LOCUS X14831 3173 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for transmembrane carcinoembryonic antigen BGPb
(formerly TM2-CEA).
ACCESSION X14831 X14784
VERSION X14831.1
KEYWORDS alternative splicing; antigen; carcinoembryonic antigen; cell
surface glycoprotein; glycoprotein; immunoglobulin superfamily;
transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3173)
AUTHORS Barnett T.
JOURNAL Submitted (20-MAR-1989) to the INSDC.
REFERENCE 2
AUTHORS Barnett T.R., Kretschmer A., Austen D.A., Goebel S.J., Hart J.T.,
Elting J.J., Kamarck M.E.
TITLE Carcinoembryonic antigens: alternative splicing accounts for the
multiple mRNAs that code for novel members of the carcinoembryonic
antigen family
JOURNAL J. Cell Biol. 108(2), 267-276(1989).
PUBMED 2537311
COMMENT The sequence overlaps with that reported by Hinoda et. al. in
Proc. Natl. Acad. Sci. USA 85:6959-6963(1988) J03858.
Data kindly reviewed (26-jul-1989) by Barnett T.R.
FEATURES Location/Qualifiers
source 1..3173
/db_xref="H-InvDB:HIT000321468"
/organism="Homo sapiens"
/chromosome="19."
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="ptcE22."
/cell_line="LOVO (ATCC CCl 229)"
/cell_type="epithelial"
/tissue_type="primary adenocarcinoma of colon"
/db_xref="taxon:9606"
CDS 73..1365
/product="TM2-CEA precursor"
/db_xref="GOA:P13688"
/db_xref="H-InvDB:HIT000321468.11"
/db_xref="HGNC:HGNC:1814"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013151"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:2GK2"
/db_xref="PDB:4QXW"
/db_xref="PDB:4WHD"
/db_xref="PDB:5DZL"
/db_xref="PDB:6AW2"
/db_xref="PDB:6GBG"
/db_xref="PDB:6GBH"
/db_xref="UniProtKB/Swiss-Prot:P13688"
/protein_id="CAA32940.1"
/translation="MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFN
VAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIY
PNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDK
DAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQ
NPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGT
FQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTDNALPQENGLSPGAI
AGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDHSNDPPNKM
NEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ"
sig_peptide 73..174
mat_peptide 175..1362
/note="mature TM2-CEA protein (AA 1-396)"
BASE COUNT 876 a 823 c 653 g 821 t
ORIGIN
1 cagccgtgct cgaagcgttc ctggagccca agctctcctc cacaggtgaa gacagggcca
61 gcaggagaca ccatggggca cctctcagcc ccacttcaca gagtgcgtgt accctggcag
121 gggcttctgc tcacagcctc acttctaacc ttctggaacc cgcccaccac tgcccagctc
181 actactgaat ccatgccatt caatgttgca gaggggaagg aggttcttct ccttgtccac
241 aatctgcccc agcaactttt tggctacagc tggtacaaag gggaaagagt ggatggcaac
301 cgtcaaattg taggatatgc aataggaact caacaagcta ccccagggcc cgcaaacagc
361 ggtcgagaga caatataccc caatgcatcc ctgctgatcc agaacgtcac ccagaatgac
421 acaggattct acaccctaca agtcataaag tcagatcttg tgaatgaaga agcaactgga
481 cagttccatg tatacccgga gctgcccaag ccctccatct ccagcaacaa ctccaaccct
541 gtggaggaca aggatgctgt ggccttcacc tgtgaacctg agactcagga cacaacctac
