LOCUS AH002636 5523 bp DNA linear HUM 01-AUG-2016
DEFINITION Homo sapiens glycoprotein CD28 (CD28) gene, complete cds,
alternatively spliced.
ACCESSION AH002636 M37812 M37813 M37814 M37815
VERSION AH002636.2
KEYWORDS glycoprotein CD28.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5523)
AUTHORS Lee,K.P., Taylor,C., Petryniak,B., Turka,L.A., June,C.H. and
Thompson,C.B.
TITLE The genomic organization of the CD28 gene. Implications for the
regulation of CD28 mRNA expression and heterogeneity
JOURNAL J. Immunol. 145 (1), 344-352 (1990)
PUBMED 2162892
COMMENT On or before Aug 1, 2016 this sequence version replaced M37812.1,
M37813.1, M37814.1, M37815.1, AH002636.1.
FEATURES Location/Qualifiers
source 1..5523
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="2q33-q34"
mobile_element 91..362
/mobile_element_type="SINE:Alu"
misc_feature 500..507
/note="AP1-like element"
gene 539..5462
/gene="CD28"
mRNA join(539..812,1149..1505,1853..1977,2415..5462)
/gene="CD28"
/product="glycoprotein CD28"
/note="G00-118-765"
mRNA join(539..812,1149..1505,1853..1977,2415..3296)
/gene="CD28"
/note="G00-118-765"
exon 539..812
/gene="CD28"
/note="number 1; G00-118-765"
CDS join(761..812,1149..1505,1853..1977,2415..2543)
/gene="CD28"
/codon_start=1
/product="glycoprotein CD28"
/protein_id="AAA51944.1"
/translation="MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSY
NLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNL
YVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVG
GVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAY
RS"
CDS join(761..812,1149..1214,1467..1505,1853..1977,2415..2543)
/gene="CD28"
/note="deleted form"
/codon_start=1
/product="glycoprotein CD28"
/protein_id="AAA51945.1"
/db_xref="GDB:G00-118-765"
/translation="MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSYNEKS
NGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRL
LHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS"
intron order(813..984,1085..1148)
/gene="CD28"
/note="G00-118-765"
/number=1
gap 985..1084
/estimated_length=unknown
exon 1149..1505
/gene="CD28"
/note="G00-118-765"
/number=2
intron order(1506..1626,1727..1852)
/gene="CD28"
/note="G00-118-765"
/number=2
gap 1627..1726
/estimated_length=unknown
exon 1853..1977
/gene="CD28"
/note="G00-118-765"
/number=3
intron order(1978..2193,2294..2414)
/gene="CD28"
/note="number 3; G00-118-765"
/number=3
gap 2194..2293
/estimated_length=unknown
exon 2415..5462
/gene="CD28"
/note="number 4"
/number=4
exon 2415..3296
/gene="CD28"
/note="number 4"
/number=4
regulatory 3284..3289
/regulatory_class="polyA_signal_sequence"
/gene="CD28"
/note="G00-118-765"
mobile_element 3367..3650
/mobile_element_type="SINE:Alu"
BASE COUNT 1424 a 1064 c 1118 g 1617 t
ORIGIN
1 ccctttcctt ttttctctct ccccttcctt ccttctttcc ttcttttctt ttcttttctt
61 ttctttctct ctttctttct gtctttcttt tctcattctg ttgccctggc tggagtgcag
121 tggcatgatc tcggctcata gcagcctcca cctcctgggt tcaagcgatt ctcctgcctt
181 agccctccct agtagctgga ttacaggtac ccaccatgat gcctggctaa ttttttgtat
