LOCUS X03934 4186 bp DNA linear HUM 27-MAR-1995
DEFINITION Human T-cell antigen receptor gene T3-delta.
ACCESSION X03934
VERSION X03934.1
KEYWORDS Alu repetitive sequence; delta chain; T-cell receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4186)
AUTHORS Tunnacliffe A., Sims J.E., Rabbitts T.H.
TITLE T3 delta pre-mRNA is transcribed from a non-TATA promoter and is
alternatively spliced in human T cells
JOURNAL EMBO J. 5(6), 1245-1252(1986).
PUBMED 3488209
COMMENT Data kindly reviewed (12-SEP-1986) by T. Rabbitts
Two forms of T3-delta mRNA are made by alternative splicing
in T cells, the shorter mRNA lacking third exon sequences.
FEATURES Location/Qualifiers
source 1..4186
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
misc_feature 274..284
/note="T-box; pot. regulatory function"
regulatory 303..317
/note="pot. promoter"
/regulatory_class="promoter"
mRNA 338..498
/note="pot. exon 1"
misc_feature 338..443
/note="pot. leader (5' UT region)"
mRNA 346..498
/note="alternate exon 1"
misc_feature 346..443
/note="alternate leader (5' UT region)"
CDS join(444..498,2458..2676,3145..3276,3561..3604,3828..3893)
/product="T3 delta protein"
/note="put. extracellular domain of T3 delta"
/db_xref="GOA:P04234"
/db_xref="HGNC:HGNC:1673"
/db_xref="InterPro:IPR003110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR015484"
/db_xref="InterPro:IPR015485"
/db_xref="InterPro:IPR032052"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1XIW"
/db_xref="UniProtKB/Swiss-Prot:P04234"
/protein_id="CAA27573.1"
/translation="MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWV
EGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPA
TVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQY
SHLGGNWARNK"
sig_peptide join(444..498,2458..2465)
intron 499..2457
/note="intron I"
misc_feature 581..875
/note="Alu repeat"
mRNA 2458..2676
/note="exon 2"
mat_peptide join(2466..2676,3145..3276,3561..3604,3828..3890)
/product="mature T3 delta protein"
/note="put. extracellular domain of T3 delta"
intron 2677..3144
/note="intron II"
mRNA 3145..3276
/note="exon 3 (alt. spliced)"
misc_feature 3170..3251
/note="hydrophobic domain of T3 delta (aa 80-106)"
intron 3277..3560
/note="intron III"
mRNA 3561..3604
/note="exon 4"
intron 3605..3827
/note="intron IV"
mRNA 3828..3890
/note="exon 5"
misc_feature 3957..3962
/note="polyadenylation signal"
BASE COUNT 942 a 982 c 1147 g 1115 t
ORIGIN
1 agatctggtg tccctggctg cctagtgaag ggtcctgaga aagatcagcc tccatgagaa
61 atctagctgc tacggcttgc gctatggggc cgacggcttc tctcaagggg cttcgagatg
121 tggcagtgtt taggttgtgt gtaaatgtgg ttgcattgtc aatagggacg ctaaagttca
181 ggccaccttt tccatattct ctgccagctc cctgctcaga gatagagcaa tttacaccgc
241 ttccttccta ccctacccct agcccacccc cactctgaaa atttcccacc atcaacggca
301 gaaagcagag aagcagacat cttctagttc ctcccccact ctcctctttc cggtacctgt
361 gagtcagcta ggggagggca gctctcaccc aggctgatag ttcggtgacc tggctttatc
421 tactggatga gttccgctgg gagatggaac atagcacgtt tctctctggc ctggtactgg
481 ctacccttct ctcgcaaggt aaggctactc caggtgggtg ggggaaggga cctgagaggg
541 acattactga tgggagtgag gcccacttga aagtgtttct tgccaggcac ggtggctcac
601 accagtaatc ccagagcttt gggaggccga agtgggagga tcctttgagg ccaggagttt
661 gagaccagtc tgagcaacat gatgagactc tatctttaca aaaaacaaaa gaattagcca
721 ggcatggtgg tgcacaactg tagtcccagc tatttgagag gctgaggcag gagggtcact
781 tgagcccggg atttcaaggc ttcagtgagc tgtgatcatg ccactgccct ccaacctagg
841 caacctgtga gaccttatct caaaaaaaaa aaaaagtgct tctcggtgct agcttcagtt
901 caccaggcac cccaggggtg tcaggagggc aggggcagga tgtagcatag agtctgggaa
961 acaggctctt ggctttgact gactccagcc atgggtgcat gtgggcctag aatgtctctc
1021 agaaggcctt aggccagaga tctgcagaaa atagctcagt acgtatgtac ctgaatctgg
