LOCUS X02996 11570 bp DNA linear VRL 18-APR-2005 DEFINITION Adenovirus type 5 left 32% of the genome (coordinates 0% to 32.39% as measured by <ad2>). ACCESSION X02996 J01967-J01968 J01970-J01972 J01974 J01976-J01979 K00515 V00025-V00027 V00029 VERSION X02996.1 KEYWORDS alternate splicing; DNA polymerase; overlapping genes; polymerase; RNA polymerase III; terminal protein; terminal repeat; transfer RNA. SOURCE Human adenovirus 5 ORGANISM Human adenovirus 5 Viruses; Adenoviridae; Mastadenovirus. REFERENCE 1 (bases 1 to 194) AUTHORS Steenbergh P.H., Maat J., Van ormondt H., Sussenbach J.S. TITLE The nucleotide sequence at the termini of adenovirus type 5 DNA JOURNAL Nucleic Acids Res. 4(12), 4371-4389(1977). PUBMED 600799 REFERENCE 2 (bases 1 to 1574) AUTHORS Van ormondt H., Maat J., De Waard A., van der Eb A.J. TITLE The nucleotide sequence of the transforming HpaI-E fragment of adenovirus type 5 DNA. JOURNAL Gene 4(4), 309-328(1978). PUBMED 744489 REFERENCE 3 (bases 1575 to 2809) AUTHORS Maat J., Van ormondt H. TITLE The nucleotide sequence of the transforming hindiii-g fragment of adenovirus type 5 dna JOURNAL Gene 6(1), 75-90(1979). PUBMED 478299 REFERENCE 4 AUTHORS Perricaudet M., Akusjarvi G., Virtanen A., Pettersson U. TITLE Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses JOURNAL Nature 281(5733), 694-696(1979). PUBMED 551290 REFERENCE 5 (bases 10524 to 10696) AUTHORS Thimmappaya B., Jones N., Shenk T. TITLE A mutation which alters initiation of transcription by RNA polymerase III on the Ad5 chromosome JOURNAL Cell 18(4), 947-954(1979). PUBMED 519773 REFERENCE 6 (bases 10555 to 10733) AUTHORS Fowlkes D.M., Shenk T. TITLE Transcriptional control regions of the adenovirus VAI RNA gene JOURNAL Cell 22(2 Pt 2), 405-413(1980). PUBMED 7448868 REFERENCE 7 (bases 2804 to 4125) AUTHORS Maat J., Van Beveren C.P., Van ormondt H. TITLE The nucleotide sequence of adenovirus type 5 early region E1: the region between map positions 8.0 (HindIII site) and 11.8 (SmaI site) JOURNAL Gene 10(1), 27-38(1980). PUBMED 6250944 REFERENCE 8 (bases 1 to 4125) AUTHORS Van ormondt H., Maat J., Van Beveren C.P. TITLE The nucleotide sequence of the transforming early region E1 of adenovirus type 5 DNA. JOURNAL Gene 11(3-4), 299-309(1980). PUBMED 6260576 REFERENCE 9 AUTHORS Perricaudet M., Le Moullec J.M., Pettersson U. TITLE Predicted structure of two adenovirus tumor antigens JOURNAL Proc. Natl. Acad. Sci. U.S.A. 77(7), 3778-3782(1980). PUBMED 6253988 REFERENCE 10 (bases 1 to 6246) AUTHORS Broker T.R. TITLE Appendix d: nucleotide sequences, transcription and translation analyses, and restriction endonuclease cleavage maps of group-c human adenoviruses JOURNAL (in) Tooze J. (Eds.); DNA TUMOR VIRUSES:937-1002; Cold Spring Harbor Laboratory (1980) REFERENCE 11 (bases 1653 to 4043) AUTHORS Bos J.L., Polder L.J., Bernards R., Schrier P.I., Van den elsen P.J., van der Eb A.J., Van ormondt H. TITLE The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets JOURNAL Cell 27(1 Pt 2), 121-131(1981). PUBMED 7326748 REFERENCE 12 (bases 4001 to 6246) AUTHORS Van Beveren C.P., Maat J., Dekker B.M., Van ormondt H. TITLE The nucleotide sequence of the gene for protein IVa2 and of the 5' leader segment of the major late mRNAs of adenovirus type 5 JOURNAL Gene 16(1-3), 179-189(1981). PUBMED 7343420 REFERENCE 13 (bases 1 to 66) AUTHORS Nagata K., Guggenheimer R.A., Hurwitz J. TITLE Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80(20), 6177-6181(1983). PUBMED 6336326 REFERENCE 14 (bases 325 to 604) AUTHORS Hearing P., Shenk T. TITLE Functional analysis of the nucleotide sequence surrounding the cap site for adenovirus type 5 region E1A messenger RNAs JOURNAL J. Mol. Biol. 167(4), 809-822(1983). PUBMED 6876165 REMARK deletion mutants REFERENCE 15 AUTHORS Downey J.F., Evelegh C.M., Branton P.E., Bayley S.T. TITLE Peptide maps and N-terminal sequences of polypeptides from early region 1A of human adenovirus 5 JOURNAL J. Virol. 50(1), 30-37(1984). PUBMED 6699947 REMARK sites; cds start for E1a proteins REFERENCE 16 (bases 6242 to 11570) AUTHORS Dekker B.M.M., Van ormondt H. TITLE The nucleotide sequence of fragment HindIII-C of human adenovirus type 5 DNA (map positions 17.1-31.7) JOURNAL Gene 27(1), 115-120(1984). PUBMED 6325298 COMMENT sites; splice sites in E1a 13S mRNA sites; splice sites and termini for E1b mRNAS Notes on the presentation of ADENO in the EMBL data library: The genetic map of Adeno is customarily presented from left to right, the 0% position being left and the 100% position being right. The two strands of Adeno are normally represented like this: r-strand: 3'------------------5' l-strand: 5'------------------3' ^ ^ 