LOCUS X16354 3464 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for transmembrane carcinoembryonic antigen BGPa
(formerly TM1-CEA).
ACCESSION X16354 X14784
VERSION X16354.1
KEYWORDS alternative splicing; antigen; carcioembryonic antigen; cell
surface glycoprotein; glycoprotein; immunoglobulin superfamily;
transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3464)
AUTHORS Barnett T.R., Kretschmer A., Austen D.A., Goebel S.J., Hart J.T.,
Elting J.J., Kamarck M.E.
TITLE Carcinoembryonic antigens: alternative splicing accounts for the
multiple mRNAs that code for novel members of the carcinoembryonic
antigen family
JOURNAL J. Cell Biol. 108(2), 267-276(1989).
PUBMED 2537311
FEATURES Location/Qualifiers
source 1..3464
/db_xref="H-InvDB:HIT000321553"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/cell_line="23.4 11+, HT-29."
/db_xref="taxon:9606"
CDS 73..1653
/product="TM1-CEA preprotein"
/db_xref="GOA:P13688"
/db_xref="H-InvDB:HIT000321553.14"
/db_xref="HGNC:HGNC:1814"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013151"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:2GK2"
/db_xref="PDB:4QXW"
/db_xref="PDB:4WHD"
/db_xref="PDB:5DZL"
/db_xref="PDB:6AW2"
/db_xref="PDB:6GBG"
/db_xref="PDB:6GBH"
/db_xref="UniProtKB/Swiss-Prot:P13688"
/protein_id="CAA34404.1"
/translation="MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFN
VAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIY
PNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDK
DAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQ
NPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGT
FQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASK
TTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAG
TYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPGAIAGIVIGVVALVALIAVALAC
FLHFGKTGRASDQRDLTEHKPSVSNHTQDHSNDPPNKMNEVTYSTLNFEAQQPTQPTS
ASPSLTATEIIYSEVKKQ"
sig_peptide 73..174
mat_peptide 175..1650
misc_feature 3430..3435
/note="put. polyA signal"
polyA_site 3454..3454
BASE COUNT 967 a 906 c 717 g 874 t
ORIGIN
1 cagccgtgct cgaagcgttc ctggagccca agctctcctc cacaggtgaa gacagggcca
61 gcaggagaca ccatggggca cctctcagcc ccacttcaca gagtgcgtgt accctggcag
121 gggcttctgc tcacagcctc acttctaacc ttctggaacc cgcccaccac tgcccagctc
181 actactgaat ccatgccatt caatgttgca gaggggaagg aggttcttct ccttgtccac
241 aatctgcccc agcaactttt tggctacagc tggtacaaag gggaaagagt ggatggcaac
301 cgtcaaattg taggatatgc aataggaact caacaagcta ccccagggcc cgcaaacagc
361 ggtcgagaga caatataccc caatgcatcc ctgctgatcc agaacgtcac ccagaatgac
421 acaggattct acaccctaca agtcataaag tcagatcttg tgaatgaaga agcaactgga
481 cagttccatg tatacccgga gctgcccaag ccctccatct ccagcaacaa ctccaaccct
541 gtggaggaca aggatgctgt ggccttcacc tgtgaacctg agactcagga cacaacctac
601 ctgtggtgga taaacaatca gagcctcccg gtcagtccca ggctgcagct gtccaatggc
661 aacaggaccc tcactctact cagtgtcaca aggaatgaca caggacccta tgagtgtgaa
721 atacagaacc cagtgagtgc gaaccgcagt gacccagtca ccttgaatgt cacctatggc
781 ccggacaccc ccaccatttc cccttcagac acctattacc gtccaggggc aaacctcagc
841 ctctcctgct atgcagcctc taacccacct gcacagtact cctggcttat caatggaaca
901 ttccagcaaa gcacacaaga gctctttatc cctaacatca ctgtgaataa tagtggatcc
961 tatacctgcc acgccaataa ctcagtcact ggctgcaaca ggaccacagt caagacgatc
1021 atagtcactg agctaagtcc agtagtagca aagccccaaa tcaaagccag caagaccaca
1081 gtcacaggag ataaggactc tgtgaacctg acctgctcca caaatgacac tggaatctcc
1141 atccgttggt tcttcaaaaa ccagagtctc ccgtcctcgg agaggatgaa gctgtcccag
1201 ggcaacacca ccctcagcat aaaccctgtc aagagggagg atgctgggac gtattggtgt
1261 gaggtcttca acccaatcag taagaaccaa agcgacccca tcatgctgaa cgtaaactat
1321 aatgctctac cacaagaaaa tggcctctca cctggggcca ttgctggcat tgtgattgga
1381 gtagtggccc tggttgctct gatagcagta gccctggcat gttttctgca tttcgggaag
1441 accggcaggg caagcgacca gcgtgatctc acagagcaca aaccctcagt ctccaaccac
1501 actcaggacc actccaatga cccacctaac aagatgaatg aagttactta ttctaccctg
1561 aactttgaag cccagcaacc cacacaacca acttcagcct ccccatccct aacagccaca
1621 gaaataattt attcagaagt aaaaaagcag taatgaaacc tgtcctgctc actgcagtgc
1681 tgatgtattt caagtctctc accctcatca ctaggagatt cctttcccct ctagggtaga
1741 ggggtgggga cagaaacaac tttctcctac tcttccttcc taataggcat ctccaggctg
1801 cctggtcact gcccctctct cagtgtcaat agatgaaagt acattgggag tctgtaggaa
1861 acccaacctt cttgtcattg aaatttggca aagctgactt tgggaaagag ggaccagaac
1921 ttcccctccc ttcccctttt cccaacctgg acttgtttta aacttgcctg ttcagagcac
1981 tcattccttc ccacccccag tcctgtccta tcactctaat tcggatttgc catagccttg
2041 aggttatgtc cttttccatt aagtacatgt gccaggaaac agcgagagag agaaagtaaa
2101 cggcagtaat gcttctccta tttctccaaa gccttgtgtg aactagcaaa gagaagaaaa
2161 ccaaatatat aaccaatagt gaaatgccac aggtttgtcc actgtcaggg ttgtctacct
2221 gtaggatcag ggtctaagca ccttggtgct tagctagaat accacctaat ccttctggca
2281 agcctgtctt cagagaaccc actagaagca actaggaaaa atcacttgcc aaaatccaag
2341 gcaattcctg atggaaaatg caaaagcaca tatatgtttt aatatcttta tgggctctgt
2401 tcaaggcagt gctgagaggg aggggttata gcttcaggag ggaaccagct tctgataaac
2461 acaatctgct aggaacttgg gaaaggaatc agagagctgc ccttcagcga ttatttaaat
2521 tattgttaaa gaatacacaa tttggggtat tgggattttt ctccttttct ctgagacatt
2581 ccaccatttt aatttttgta actgcttatt tatgtgaaaa gggttatttt tacttagctt
2641 agctatgtca gccaatccga ttgccttagg tgaaagaaac caccgaaatc cctcaggtcc
2701 cttggtcagg agcctctcaa gatttttttt gtcagaggct ccaaatagaa aataagaaaa
2761 ggttttcttc attcatggct agagctagat ttaactcagt ttctaggcac ctcagaccaa
2821 tcatcaacta ccattctatt ccatgtttgc acctgtgcat tttctgtttg cccccattca
2881 ctttgtcagg aaaccttggc ctctgctaag gtgtatttgg tccttgagaa gtgggagcac
2941 cctacaggga cactatcact catgctggtg gcattgttta cagctagaaa gctgcactgg
3001 tgctaatgcc ccttgggaaa tggggctgtg aggaggagga ttataactta ggcctagcct
3061 cttttaacag cctctgaaat ttatcttttc ttctatgggg cttataaatg tatcttataa
3121 taaaaaggaa ggacaggagg aagacaggca aatgtacttc tcacccagtc ttctacacag
3181 atggaatctc tttggggcta agagaaaggt tttattctat attgcttacc tgatctcatg
3241 ttaggcctaa gaggctttct ccaggaggat tagcttggag ttctctatac tcaggtacct
3301 ctttcagggt tttctaaccc tgacacggac tgtgcatact ttccctcatc catgctgtgc
3361 tgtgttattt aatttttcct ggctaagatc atgtctgaat tatgtatgaa aattattcta
3421 tgtttttata ataaaaataa tatatcagac atcgaaaaaa aaaa
//