241 tttcaatgga gacggggttt caccatgttg gccaggctcg tcttgacctc ctggcctcaa
301 atgatccacc cactttggcc tcccaaattg ctggcattac aggcgtgagc cactgcaccc
361 ggcctgttcc ttcttaagaa cactttgtct cccctttaat ctctgctgga tttcaagcac
421 cccttttaca caactcttga tatccatcaa taaagaataa ttcccataag cccatcatgt
481 agtgaccgac tatttttcag tgacaaaaaa aaagtcttta aaaatagaag taaaagtcta
541 aagtcatcaa aacaacgtta tatcctgtgt gaaatgctgc agtcaggatg ccttgtggtt
601 tgagtgcctt gatcatgtgc cctaagggga tggtggcggt ggtggtggcc gtggatgacg
661 gagactctca ggccttggca ggtgcgtctt tcagttcccc tcacacttcg ggttcctcgg
721 ggaggagggg ctggaaccct agcccatcgt caggacaaag atgctcaggc tgctcttggc
781 tctcaactta ttcccttcaa ttcaagtaac aggtaaacaa tgttaatgtc tttctttctg
841 taaatatttt ttgaggtctt ccaattggct tagtttattt taaatttcta acaatgtgtg
901 aaatttgaac atttgaagtg tagttttgct gtaatagggc aatgtgttat tttgaaaatc
961 attgattctc agactacata tagannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1081 nnnngctctc aggaagaaaa attatcctta tattcttgtt ctaagcaaat gatttttttt
1141 tcccccagga aacaagattt tggtgaagca gtcgcccatg cttgtagcgt acgacaatgc
1201 ggtcaacctt agctgcaagt attcctacaa tctcttctca agggagttcc gggcatccct
1261 tcacaaagga ctggatagtg ctgtggaagt ctgtgttgta tatgggaatt actcccagca
1321 gcttcaggtt tactcaaaaa cggggttcaa ctgtgatggg aaattgggca atgaatcagt
1381 gacattctac ctccagaatt tgtatgttaa ccaaacagat atttacttct gcaaaattga
1441 agttatgtat cctcctcctt acctagacaa tgagaagagc aatggaacca ttatccatgt
1501 gaaaggtaac atacaacttt accagtgtac caccctaaag taatggtttt caaatgcagt
1561 cctgaaaact gggttgtggt cagtggtggg gttgaataag gcctaagtga tttgatacta
1621 acaaagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncact ctaagctggt
1741 gatatgttta atatttttat ttctttcaca tttttctctg atgttcacaa ggaaggaaat
1801 gcactcaatt gctattcctg tatcatttaa tccactctat tttgtttttc agggaaacac
1861 ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct ggtggtggtt
1921 ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggta
1981 agagaagcag cactgctttt atgtaacttt tccactgcac atgaaatctg aacacattca
2041 agaattttgc ctatgtggtt tattttctgt ttaatatagg atgatgattt tcttttcccc
2101 atgcttgagt aggttctctt ttagcttgtt caactctatc tgagataaaa atctgatatg
2161 agttagattt ccagaaggca ttgagtaggt ggtnnnnnnn nnnnnnnnnn nnnnnnnnnn
2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2281 nnnnnnnnnn nnnaaaggtt agtgttttag tgtctctgtc atttgacagt taatattatg
2341 aatagttgtg cccacagtct tagaactcct tccatgacat tgtccctcca tactgacact
2401 tctctttcct gcaggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca
2461 tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg
2521 acttcgcagc ctatcgctcc tgacacggac gcctatccag aagccagccg gctggcagcc
2581 cccatctgct caatatcact gctctggata ggaaatgacc gccatctcca gccggccacc
2641 tcaggcccct gttgggccac caatgccaat ttttctcgag tgactagacc aaatatcaag
2701 atcattttga gactctgaaa tgaagtaaaa gagatttcct gtgacaggcc aagtcttaca
2761 gtgccatggc ccacattcca acttaccatg tacttagtga cttgactgag aagttagggt
2821 agaaaacaaa aagggagtgg attctgggag cctcttccct ttctcactca cctgcacatc
2881 tcagtcaagc aaagtgtggt atccacagac attttagttg cagaagaaag gctaggaaat
