LOCUS X62822 2699 bp mRNA linear HUM 24-FEB-1992
DEFINITION H.sapiens gene encoding beta-galactoside
alpha-2,6-sialyltransferase.
ACCESSION X62822
VERSION X62822.1
KEYWORDS beta-galactoside alpha 2,6-sialyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2699)
AUTHORS Bast B.J., Zhou L., Freeman G.J., Colley K.J., Ernst T.J.,
Munro J., Tedder T.F.
TITLE The HB-6, CDw75, and CD76 differentiation antigens are unique
cell-surface carbohydrate determinants generated by the
beta-galactoside alpha 2,6-sialyltransferase
JOURNAL J. Cell Biol. 116(2), 423-435(1992).
PUBMED 1730763
REFERENCE 2 (bases 1 to 2699)
AUTHORS Tedder T.F.
JOURNAL Submitted (22-OCT-1991) to the INSDC. T.F. Tedder, Dana-Farber
Cancer Institute, Division of Tumor Immunology, 44 Binney Street,
Boston MA02115-6084, USA
FEATURES Location/Qualifiers
source 1..2699
/db_xref="H-InvDB:HIT000322544"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="Adult"
/clone_lib="spleen cDNA library cloned into CDM8 vector"
/clone="pHB-6"
/cell_type="Lymphocyte"
/tissue_type="Spleen"
/db_xref="taxon:9606"
5'UTR 1..310
CDS 311..1531
/product="beta-galactoside alpha-2,6-sialyltransferase"
/EC_number="2.4.99.1"
/db_xref="GOA:P15907"
/db_xref="H-InvDB:HIT000322544.12"
/db_xref="HGNC:HGNC:10860"
/db_xref="InterPro:IPR001675"
/db_xref="InterPro:IPR012163"
/db_xref="InterPro:IPR038578"
/db_xref="PDB:4JS1"
/db_xref="PDB:4JS2"
/db_xref="UniProtKB/Swiss-Prot:P15907"
/protein_id="CAA44634.1"
/translation="MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKE
FQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSS
KNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPF
NTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN
FQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYN
FFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTL
CDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYL
LGKATLPGFRTIHC"
mat_peptide 311..1528
/standard_name="sialyltransferase"
/product="The protein product is beta-galactoside
alpha-2,6-sialyltransferase which occurs as a membrane
bound protein with a subcellular location within the Golgi
apparatus."
/note="This protein also occurs as a soluble form in body
fluids which seems to be a proteolytic fragment of the
mambrane-bound form."
/note="The protein product is only detected within the
Golgi apparatus of cells and is not expressed on the cell
surface at detectable levels."
/note="The protein product is not the CDw75 leukocyte
differentiation antigen; the enzymatic activity of the
sialyltransferase generates a critical component of the
CDw75 antigen."
sig_peptide 338..388
/note="Likely transmembrane spanning domain."
3'UTR 1532..2699
BASE COUNT 692 a 708 c 625 g 674 t
ORIGIN
1 ctaaaggttc ctgtagggcg gcacaaccag ggagggcgtg gaagctctgc atcccttctc
61 ccataccttg ctctacacat ctcttcatct gtatcctctg cagcatcctt gatgataaac
121 cagtaaatat gagttttgat catcctgaga aaaatgggcc ttggcctgca gacccaataa
181 accttccctc ccatggataa tagtgctaat tcctgaggac ctgaagggcc tgccgcccct
241 gggggattag ccagaagcag gcttgttttc ctgctcagaa caaagtgact tccctgaaca
301 catcttcatt atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt
361 tcttctgttt gcagtcatct gtgtgtggaa ggaaaagaag aaagggagtt actatgattc
421 ctttaaattg caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg
481 gtctgattcc cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac
541 cctcggcagt ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa
601 caaggacagc tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct
661 aagcatgaac aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc
721 agaggccctg cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga
781 ttttcccttc aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa
841 ggctgggcct tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca
901 actaggcaga gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc
961 caacttccaa caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt
1021 taccacagag aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg
1081 ggacccatct gtataccact cagatatccc aaagtggtac cagaatccgg attataattt
1141 ctttaacaac tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa
1201 gccccagatg ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca
1261 gccaaacccc ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca
1321 ggtggatatt tatgagttcc tcccatccaa gcgcaagact gacgtgtgct actactacca
1381 gaagttcttc gatagtgcct gcacgatggg tgcctaccac ccgctgctct atgagaagaa
1441 tttggtgaag catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac
1501 actgcctggc ttccggacca ttcactgcta agcacaggct cctcactctt ctccatcagg
1561 cattaaatga atggtctctt ggccacccca gcctgggaag aacattttcc tgaacaattc
1621 cagcctgctc cttttactct aggggcctct gtcagcaaga ccatgggggc ttcaagagcc
1681 tgtggtcagg aaatcaggtc cagccttccc tgtagccaga cagtttatga gcccagagcc
1741 tcctgccaca cacatgcaca catatctagc attctttcca gacagcatcc tccccgcctt
1801 ccaccttggt agatgcaagg tctatctctc ccatcagggc tgccaaagct gggctttgtt
1861 tttcccagca gaatgatgcc attctcacaa accaatgctc tatattgctt gaagtctgca
1921 tctaaatatt gatttcacgt tttaaagaaa ttctcttaaa ttacaattgt gcccaatgca
1981 gggtggctct ggggggcaag taggtggtac aggggattgg aaacatcgtc cgcgcctcca
2041 gagaaaagtt gctcccgagg tccatgcccc tggaacgtgt tcctatcact ctggctggtt
2101 gggctggtcc ttagactggg tgcttatgat taaagggtct tggttagccc actttccctc
2161 tccatgtgga gatggaaggt agagaaggat acagtgtcta tcctcaagtt gctacggttc
2221 agtgagagag gcagacatct gaacaggcag gtaggattca gtgtgctcag tgcactgggg
2281 atttggagag agatgggctt gctctctctg tgcacccagg agggccacgc acttaaaact
2341 gagtttgtgg atcagagaag gctttatagc acaggggcat tcagatgagt cttagaggaa
2401 gagaagaaac atggcaagca gattacatct gagccgtttg aattgtgttt ttctttcttc
2461 ccatgtttat tttctaagat ctacctgaac ttagagactc aagatatttt tttaggaaac
2521 ctcctaccca tgtctgaggt agcaagtgca gcctcacgac agataccagg caatccagag
2581 ccacaaaacg tgattcctcc agctctgcct ggcctgaccc tgtcctgtca gctgggttta
2641 cataccagtc ccattcttcc ttttcaatac ctacccccaa atcttctcct aaccctaga
//