LOCUS       AH003329                5471 bp    DNA     linear   HUM 10-JUN-2016
DEFINITION  Homo sapiens CTLA-4 counter-receptor B7.2 (B7.2) gene, complete
            cds.
ACCESSION   AH003329 U17715 U17716 U17717 U17718 U17719 U17720 U17721 U17722
VERSION     AH003329.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (sites)
  AUTHORS   Azuma,M., Ito,D., Yagita,H., Okumura,K., Phillips,J.H., Lanier,L.L.
            and Somoza,C.
  TITLE     B70 antigen is a second ligand for CTLA-4 and CD28
  JOURNAL   Nature 366 (6450), 76-79 (1993)
   PUBMED   7694153
REFERENCE   2  (bases 173 to 292; 579 to 1050; 1151 to 1634; 1735 to 2475; 2576
            to 3312; 3413 to 3983; 4084 to 4741; 4842 to 5471)
  AUTHORS   Freeman,G.J., Gribben,J.G., Boussiotis,V.A., Ng,J.W., Restivo,V.A.
            Jr., Lombard,L.A., Gray,G.S. and Nadler,L.M.
  TITLE     Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human
            T cell proliferation
  JOURNAL   Science 262 (5135), 909-911 (1993)
   PUBMED   7694363
REFERENCE   3  (bases 1 to 5471)
  AUTHORS   Jellis,C.L., Wang,S.S., Rennert,P., Borriello,F., Sharpe,A.H.,
            Green,N.R. and Gray,G.S.
  TITLE     Genomic organization of the gene coding for the costimulatory human
            B-lymphocyte antigen B7-2 (CD86)
  JOURNAL   Immunogenetics 42 (2), 85-89 (1995)
   PUBMED   7541777
REFERENCE   4  (bases 1 to 5471)
  AUTHORS   Jellis,C.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-1994) Cindy L. Jellis, Molecular Biology,
            Repligen Corporation, One Kendall Square, Building 700, Cambridge,
            MA 02139, USA
COMMENT     On or before Jun 10, 2016 this sequence version replaced U17715.1,
            U17716.1, U17717.1, U17718.1, U17719.1, U17720.1, U17721.1,
            U17722.1, AH003329.1.
FEATURES             Location/Qualifiers
     source          1..5471
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          1..478
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1390-A1 hB7.2 genomic DNA (exon 1)"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          579..1050
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1390-A1"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          1151..1634
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1307-7C Human B7.2 genomic DNA"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          1735..2475
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1307-7C"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          2576..3312
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1307-7C"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          3413..3983
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1307-7C"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          4084..4741
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1-1307-7C"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     source          4842..5471
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="DMPC-HFF no.1"
                     /sex="male"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
                     /clone_lib="Du Pont Merck Pharmaceutical Company Human
                     foreskin Fibroblast P1 Library no.1"
     gene            173..5177
                     /gene="B7.2"
     exon            173..292
                     /gene="B7.2"
                     /note="alternative 5' exon"
                     /citation=[2]
                     /citation=[3]
                     /number=1
     mRNA            join(279..292,1411..1460,1975..2310,2727..3029,3582..3725,
                     4357..4402,5064..5177)
                     /gene="B7.2"
                     /note="starts with alternative first exon 1"
                     /citation=[2]
     gap             479..578
                     /estimated_length=unknown
     mRNA            join(678..819,1411..1460,1975..2310,2727..3029,3582..3725,
                     4357..4402,5064..5177)
                     /gene="B7.2"
                     /note="starts with alternative first exon 2"
                     /citation=[1]
     exon            678..819
                     /gene="B7.2"
                     /note="alternative 5' exon"
