LOCUS AB000732 4474 bp DNA linear HUM 05-FEB-1999
DEFINITION Homo sapiens IRS-2 gene for insulin receptor substrate-2, complete
cds.
ACCESSION AB000732
VERSION AB000732.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4474)
AUTHORS Asano,T.
TITLE Direct Submission
JOURNAL Submitted (27-JAN-1997) to the DDBJ/EMBL/GenBank databases.
Contact:Tomoichiro Asano
University of Tokyo, 3rd Department of Internal Medicine; 7-3-1
Hongo, Bunkyo-ku, Tokyo 113, Japan
REFERENCE 2
AUTHORS Ogihara,T., Isobe,T., Ichimura,T., Taoka,M., Funaki,M., Sakoda,H.,
Onishi,Y., Inukai,K., Anai,M., Fukushima,Y., Kikuchi,M.,
Yazaki,Y., Oka,Y. and Asano,T.
TITLE 14-3-3 protein binds to insulin receptor substrate-1, one of the
binding sites of which is in the phosphotyrosine binding domain
JOURNAL J. Biol. Chem. 272, 25267-25274 (1997)
COMMENT Sequence updated (22-Jan-1998)
FEATURES Location/Qualifiers
source 1..4474
/db_xref="taxon:9606"
/mol_type="genomic DNA"
/organism="Homo sapiens"
CDS 1..3975
/codon_start=1
/gene="IRS-2"
/product="insulin receptor substrate-2"
/protein_id="BAA24500.1"
/transl_table=1
/translation="MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGH
KRFFVLRGPGAGGDKATAGGGSAPQPPRLEYYESEKNWRSKAGAPKRVIALDCCLNIN
KRADPKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPA
ASCSASLPGAVGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYR
LCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADD
SVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPS
QTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPLSP
GPVRAPLSRSHTLIGGCRAAGTKWHCFPAGGGLQHSRSMSMPVEHLPPAATSPGSLSS
SSDHGWGSYPPPPGPHPLLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPG
DLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQD
LDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVA
YHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPAS
VSAPKQILQPRAAAAAAAAVPFAGPAGPAPTFAAGRTFPASGGGYKASSPAESSPEDS
GYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRGV
PGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATPGPTQAASAFGA
GPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPK
SPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPALSLGSGTPGTSSDSRQR
SPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQ
PPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIA
APPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRR
HSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSP
RQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLKYIAIDVREEP
GLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTRGGCGGPGPGAPAPCPTT
YAQH"
BASE COUNT 720 a 1659 c 1408 g 687 t
ORIGIN
1 atggcgagcc cgccgcggca cgggccgccc gggccggcga gcggagacgg ccccaacctc
61 aacaacaaca acaacaacaa caaccacagc gtgcgcaagt gcggctacct gcgcaagcag
121 aagcatggcc acaagcgctt cttcgtgctg cgcggacccg gcgcgggcgg cgacaaggcc
181 acggcgggcg gggggtcggc gccgcaaccg ccgcggctcg agtactacga aagcgaaaaa
241 aattggcgga gcaaggcagg cgcgccgaaa cgggtgatcg ctctcgactg ctgcctgaac
301 atcaacaagc gcgccgaccc caagcacaag tacctgatcg ccctctacac caaggacgag
361 tacttcgccg tggccgccga gaacgagcag gagcaggagg gctggtaccg cgcgctcacc
421 gacctggtca gcgagggccg cgcggccgcc ggagacgcgc cccccgccgc cgcgcccgcc
481 gcgtcctgca gcgcctccct gcccggcgcc gtgggcggtt ctgccggcgc cgccggggcc
541 gaggacagct acgggctggt ggctcccgcc acggccgcct accgtgaggt gtggcaggtg
601 aacctgaagc ccaagggtct gggccagagc aagaacctga cgggggtgta ccgtctgtgc
661 ctgtctgcgc gcaccatcgg cttcgtgaag ctcaactgcg agcagccgtc ggtgacgctg
721 cagctcatga acatccgccg ctgcggccac tcggacagct tcttcttcat cgaggtgggc
781 cgctcggccg tcacaggccc cggcgagctg tggatgcagg cggacgactc ggtggtggcg
841 cagaacatcc acgagaccat cctggaggcc atgaaggcgc tcaaggagct cttcgagttc
901 cggccgcgca gtaagagcca atcgtcgggg tcgtcggcca cgcaccccat cagcgtcccc
961 ggcgcgcgcc gccaccacca cctggtcaac ctgcccccca gccagacggg cctggtgcgc
1021 cgctcgcgca ccgacagcct ggccgccacc ccgccggcgg ccaagtgcag ctcgtgccgg
1081 gtgcgcaccg ccagcgaggg cgacggcggc gcggcggcgg gagcggcggc cgcgggcgcc