0% 100% This often causes confusion because the generally accepted way to represent DNA molecules is: 5'------------------3' 3'------------------5' Here Adeno virus sequences are always given in 5' to 3' direction and the sequence of the l-strand is displayed irrespective of the direction the viral transcription takes. This sequence corresponds to bases 1 to 11560 of <ad2>, which serve as some basis for the annotation of sites. the differences between <ad2> and <ad5> are too many to report herein, however a printout of those is available upon request from genbank. the map coordinates in the sites presume 360 bases per map unit. although there are approximately 115 sequence differences between the two strains over this region, no site difference exceeds 0.02% by this calculation. the sequence represents the early mrna transcripts e1a and e1b and the intermediate mrna transcript ix, all of which are transcribed rightwardly off the r-strand; the iva2 and e2b mrnas which are transcribed leftwardly off the l-strand ((indicated by "(c)" and "comp strand" below)); and the 5' end of the 28 kb major late mrna. the cap sites and possible promoter sequences for these are summarized in the following table: mrna cap site possible promoter region ------ ---------- -------------------------- e1a 499 tatttata at bases 468-475 [6] e1b 1702 tatataa at bases 1672-1678[6] ix 3582 tatataa at bases 3551-3557 [6] iva2 5838 +/- 2 (c) tacaaa at bases 5979-5974 on the comp strand [10] major 6049 tataaaa at bases 6018-6024 [10] as with ad2, not all the transcripts from this region have been characterized at the sequence level. the nine proteins given in features table below are not the only possible gene products (see the main adenovirus 2 entry). large amounts of small rnas are produced from the vai and vaii genes late in development for unknown reasons. [5] and [6] demonstrate that vai gene activity influences vaii expression; that the 5' flank affects the start site of the rna but that an intragenic promoter (bases 10626 to 10690 below) determines whether the rna is actually produced; and that there is striking similarity between this rna and trna. FEATURES Location/Qualifiers source 1..11570 /organism="Human adenovirus 5" /mol_type="genomic DNA" /db_xref="taxon:28285" precursor_RNA 499..1632 /note="primary transcript of E1A region" mRNA join(499..1112,1229..1632) /note="mRNA 1 (part 1)" mRNA join(499..974,1229..1632) /note="mRNA 2 (part 1)" CDS join(560..1112,1229..1545) /note="E1a protein from 13s mrna (32k,regulation and transformation)" /db_xref="GOA:P03255" /db_xref="InterPro:IPR014410" /db_xref="PDB:2KJE" /db_xref="PDB:2R7G" /db_xref="UniProtKB/Swiss-Prot:P03255" /protein_id="CAB40663.1" /translation="MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLH ELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQP EQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYH RRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPT SPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEP GQPLDLSCKRPRP" CDS join(560..974,1229..1545) /note="E1a protein from 12s mrna (26k, regulation and tranformation)" /db_xref="GOA:P03255" /db_xref="InterPro:IPR014410" /db_xref="PDB:2KJE" /db_xref="PDB:2R7G" /db_xref="UniProtKB/Swiss-Prot:P03255" /protein_id="CAB40664.1" /translation="MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLH ELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQP EQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGPVSEPEPEPEPEPEPARPTRR PKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQ AVECIEDLLNEPGQPLDLSCKRPRP" CDS join(560..637,1229..1318) /note="putative E1a protein from 9s mrna (splice sites determined for ad2)" /db_xref="GOA:P03255" /db_xref="InterPro:IPR014410" /db_xref="PDB:2KJE" /db_xref="PDB:2R7G" /db_xref="UniProtKB/Swiss-Prot:P03255" /protein_id="CAB40665.1" /translation="MRHIICHGGVITEEMAASLLDQLIEEVLCLNLSLSPSQNRSLQD LPAVLKWRLLS" intron 975..1228 /note="intron of mRNA 2" intron 1113..1228 /note="intron of mRNA 1" polyA_site 1632..1632 precursor_RNA 1702..4070 /note="primary transcript of E1B region" mRNA join(1702..3510,3595..4070) /note="mRNA 4" mRNA 1702..2255 /note="mRNA 5 (part 1)" precursor_RNA 1704..4070 /note="primary transcript of E1B region (alternate mRNA start site)" mRNA join(1704..3510,3595..4070) /note="mRNA 4, alternate mRNA start site" mRNA join(1704..2255,3595..4070) /note="mRNA 5, alternate mRNA start site" CDS 1714..2244 /product="E1b 21k protein" /note="mRNA 5 first reading frame" /db_xref="GOA:P03246" /db_xref="InterPro:IPR002475" /db_xref="InterPro:IPR002924" /db_xref="UniProtKB/Swiss-Prot:P03246" /protein_id="CAA26741.1" /translation="MEAWECLEDFSAVRNLLEQSSNSTSWFWRFLWGSSQAKLVCRIK EDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKTLDFSTPGRAAAAVAFLSFIKDK WSEETHLSGGYLLDFLAMHLWRAVVRHKNRLLLLSSVRPAIIPTEEQQQQQEEARRRR QEQSPWNPRAGLDPRE" CDS 2019..3509 /note="E1b 55k protein (transformation)" /db_xref="GOA:P03243" /db_xref="InterPro:IPR002612" /db_xref="InterPro:IPR006717" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="UniProtKB/Swiss-Prot:P03243" /protein_id="CAA26743.1" /translation="MERRNPSERGVPAGFSGHASVESGCETQESPATVVFRPPGDNTD GGAAAAAGGSQAAAAGAEPMEPESRPGPSGMNVVQVAELYPELRRILTITEDGQGLKG VKRERGACEATEEARNLAFSLMTRHRPECITFQQIKDNCANELDLLAQKYSIEQLTTY WLQPGDDFEEAIRVYAKVALRPDCKYKISKLVNIRNCCYISGNGAEVEIDTEDRVAFR CSMINMWPGVLGMDGVVIMNVRFTGPNFSGTVFLANTNLILHGVSFYGFNNTCVEAWT DVRVRGCAFYCCWKGVVCRPKSRASIKKCLFERCTLGILSEGNSRVRHNVASDCGCFM LVKSVAVIKHNMVCGNCEDRASQMLTCSDGNCHLLKTIHVASHSRKAWPVFEHNILTR CSLHLGNRRGVFLPYQCNLSHTKILLEPESMSKVNLNGVFDMTMKIWKVLRYDETRTR CRPCECGGKHIRNQPVMLDVTEELRPDHLVLACTRAEFGSSDEDTD" CDS join(2019..2255,3595..3612) /note="mRNA 5 second reading frame (part 1)" /db_xref="GOA:P03243" /db_xref="InterPro:IPR002612" /db_xref="InterPro:IPR006717" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="UniProtKB/Swiss-Prot:P03243" /protein_id="CAB40666.1" /translation="MERRNPSERGVPAGFSGHASVESGCETQESPATVVFRPPGDNTD GGAAAAAGGSQAAAAGAEPMEPESRPGPSGMNVVQQPPPP" intron 2256..3594 /note="intron of mRNA 5" intron 3511..3594 /note="intron of mRNA 4" mRNA 3580..4070 /note="mRNA IX" CDS 3609..4031 /note="IX protein (hexon-associated protein)" /db_xref="GOA:P03281" /db_xref="InterPro:IPR005641" /db_xref="PDB:6B1T" /db_xref="PDB:6CGV" /db_xref="UniProtKB/Swiss-Prot:P03281" /protein_id="CAA26746.1" /translation="MSTNSFDGSIVSSYLTTRMPPWAGVRQNVMGSSIDGRPVLPANS TTLTYETVSGTPLETAASAAASAAAATARGIVTDFAFLSPLASSAASRSSARDDKLTA LLAQLDSLTRELNVVSQQLLDLRQQVSALKASSPPNAV" polyA_site complement(4060..4060) mRNA complement(4060..5427) /note="mRNA IVa2 (part 2)" precursor_RNA complement(4060..5836) /note="primary transcript of IVa2 region (alternate mRNA start site)" precursor_RNA complement(4060..5838) /note="primary transcript of IVa2 region" polyA_site 4070..4070 CDS complement(join(4091..5427,5706..5718)) /note="reading frame IVa2" /db_xref="GOA:P03271" /db_xref="InterPro:IPR003389" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/Swiss-Prot:P03271" /protein_id="CAB40667.1" /translation="METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPA PVERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEQVTELWDRLELLGQTLKSMP TADGLKPLKNFASLQELLSLGGERLLADLVRENMRVRDMLNEVAPLLRDDGSCSSLNY QLHPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQ ICEGNYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIA IIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIAN LKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNT TPQHEALQWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK" CDS complement(5197..8367) /note="DNA polymerase" /db_xref="GOA:P04495" /db_xref="InterPro:IPR004868" /db_xref="InterPro:IPR006172" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR014382" /db_xref="InterPro:IPR017964" /db_xref="InterPro:IPR023211" /db_xref="UniProtKB/Swiss-Prot:P04495" /protein_id="CAA26749.1" /translation="MDSSHLRDVVIKLRPPRADIWTLGSRGVVVRSTVTPLEQPDGQG QAAEVEDHQPNPPGEGLKFPLCFLVRGRQVNLVQDVQPVHRCQYCARFYKSQHECSAR RRDFYFHHINSHSSNWWREIQFFPIGSHPRTERLFVTYDVETYTWMGAFGKQLVPFML VMKFGGDEPLVTAARDLAANLGWDRWEQDPLTFYCITPEKMAIGRQFRTFRDHLQMLM ARDLWSSFVASNPHLADWALSEHGLSSPEELTYEELKKLPSIKGIPRFLELYIVGHNI NGFDEIVLAAQVINNRSEVPGPFRITRNFMPRAGKILFNDVTFALPNPRSKKRTDFLL WEQGGCDDTDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCAYQAVNQFYML GSYRSEADGFPIQEYWKDREEFVLNRELWKKKGQDKYDIIKETLDYCALDVQVTAELV NKLRDSYASFVRDAVGLTDASFNVFQRPTISSNSHAIFRQIVFRAEQPARSNLGPDLL APSHELYDYVRASIRGGRCYPTYLGILREPLYVYDICGMYASALTHPMPWGPPLNPYE RALAARAWQQALDLQGCKIDYFDARLLPGVFTVDADPPDETQLDPLPPFCSRKGGRLC WTNERLRGEVATSVDLVTLHNRGWRVHLVPDERTTVFPEWRCVAREYVQLNIAAKERA DRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDAATLKGITAGQVNIKSSSF LETDNLSAEVMPAFQREYSPQQLALADSDAEESEDERAPTPFYSPPSGTPGHVAYTYK PITFLDAEEGDMCLHTLERVDPLVDNDRYPSHLASFVLAWTRAFVSEWSEFLYEEDRG TPLEDRPLKSVYGDTDSLFVTERGHRLMETRGKKRIKKHGGNLVFDPERPELTWLVEC ETVCGACGADAYSPESVFLAPKLYALKSLHCPSCGASSKGKLRAKGHAAEGLDYDTMV KCYLADAQGEDRQRFSTSRTSLKRTLASAQPGAHPFTVTQTTLTRTLRPWKDMTLARL DEHRLLPYSESRPNPRNEEICWIEMP" intron complement(5428..5705) /note="intron of mRNA IVa2" mRNA complement(5706..5836) /note="mRNA IVa2 (part 1) (alternate mRNA start site)" mRNA complement(5706..5838) /note="mRNA IVa2 (part 1)" mRNA 6049..6089 /note="major late mRNA (1st leader)" misc_RNA 6049..6049 /note="cap-site for late mRNAs" intron 6090..7110 /note="intron" mRNA 7111..7182 /note="major late mRNA (2nd leader)" intron 7183..7951 /note="intron" mRNA 7952..8391 /note="mRNA (i leader)" intron 8392..9643 CDS complement(8583..10544) /note="terminal protein" /protein_id="CAA26750.1" /translation="MEHFLPLRNIWNRVRDFPRASTTAAGITWMSRYIYGYHRLMLED LAPGAPATLRWPLYRQPPPHFLVGYQYLVRTCNDYVFDSRAYSRLRYTELSQPGHQTV NWSVMANCTYTINTGAYHRFVDMDDFQSTLTQVQQAILAERVVADLALLQPMRGFGVT RMGGRGRHLRPNSAAAAAIDARDAGQEEGEEEVPVERLMQDYYKDLRRCQNEAWGMAD RLRIQQAGPKDMVLLSTIRRLKTAYFNYIISSTSARNNPDRRPLPPATVLSLPCDCDW LDAFLERFSDPVDADSLRSLGGGVPTQQLLRCIVSAVSLPHGSPPPTHNRDMTGGVFQ LRPRENGRAVTETMRRRRGEMIERFVDRLPVRRRRRRVPPPPPPPEEEEGEALMEEEI EEEEEAPVAFEREVRDTVAELIRLLEEELTVSARNSQFFNFAVDFYEAMERLEALGDI NESTLRRWVMYFFVAEHTATTLNYLFQRLRNYAVFARHVELNLAQVVMRARDAEGGVV YSRVWNEGGLNAFSQLMARISNDLAATVERAGRGDLQEEEIEQFMAEIAYQDNSGDVQ EILRQAAVNDTEIDSVELSFRLKLTGPVVFTQRRQIQEINRRVVAFASNLRAQHQLLP ARGADVPLPPLPAGPEPPLPPGARPRHRF" mRNA 9644..9733 /note="major late mRNA (3rd leader)" intron 9734..11049 mRNA 10617..10778 /note="Va1 RNA" mRNA 10620..10778 /note="Va1 RNA (alternative 5' start)" mRNA 10875..11035 /note="Va2 RNA" CDS 11050..>11570 /note="52.55K protein" /db_xref="GOA:P04496" /db_xref="InterPro:IPR004292" /db_xref="InterPro:IPR037536" /db_xref="UniProtKB/Swiss-Prot:P04496" /protein_id="CAA26751.1" /translation="MHPVLRQMRPPPQQRQEQEQRQTCRAPSPPPTASGGATSAVDAA ADGDYEPPRRRARHYLDLEEGEGLARLGAPSPERYPRVQLKRDTREAYVPRQNLFRDR EGEEPEEMRDRKFHAGRELRHGLNRERLLREEDFEPDARTGISPARAHVAAADLVTAY EQTVNQEINFQKS" mRNA 11050..>11570 /note="mRNA (52,55 k)" BASE COUNT 2298 a 2903 c 3726 g 2643 t ORIGIN 1 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 61 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 121 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 181 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 241 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 301 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 361 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 421 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 481 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 541 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 601 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 661 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 721 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 781 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 841 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 901 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 961 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1021 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1081 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1141 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1201 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1261 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1321 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1381 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1441 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1501 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1561 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1621 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1681 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1741 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1801 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1861 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1921 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1981 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2041 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2101 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2161 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2221 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2281 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2341 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2401 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2461 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2521 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2581 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2641 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2701 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2761 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2821 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2881 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2941 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3001 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3061 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3121 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3181 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3241 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3301 