LOCUS       AB002378                5790 bp    mRNA    linear   HUM 19-SEP-2015
DEFINITION  Homo sapiens ARHGEF11/KIAA0380 mRNA for KIAA0380 protein.
ACCESSION   AB002378
VERSION     AB002378.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5790)
  AUTHORS   Ohara,O., Nagase,T., Kikuno,R. and Nomura,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAR-1997) to the DDBJ/EMBL/GenBank databases.
            Contact:Osamu Ohara
            Kazusa DNA Research Institute; 1532-3, Yana, Kisarazu, Chiba
            292-0812, Japan
REFERENCE   2
  AUTHORS   Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.,
            Miyajima,N., Tanaka,A., Kotani,H., Nomura,N. and Ohara,O.
  TITLE     Prediction of the coding sequences of unidentified human genes.
            VII. The complete sequences of 100 new cDNA clones from brain
            which can code for large proteins in vitro
  JOURNAL   DNA Res. 4, 141-150 (1997)
REFERENCE   3
  AUTHORS   Fukuhara,S., Murga,C., Zohar,M., Igishi,T. and Gutkind,J.S.
  TITLE     A novel PDZ domain containing guanine nucleotide exchange factor
            links heterotrimeric G proteins to Rho
  JOURNAL   J. Biol. Chem. 274, 5868-5879 (1999)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..5790
                     /clone="HH0518"
                     /clone_lib="pBluescriptII SK plus"
                     /db_xref="H-InvDB:HIT000000086"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /sex="male"
                     /tissue_type="brain"
     CDS             746..5314
                     /citation=[3]
                     /codon_start=1
                     /gene="ARHGEF11/KIAA0380"
                     /note="PDZ-RhoGEF"
                     /product="KIAA0380 protein"
                     /protein_id="BAA20834.3"
                     /transl_table=1
                     /translation="MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLV
                     QRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSH
                     LEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPP
                     QRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQE
                     GDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVP
                     STGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQ
                     ADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLR
                     NSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVA
                     EKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKW
                     LPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVR
                     NIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRS
                     RKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIES
                     PSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN
                     ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKK
                     LREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLF
                     MQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR
                     EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPL
                     TWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNA
                     VLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAA
                     PMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVL
                     LEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALED
                     VENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEG
                     DNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
                     KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSE
                     APMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKL
                     NRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNS
                     HELGPCPEDGSDAPLEDSTADAAASPGP"
BASE COUNT         1419 a         1636 c         1515 g         1220 t
ORIGIN      
        1 aattggctca tttaagaatt tcaaaacatt taatgtaaaa gctttttttt ttttaaggaa
       61 gtccataaat tttggttccc agggttgcac tggacttgga aggagtgctg ttgtgtacat
      121 actattgtat ggttttattt attattttac tgtacaaatc agccgaaaga atttttccaa
      181 gtgccatttc ggatttatta atcctttttt ttttcctttc ctcaaagata tttgctgttg
      241 tcatattaag cattggagac tagaaaatta ctttccccct ttgagctaga gggtctcttg
      301 ccaacagaag gacagctgag aaagctggat ttaaaggatg gttttatctg tactttgcag
      361 ttaacagtga tattttgaag gcacattttt ctgtgattca tttttttttg gccatagtgc
      421 taaccttgaa gagattcgtg gctgggtttt tggtttctga gaaggtcgta gtttttcctc
      481 ttttcctttt tttttttctt ttttcttttc ttttcttttt ttttaaagcg ggggagggga
      541 agaggggctg agaaaggaaa tcatgttcac tggtagaagt agagtggagc atcagttacc
      601 agggtcctga gagctggagg agaaaggatt ctatcttcaa gttgggaggc cctcctctca
      661 ccttgctcaa aaattgcaag cgattcaatc ctgatcaaga caccaaagct acaggattct
      721 ggaaccgtgg agacaccgag aaaccatgag tgtaaggtta ccccagagta tagacaggtt
      781 aagtagcctg tcttctctgg gagattctgc accagagcgc aagtcccctt cccaccatcg
      841 ccagccttcg gatgcctctg agacaacagg tctcgttcaa cgctgtgtca ttatccaaaa
      901 ggaccagcat ggcttcggct tcacagtcag tggggatcgc attgttctgg tgcagtctgt
      961 gcggcctgga ggtgcagcca tgaaggccgg tgtgaaagag ggcgaccgga tcatcaaagt
     1021 caacggcacc atggtgacca atagctcaca cctggaagtg gtaaagctga tcaaatctgg
     1081 cgcctatgtc gcactcaccc tcctgggctc ttcaccttca tccatgggca tctctgggct
     1141 ccagcaggac ccatccccag caggagctcc ccgaatcacg tcagtgatcc cctcaccacc
     1201 acctcctcca cctctaccac ctccacaacg catcacagga cccaaacctc tgcaggatcc
     1261 cgaagttcaa aaacatgcca cccagatcct caggaatatg ctgaggcagg aagaaaaaga
     1321 attacaggac atacttccac tatatggtga caccagccag agaccatcag aaggccggct
     1381 ctctctggat tcccaggagg gggacagtgg cttggactct gggacagaac gctttccttc
     1441 cctcagtgag tcattgatga atcggaactc ggtactgtca gaccctgggc tagacagtcc
     1501 tcgaacctcc cctgtgatca tggccagggt ggcccagcac cacaggcggc agggctcgga
     1561 tgcagcagtc ccctcaaccg gtgaccaggg tgtagatcaa agcccaaagc ctttaattat
     1621 tggcccagag gaagactatg acccgggtta tttcaacaac gagagcgaca tcatattcca
     1681 ggatctggag aaactgaagt ctcggccagc tcacctgggg gtttttctac gttacatctt
     1741 ctctcaggcg gaccccagtc cactgctttt ttacctgtgt gcagaagttt atcagcaggc
     1801 aagccccaag gattcccgaa gcttggggaa agacatctgg aatattttcc tggagaaaaa
     1861 tgcgcctctg agagtgaaga tccctgagat gctacaggct gaaattgact cgcgcctgcg
     1921 gaacagcgaa gatgcccgtg gtgttctctg tgaagctcaa gaggcagcca tgcctgagat
     1981 ccaagagcag atccacgact acagaacgaa gcgcacactg gggctgggca gcctgtatgg
     2041 tgaaaatgac ctgctggacc tggatgggga ccctctccga gagcgccaag tggctgagaa
     2101 gcagctggct gcccttggag atattttgtc caagtatgag gaagacagga gcgcccccat
     2161 ggacttcgcc ctcaatacct acatgagcca tgctgggatc cgtcttcgag aggcacgacc
     2221 ttccaacaca gctgaaaagg cccagtctgc tcctgacaag gacaagtggc taccgttctt
     2281 ccctaagacc aagaagagca gcaattccaa gaaagaaaag gatgccttgg aggacaagaa
     2341 gcgaaaccct atcctcaaat acattgggaa gcccaaaagc tcttctcaaa gcacatttca
     2401 tattcccttg tcccctgtgg aagtcaaacc aggcaatgtg aggaacatca ttcagcactt
     2461 tgagaacaac cagcagtatg atgccccaga acctgggaca caacgactct cgaccggaag
     2521 ctttcctgag gacctgctgg agagtgacag ttcacgctca gagattcgcc tgggccgctc
     2581 tgaaagcctc aagggccggg aagagatgaa acggtctcga aaggcagaga acgtgccccg
     2641 ctctcgcagt gatgttgaca tggatgctgc tgcggaggct actcgcctgc accagtcagc
     2701 ctcgtcctct acctccagcc tctccaccag gtctcttgag aacccaaccc ctccattcac
     2761 tcccaaaatg ggccgcagga gcattgagtc ccccagtttg gggttctgca cagataccct
