LOCUS HUMMHCD8A 7319 bp DNA linear HUM 07-JAN-1995
DEFINITION Human MHC class I CD8 alpha-chain (Leu-2/T8) gene, complete cds.
ACCESSION M27161
VERSION M27161.1
KEYWORDS cell surface antigen; cell surface glycoprotein; class I gene;
integral membrane protein; major histocompatibility complex.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7319)
AUTHORS Nakayama,K., Tokito,S., Okumura,K. and Nakauchi,H.
TITLE Structure and expression of the gene encoding CD8 alpha chain
(Leu-2/T8)
JOURNAL Immunogenetics 30 (5), 393-397 (1989)
PUBMED 2509342
COMMENT Original source text: Human DNA, clone pLE2B13.5.
Draft entry and computer-readable sequence for [1] kindly submitted
by K.-i.Nakayama, 31-AUG-1989.
FEATURES Location/Qualifiers
source 1..7319
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="2p12"
prim_transcript <1..>7319
/note="MHC CD8 alpha-chain mRNA and introns"
misc_feature 238..256
/note="initiator-like sequence"
misc_feature 476..485
/note="Tcr v-beta decamer-like sequence"
CDS join(619..667,763..1116,1700..1810,2017..2127,2890..2920,
5504..5555)
/note="MHC CD8 alpha-chain (Leu-2/T8)"
/codon_start=1
/protein_id="AAA59674.1"
/translation="MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQ
VLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTL
SDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLR
PEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCP
RPVVKSGDKPSLSARYV"
gene 619..667
/gene="CD8A"
exon <619..667
/gene="CD8A"
/note="MHC CD8 alpha-chain (Leu-2/T8); G00-120-581"
/number=1
intron 668..762
/note="CD8 alpha-chain intron A"
exon 763..1116
/number=2
intron 1117..1699
/note="CD8 alpha-chain intron B"
exon 1700..1810
/number=3
intron 1811..2016
/note="CD8 intron C"
exon 2017..2127
/number=4
intron 2128..2889
/note="CD8 intron D"
exon 2890..2920
/number=5
intron 2921..5503
/note="CD8 intron E"
exon 5504..>5555
/note="MHC CD8 alpha-chain (Leu-2/T8)"
/number=6
BASE COUNT 1690 a 1933 c 1837 g 1856 t
ORIGIN 1 bp upstream of HindIII site; chromosome 2p12.
1 aagcttcggc tgctgccgcc ctcatggaaa tctcctgggg gaagggagag ggtccttcct
61 cggtgaaaac tggggctgct ctagcgagtt cctcagaagc gggcaggtcg ctagctcctc
121 ttccttttca gccctcagtg cccattttgc caataaaaag tcccaaggtg acagtacaag
181 agacgccttt agtgaaggca aaggaaggga cactcccctc ctttgctgcc tactctcgcc
241 ctcacttctt gaaatctttg gtctcccttc acccactctg tcactctcac aagacaacca
301 tttccaagga ctatttccaa gcccttttcc tcatccccaa acccgcagtt ttcagctgcc
361 cccagttgcc tggccaggct gcctcgacgg ccctattcac gggccccagc ctcctcgccg
421 ggctggaagg cgacaaccgc gaaaaggagg gtgactctcc tcggcggggg cttcgggtga
481 catcacatcc tccaaatgcg aaatcaggct ccgggccggc cgaagggcgc aactttcccc
541 cctcggcgcc ccaccggctc ccgcgcgcct cccctcgcgc ccgagcttcg agccaagcag
601 cgtcctgggg agcgcgtcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg
661 ctgctccgtg agtttgagac gcccgggaag gcaggggatg gggcgggcgg ggggcggggg
721 gctcgggact gcttgctcag cctcgctgct tgcctcctgc agacgccgcc aggccgagcc
781 agttccgggt gtcgccgctg gatcggacct ggaacctggg cgagacagtg gagctgaagt
841 gccaggtgct gctgtccaac ccgacgtcgg gctgctcgtg gctcttccag ccgcgcggcg