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3361 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3421 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3481 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3541 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3601 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3661 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3721 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3781 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3841 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3901 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3961 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4021 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt 4081 cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt 4141 cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat 4201 acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg 4261 gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt 4321 ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt 4381 taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt 4441 tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag 4501 tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact 4561 tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg 4621 gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt 4681 ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg 4741 gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg 4801 ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg 4861 gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc 4921 cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc 4981 tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt 5041 ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag 5101 caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa 5161 gcagttccag gcggtcccac agctcggtca cctgctctac ggcatctcga tccagcatat 5221 ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag 5281 acgggccagg gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac 5341 ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct 5401 ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt 5461 gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc 5521 gccgcacgag gggcagtgca gacttttgag ggcgtagagc ttgggcgcga gaaataccga 5581 ttccggggag taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca 5641 ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt 5701 cttacctctg gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc 5761 cccgtataca gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag 5821 aaactcggac cactctgaga caaaggctcg cgtccaggcc agcacgaagg aggctaagtg 5881 ggaggggtag cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat 5941 gtcgccctct tcggcatcaa ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg 6001 tgttcctgaa ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc 6061 atcgctgtct gcgagggcca gctgttgggg tgagtactcc ctctgaaaag cgggcatgac 6121 ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc 6181 ggtgatgcct ttgagggtgg ccgcatccat ctggtcagaa aagacaatct ttttgttgtc 6241 aagcttggtg gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag 6301 ggtttggttt ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc 6361 gcgcgcaacg caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac 6421 gcgccaaccg cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag 6481 gcgctcgttg gtccagcaga ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc 6541 tagctgcgtc tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc 6601 gtcgaagtag tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc 6661 aagcgcgcgc tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga 6721 ggcgtacatg ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt 6781 agggtagcat cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg 6841 agcgaggagg tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg 6901 cctgaagatg gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc 6961 gtctgtgaga cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac 7021 cagctcggcg gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc 7081 atacttatcc tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc 7141 tttccagtac tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta 7201 gaactggttg acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg 7261 cgcggccttc cggagcgagg tgtgggtgag cgcaaaggtg tccctgacca tgactttgag 7321 gtactggtat ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt 7381 gcgctttttg gaacgcggat ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc 7441 cgcgcgaggc ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt 7501 aattacctgg gcggcgagca cgatctcgtc aaagccgttg atgttgtggc ccacaatgta 