LOCUS       Y00157                  5310 bp    DNA     linear   ROD 14-NOV-2006
DEFINITION  Murine Lyt-2.2 gene for differentiation antigen.
ACCESSION   Y00157
VERSION     Y00157.1
KEYWORDS    alternate splicing; differentiation antigen; glycoprotein;
            immunoglobulin superfamily; Lyt-2.2 gene.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5310)
  AUTHORS   Nakauchi H., Tagawa M., Nolan G.P., Herzenberg L.A.
  TITLE     Isolation and characterization of the gene for the murine T cell
            differentiation antigen and immunoglobulin-related molecule, Lyt-2
  JOURNAL   Nucleic Acids Res. 15(10), 4337-4347(1987).
   PUBMED   3495785
COMMENT     alternative splicing of the two intracytoplasmic exons (IV and V)
            yields the 38 kDa alpha and 34 kDa alpha' Lyt2-polypeptides;
            the 34 kDa alpha' Lyt2-polypeptide is formed by splicing of the
            transmembrane donor site (exon 3) directly to the fifth exon, thus
            deleting exon 4 from the mRNA; loss of exon 4 effects a frameshift
FEATURES             Location/Qualifiers
     source          1..5310
                     /organism="Mus musculus"
                     /strain="B10.A"
                     /mol_type="genomic DNA"
                     /clone_lib="lambda J1 phage"
                     /clone="p6CCA"
                     /tissue_type="liver"
                     /db_xref="taxon:10090"
     regulatory      94..99
                     /note="TATA-box"
                     /regulatory_class="promoter"
     mRNA            join(123..897,1394..1498,1649..1759)
     precursor_RNA   123..4477
                     /note="primary transcript"
     misc_feature    303..317
                     /note="cd/pd regulatory sequence"
     misc_feature    326..340
                     /note="cd/pd regulatory sequence"
     CDS             join(456..897,1394..1498,1649..1759,2772..2802,3730..3781)
                     /product="Lyt-2.2 protein"
                     /db_xref="GOA:P01731"
                     /db_xref="InterPro:IPR003599"
                     /db_xref="InterPro:IPR007110"
                     /db_xref="InterPro:IPR013106"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR015468"
                     /db_xref="InterPro:IPR036179"
                     /db_xref="MGI:MGI:88346"
                     /db_xref="PDB:1BQH"
                     /db_xref="PDB:1NEZ"
                     /db_xref="PDB:2ARJ"
                     /db_xref="PDB:2ATP"
                     /db_xref="PDB:3B9K"
                     /db_xref="PDB:3DMM"
                     /db_xref="UniProtKB/Swiss-Prot:P01731"
                     /protein_id="CAA68352.2"
                     /translation="MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAE
                     LGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVYMASSHNKITWDEKLNSSKLFS
                     AMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTP
                     SPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICY
                     HRSRKRVCKCPRPLVRQEGKPRPSEKIV"
     intron          898..1393
                     /number=1
     exon            1394..1498
                     /number=2
     intron          1499..1648
                     /number=2
     exon            1649..1759
                     /number=3
     intron          1760..2771
                     /number=3
     exon            2772..2802
                     /number=4
     intron          2803..3729
                     /number=4
     exon            3730..4477
                     /number=5
     misc_feature    3735..3737