901 ccgccgccag tcccaccttc ctcctatacc tctcccaaaa caagcccaag gcggccgagg
961 ggctggacac ccagcggttc tcgggcaaga ggttggggga caccttcgtc ctcaccctga
1021 gcgacttccg ccgagagaac gagggctact atttctgctc ggccctgagc aactccatca
1081 tgtacttcag ccacttcgtg ccggtcttcc tgccaggtcc gcgcgccggg ttgcnncacc
1141 tctccgcgtg gggcttgggg ttcacctcaa cctgttttcc acacctgggc cctgctttca
1201 agcctcttag cgcacctgga agcgacttag atactgttcc catttcacag acacagcaaa
1261 ctgaggctaa cgcgaggctg agtagggact ggggatggct ttttacgtcc ggccgatctg
1321 gactcgagtt cggattcttg tgtgattctg ggcaaatgac ttaaattatc tgcgcctccg
1381 tttgctcgtg ggtaaaatgc ggacagcaat caacccgcgc tccagggttg ctggttcagc
1441 ccgggagaga ggccaggtgc aggggagctg gctcctgcgc tccggctctg ggcgccgcgt
1501 gcgctgggct gagccgaggc ccgagcacag ggctccgcgc gcatcccggg gtccccatcc
1561 tgtctcctct gctatccctt ctcccaggaa aaccgggaaa aagcatcccc gtagggaaag
1621 gtgcgcgagg ccagggctag ggcaagaaca cctccataac cccagcctgg cccccaacca
1681 cgctctgttg ctcttgcagc gaagcccacc acgacgccag cgccgcgacc accaacaccg
1741 gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg
1801 gggggcgcag gtgaggcgtg cgggggcccg gggcgggggc ggcacgcacc gcggggagag
1861 cccatgccag ggacagccct gatactgtag gtagagtcaa gggctgtcca agtggtggga
1921 aaccgagatc tgaggcggag agacgttccc gggacggtgg ggcggttggg aggtcccggg
1981 ccctctccta aatgtcggcg tctttggtgt cgtcagtgca cacgaggggg ctggacttcg
2041 cctgtgatat ctacatctgg gcgcccctgg ccgggacttg tggggtcctt ctcctgtcac
2101 tggttatcac cctttactgc aaccacagta agtcccgagg aatcgcggcg ggaaggagtc
2161 ggccccgctc ctgcccttgg ctctgctagc tccaggcgga ccttgcgagg ggggagcttg
2221 gggttgagtt ttctgggact cccgagctgc cccgcaggta caggcacttc tttctgggag
2281 atagaatgcg agaaagccct tcccgctcct tgcgctctcg gagaggtttt gggagacaaa
2341 gccgcgttcc cagagccgct gcagcgggtg tgttccgtcg acgaagctcg cagcgcgcgc
2401 gcacatgtct ggacacatga caaacgcccg ccgggagggg gccgctgtgg ccgagtcaag
2461 tgcccaggag ggttagtcaa aaccaccatc agtttgaggt tcgtccttgg ccctcttcgg
2521 cgaaccgccc accctgcttt gggtcccatg caagagaggt gccggatcag gtctgcaggc
2581 tccccgcttt cgcccgcgtc tgtagttgca atttttttta attgatgctt gagacgaagg
2641 atggataaga agcccttacc cggctctcaa gagttataat cctcaaagaa ataggggaaa
2701 ggaaggagaa ttcgtagagg caattcccta tttgcctcat ccaatttcag cccatgatcg
2761 ttctgaaatg attttttgta aaaccaaaaa acagcagcaa caacaacagc aacaacaaaa
2821 aatacactgt ctttggggac tattgatgga taggggcact cactttttcc cttctttttc
2881 cttatccagg gaaccgaaga cgtgtttgca aatgtccccg gtgagtctct tttgaactct
2941 cagcctgctc accttggcca gccctggggt ggggtcctgg tttccccagc agcaaatagt
3001 gggaactttt cccagagaga ggtcatggcc gtgaaatcct ggggcaggga gtcagccagt
3061 tcctgagcaa agagaggcca aggctggcat ctggcctgtg tctttgagaa aaaggaggcc
3121 cgggttaggc gggtgccaac agcagtgtga ctccagtaaa tctccatctt atttgacctg
3181 gcacttccaa aaaaaaaaaa aaaaaacctg agggattccc ccaatttatc ctagctcctc
3241 gtaggacctg acctcctctt tattctgatt attccatctg ggttttgttg ttttcttaag
3301 aaaacaattt tttttcctac ttggctggtc tagttttttg agggagagcc aatcttttat
3361 cagctgaacc aaaataataa tggctttggt tgctaacttc tctgtgtcat gtaggacctt
3421 ggtttgctgc caaggactgg agtagaaaaa aggggaacga gatgcaggga caattggcta