7561 aagttccaag aagcgcggga tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt 7621 gagctcttca ggggagctga gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt 7681 ggaagcgacg aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa 7741 ggtcctaaac tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg 7801 gtcttgttcc cagcggtccc atccaaggtt cgcggctagg tctcgcgcgg cagtcactag 7861 aggctcatct ccgccgaact tcatgaccag catgaagggc acgagctgct tcccaaaggc 7921 ccccatccaa gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg 7981 cgagccgatc gggaagaact ggatctcccg ccaccaattg gaggagtggc tattgatgtg 8041 gtgaaagtag aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc 8101 gcagtactgg cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg 8161 cacaaggaag cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc 8221 tacttcggct gcttgtcctt gaccgtctgg ctgctcgagg ggagttacgg tggatcggac 8281 caccacgccg cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac 8341 aacatcgcgc agatgggagc tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg 8401 gagctcctgc aggtttacct cgcatagacg ggtcagggcg cgggctagat ccaggtgata 8461 cctaatttcc aggggctggt tggtggcggc gtcgatggct tgcaagaggc cgcatccccg 8521 cggcgcgact acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc 8581 atctaaaagc ggtgacgcgg gcgagccccc ggaggtaggg ggggctccgg acccgccggg 8641 agagggggca ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg 8701 ttgctggcga acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag 8761 acgacgggcc cggtgagctt gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg 8821 ttgacggcgg cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatc 8881 tcggccatga actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg 8941 gtggcggcga ggtcgttgga aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc 9001 tcgttccaga cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc 9061 tgcgcgagat tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag 9121 aggtagttga gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc 9181 aacgtggatt cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc 9241 acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga 9301 cggatgagct cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct 9361 tcttcttcaa tctcctcttc cataagggcc tccccttctt cttcttctgg cggcggtggg 9421 ggagggggga cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc 9481 atctccccgc ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc 9541 agttggaaga cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccatgcggc 9601 agggatacgg cgctaacgat gcatctcaac aattgttgtg taggtactcc gccgccgagg 9661 gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag 9721 tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg 9781 tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg 9841 gtcgacagaa gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg 9901 ccccaggctt cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct 9961 accggcactt cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg 10021 gcggcggagt ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc 10081 ctcatcggct gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc 10141 acctgcgtga gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg 10201 ttgatggtgt aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc 10261 gagagctcgg tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa 10321 gtccgcacca ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc 10381 cagcgtaggg tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg 10441 tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg 10501 cggacgcggt tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg 10561 ccggtcaggc gcgcgcaatc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg 10621 ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 10681 tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 10741 caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 10801 gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 10861 gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc 10921 gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 10981 ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 11041 ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 11101 caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 11161 acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 11221 cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 11281 cggtacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac 11341 ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca 11401 gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 11461 cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 11521 accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt //