LOCUS HSU50062 2617 bp mRNA linear HUM 18-AUG-1998
DEFINITION Homo sapiens RIP protein kinase mRNA, complete cds.
ACCESSION U50062
VERSION U50062.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2617)
AUTHORS Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
TITLE TNF-dependent recruitment of the protein kinase RIP to the TNF
receptor-1 signaling complex
JOURNAL Immunity 4 (4), 387-396 (1996)
PUBMED 8612133
REFERENCE 2 (bases 1 to 2617)
AUTHORS Huang,J., Hsu,H., Baichwal,V.R. and Goeddel,D.V.
TITLE Direct Submission
JOURNAL Submitted (26-FEB-1996) Biology, Tularik Inc., 270 East Grand
Avenue, South San Francisco, CA 94080, USA
REFERENCE 3 (bases 1 to 2617)
AUTHORS Huang,J., Hsu,H., Baichwal,V.R. and Goeddel,D.V.
TITLE Direct Submission
JOURNAL Submitted (18-AUG-1998) Biology, Tularik Inc., 270 East Grand
Avenue, South San Francisco, CA 94080, USA
REMARK Sequence update by submitter
COMMENT On Aug 18, 1998 this sequence version replaced gi:1236942.
FEATURES Location/Qualifiers
source 1..2617
/db_xref="H-InvDB:HIT000220129"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="umbilical vein endothelium"
CDS 1..2016
/note="Ser/Thr protein kinase; protein has death domain
sequence at the carboxyl terminus"
/codon_start=1
/product="RIP protein kinase"
/protein_id="AAC32232.1"
/translation="MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIM
KTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMH
VLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA
SFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVL
WAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARP
TFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSN
SATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMD
RQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTVYSSAASHGNAVH
QPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPET
NYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKE
EPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGL
KEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN"
BASE COUNT 794 a 586 c 659 g 574 t
ORIGIN
1 atgcaaccag acatgtcctt gaatgtcatt aagatgaaat ccagtgactt cctggagagt
61 gcagaactgg acagcggagg ctttgggaag gtgtctctgt gtttccacag aacccaggga
121 ctcatgatca tgaaaacagt gtacaagggg cccaactgca ttgagcacaa cgaggccctc
181 ttggaggagg cgaagatgat gaacagactg agacacagcc gggtggtgaa gctcctgggc
241 gtcatcatag aggaagggaa gtactccctg gtgatggagt acatggagaa gggcaacctg
301 atgcacgtgc tgaaagccga gatgagtact ccgctttctg taaaaggaag gataattttg
361 gaaatcattg aaggaatgtg ctacttacat ggaaaaggcg tgatacacaa ggacctgaag
421 cctgaaaata tccttgttga taatgacttc cacattaaga tcgcagacct cggccttgcc
481 tcctttaaga tgtggagcaa actgaataat gaagagcaca atgagctgag ggaagtggac
541 ggcaccgcta agaagaatgg cggcaccctc tactacatgg cgcccgagca cctgaatgac
601 gtcaacgcaa agcccacaga gaagtcggat gtgtacagct ttgctgtagt actctgggcg
661 atatttgcaa ataaggagcc atatgaaaat gctatctgtg agcagcagtt gataatgtgc
721 ataaaatctg ggaacaggcc agatgtggat gacatcactg agtactgccc aagagaaatt
781 atcagtctca tgaagctctg ctgggaagcg aatccggaag ctcggccgac atttcctggc
841 attgaagaaa aatttaggcc tttttattta agtcaattag aagaaagtgt agaagaggac
901 gtgaagagtt taaagaaaga gtattcaaac gaaaatgcag ttgtgaagag aatgcagtct
961 cttcaacttg attgtgtggc agtaccttca agccggtcaa attcagccac agaacagcct
1021 ggttcactgc acagttccca gggacttggg atgggtcctg tggaggagtc ctggtttgct
1081 ccttccctgg agcacccaca agaagagaat gagcccagcc tgcagagtaa actccaagac
1141 gaagccaact accatcttta tggcagccgc atggacaggc agacgaaaca gcagcccaga
1201 cagaatgtgg cttacaacag agaggaggaa aggagacgca gggtctccca tgaccctttt
1261 gcacagcaaa gaccttacga gaattttcag aatacagagg gaaaaggcac tgtttattcc
1321 agtgcagcca gtcatggtaa tgcagtgcac cagccctcag ggctcaccag ccaacctcaa
1381 gtactgtatc agaacaatgg attatatagc tcacatggct ttggaacaag accactggat
1441 ccaggaacag caggtcccag agtttggtac aggccaattc caagtcatat gcctagtctg
1501 cataatatcc cagtgcctga gaccaactat ctaggaaata cacccaccat gccattcagc
1561 tccttgccac caacagatga atctataaaa tataccatat acaatagtac tggcattcag
1621 attggagcct acaattatat ggagattggt gggacgagtt catcactact agacagcaca
1681 aatacgaact tcaaagaaga gccagctgct aagtaccaag ctatctttga taataccact
1741 agtctgacgg ataaacacct ggacccaatc agggaaaatc tgggaaagca ctggaaaaac
1801 tgtgcccgta aactgggctt cacacagtct cagattgatg aaattgacca tgactatgag
1861 cgagatggac tgaaagaaaa ggtttaccag atgctccaaa agtgggtgat gagggaaggc
1921 ataaagggag ccacggtggg gaagctggcc caggcgctcc accagtgttc caggatcgac
1981 cttctgagca gcttgattta cgtcagccag aactaaccct ggatgggcta cggcagctga
2041 agtggacgcc tcacttagcg gataacccca gaaagttggc tgcctcagag cattcagaat
2101 tctgtcctca ctgatagggg ttctgtgtct gcagaaattt ngtttcctgt acttcatagc
2161 tggagaatgg ggaaagaaat ctgcagcaaa ggggtctcac tctgttgcca ggctggtctc
2221 aaacttctgg actcaagtga tcctcccgcc tcggccttcc aaagtgctgg gatatcaggc
2281 actgagccac tgcgcccagt caacaatccg ntctgaggaa agcgtaagca ggaagacctc
2341 ttaatggcat agcaccaata aaaaaatgac tcctagttgt gtttggaaag ggagagaaga
2401 gatgtctgag gaaggtcatg ttctttcagc ttatggcatt tcctagagtt tngttgaagc
2461 aagaagaaaa actcagagaa tataaaatca actttnaaaa ttgtgtgctc tcttcttcac
2521 gtaggctcct gttaaaaaca aagtgcagtc agattctaag ccctgttcag agacttcgcg
2581 gatcacagct gcagctcacc gccacatcac aggatcc
//