                     /note="translation stop in 34 kDa Lyt2"
     misc_feature    4434..4438
                     /note="cactg motif"
     regulatory      4457..4463
                     /regulatory_class="polyA_signal_sequence"
     misc_feature    4475..4479
                     /note="cactg motif"
     polyA_site      4477..4477
                     /note="polyA site"
BASE COUNT         1312 a         1283 c         1315 g         1400 t
ORIGIN      
        1 aagcttggga acccagaaac ctatctacaa gaaaaagaaa agggagagtg ggcactcctc
       61 tcccttcatg tcctgtcact ctcatatttt ttttattaag atttaatctt tatccttctt
      121 ctttcagcca ctcttgcaga agaacaattc ctaagggtcc cttccaagtg ttttctcttc
      181 cccaaatctc agttttcaat tcctcccact tgctctgcaa gggtgcattc tcactctgag
      241 ttcccaggcc cctaaaaggt ggttgacact ctttggtggg gactttgggt gacatcatat
      301 cctcacatag gaaatcagct ctgtctgcag ctggctaaag gagcagtttc cccgacccta
      361 cacgcctccc ccaccgcacc tcctccgccc tgttcctggg cccctcccct agagccctag
      421 cttgacctaa gctgcttgct ggtggagagc acaccatggc ctcaccgttg acccgctttc
      481 tgtcgctgaa cctgctgctg ctgggtgagt cgattatcct ggggagtgga gaagctaagc
      541 cacaggcacc cgaactccga atctttccaa agaaaatgga cgccgaactt ggtcagaagg
      601 tggacctggt atgtgaagtg ttggggtccg tttcgcaagg atgctcttgg ctcttccaga
      661 actccagctc caaactcccc cagcccacct tcgtttatat ggcttcatcc cacaacaaga
      721 taacgtggga cgagaagctg aattcgtcga aactgttttc tgccatgagg gacacgaata
      781 ataagtacgt tctcaccctg aacaagttca gcaaggaaaa cgaaggctac tatttctgct
      841 cagtcatcag caactcggtg atgtacttca gttctgtcgt gccagtcctt cagaaaggtt
      901 tggaagtgga ggttcccgtc tcctgggttt taggggtcac atctgaacaa gtttcacgca
      961 gattccctct tcttaaatct cttggggcct cttggaggtg atttctatac tgtccccatt
     1021 ttacagacca aaaagttgag gctgaggtgc tgggtggact tggaagtgat ttttaaacgc
     1081 cctggatctg ggctggagtc tggatgcacg tgtgatcctg cccctgttgg ctccaggata
     1141 gaattttggt attgactcca gctttgggtt ggtggaggcc gcagtcgctt agatctgatc
     1201 taggcacatt ggcccaaatc acacttggct ccgcgtgtgg cagcagcgga gtagcccagc
     1261 acgtatccag gggttccttc ttcctctagt taaaagctag gaaacggctc cttcttgggt
     1321 aaaggctaag tggaaagggg ctggtgcatc cacaattcca gcttgacccg caggcaccct
     1381 attgcttttg cagtgaactc tactactacc aagccagtgc tgcgaactcc ctcacctgtg
     1441 caccctaccg ggacatctca gccccagaga ccagaagatt gtcggccccg tggctcaggt
     1501 tagtgctctc aagcgattga gataagcaga tagcctgggg tggaaaatcc tgatcttgga
     1561 ggggagacct ggaccgggag acgtgctggg ggcagggttg ggggctgtcc agagggtttc
     1621 taaattccat tcattcggat cttgtcagtg aaggggaccg gattggactt cgcctgtgat
     1681 atttacatct gggcaccctt ggccggaatc tgcgtggccc ttctgctgtc cttgatcatc
     1741 actctcatct gctaccacag taagttctgg gagttccccc catccagccc ccaccacccc
     1801 cccaccccac ccccgccaag agactgcttt gtgctccagg aggagtctgc agctttgtgc
     1861 ctgctccaga cagccttcag ggagattact tttaggttgg ggaaaagggg gagggcgttc
     1921 cagctgacct ataggaccag tgtagtgggt tctttcttga aggcaggaga caggtatacc
     1981 accccactgc tctttccacc ctctgggaac ttttcagaac agagccctgt tccaggatcc
     2041 ccaagagcag ccaaatcagc agttagcaca gccaggataa cttaagcaca ctaaggaggg
     2101 gtttacatac cgtgagacca gggcccaaga aggctgagtc acaaccatga ctggcttgag
     2161 atttgcctta atcccacctc acaaaccatt cactcctctg agtctataca gtgattacac
     2221 caaccaggtc aacagattcc cagagacact cacatctcga tttacaatgc ctctcccttc
     2281 ccaagaaagg gtttcctttc atgttgtcta gactatccta caactagtta ggtagcctag
     2341 gataacccca aacttctgat ctgatccttc tgccttcctt cattttggga gtgctgggac
     2401 aacgggcata ggcaccaaac caaatttaaa atgttttctt ttattatgta tttatgcatt
