LOCUS HUMVCAM1A 5607 bp DNA linear HUM 14-JAN-1995
DEFINITION Human vascular cell adhesion molecule-1 (VCAM1) gene, complete CDS.
ACCESSION M73255
VERSION M73255.1
KEYWORDS immunoglobulin super gene family; leukocyte adhesion molecule;
transmembrane protein; vascular cell adhesion molecule-1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5607)
AUTHORS Cybulsky,M.I., Fries,J.W., Williams,A.J., Sultan,P., Eddy,R.,
Byers,M., Shows,T., Gimbrone,M.A. Jr. and Collins,T.
TITLE Gene structure, chromosomal location, and basis for alternative
mRNA splicing of the human VCAM1 gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7859-7863 (1991)
PUBMED 1715583
COMMENT Original source text: Homo sapiens (tissue library: EMBL3)
periferal blood DNA.
FEATURES Location/Qualifiers
source 1..5607
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="1p32-p31"
/tissue_type="periferal blood"
/tissue_lib="EMBL3"
regulatory 495..499
/regulatory_class="TATA_box"
/gene="VCAM1"
/experiment="experimental evidence, no additional details
recorded"
/note="G00-127-922"
gene join(519..706,779..1054,1127..1447,1520..1786,1859..2134,
2207..2527,2897..3163,3236..3502,3922..4841)
/gene="VCAM1"
mRNA join(519..706,779..1054,1127..1447,1520..1786,1859..2134,
2207..2527,2897..3163,3236..3502,3922..4841)
/gene="VCAM1"
/note="G00-127-922"
exon 519..706
/gene="VCAM1"
/note="G00-127-922"
/number=1
CDS join(643..706,779..1054,1127..1447,1520..1786,1859..2134,
2207..2527,2897..3163,3236..3502,3922..4082)
/gene="VCAM1"
/number=2
/codon_start=1
/product="vascular cell adhesion molecule-1"
/protein_id="AAA61270.1"
/db_xref="GDB:G00-127-922"
/translation="MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVS
LTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESR
KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMK
SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ
VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL
TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT
CSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKL
EKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI
EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN
VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTL
ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCT
CGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT
LDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV"
exon 779..1054
/gene="VCAM1"
/note="G00-127-922"
/number=2
exon 1127..1447
/gene="VCAM1"
/note="G00-127-922"
/number=3
exon 1520..1786
/gene="VCAM1"
/note="G00-127-922"
/number=4
exon 1859..2134
/gene="VCAM1"
/note="G00-127-922"
/number=5
exon 2207..2527
/gene="VCAM1"
/note="G00-127-922"
/number=6
exon 2897..3163
/gene="VCAM1"
/note="G00-127-922"
/number=7
exon 3236..3502
/gene="VCAM1"
/note="G00-127-922"
/number=8
exon 3922..4841
/gene="VCAM1"
/note="G00-127-922"
/number=9
BASE COUNT 1593 a 1081 c 1185 g 1726 t
ORIGIN chromosome 1, map position 1p31-32.
1 gaagttatgg tgtccctttt ttaaaaaatg actcatcaaa agaaataact ttttcctttc
61 tcttgtaaga gaaaaaaatt aatctctttt agaattgcaa acatatttcc ttgatggaga
121 aaatcaattc acatggcata gtcgttattt atccagttca aaaaccagag tagaatttac
181 tactctgtct ccattttttc tctccccacc cccttaaccc acattggatt cagaaagctt