     2821 ccttccccac ctcctagagg atgatctggg ccagctgtct gacctggagc cagagccaga
     2881 tgcccaaaat tggcagcata cagtgggcaa ggatgtggtg gctgggctaa cccagcggga
     2941 gattgaccgg caagaggtca tcaatgagct gtttgtgact gaagcttccc acctgcgcac
     3001 actccgggtc ctggacctga tcttctacca gcgaatgaag aaggagaacc tgatgccccg
     3061 ggaggagctg gcccggctct tcccgaacct gcctgaactc atagagattc acaattcctg
     3121 gtgtgaagcc atgaagaagc tccgggagga aggccccatc atcaaagaga tcagtgacct
     3181 catgctggcc cggtttgatg gccctgcccg agaggaactc cagcaagtgg ctgcacagtt
     3241 ctgttcctat cagtcaatag ccctagagct aatcaagacc aagcaacgca aggagagtcg
     3301 attccagctc ttcatgcagg aggctgagag ccaccctcag tgtcggcggc tgcagctgag
     3361 agacctcatc atctctgaga tgcagcggct caccaagtac ccgctgctgc tggagagcat
     3421 catcaagcac acagagggtg gcacctctga gcatgagaag ctgtgccggg cccgggacca
     3481 gtgccgggag attctcaagt atgtgaatga agcggtaaaa caaacagaga accgccaccg
     3541 tttagagggc taccagaaac gcctggatgc caccgccctg gagagggcca gcaaccccct
     3601 ggcagcagag ttcaagagcc tggatcttac aaccagaaaa atgatccatg agggacccct
     3661 gacctggagg atcagcaagg ataagacctt ggacctccac gtgctgctgc tggaggacct
     3721 cctagtgctg ctacagaaac aggatgagaa gctattgctg aagtgccaca gcaagactgc
     3781 tgtgggctcc tcagacagca agcagacctt cagccccgtg ctcaagctca atgctgtgct
     3841 catccgctct gtggccacag ataaacgggc cttcttcatc atctgcacct ccaagctggg
     3901 cccaccccag atctatgagc tggttgcatt gacgtcatca gacaagaaca catggatgga
     3961 gctcttagaa gaggccgtgc ggaatgccac caggcacccc ggagctgccc caatgcccgt
     4021 ccatcctcca cccccaggtc cccgggagcc agcccagcag ggccccacac ccagcagggt
     4081 agaactggat gactcagacg tgttccatgg tgaacctgaa cctgaggagc tgcctggagg
     4141 cactgggtcc cagcagaggg tccaagggaa gcaccaggtc ctgctagagg accctgagca
     4201 ggagggcagt gcagaggaag aggaactggg tgtcctgcct tgcccttcca catccctgga
     4261 tggagagaac aggggcatca ggacaaggaa ccccatccac ttggccttcc caggccctct
     4321 gttcatggaa gggctcgctg actccgctct ggaagatgtg gagaacctgc gacatctgat
     4381 cctgtggagc ctgctgccag gtcacaccat ggaaactcag gctgcccagg agcccgagga
     4441 cgacctgaca cccacacctt ctgtcatcag cgtcacctct cacccctggg acccaggctc
     4501 cccagggcaa gcaccccctg ggggtgaagg ggacaacacc cagcttgcag ggctggaggg
     4561 ggaacggcca gagcaggaag acatgggtct ctgttctctg gaacacctac ccccaaggac
     4621 cagaaattct gggatatggg agtctccaga actggacagg aatctggctg aagatgcttc
     4681 aagcacagag gcagcaggag gttacaaagt tgtgagaaaa gctgaggtgg caggcagcaa
     4741 ggttgtccct gcactaccag agagtggcca gtcagagcct gggccacctg aagtggaagg
     4801 cggaacaaag gctacgggga actgctttta tgtcagcatg ccatcaggac ccccggactc
     4861 aagcaccgac cactcagagg cacccatgag cccccctcag cctgacagcc tccctgcagg
     4921 gcagacagag cctcagcctc agctgcaggg aggcaacgat gatccaagac gccccagccg
     4981 ctctcctcca agcctggccc tcagggacgt gggcatgatc ttccatacca ttgagcagct
     5041 cactctcaag ctcaacaggc tcaaggatat ggagctggcc cacagagagc tgctcaagtc
     5101 ccttggggga gagtcatctg gtggcaccac gcctgtgggc agtttccaca cagaagcagc
     5161 tagatggaca gatggctccc tctcacctcc cgctaaggag cccctagctt ctgactccag
     5221 gaacagccat gaactggggc cctgccctga ggatggctct gacgcccccc tggaagacag
     5281 cacagcagac gcagccgcgt caccaggacc ataaccgtac aaaccaccaa atcctctgcg
     5341 tccccactcc tccttcaggg actggcctga gaccggggca cagggtaggg gggatcccaa
     5401 cactcctccc tgtggaggag gcagttaggg aaactaggat ccagccaagg cccgggggga
     5461 gacccgcatg ttgcttggtc tgctcaagtc ggagtcaggt ttcagtgtct tttccctccc
     5521 ttagcccaac cctccaaggc ctcatgtctc ctaagcatgc tgactgcatc cgaaaggccc
     5581 ccactcacca tggtctgccc tcaccccaca tatgtgtgta cacgcgcacg cctgtatgtg
     5641 cgctgccctc agacatgcaa gtgaaaggag gaggcttctg tgtaaatgca ctttcttcct
     5701 cccctctttc tccataagac cccaggcaga ggtgggtgcc tcccctcccc tctttgtcac
     5761 tttggtttcc tataaatatg tatgtatcgt
//