1141 aggccggtgt cggtggctgg gagccccctg agccccgggc cggtgcgcgc gcccctgagc
1201 cgctcgcaca ccctgatcgg cggctgccgg gccgcgggaa caaagtggca ttgcttcccg
1261 gcagggggcg gattgcaaca cagccgttcg atgtccatgc ccgtggagca tttgccgcca
1321 gccgccacca gcccgggttc cttgtcttcc agcagcgacc acggttgggg ttcttacccg
1381 ccgccgcccg gcccgcaccc gcttttgccg catccgttgc accacggccc cggccagcgg
1441 ccttccagcg gcagcgcttc cgcttcgggc tcccccagcg accccggttt catgtccctg
1501 gacgagtacg gctccagccc aggcgacctg cgcgccttct gcagccaccg aagcaacacg
1561 cccgagtcca tcgcggagac gcccccggcc cgagacggcg gcggcggcgg tgagttttac
1621 gggtacatga ccatggacag gcccctgagc cactgtggcc gctcctaccg ccgggtctcg
1681 ggggacgcgg cccaggacct ggaccgaggg ctgcgcaaga ggacctactc cctgaccacg
1741 ccagcccggc agcggccggt gccccagccc tcctctgcct cgctggatga atacaccctg
1801 atgcgggcca ccttctcggg cagcgcgggc cgcctctgcc cgtcctgccc cgcgtcctct
1861 cccaaggtgg cctaccaccc ctacccagag gactacggag acatcgagat cggctcccac
1921 aggagctcca gcagcaacct gggggcagac gacggctaca tgcccatgac gcccggcgcg
1981 gcccttgcgg gcagtgggag cggcagctgc aggagcgacg actacatgcc catgagcccc
2041 gccagcgtgt ccgcccccaa gcagattttg cagcccaggg ccgccgccgc cgccgccgcc
2101 gccgtgcctt ttgcggggcc tgcggggcca gcacccacct ttgcggcggg caggacattc
2161 ccggcgagtg ggggcggcta caaggccagc tcgcccgccg agagctcccc cgaggacagt
2221 gggtacatgc gcatgtggtg cggttccaag ctgtccatgg agcatgcaga tggcaagctg
2281 ctgcccaacg gggactacct caacgtgtcc cccagcgacg cggtcaccac gggcaccccg
2341 cccgacttct tctccgcagc cctgcacccc ggcggggagc cgctcagggg cgttcccggc
2401 tgctgctaca gctccttgcc ccgctcctac aaggccccct acacctgtgg cggggacagc
2461 gaccagtacg tgctcatgag ctcccccgtg gggcgcatcc tggaggagga gcgtctggag
2521 cctcaggcca ccccagggcc cacccaggcg gccagcgcct tcggggccgg ccccacgcag
2581 ccccctcacc ctgtagtgcc ttcgcccgtg cggcctagcg gcggccgccc ggagggcttc
2641 ttgggccagc gcggccgggc ggtgaggccc acgcgcctgt ccctggaggg gctgcccagc
2701 ctgcccagca tgcacgagta cccactgcca ccggagccca agagccccgg cgagtacatc
2761 aacatcgact ttggcgagcc cggggcccgc ctgtcgccgc ccgcgcctcc cctgctggcg
2821 tcggcggcct cgtcctcatc gctattgtcc gccagcagcc cggccttgtc gttgggctca
2881 ggcaccccgg gcaccagcag cgacagccgg cagcggtctc cgctctccga ctacatgaac
2941 ctcgacttca gctcccccaa gtctcctaag ccgggcgccc cgagcggcca ccccgtgggc
3001 tccttggacg gcctcctgtc ccccgaggcc tcctccccgt atccgccgtt gcccccgcgt
3061 ccgtccgcgt ccccgtcgtc gtctctgcag ccgccgccac cgccgccggc cccgggggag
3121 ctgtaccgcc tgccccccgc ctcggccgtt gccaccgccc agggcccggg cgccgcctca
3181 tcgttgtcct cggacaccgg ggacaatggt gactacaccg agatggcttt tggtgtggcc
3241 gccaccccgc cgcaacctat cgcggccccc ccgaagccag aagctgcccg cgtggccagc
3301 ccgacgtcgg gcgtgaagag gctgagcctc atggagcagg tgtcgggagt cgaggccttc
3361 ctgcaggcca gccagccccc ggacccccac cgcggcgcca aggtcatccg cgcagacccg
3421 caggggggcc gccgccgcca cagttccgag accttctcct ccaccacgac ggtcaccccc
3481 gtgtccccgt ccttcgccca caaccccaag cgccacaact cggcctccgt ggaaaatgtc
3541 tctctcagga aaagcagcga gggcggcgtg ggtgtcggcc ctggaggggg cgacgagccg
3601 cccacctccc cacgacagtt gcagccggcg ccccctttgg caccgcaggg ccggccgtgg
3661 accccgggtc agcccggggg cttggtcggt tgtcctggga gcggtggatc gcccatgcgc
3721 agagagacct ctgccggttt ccagaatggt ctcaagtaca tcgccatcga cgtgagggag
3781 gagcccgggc tgccacccca gccgcagccg ccgccgccgc cgcttcctca gccgggagac
3841 aagagctcct ggggccggac ccgaagcctc gggggtctca tcagcgctgt gggcgtcggc
3901 agcacccgcg gcgggtgcgg ggggccgggt cccggtgccc ctgccccctg cccaacaacc
3961 tacgcccagc attgacttct tgtcccacca cttgaaggag gccaccattg tgaaagagtg
4021 aagatctgtc tggctttatc accaggatgt cacatgtcag agaatatcat taaaagaaga
4081 cgctcagcac tgtttcagcc cgaagctgct tgcagttttc ttttggatct gagcaatgac
4141 tgtgtttgga aacatctgtg gactctgtta gatgaggcac caacaaggca aggtcacctg
4201 cctctttccc ttgttcccgg atggggcatt catcattgtg ctgtttgcgt tttgttttgt
4261 tttgttttaa caaaattagc tgaagaagtt attctcaaga aaattggatg ttttcattgg
4321 ccttcttaaa ttgtggccag tgtcttttaa tttcttcttc ttttcctttt ggcaaagcag
4381 atataaccct cagcatgcta ggagagtgca cccgtacact atggaagtgg taaaatctgg
4441 tatttactgg cttacactca aaacgaccac agtc
//