241 cattctgcaa tcagcattgt cctttatctt tccagtaaag atagcctttt ggagtcgaag
301 atgaggaaaa gcctgtattt tatagtcttg gaagtgtctt cttttgccag gacagagaga
361 ggagcttcag cagtgagagc aactgaaggg gttaatagtg gaacttggct gggtgtctgt
421 taaacttttt tccctggctc tgccctgggt ttccccttga agggatttcc ctccgcctct
481 gcaacaagac cctttataaa gcacagactt tctatttcac tccgcggtat ctgcatcggg
541 cctcactggc ttcaggagct gaataccctc ccaggcacac acaggtggga cacaaataag
601 ggttttggaa ccactatttt ctcatcacga cagcaactta aaatgcctgg gaagatggtc
661 gtgatccttg gagcctcaaa tatactttgg ataatgtttg cagcttgtaa gttatttccc
721 ttcatctgtt tcaaatgtta gnnggtaaat ttgcttctgt ctttttttgc ttttgcagct
781 caagctttta aaatcgagac caccccagaa tctagatatc ttgctcagat tggtgactcc
841 gtctcattga cttgcagcac cacaggctgt gagtccccat ttttctcttg gagaacccag
901 atagatagtc cactgaatgg gaaggtgacg aatgagggga ccacatctac gctgacaatg
961 aatcctgtta gttttgggaa cgaacactct tacctgtgca cagcaacttg tgaatctagg
1021 aaattggaaa aaggaatcca ggtggagatc tactgtgagt gctttagaaa atctttgttt
1081 ttctctcaan naaaagccca tccatgtatt tgtttggcct tttcagcttt tcctaaggat
1141 ccagagattc atttgagtgg ccctctggag gctgggaagc cgatcacagt caagtgttca
1201 gttgctgatg tatacccatt tgacaggctg gagatagact tactgaaagg agatcatctc
1261 atgaagagtc aggaatttct ggaggatgca gacaggaagt ccctggaaac caagagtttg
1321 gaagtaacct ttactcctgt cattgaggat attggaaaag ttcttgtttg ccgagctaaa
1381 ttacacattg atgaaatgga ttctgtgccc acagtaaggc aggctgtaaa agaattgcaa
1441 gtctacagta agtacttgtg cgatgtgttc cagtctttgt ggnnttagca attgctaata
1501 ttattttttg ccctttcagt atcacccaag aatacagtta tttctgtgaa tccatccaca
1561 aagctgcaag aaggtggctc tgtgaccatg acctgttcca gcgagggtct accagctcca
1621 gagattttct ggagtaagaa attagataat gggaatctac agcacctttc tggaaatgca
1681 actctcacct taattgctat gaggatggaa gattctggaa tttatgtgtg tgaaggagtt
1741 aatttgattg ggaaaaacag aaaagaggtg gaattaattg ttcaaggtga gtagaatgtg
1801 aaaaaggaat gataaaggtg cnntgttctt ttcatcttgt tttccacctg tgtcccagag
1861 aaaccattta ctgttgagat ctcccctgga ccccggattg ctgctcagat tggagactca
1921 gtcatgttga catgtagtgt catgggctgt gaatccccat ctttctcctg gagaacccag
1981 atagacagcc ctctgagcgg gaaggtgagg agtgagggga ccaattccac gctgaccctg
2041 agccctgtga gttttgagaa cgaacactct tatctgtgca cagtgacttg tggacataag
2101 aaactggaaa agggaatcca ggtggagctc tactgtaagt ggttttcaga attgtttact
2161 gttttttttn ncaagaataa aaatcgtttt tgcttgcgat ttgcagcatt ccctagagat
2221 ccagaaatcg agatgagtgg tggcctcgtg aatgggagct ctgtcactgt aagctgcaag
2281 gttcctagcg tgtaccccct tgaccggctg gagattgaat tacttaaggg ggagactatt
2341 ctggagaata tagagttttt ggaggatacg gatatgaaat ctctagagaa caaaagtttg
2401 gaaatgacct tcatccctac cattgaagat actggaaaag ctcttgtttg tcaggctaag
2461 ttacatattg atgacatgga attcgaaccc aaacaaaggc agagtacgca aacactttat
2521 gtcaatggta agtacatatg tgaggtatct acagtttaat acnntatggt attagctgag
2581 ctcactcgtg cattttcagt aaggttagca gggctggctg gtctcagatg acttcaccca
2641 catgtctgga gccatatctt ggatgacttg gcctctcttt ctttatgtgg tgtcaccctg
2701 aggaacagta gcctagattt actctccaga gctcagtgtt tcaagaaggt gtaaatgaaa
2761 gcagcctctt caaggcctgg gtttggaagt cctacagtgt tacttcttct tccacattca
2821 attggttaaa gtgagtcatg aggccagcct agagattcan nataggtcaa gctaacaagc
2881 gtctctgcct tttcagttgc ccccagagat acaaccgtct tggtcagccc ttcctccatc
