LOCUS X01057 2335 bp mRNA linear HUM 22-JUL-1993 DEFINITION Human mRNA for interleukin-2 receptor. ACCESSION X01057 X01058 X01402 VERSION X01057.1 KEYWORDS alternate splicing; interleukin receptor; signal peptide. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2335) AUTHORS Leonard W.J., Depper J.M., Crabtree G.R., Rudikoff S., Pumphrey J., Robb R.J., Kroenke M., Svetlik P.B., Peffer N.J., Waldmann T.A., Greene W.C. TITLE Molecular cloning and expression of cDNAs for the human interleukin-2 receptor JOURNAL Nature 311(5987), 626-631(1984). PUBMED 6090948 REFERENCE 2 (bases 1 to 1309) AUTHORS Nikaido T., Shimizu A., Ishida N., Sabe H., Teshigawara K., Maeda M., Uchiyama T., Yodoi J., Honjo T. TITLE Molecular cloning of cDNA encoding human interleukin-2 receptor JOURNAL Nature 311(5987), 631-635(1984). PUBMED 6090949 REFERENCE 3 (bases 1 to 862) AUTHORS Cosman D., Cerretti D.P., Larsen A., Park L., March C., Dower S., Gillis S., Urdal D. TITLE Cloning, sequence and expression of human interleukin-2 receptor JOURNAL Nature 312(5996), 768-771(1984). PUBMED 6096720 REFERENCE 4 AUTHORS Behn-Krappa A., Doerfler W. TITLE The state of DNA methylation in the promoter and exon 1 regions of the human gene for the interleukin-2 receptor alpha chain (IL-2R alpha) in various cell types JOURNAL Hum. Mol. Genet. 2(7), 993-999(1993). PUBMED 8364583 FEATURES Location/Qualifiers source 1..2335 /db_xref="H-InvDB:HIT000320885" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" mRNA join(<1..497,764..>2335) /note="put. fragment of 3,3 Kb mRNA" CDS 181..999 /product="interleukin-2 receptor" /db_xref="GOA:P01589" /db_xref="H-InvDB:HIT000320885.14" /db_xref="HGNC:HGNC:6008" /db_xref="InterPro:IPR000436" /db_xref="InterPro:IPR015486" /db_xref="InterPro:IPR035976" /db_xref="PDB:1ILM" /db_xref="PDB:1ILN" /db_xref="PDB:1Z92" /db_xref="PDB:2B5I" /db_xref="PDB:2ERJ" /db_xref="PDB:3IU3" /db_xref="PDB:3NFP" /db_xref="UniProtKB/Swiss-Prot:P01589" /protein_id="CAA25525.1" /translation="MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEG TMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQK ERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALH RGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTT DFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI" sig_peptide 181..243 /note="signal peptide (aa -21 to -1)" mat_peptide 244..996 /product="interleukin-2 receptor" variation 895..895 /note="existing variant with T changed to C" regulatory 1523..1528 /regulatory_class="polyA_signal_sequence" unsure 1604..1604 /note="T maybe C" BASE COUNT 690 a 592 c 573 g 480 t ORIGIN 1 gaattccccc cccccccccc cgagagactg gatggaccca caagggtgac agcccaggcg 61 gaccgatctt cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg 121 ggccttctgc agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag 181 atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag 241 gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc 301 tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc 361 gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt 421 caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa 481 cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc 541 cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat 601 catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac 661 agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc 721 cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag 781 gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt 841 caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag 901 gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc 961 tggcagcgga gacagaggaa gagtagaaga acaatctaga aaaccaaaag aacaagaatt 1021 tcttggtaag aagccgggaa cagacaacag aagtcatgaa gcccaagtga aatcaaaggt 1081 gctaaatggt cgcccaggag acatccgttg tgcttgcctg cgttttggaa gctctgaagt 1141 cacatcacag gacacggggc agtggcaacc ttgtctctat gccagctcag tcccatcaga 1201 gagcgagcgc tacccacttc taaatagcaa tttcgccgtt gaagaggaag ggcaaaacca 1261 ctagaactct ccatcttatt ttcatgtata tgtgttcatt aaagcatgaa tggtatggaa 1321 ctctctccac cctatatgta gtataaagaa aagtaggttt acattcatct cattccaact 1381 tcccagttca ggagtcccaa ggaaagcccc agcactaacg taaatacaca acacacacac 1441 tctaccctat acaactggac attgtctgcg tggttccttt ctcagccgct tctgactgct 1501 gattctcccg ttcacgttgc ctaataaaca tccttcaaga actctgggct gctacccaga 1561 aatcatttta cccttggctc aatcctctaa gctaaccccc ttctactgag ccttcagtct 1621 tgaatttcta aaaaacagag gccatggcag aataatcttt gggtaacttc aaaacggggc 1681 agccaaaccc atgaggcaat gtcaggaaca gaaggatgaa tgaggtccca ggcagagaat 1741 catacttagc aaagttttac ctgtgcgtta ctaattggcc tctttaagag ttagtttctt 1801 tgggattgct atgaatgata ccctgaattt ggcctgcact aatttgatgt ttacaggtgg 1861 acacacaagg tgcaaatcaa tgcgtacgtt tcctgagaag tgtctaaaaa caccaaaaag 1921 ggatccgtac attcaatgtt tatgcaagga aggaaagaaa gaaggaagtg aagagggaga 1981 agggatggag gtcacactgg tagaacgtaa ccacggaaaa gagcgcatca ggcctggcac 2041 ggtggctcag gcctataacc ccagctccct aggagaccaa ggcgggagca tctcttgagg 2101 ccaggagttt gagaccagcc tgggcagcat agcaagacac atccctacaa aaaattagaa 2161 attggctgga tgtggtggca tacgcctgta gtcctagcca ctcaggaggc tgaggcagga 2221 ggattgcttg agcccaggag ttcgaggctg cagtcagtca tgatggcacc actgcactcc 2281 agcctgggca acagagcaag atcctgtctt taaggaaaaa aagacaaggg aattc //