601 ctgtggtgga taaacaatca gagcctcccg gtcagtccca ggctgcagct gtccaatggc
661 aacaggaccc tcactctact cagtgtcaca aggaatgaca caggacccta tgagtgtgaa
721 atacagaacc cagtgagtgc gaaccgcagt gacccagtca ccttgaatgt cacctatggc
781 ccggacaccc ccaccatttc cccttcagac acctattacc gtccaggggc aaacctcagc
841 ctctcctgct atgcagcctc taacccacct gcacagtact cctggcttat caatggaaca
901 ttccagcaaa gcacacaaga gctctttatc cctaacatca ctgtgaataa tagtggatcc
961 tatacctgcc acgccaataa ctcagtcact ggctgcaaca ggaccacagt caagacgatc
1021 atagtcactg ataatgctct accacaagaa aatggcctct cacctggggc cattgctggc
1081 attgtgattg gagtagtggc cctggttgct ctgatagcag tagccctggc atgttttctg
1141 catttcggga agaccggcag ggcaagcgac cagcgtgatc tcacagagca caaaccctca
1201 gtctccaacc acactcagga ccactccaat gacccaccta acaagatgaa tgaagttact
1261 tattctaccc tgaactttga agcccagcaa cccacacaac caacttcagc ctccccatcc
1321 ctaacagcca cagaaataat ttattcagaa gtaaaaaagc agtaatgaaa cctgtcctgc
1381 tcactgcagt gctgatgtat ttcaagtctc tcaccctcat cactaggaga ttcctttccc
1441 ctgtagggta gaggggtggg gacagaaaca actttctcct actcttcctt cctaataggc
1501 atctccaggc tgcctggtca ctgcccctct ctcagtgtca atagatgaaa gtacattggg
1561 agtctgtagg aaacccaacc ttcttgtcat tgaaatttgg caaagctgac tttgggaaag
1621 agggaccaga acttcccctc ccttcccctt ttcccaacct ggacttgttt taaacttgcc
1681 tgttcagagc actcattcct tcccaccccc agtcctgtcc tatcactcta attcggattt
1741 gccatagcct tgaggttatg tccttttcca ttaagtacat gtgccaggaa acagcgagag
1801 agagaaagta aacggcagta atgcttctcc tatttctcca aagccttgtg tgaactagca
1861 aagagaagaa aatcaaatat ataaccaata gtgaaatgcc acaggtttgt ccactgtcag
1921 ggttgtctac ctgtaggatc agggtctaag caccttggtg cttagctaga ataccaccta
1981 atccttctgg caagcctgtc ttcagagaac ccactagaag caactaggaa aaatcacttg
2041 ccaaaatcca aggcaattcc tgatggaaaa tgcaaaagca catatatgtt ttaatatctt
2101 tatgggctct gttcaaggca gtgctgagag ggaggggtta tagcttcagg agggaaccag
2161 cttctgataa acacaatctg ctaggaactt gggaaaggaa tcagagagct gcccttcagc
2221 gattatttaa attgttaaag aatacacaat ttggggtatt gggatttttc tccttttctc
2281 tgagacattc caccatttta atttttgtaa ctgcttattt atgtgaaaag ggttattttt
2341 acttagctta gctatgtcag ccaatccgat tgccttaggt gaaagaaacc accgaaatcc
2401 ctcaggtccc ttggtcagga gcctctcaag attttttttg tcagaggctc caaatagaaa
2461 ataagaaaag gttttcttca ttcatggcta gagctagatt taactcagtt tctaggcacc
2521 tcagaccaat catcaactac cattctattc catgtttgca cctgtgcatt ttctgtttgc
2581 ccccattcac tttgtcagga aaccttggcc tctgctaagg tgtatttggt ccttgagaag
2641 tgggagcacc ctacagggac actatcactc atgctggtgg cattgtttac agctagaaag
2701 ctgcactggt gctaatgccc cttgggaaat ggggctgtga ggaggaggat tataacttag
2761 gcctagcctc ttttaacagc ctctgaaatt tatcttttct tctatggggt ctataaatgt
2821 atcttataat aaaaaggaag gacaggagga agacaggcaa atgtacttct cacccagtct
2881 tctacacaga tggaatctct ttggggctaa gagaaaggtt ttattctata ttgcttacct
2941 gatctcatgt taggcctaag aggctttctc caggaggatt agcttggagt tctctatact
3001 caggtacctc tttcagggtt ttctaaccct gacacggact gtgcatactt tccctcatcc
3061 atgctgtgct gtgttattta atttttcctg gctaagatca tgtctgaatt atgtatgaaa
3121 attattctat gtttttataa taaaaataat atatcagaca tcgaaaaaaa aaa
//