2941 ctggaggaag gcagttctgt gaatatgaca tgcttgagcc agggctttcc tgctccgaaa
3001 atcctgtgga gcaggcagct ccctaacggg gagctacagc ctctttctga gaatgcaact
3061 ctcaccttaa tttctacaaa aatggaagat tctggggttt atttatgtga aggaattaac
3121 caggctggaa gaagcagaaa ggaagtggaa ttaattatcc aaggtgagca gagtgtgagt
3181 aatgagttat ccttgctann ctcaatcagg gatgtctttt aaattctctt tacagttact
3241 ccaaaagaca taaaacttac agcttttcct tctgagagtg tcaaagaagg agacactgtc
3301 atcatctctt gtacatgtgg aaatgttcca gaaacatgga taatcctgaa gaaaaaagcg
3361 gagacaggag acacagtact aaaatctata gatggcgcct ataccatccg aaaggcccag
3421 ttgaaggatg cgggagtata tgaatgtgaa tctaaaaaca aagttggctc acaattaaga
3481 agtttaacac ttgatgttca aggtgagttt gttttgagtt tttgttttct tggtaatnna
3541 agccttaccg tatgtatgtt ttccatcttc acagtacctc ctcaaaacat gagaatagct
3601 gtatagctat acatccatct agaaatgtta aagaagggga aaacatcacg attatatatg
3661 aaacttctag tcatccacct gcagtgatta tcctgaaaag aattgatcta gccaatgaag
3721 ttactatgtg ttcaaagaag ggaacattta ctttgtatca tgtcactcaa aatgattcag
3781 gggtatatgt aatcagtgct tccaatgagg ttggggatga ttctggacag attgcaatct
3841 cagttatgag taggttgaat ttactcatcc ctattttctt taatnntaga cattaattgc
3901 atccattttg ttattttcca ggaagagaaa acaacaaaga ctatttttct cctgagcttc
3961 tcgtgctcta ttttgcatcc tccttaataa tacctgccat tggaatgata atttactttg
4021 caagaaaagc caacatgaag gggtcatata gtcttgtaga agcacagaaa tcaaaagtgt
4081 agctaatgct tgatatgttc aactggagac actatttatc tgtgcaaatc cttgatactg
4141 ctcatcattc cttgagaaaa acaatgagct gagaggcaga cttccctgaa tgtattgaac
4201 ttggaaagaa atgcccatct atgtcccttg ctgtgagcaa gaagtcaaag taaaacttgc
4261 tgcctgaaga acagtaactg ccatcaagat gagagaactg gaggagttcc ttgatctgta
4321 tatacaataa cataatttgt acatatgtaa aataaaatta tgccatagca agattgctta
4381 aaatagcaac actctatatt tagattgtta aaataactag tgttgcttgg actattataa
4441 tttaatgcat gttaggaaaa tttcacatta atatttgctg acagctgacc tttgtcatct
4501 ttcttctatt ttattccctt tcacaaaatt ttattcctat atagtttatt gacaataatt
4561 tcaggttttg taaagatgcc gggttttata tttttataga caaataataa gcaaagggag
4621 cactgggttg actttcaggt actaaatacc tcaacctatg gtataatggt tgactgggtt
4681 tctctgtata gtactggcat ggtacggaga tgtttcacga agtttgttca tcagactcct
4741 gtgcaacttt cccaatgtgg cctaaaaatg caacttcttt ttattttctt ttgtaaatgt
4801 ttaggttttt ttgtatagta aagtgataat ttctggaatt agaatggttg tatgtttatt
4861 tattataaac tgcctccttt agtcacgttg tagctctttc tgaagtgcta agttataaga
4921 gtaaaatatt caaactatgg aaataatacg gatactcaaa atgtgaccct cagactacta
4981 ttattaaaat tactgtagga acttgataaa aatgtagatt tcttggtgcc agactaagat
5041 attgaataga agtgtctagt ttttggtcct tggaatctgc aattttttaa tttagaaaaa
5101 tatacataaa aagatttaat gcagatgaac atgcacatgt taatgggcaa caaatgaaca
5161 cctgtgtaca gaacattaag agcaagagat agtaaaacta ttcttcagag ccttttatat
5221 accacatagt gatggcagca ctcttccctc actgagcagt aacccataaa tattgtgaat
5281 catacattga tcatttccat gcttcctttg gagttttttt tttttttttt tttttttgag
5341 acggagtctc gctctgtcgc ccaggctgga gtgcagtggc gccacctcgc atctcggctg
5401 gctgcaagct ccgcctcctg ggttcacgcc attctcctgc ctcagtctcc ctagtagctg
5461 ggactacagg cgcccgcacc acgcctggct aatttttttg tatttttagt agagacgggg
5521 tttcactgtg ttagccagga tggcctcgat ctcctgacct cgtgatccgc ccgcctcgga
5581 cctcccaaag tgctgggatt acaggnn
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