                     /citation=[1]
                     /citation=[3]
                     /number=2
     gap             1051..1150
                     /estimated_length=unknown
     exon            1411..1460
                     /gene="B7.2"
                     /number=3
     CDS             join(1415..1460,1975..2310,2727..3029,3582..3725,
                     4357..4402,5064..5160)
                     /gene="B7.2"
                     /codon_start=1
                     /product="CTLA-4 counter-receptor B7.2"
                     /protein_id="AAA86473.1"
                     /translation="MGLSNILFVMAFLLSGAAPLEIQAYFNETADLPCQFANSQNQSL
                     SELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLY
                     QCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEP
                     KKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDK
                     TRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKC
                     GTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF"
     gap             1635..1734
                     /estimated_length=unknown
     exon            1975..2310
                     /gene="B7.2"
                     /number=4
     gap             2476..2575
                     /estimated_length=unknown
     exon            2727..3029
                     /gene="B7.2"
                     /number=5
     gap             3313..3412
                     /estimated_length=unknown
     exon            3582..3725
                     /gene="B7.2"
                     /number=6
     gap             3984..4083
                     /estimated_length=unknown
     exon            4357..4402
                     /gene="B7.2"
                     /number=7
     gap             4742..4841
                     /estimated_length=unknown
     exon            5064..5177
                     /gene="B7.2"
                     /number=8
BASE COUNT         1302 a         1014 c         1062 g         1393 t
ORIGIN      
        1 actgaattat atattcttta atacatatag acctacgtca atgagtttaa actgcaagga
       61 aagggttaaa tttcttcctc aagtgtggtc aaaatctgta gagaaaagag gaacagcttc
      121 tcttaaagaa agttagctgg gtaggtatac agacattgcc gaggaaggct tgcacagggt
      181 gaaagctttg cttctctgct gctgtaacag ggactagcac agacacacgg atgagtgggg
      241 tcatttccag atattaggtc acagcagaag cagccaaaat ggatccccag tggtgagtaa
      301 taattcttat tctttgcaga gaagttatga gttgtgactg cagggaaagg ctgaggttga
      361 agatggtgct ttgatgtgtg tccttcactt agttcctaag tggagaagct ttctttttct
      421 acaaaagatc tttggcacat aaaggcaaga attatttgca atgcccaaag cagttcatnn
      481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntc cctggctgtg gtgttgtttc
      601 tctgtttctt ttcccccttc tgtttttttc tgtatttgag ttctaccgtc agtcctggca
      661 ttatttctct ctcgacaagg agccttagga ggtgcgggga gctcgcgata ctccttttgg
      721 tttattctta ccaccttgct tctgtgttcc ttgggaatgc tgctgtgctt atgcatctgg
      781 tctctttttg gagctacagt ggacaggcat ttgtgacagg tatgtttgtg gaggctcaga
      841 cgcctaggga gtggcatgag ataaagctgc aagctgcatc tggggcagaa atgctgatgt
      901 gctaatggcc ggccagagaa tgagtaaaag ggattgcaga gagcatgctt aaaacctctg
      961 accatgcagg tttgcttctc agattgacta cattggaggt gggatattac aaaaatctgt
     1021 ctcttcctgc cagatccctt catctgtttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn agaaacatct tttctgccca caattccatt ggctagaaac cagtctcatg
     1201 gcctgtataa ctgcagggga ggctgggaaa tgtgacctat cgatggagct aagagcaaaa
     1261 ggaaatggct ttgatgaagc cctggcattg tctctgcaca cccgagaacc caagtgaatc
     1321 ccaaactcca cgtccaggtc atgttttggt gaacatcggt tttcagtttc cttttctaat
     1381 caagttttac cttttttttc tcgactctag cactatggga ctgagtaaca ttctctttgt
     1441 gatggccttc ctgctctctg gtaagaacct ttcagctttg ttaagtcctg gaatcctact
     1501 gtctcctgat gagtctgacc acaggaagcc aggcctgaga cttggggggt tttactcact
     1561 ttctactgag cattggacaa gaccacatgc aaaaaagact ttcctggaga agaaggaagt
     1621 gttatgattg agagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaactga
     1741 ggctcatgaa gagttgcagg ttgtaccagg ccacacattt agtcagcggt gaagccagga
     1801 ccaaggtcct aatctccaga tgcccagcag atgtgcacag ttccagaact taatatctta
     1861 ttcttcagca tgattactga taagatagta tctgggtatt gtataaagag aaatggaggt
     1921 tttttcccct ttcctcttgt ttctccctcc ctaatcctta accttctttt ttaggtgctg
     1981 ctcctctgga gattcaagct tatttcaatg agactgcaga cctgccatgc caatttgcaa
     2041 actctcaaaa ccaaagcctg agtgagctag tagtattttg gcaggaccag gaaaacttgg
     2101 ttctgaatga ggtatactta ggcaaagaga aatttgacag tgttcattcc aagtatatgg
     2161 gccgcacaag ttttgattcg gacagttgga ccctgagact tcacaatctt cagatcaagg
     2221 acaagggctt gtatcaatgt atcatccatc acaaaaagcc cacaggaatg attcgcatcc
     2281 accagatgaa ttctgaactg tcagtgcttg gtatgtggtc aatggtgtgt gttcagattc
     2341 ttagccttct cagatgagac tgcaaatgag ttagaaaaac actggagggg gacttgaggg
     2401 gcccagggga aaaggggggt ctatagagag aaggcagagg acagccactt ctgggaagtg
     2461 catttgaagg gagtgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnctcac
     2581 cttgggctga gggtcacatt ttagacaccc tgaggctccc aggtgtgccc caatgagccc
     2641 cagatcaagt acccagttat ttgctattcc ctcctagata catctaaact tagattgatt
     2701 tttttttatc tctcttctgc tttcagctaa cttcagtcaa cctgaaatag taccaatttc
     2761 taatataaca gaaaatgtgt acataaattt gacctgctca tctatacacg gttacccaga
     2821 acctaagaag atgagtgttt tgctaagaac caagaattca actatcgagt atgatggtat
     2881 tatgcagaaa tctcaagata atgtcacaga actgtacgac gtttccatca gcttgtctgt
     2941 ttcattccct gatgttacga gcaatatgac catcttctgt attctggaaa ctgacaagac
     3001 gcggctttta tcttcacctt tctctatagg taaagctgtt ttccaagact atttctttca
     3061 gcaggtatta tacacaaatg cttaaggcag atcatccaat gtccccgact tgctaggaaa
     3121 cctccaactg ggccatttta tgacgctgtt aggaaggacc cagatggagg tctcctgctt
     3181 ctcctgagtg atgcagggtc caggaggcta cgagcctatg ttgcacttga agaaatatgc
     3241 ttttagccct gaaactgact cagtctcttg gcttaccttt ggatggagga ttctgaagtc
     3301 tcgattttaa aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnctgaggcc
     3421 ctgagcctgg gactttctat ggcctcctat tgtggatttc aggcttctct ggccttagag
     3481 ccctggggag aggctggcag gtaaatggag agaagagcag ctagcagaaa ccttttgtaa
     3541 atgactctcc tggctgattg aaaatttgtg gtcatttgta gagcttgagg accctcagcc
     3601 tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta tatgtgtgat
     3661 ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca actcttataa
     3721 atgtggtgag tgagtccttg tcctccccac agactgtcac tttgcaccta cttcccaatc
     3781 ggctggctgc cttccggagc ttgttggctg agcctagact ggcaaaaagt caggaagttg
     3841 ttgggaaaaa aggttttccc ttggagtttt gagcctatac agactggcag tagcagataa
     3901 tgctgctctc ggacttcata gaaaggcgac atttctaacc tctggtttta caatgtactt
     3961 ctggtttcca ggaaaactga attnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4081 nnnttttggt tagccaggat agagatataa gtgggagatc tatttccagt gttagaattt
     4141 aaggcacagt gagaaaggga aggcatatac tttttgaatg caagaaactt cttcccaatc
     4201 cccctgaaat tgcatcattt gagtaactat ctcttccata tataaagtca caacaatttc
     4261 tctctcagtc ccagaacttt gaagcctttt caaactttcc ttcttttggt atctaggagg
     4321 aatagatttt tgaagattgt tcttggtgtc tttcaggaac caacacaatg gagagggaag
     4381 agagtgaaca gaccaagaaa aggcaaatcc tgaccctgag acattgatga gagaggtata
     4441 atccccagag tgcctgttac ttgaataggc ttatgcctaa catatgttga gacctcagca
     4501 aacctgaact aatggagagg gagaggaaaa taaaactagt taagaactgg aagaaaataa
     4561 cctgataatg gatgacaggg tatccaatgc acaatgccca gaaagcatga caagctctgt
     4621 catggtcaag taaaagtcaa taccaaagac ttcagaggtg gtgaacatgg gcttcatctt
     4681 atctgccaca gtaaccccag gtacctggca cagtgcccta gatttagtgg gcatcccctc
     4741 annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ncatgggaag gcccaggcag
     4861 aaataaaggg tagctcatga agcatagatg acagtgtaga ccgtggttct tttctcttgc
     4921 tttctccacc tttctcttca atagtttgtt tctcctcatt gctgttccaa tggcaacctc
     4981 tattctgccc tatcattgaa atctagaaaa agaaagtagc tcaaatgtga aatatcacct
     5041 aatcttttct tctatttctc cagagaaaaa atccatatac ctgaaagatc tgatgaagcc
     5101 cagcgtgttt ttaaaagttc gaagacatct tcatgcgaca aaagtgatac atgtttttaa
     5161 ttaaagagta aagcccatac aagtattcat tttttctacc ctttcctttg taagttcctg
     5221 ggcaaccttt ttgatttctt ccagaaggca aaaagacatt accatgagta ataagggggc
     5281 tccaggactc cctctaagtg gaatagcctc cctgtaactc cagctctgct ccgtatgaca
     5341 agaggagact ttaattctct tactgcttct tttcacttca gagcacactt atgggccaag
     5401 cccagcttaa tggctcatga cctggaaata aaatttagga ccaatacctc ctccagatca
     5461 gattcttctc t
//