1081 gactggccat gggagcacag cttcctgcac tactcctttt aggcctgatg gcctctggaa
1141 tcaggactct tgtttgtttg gccatgatta tgtcatccct ggaggcatgt cctagcactt
1201 atgtgaatgc tttaagagaa gttaacttta ggttgagcag gacggaggga agatttgagg
1261 ggttgttaca tggtaggatt ttaactcatc tcagtttgcc aatttcagtt ttaaaatgga
1321 aagtcccatg tccgaggaac cccttcaaca ctaagcaaac tgggtccaat ggtcacctaa
1381 tagttggctg cactagggca ctcaggattt ccactggaga cagatccctg aagaggacgc
1441 gactgtagga cgtgaagcat ttgatgtgca tgtgtctccc tgaggataca tgcatatact
1501 tccaacctgc ttcagaagtg tgagcaacag ctgtttcagg gttttctaga agatgctctt
1561 gtatccaaat ttgggactta gtgtgaagcc caggatgaat gaatgtagcc tccacttttc
1621 cctgtgtttg gaggcataga ctgtagtgcc tctgtggcct gtggagatgt gctcaggctg
1681 tcagaggaac tcactgcatc tggaatgttg ctgcactcac ctccagccct aaaagtctcc
1741 cacaagactt gacttgtgag gagctctagg gatggattca ataaaatttt tttcctgttc
1801 tcctccttct aaccaagggt ggaaaactgt acatgggatt tgccctggtc ccgttctgga
1861 ccacttggct gataattcag gggctggtaa accagctggt ctccacccac agccatccct
1921 ggccctggga aaggcttcag tgttgagagc cccgctttct tggttgtcaa tggagcaggg
1981 gcaatgagga aggatgagga taagaagctg aagtgggagt gttgtagatg gctgggaagt
2041 ggaattagat gtttccttga agaaaaaatg cagacatttc caatcgagga atgttcttct
2101 gtctttccac atcttccagg tgcttcagtg gtccgtgctc cccctactcc tcatcagtgg
2161 tctggattca tttccaggaa ggtgcttggg tcaatcctgc tctgaggggt cctcttttgc
2221 accaaggccc caagacctgt cctctgcttg aatggcatcc tcatgtcccc cttgacccct
2281 gcagttggtg gggaactttc tgaaggcttt ttcttgtgac ttctgtctct cttgatggaa
2341 gccataaact gtcctggacc aggaaaatgg tctctgttaa gtatgagctt ccgcagaaca
2401 aagggcttgg tgcagatcaa agagctgtct ccaactgtga tattttttcc cctttagtga
2461 gccccttcaa gatacctata gaggaacttg aggacagagt gtttgtgaat tgcaatacca
2521 gcatcacatg ggtagaggga acggtgggaa cactgctctc agacattaca agactggacc
2581 tgggaaaacg catcctggac ccacgaggaa tatataggtg taatgggaca gatatataca
2641 aggacaaaga atctaccgtg caagttcatt atcgaagtac gtgcttcctg aaccctttgg
2701 gttggaatgg atagggcttc tggatgtgag aactttctgg ctagagaggg atatggtgaa
2761 cccatctgtt ctctaaacaa agtgaggtca ctattgtaat ggtacaagcc agatttgggg
2821 accttcaaag tggaagagag agcttaactc agcaagacag agcagtaggg gtcatgttac
2881 tgcagccttg gttgggtgag aggtttggcc caccaccttg ttcaaggtcc caaaagctga
2941 gattacttct tggctcttcc cagggattcc ttaggatgca gggtggagga aggtgtggca
3001 agcccatcac caggcctttc tcccagggtc ttattgaagt ttgggttttg gcataagaga
3061 tctaagggtt gccctaggag gcagaggatg gttccctgat cttaaaggct ctcaacctct
3121 cctctctcct cccttccccc acagtgtgcc agagctgtgt ggagctggat ccagccaccg
3181 tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg ggagtcttct
3241 gctttgctgg acatgagact ggaaggctgt ctgggggtta gtggaagagc agagcatgag
3301 agtgtgtttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtaccag tgagcttatg
3361 caccagctaa ggaatggggc tggtggtagg tttagtctca gctgggagtt actcttgcaa
3421 tctcctaaag actcctagaa ctttgactgt tgaaagaact tgtgtgttca tatcactcat
3481 gcagacttct gagggtgtgg gagggtggat ctcacagtcc catctgctag gccattgatg
3541 tctctctctg gttcttctag ctgccgacac acaagctctg ttgaggaatg accaggtcta
3601 tcaggtgagc gttgagggga aggaggcagg aatgaaggga gggtaagtgg ggatagagag
3661 gctgacactg aatgctgttt gcacgtggga agggtcctac tggggagttc attgctgggt
3721 gtgactggag aggtcaggca ggagctctca tcgtcagggc ctgctggggc ccttccttga
3781 agagttctaa ccctgcctcc tgaccgtttg ctcttctcct ctcttagccc ctccgagatc
3841 gagatgatgc tcagtacagc caccttggag gaaactgggc tcggaacaag tgaacctgag
3901 actggtggct tctagaagca gccattacca actgtacctt cccttcttgc tcagccaata
3961 aatatatcct ctttcactca gcaggtgcct gggcttctta aggctcctgg gcaaggcgtg
4021 ggagttgtcc tgacttgctt gggatctcgc cctcctacct acctgtttct tccttcatct
4081 ccttccttcc tctgcctcac acagacagtg tgttgggcag tctctcgcca catcctggct
4141 gtctggtgtt tctagcccac agggctccct gggtgaaggg tctgcg
//