LOCUS       HUMATCT4A               1742 bp    DNA     linear   HUM 24-JAN-1994
DEFINITION  Human T4 surface glycoprotein CD4 gene, complete cds.
ACCESSION   M35160
VERSION     M35160.1
KEYWORDS    glycoprotein; immunoglobulin super gene family; recognition
            antigen; surface antigen.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Hodge,T.W., Sasso,D.R. and McDougal,J.S.
  TITLE     Humans with OKT4-epitope deficiency have a single nucleotide base
            change in the CD4 gene, resulting in substitution of TRP240 for
            ARG240
  JOURNAL   Hum. Immunol. 30 (2), 99-104 (1991)
   PUBMED   1708753
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Hodge,T.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-1990) T.W. Hodge, A-25 Bldg. 1, Rm. 1226, Centers
            for Disease Control, 1600 Clifton Rd. Atlanta, GA 30333 USA
COMMENT     A cytosine to thymidine transition at nucleotide position 868
            results in substitution of TRP-240 for ARG-240.
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Homo sapiens"
                     /mol_type="unassigned DNA"
                     /db_xref="taxon:9606"
                     /haplotype="OKT4-negative"
     gene            76..1452
                     /gene="CD4"
     CDS             76..1452
                     /gene="CD4"
                     /note="T4 surface glycoprotein precursor"
                     /codon_start=1
                     /protein_id="AAA16069.1"
                     /translation="MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTAS
                     QKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIE
                     DSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRG
                     KNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQ
                     VEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKWVTQDPKLQMGK
                     KLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPT
                     SPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWST
                     PVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHR
                     FQKTCSPI"
     sig_peptide     76..150
                     /gene="CD4"
                     /note="T4 surface glycoprotein signal peptide"
     mat_peptide     151..1449
                     /gene="CD4"
                     /product="T4 surface glycoprotein mature peptide"
     variation       792
                     /gene="CD4"
                     /note="g in OKT4 epitope deficiency; c in wt"
BASE COUNT          405 a          491 c          466 g          380 t
ORIGIN      
        1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc
       61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa
      121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat
      181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac
      241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag
      301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc
      361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag
      421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag
      481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt
      541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag
      601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc
      661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag
      721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt
      781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac
      841 ctgaagaaca aggaagtgtc tgtaaaatgg gttacccagg accctaagct ccagatgggc
      901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga
      961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg
     1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc
     1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag
     1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg
     1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag
     1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc
     1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc
     1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt
     1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc
     1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt
     1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag
     1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct
     1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat
     1741 cc
//