LOCUS HSU04313 2566 bp mRNA linear HUM 11-JUN-1994
DEFINITION Human maspin mRNA, complete cds.
ACCESSION U04313
VERSION U04313.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2566)
AUTHORS Zou,Z., Anisowicz,A., Hendrix,M.J., Thor,A., Neveu,M., Sheng,S.,
Rafidi,K., Seftor,E. and Sager,R.
TITLE Maspin, a serpin with tumor-suppressing activity in human mammary
epithelial cells
JOURNAL Science 263 (5146), 526-529 (1994)
PUBMED 8290962
REFERENCE 2 (bases 1 to 2566)
AUTHORS Anisowicz,A.
TITLE Direct Submission
JOURNAL Submitted (10-DEC-1993) Anthony Anisowicz, Cancer Genetics, Dana
Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..2566
/db_xref="H-InvDB:HIT000217544"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolate="76N"
/db_xref="taxon:9606"
/clone="Z32-1"
/sex="female"
/cell_line="76N"
/cell_type="epithelial"
/tissue_type="mammary"
/clone_lib="76N cDNA library in lambda Zap II"
5'UTR 1..75
CDS 76..1203
/codon_start=1
/product="maspin"
/protein_id="AAA18957.1"
/translation="MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQV
GAKGDTANEIGQVLHFENVKDIPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLST
EFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKIL
VVNAAYFVGKWMKKFPESETKECPFRLNKTDTKPVQMMNMEATFCMGNIDSINCKIIE
LPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKF
KVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSI
EVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP"
misc_feature 1093..1098
/note="putative serpin reactive center"
3'UTR 1201..2566
regulatory 2545..2550
/regulatory_class="polyA_signal_sequence"
BASE COUNT 786 a 526 c 504 g 750 t
ORIGIN
1 ggcacgagtt gtgctcctcg cttgcctgtt ccttttccac gcattttcca ggataactgt
61 gactccaggc ccgcaatgga tgccctgcaa ctagcaaatt cggcttttgc cgttgatctg
121 ttcaaacaac tatgtgaaaa ggagccactg ggcaatgtcc tcttctctcc aatctgtctc
181 tccacctctc tgtcacttgc tcaagtgggt gctaaaggtg acactgcaaa tgaaattgga
241 caggttcttc attttgaaaa tgtcaaagat ataccctttg gatttcaaac agtaacatcg
301 gatgtaaaca aacttagttc cttttactca ctgaaactaa tcaagcggct ctacgtagac
361 aaatctctga atctttctac agagttcatc agctctacga agagacccta tgcaaaggaa
421 ttggaaactg ttgacttcaa agataaattg gaagaaacga aaggtcagat caacaactca
481 attaaggatc tcacagatgg ccactttgag aacattttag ctgacaacag tgtgaacgac
541 cagaccaaaa tccttgtggt taatgctgcc tactttgttg gcaagtggat gaagaaattt
601 cctgaatcag aaacaaaaga atgtcctttc agactcaaca agacagacac caaaccagtg
661 cagatgatga acatggaggc cacgttctgt atgggaaaca ttgacagtat caattgtaag
721 atcatagagc ttccttttca aaataagcat ctcagcatgt tcatcctact acccaaggat
781 gtggaggatg agtccacagg cttggagaag attgaaaaac aactcaactc agagtcactg
841 tcacagtgga ctaatcccag caccatggcc aatgccaagg tcaaactctc cattccaaaa
901 tttaaggtgg aaaagatgat tgatcccaag gcttgtctgg aaaatctagg gctgaaacat
961 atcttcagtg aagacacatc tgatttctct ggaatgtcag agaccaaggg agtggcccta
1021 tcaaatgtta tccacaaagt gtgcttagaa ataactgaag atggtgggga ttccatagag
1081 gtgccaggag cacggatcct gcagcacaag gatgaattga atgctgacca tccctttatt
1141 tacatcatca ggcacaacaa aactcgaaac atcattttct ttggcaaatt ctgttctcct
1201 taagtggcat agcccatgtt aagtcctccc tgacttttct gtggatgccg atttctgtaa
1261 actctgcatc cagagattca ttttctagat acaataaatt gctaatgttg ctggatcagg
1321 aagccgccag tacttgtcat atgtagcctt cacacagata gacctttttt tttttccaat
1381 tctatctttt gtttcctttt ttcccataag acaatgacat acgcttttaa tgaaaaggaa
1441 tcacgttaga ggaaaaatat ttattcatta tttgtcaaat tgtccggggt agttggcaga
1501 aatacagtct tccacaaaga aaattcctat aaggaagatt tggaagctct tcttcccagc
1561 actatgcttt ccttctttgg gatagagaat gttccagaca ttctcgcttc cctgaaagac
1621 tgaagaaagt gtagtgcatg ggacccacga aactgccctg gctccagtga aacttgggca
1681 catgctcagg ctactatagg tccagaagtc cttatgttaa gccctggcag gcaggtgttt
1741 attaaaattc tgaattttgg ggattttcaa aagataatat tttacataca ctgtatgtta
1801 tagaacttca tggatcagat ctggggcagc aacctataaa tcaacacctt aatatgctgc
1861 aacaaaatgt agaatattca gacaaaatgg atacataaag actaagtagc ccataagggg
1921 tcaaaatttg ctgccaaatg cgtatgccac caacttacaa aaacacttcg ttcgcagagc
1981 ttttcagatt gtggaatgtt ggataaggaa ttatagacct ctagtagctg aaatgcaaga
2041 ccccaagagg aagttcagat cttaatataa attcactttc atttttgata gctgtcccat
2101 ctggtcatgt ggttggcact agactggtgg caggggcttc tagctgactc gcacagggat
2161 tctcacaata gccgatatca gaatttgtgt tgaaggaact tgtctcttca tctaatatga
2221 tagcgggaaa aggagaggaa actactgcct ttagaaaata taagtaaagt gattaaagtg
2281 ctcacgttac cttgacacat agtttttcag tctatgggtt tagttacttt agatggcaag
2341 catgtaactt atattaatag taatttgtaa agttgggtgg ataagctatc cctgttgccg
2401 gttcatggat tacttctcta taaaaaatat atatttacca aaaaattttg tgacattcct
2461 tctcccatct cttccttgac atgcattgta aataggttct tcttgttctg agattcaata
2521 ttgaatttct cctatgctat tgacaataaa atattattga actacc
//