LOCUS HSU04343 1424 bp mRNA linear HUM 15-JUL-1996
DEFINITION Human CD86 antigen mRNA, complete cds.
ACCESSION U04343
VERSION U04343.1
KEYWORDS B70; B7-2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1424)
AUTHORS Azuma,M., Ito,D., Yagita,H., Okumura,K., Phillips,J.H., Lanier,L.L.
and Somoza,C.
TITLE B70 antigen is a second ligand for CTLA-4 and CD28
JOURNAL Nature 366 (6450), 76-79 (1993)
PUBMED 7694153
REFERENCE 2 (bases 1 to 1424)
AUTHORS Fernandez-Ruiz,E., Somoza,C., Sanchez-Madrid,F. and Lanier,L.L.
TITLE CD28/CTLA-4 ligands: the gene encoding CD86 B(B70/B7.2) maps to the
same region as CD80 (B7/B7.1) gene in human chromosome 3q13-q23
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1424)
AUTHORS Somoza,C.
TITLE Direct Submission
JOURNAL Submitted (14-DEC-1993) Chamorro Somoza, Human Immunology, DNAX
Research Institute of Molecular and Cellular Biology, 901
California Avenue, Palo Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..1424
/db_xref="H-InvDB:HIT000217545"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q13-q23"
/cell_line="JY EBV B lymphoblastoid line"
gene 1..1424
/gene="CD86"
CDS 148..1119
/gene="CD86"
/note="common synonyms are B7-2 and B70; B70 antigen;
B7-2"
/codon_start=1
/product="CD86 antigen"
/protein_id="AAB03814.1"
/translation="MGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSL
SELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLY
QCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEP
KKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDK
TRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKC
GTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF"
sig_peptide 148..195
/gene="CD86"
misc_feature 865..933
/gene="CD86"
/note="transmembrane domain"
misc_feature 964..972
/gene="CD86"
/note="PKC phosphorylation site"
misc_feature 1012..1020
/gene="CD86"
/note="PKC phosphorylation site"
misc_feature 1075..1083
/gene="CD86"
/note="PKC phosphorylation site"
BASE COUNT 429 a 306 c 284 g 405 t
ORIGIN
1 aggagcctta ggaggtacgg ggagctcgca aatactcctt ttggtttatt cttaccacct
61 tgcttctgtg ttccttggga atgctgctgt gcttatgcat ctggtctctt tttggagcta
121 cagtggacag gcatttgtga cagcactatg ggactgagta acattctctt tgtgatggcc
181 ttcctgctct ctggtgctgc tcctctgaag attcaagctt atttcaatga gactgcagac
241 ctgccatgcc aatttgcaaa ctctcaaaac caaagcctga gtgagctagt agtattttgg
301 caggaccagg aaaacttggt tctgaatgag gtatacttag gcaaagagaa atttgacagt
361 gttcattcca agtatatggg ccgcacaagt tttgattcgg acagttggac cctgagactt
421 cacaatcttc agatcaagga caagggcttg tatcaatgta tcatccatca caaaaagccc
481 acaggaatga ttcgcatcca ccagatgaat tctgaactgt cagtgcttgc taacttcagt
541 caacctgaaa tagtaccaat ttctaatata acagaaaatg tgtacataaa tttgacctgc
601 tcatctatac acggttaccc agaacctaag aagatgagtg ttttgctaag aaccaagaat
661 tcaactatcg agtatgatgg tattatgcag aaatctcaag ataatgtcac agaactgtac
721 gacgtttcca tcagcttgtc tgtttcattc cctgatgtta cgagcaatat gaccatcttc
781 tgtattctgg aaactgacaa gacgcggctt ttatcttcac ctttctctat agagcttgag
841 gaccctcagc ctcccccaga ccacattcct tggattacag ctgtacttcc aacagttatt
901 atatgtgtga tggttttctg tctaattcta tggaaatgga agaagaagaa gcggcctcgc
961 aactcttata aatgtggaac caacacaatg gagagggaag agagtgaaca gaccaagaaa
1021 agagaaaaaa tccatatacc tgaaagatct gatgaagccc agcgtgtttt taaaagttcg
1081 aagacatctt catgcgacaa aagtgataca tgtttttaat taaagagtaa agcccataca
1141 agtattcatt ttttctaccc tttcctttgt aagttcctgg gcaacctttt tgatttcttc
1201 cagaaggcaa aaagacatta ccatgagtaa taagggggct ccaggactcc ctctaagtgg
1261 aatagcctcc ctgtaactcc agctctgctc cgtatgccaa gaggagactt taattctctt
1321 actgcttctt ttcacttcag agcacactta tgggccaagc ccagcttaat ggctcatgac
1381 ctggaaataa aatttaggac caataaaaaa aaaaaaaaaa aaaa
//