcaggtg tccattgccc
901 taagctctca ctggatcaat cctcgaagaa tgaccgacca cagcatcaaa gaatgtcaaa
961 aatctctgga ctttgtacta ggttggtttg ccaaacccgt atttattgat ggtgactatc
1021 ccgagagcat gaagaataac ctttcatcta ttctgcctga ttttactgaa tctgagaaaa
1081 agttcatcaa aggaactgct gacttttttg ctctttgctt tggacccacc ttgagttttc
1141 aacttttgga ccctcacatg aagttccgcc aattggaatc tcccaacctg aggcaactgc
1201 tttcctggat tgaccttgaa tttaaccatc ctcaaatatt tattgtggaa aatggctggt
1261 ttgtctcagg gaccaccaag agagatgatg ccaaatatat gtattacctc aaaaagttca
1321 tcatggaaac cttaaaagcc atcaagctgg atggggtgga tgtcatcggg tataccgcat
1381 ggtccctcat ggatggtttc gagtggcaca gaggttacag catcaggcgt ggactcttct
1441 atgttgactt tctaagccag gacaagatgt tgttgccaaa gtcttcagcc ttgttctacc
1501 aaaagctgat agagaaaaat ggcttccctc ctttacctga aaatcagccc ctagaaggga
1561 catttccctg tgactttgct tggggagttg ttgacaacta cattcaagta gataccactc
1621 tgtctcagtt taccgacctg aatgtttacc tgtgggatgt ccaccacagt aaaaggctta
1681 ttaaagtgga tggggttgtg accaagaaga ggaaatccta ctgtgttgac tttgctgcca
1741 tccagcccca gatcgcttta ctccaggaaa tgcacgttac acattttcgc ttctccctgg
1801 actgggccct gattctccct ctgggtaacc agtcccaggt gaaccacacc atcctgcagt
1861 actatcgctg catggccagc gagcttgtcc gtgtcaacat caccccagtg gtggccctgt
1921 ggcagcctat ggccccgaac caaggactgc cgcgcctcct ggccaggcag ggcgcctggg
1981 agaaccccta cactgccctg gcctttgcag agtatgcccg actgtgcttt caagagctcg
2041 gccatcacgt caagctttgg ataacgatga atgagccgta tacaaggaat atgacataca
2101 gtgctggcca caaccttctg aaggcccatg ccctggcttg gcatgtgtac aatgaaaagt
2161 ttaggcatgc tcagaatggg aaaatatcca tagccttgca ggctgattgg atagaacctg
2221 cctgcccttt ctcccaaaag gacaaagagg tggccgagag agttttggaa tttgacattg
2281 gctggctggc tgagcccatt ttcggctctg gagattatcc atgggtgatg agggactggc
2341 tgaaccaaag aaacaatttt cttcttcctt atttcactga agatgaaaaa aagctaatcc
2401 agggtacctt tgactttttg gctttaagcc attataccac catccttgta gactcagaaa
2461 aagaagatcc aataaaatac aatgattacc tagaagtgca agaaatgacc gacatcacgt
2521 ggctcaactc ccccagtcag gtggcggtag tgccctgggg gttgcgcaaa gtgctgaact
2581 ggctgaagtt caagtacgga gacctcccca tgtacataat atccaacgga atcgatgacg
2641 ggctgcatgc tgaggacgac cagctgaggg tgtattatat gcagaattac ataaacgaag
2701 ctctcaaagc ccacatactg gatggtatca atctttgcgg atactttgct tattcgttta
2761 acgaccgcac agctccgagg tttggcctct atcgttatgc tgcagatcag tttgagccca
2821 aggcatccat gaaacattac aggaaaatta ttgacagcaa tggtttcccg ggcccagaaa
2881 ctctggaaag attttgtcca gaagaattca ccgtgtgtac tgagtgcagt ttttttcaca
2941 cccgaaagtc tttactggct ttcatagctt ttctattttt tgcttctatt atttctctct
3001 cccttatatt ttactactcg aagaaaggca gaagaagtta caaatagttc tgaacatttt
3061 tctattcatt cattttgaaa taattatgca gacacatcag ctgttaacca tttgcacctc
3121 taagtgttgt gaaactgtaa atttcataca tttgacttct agaaaacatt tttgtggctt
3181 atgacagagg ttttgaaatg ggcataggtg atcgtaaaat attgaataat gcgaatagtg
3241 cctgaatttg ttctcttttt gggtgattaa aaaactgaca ggcactataa tttctgtaac
3301 acactaacaa aagcatgaaa aataggaacc acaccaatgc aacatttgtg cagaaatttg
3361 aatgacaaga ttaggaatat tttcttctgc acccacttct aaatttaatg tttttctgga
3421 agtagtaatt gcaagagttc gaatagaaag ttatgtacca agtaaccatt tctcagctgc
3481 cataataatg cctagtggct tcccctctgt caaatctagt ttcctatgga aaagaagatg
3541 gcagatacag gagagacgac agagggtcct aggctggaat gttcctttcg aaagcaatgc
3601 ttctatcaaa tactagtatt aatttatgta tctggttaat gacatacttg gagagcaaat
3661 tatggaaatg tgtattttat atgatttttg aggtcctgtc taaaccctgt gtccctgagg
3721 gatctgtctc actggcatct tgttgagggc cttgcacata ggaaactttt gataagtatc
3781 tgcggaaaaa caaacatgaa tcctgtgata ttgggctctt caggaagcat aaagcaattg
3841 tgaaatacag tataccgcag tggctctagg tggaggaaag gaggaaaaag tgcttattat
3901 gtgcaacatt atgattaatc tgattataca ccatttttga gcagatcttg gaatgaatga
3961 catgaccttt ccctagagaa taaggatgaa ataatcactc attctatgaa cagtgacact
4021 actttctatt ctttagctgt actgtaattt ctttgagttg atagttttac aaattcttaa
4081 taggttcaaa agcaatctgg tctgaataac actggatttg tttctgtgat ctctgaggtc
4141 tattttatgt ttttgctgct acttctgtgg aagtagcttt gaactagttt tactttgaac
4201 tttcacgctg aaacatgcta gtgatatcta gaaagggcta attaggtctc atcctttaat
4261 gccccttaaa taagtcttgc tgattttcag acagggaagt ctctctatta cactggagct
4321 gttttataga taagtcaata ttgtatcagg caagataaac caatgtcata acaggcattg
4381 ccaacctcac tgacacaggg tcatagtgta taataatata ctgtactata taatatatca
4441 tctttagagg tatgattttt tcatgaaaga taagcttttg gtaatattca ttttaaagtg
4501 gacttattaa aattggatgc tagagaatca agtttatttt atgtatatat ttttctgatt
4561 ataagagtaa tatatgttca ttgtaaaaat ttttaaaaca cagaaactat atgcaaagaa
4621 aaaataaaaa ttatctataa tctcagaacc cagaaatagc cactattaac atttcctacg
4681 tattttattt tacatagatc atattgtata tagttagtat ctttattaat ttttattatg
4741 aaactttcct ttgtcattat tagtcttcaa aagcatgatt tttaatagtt gttgagtatt
4801 ccaccacagg aatgtatcac aacttaaccg ttcccgtttg ttagactagt ttcttattaa
4861 tgttgatgaa tgttgtttaa aaataatttt gttgctacat ttactttaat ttccttgact
4921 gtaaagagaa gtaattttgc tccttgataa agtattatat taataataaa tctgcctgca
4981 actttttgcc ttctttcata atc
//