2941 cattcctttt ggttaaatgg gtgtttaatc ttttggttag tgggttaaac ggggtaagtt
3001 agagtagggg gagggatagg aagacatatt taaaaaccat taaaacactg tctcccactc
3061 atgaaatgag ccacgtagtt cctatttaat gctgttttcc tttagtttag aaatacatag
3121 acattgtctt ttatgaattc tgatcatatt tagtcatttt gaccaaatga gggatttggt
3181 caaatgaggg attccctcaa agcaatatca ggtaaaccaa gttgctttcc tcactccctg
3241 tcatgagact tcagtgttaa tgttcacaat atactttcga aagaataaaa tagttctcct
3301 acatgaagaa agaatatgtc aggaaataag gtcactttat gtcaaaatta tttgagtact
3361 atgggacctg gcgcagtggc tcatgcttgt aatcccagca ctttgggagg ccgaggtggg
3421 cagatcactt gagatcagga ccagcctggt caagatggtg aaactccgtc tgtactaaaa
3481 atacaaaatt tagcttggcc tggtggcagg cacctgtaat cccagctgcc caggaggctg
3541 aggcatgaga atcgcttgaa cctggcaggc ggaggttgca gtgagccgag atagtgccac
3601 agctctccag cctgggcgac agagtgagac tccatctcaa acaacaacaa caacaacaac
3661 aacaacaaca aaccacaaaa ttatttgagt actgtgaagg attatttgtc taacagttca
3721 ttccaatcag accaggtagg agctttcctg tttcatatgt ttcagggttg cacagttggt
3781 ctctttaatg tcggtgtgga gatccaaagt gggttgtgga aagagcgtcc ataggagaag
3841 tgagaatact gtgaaaaggg atgttagcat tcattagagt atgaggatga gtcccaagaa
3901 ggttctttgg aaggaggacg aatagaatgg agtaatgaaa ttcttgccat gtgctgagga
3961 gatagccagc attaggtgac aatcttccag aagtggtcag gcagaaggtg ccctggtgag
4021 agctccttta cagggacttt atgtggttta gggctcagag ctccaaaact ctgggctcag
4081 ctgctcctgt accttggagg tccattcaca tgggaaagta ttttggaatg tgtcttttga
4141 agagagcatc agagttctta agggactggg taaggcctga ccctgaaatg accatggata
4201 tttttctacc tacagtttga gtcaactaga atatgcctgg ggaccttgaa gaatgccctt
4261 cagtggccct caccatttgt tcatgcttca gttaattcag gtgttgaagg agcttaggtt
4321 ttagaggcac gtagacttgg ttcaagtctc gttagtagtt gaatagcctc aggcaagtca
4381 ctgcccacct aagatgatgg ttcttcaact ataaatggag ataatggtta caaatgtctc
4441 ttcctatagt ataatctcca taagggcatg gcccaagtct gtctttgact ctgcctatcc
4501 ctgacgttta gtagcatgcc cgacatacaa tgttagctat tggtattatt gccatataga
4561 taaattatgt ataaaaatta aactgggcaa tagcctaaga aggggggaat attgtaacac
4621 aaatttaaac ccactacgca gggatgaggt gctataatat gaggaccttt taacttccat
4681 cattttcctg tttcttgaaa tagtttatct tgtaatgaaa tataaggcac ctcccacttt
4741 tatgtataga aagaggtctt ttaatttttt tttaatgtga gaaggaaggg aggagtagga
4801 atcttgagat tccatatcga aaatactgta ctttggttga tttttaagtg ggcttccatt
4861 ccatggattt aatcagtccc aagaagatca aactcagcag tacttgggtg ctgaagaact
4921 gttggattta ccctggcacg tgtgccactt gcccagcttc ttgggcacac agagttcttc
4981 aatccaagtt atcagattgt atttgaaaat gacagagctg gagagttttt tgaaatggca
5041 gtggcaaata aataaatact tttttttaaa tggaaagact tgatctatgg taataaatga
5101 ttttgttttc tgactggaaa aataggccta ctaaagatga atcacacttg agatgtttct
5161 tactcactct gcacagaaac aaagaagaaa tgttatacag ggaagtccgt tttcactatt
5221 agtatgaacc aagaaatggt tcaaaaacag tggtaggagc aatgctttca tagtttcaga
5281 tatggtagtt atgaagaaaa caatgtcatt tgctgctatt attgtaagag tcttataatt
5341 aatggtactc ctataatttt tgattgtgag ctcacctatt tgggttaagc atgccaattt
5401 aaagagacca agtgtatgta cattatgttc tacatattca gtgataaaat tactaaacta
5461 ctatatgtct gctttaaatt tgtactttaa tattgtcttt tggtattaag aaagatatgc
5521 ttt
//