     2461 tatttatttg ggtttttttt aaaggcaggg tttctctgtg tagccctggg tgtcctggaa
     2521 ctcacctgta gaccagggtc ggcctcaaac tcagaaatcc gcctgcctct gccttccaag
     2581 tggtgggatt aaagcgtggg tgaccacagc ctggctgaaa tgttttattt ttaattggaa
     2641 cttgaggaaa gagtaggcaa agtagtgttc actccaagtg ttgaagagtt ctgagactca
     2701 aagttctgga gcagaggaag ctatagaaac ggtatctggc aggtattcat tctcccttct
     2761 tccttgtcta gggagccgaa agcgtgtttg caaatgtccc aggtgagtaa cgtctctgat
     2821 ctgtaggtct cgtcacgctg ggcagccgtg gtcccagtgg tgaggtttgg gaatctttcc
     2881 tagagagaga ggtcatgcca gtgaagtcct ggtggcaggg gaccaggagt cagccagatc
     2941 ctgaactagg agaagcagaa agctggtgag gtgctggaat tcattcctga gaaaaggaag
     3001 gaccacagac gtgctcagtg ggacagcagc aggactgagt tgcaggggac tagctgaacg
     3061 aggaaaggtg ttcagtattt tcaggacctg gagtgagctt ggtagcttct gcaagacaat
     3121 tacttatgct tactttttct gaatactctc attttgaaat gtaaaataga aaagcccgtc
     3181 cttgcactaa accccggagc tatgaagatt agttccctag acagtcacag gtccaagtct
     3241 cagcctaaag cagagggttt ctacagggcc actcaggtct ctcacttttc gtgtgacatt
     3301 aagctcagca ctgtgcttgg ttgagggtgc actcacactc ttctggattc tcagttttgg
     3361 gctactggga taagagtcag gccaccgctg acttaaacaa cagctctaat ctcacctcct
     3421 ggactcagaa gtccagaagc ctaactgggc atagatgcta cttcagctgc ctaagagttg
     3481 tgtgacctga ggcagggtct ttaaactctc ctgagcagtg cagacccctc tttgggtgcc
     3541 ttgaggacga aaggaaaggg tggctgaggt aattcattca ttaatgtcta aggacaaatt
     3601 ctcaaagcca tcaaaaactg agtgtgtgtg tgtgcgcgcg cgtgcgcgcg cgctcgcgtg
     3661 ctggtactac tttaaagagg ttctagccac aatgatagtt gatctcttgt gtatctttgt
     3721 ctctttcagg ccgctagtca gacaggaagg caagcccaga ccttcagaga aaattgtgta
     3781 aaatggcacc gccaggaagc tacaactact acatgacttc agagatctct tcttgcaaga
     3841 gccaggccct cctttttcaa gtttcctgct gtcttatgta ttgccctctg tattgtttta
     3901 gtaggggtgt gatggggaca gttccttttt ctttatgaat tctctttgac acaaagcata
     3961 cttgtatgca tacaatggga gtaatgagca gactgtaaca ccagagctag ttccagtttc
     4021 ggggtccatg tcgctggtgg cctcagcacc cacttgatat aaatctcctg tctgcccatc
     4081 atatagaaga agctgaagat cagaggtgga aacagcagga tctgtagacc cggagagaac
     4141 ccaagctaga ggaaccctca ctgactggtg cagggatctc acccccatcc cctgagctct
     4201 ctgtttaggt atgtgtcttt agtatagcat gcttgtgcct caaactgcaa ggaagcaagt
     4261 ggtatgaatc tgtgatctgc tcagctctgg ctgtgaggat cagatgtaac aaatcaaagt
     4321 caggagaact gcctttagcg gtgcacctgg acatcagagc cccttgtaag aactgggaaa
     4381 ttgctggcag tctagtggag cgtacggtaa atctggaaaa cactcccctc tgtcactgaa
     4441 ggctgtagta gaatccaatt aaagctattc aaaccactgc cgcagaccct ctcctgtgtc
     4501 tgcgtggaat gggtctctcg agcaggtggg caaagcgtag gattaaactg acaaacagat
     4561 gcacacagga gaggcgttga atctgaatgt aatgtcaggt cgaacctcgg actttttata
     4621 atacagaaaa aattccaggg gcgatatgtc acaccagaca aggtacactg aaatttacca
     4681 gatacaagag aatgacttcg aaaggaattt gcaggaacta gataaatgtt tacaatagag
     4741 attatcagcc ctgcctagga tcatcagcct agtgccaggt aagaatttca cactttagtt
     4801 taaaagcacc agggggtaat tactcttggc aggcctcaag aataatgtag tgtcacggac
     4861 ccctaaattc ctaggccttg ttaaatctta tcttgtctgg agaatcccca tttatcagga
     4921 gagtatctca acttgctctt ggcatggaat gtagcctgta ctaaagattt ttatctcagt
     4981 gagattccca ggctctttct gcagaccaga tgagctaatg gccttgttta ttgtaatgct
     5041 taattagtta ctgaataagt taaactcctt gctgttatct gggatcttgg aacaatgggg
     5101 gcgctggggg ggggggcggg ggggctttag ctatgtcaga attcaatctt aaaaggcact
     5161 tacaataggg taatgcttaa tagagggcac atggatccat acactagact aacgcgggag
     5221 tggaaaatta atttatggtt tagagggaac gccagactcc aggagggaat ttctgtgaaa
     5281 ctcttttcct tgtgggcagc ttccaagctt
//