3481 tctggcagct caagtgactg cctcatccag tttcagccca tgatcacaca cacacacaca
3541 cacacacaca cactctctct ctctctctcc ctctctgtta aaaacctctc tccacccgtt
3601 ggctgaggca tccctgtggt agcatctaac aagtgcctgc tctagtcagg cactgtgata
3661 ggggtaatac tccccatctc tcttaatcct cacagcaact ttgtgccatc tcatggctca
3721 gggattagta aagtggcaaa ggcacattaa actcagatta tcaatagtaa taaccatttg
3781 atgaaagcct acaacgcacg ttacttgctt tatagatttt ttttaatttt aagttttatg
3841 acaactttta aagtagtcat gattacctgc atttacagat aaggaaactg aggcttagaa
3901 catttagtga tttgtccaag gtcatactgc ccgggagctg caacttccat ccaaagctca
3961 gacaccttcc ccatggctgc aggctgaagt gttaaggata accgactgtg tacaccagtt
4021 cttttcagta gatgaaatat tttacatttt atacctggag tttgcatttt atactccttt
4081 acatttttct gagggaatcc aagttcagga ctttacacat tgttgttttt agcaatggaa
4141 atgcaatgga tttccaatgc atatgttaca ggtgatatac caaggggata aagactttaa
4201 aaatgagccg ggtattgtgg tgcatgccta taatccgggc tactcaggag gctgaggcag
4261 gagaatcgct tgaacgtggg aggcggaggt tgcagtgagc tgagatcgta ccactgcact
4321 ccagcctggg taacagagca agattccatc tcacaaaaaa aaaaaaaagt ggggggggaa
4381 gtttttagct tttcttttct tttcttttct tttttttttt tttttttttt tgagacggag
4441 tctcgctatc tcgcccaggc tggagtgcag tggtgcgatc tcggctcact gcaagctccg
4501 cctcccgggt tcacgccatt ctcctgcctc aacctcccaa gtagctggga ctacaggcac
4561 ccgcccagct gggactacag gcacccgcca caacacccgg ctaatttttt gtatttttag
4621 tagagacggg gtttcaccgt gttagccagg atggtctcga tctcctgacc tcgtgatccg
4681 cccgccttgg cctcccaaag tgctgggatt ataggcgtga gctaccgcac ccggccagtt
4741 tttagcattt ttattattca gggtgcactt tggaactttt gcagaaggac catccctttt
4801 ctcgatcttt tctgaaaact ctcattgtga gatgaataac tgagaataaa gttctgcctt
4861 aaaatacaaa gctatacaga ttaaacacac ctgggaaatt ccaacacccg agttaatata
4921 ctcagtgatg atggtgggcc gctcagcttc aacagagagg ttttagaggg ctgagagtgc
4981 agacatgacg ctcatgatga attagcatgt ttacaaggtg ctagcctggt gctgaattaa
5041 cacgttttta gcgtaacatc atttggctga tggtggtgat ttgctcacat cctcctctct
5101 ccctgtcatc ctccggggct gagaatcagg tcagctaatg actttggtta tcagtctcac
5161 tctcacacct ctgtggagac cttgacaggg gctccaggaa gctagactaa ctcggtttag
5221 atcctggctc agccacctcc tagatgtgtg accttgggca agtttaactt ctcaatctca
5281 gtgcccaccc ttaaggctgc tgtgaggatt acatgagatg gtgcaagtaa ggcatttagc
5341 acgggtgctg tgctgacgtc attcacccag tcccatgctg gtgccccagg aacaggttct
5401 cagacctttc aaaggctggg ggattgggag gctggacgtg gctggatgga tgctgcactg
5461 gcggggttct ggctacaatg atggtcgctt tcctctcttt caggcctgtg gtcaaatcgg
5521 gagacaagcc cagcctttcg gcgagatacg tctaaccctg tgcaacagcc actacattac
5581 ttcaaactga gatccttcct tttgagggag caagtccttc cctttcattt tttccagtct
5641 tcctccctgt gtattcattc tcatgattat tattttagtg ggggcggggt gggaaagatt
5701 actttttctt tatgtgtttg acgggaaaca aaactaggta aaatctacag tacaccacaa
5761 gggtcacaat actgttgtgc gcacatcgcg gtagggcgtg gaaaggggca ggccagagct
5821 acccgcagag ttctcagaat catgctgaga gagctggagg cacccatgcc atctcaacct
5881 cttccccgcc cgttttacaa agggggaggc taaagcccag agacagcttg atcaaaggca
5941 cacagcaagt cagggttgga gcagtagctg gagggacctt gtctcccagc tcagggctct
6001 ttcctccaca ccattcaggt ctttctttcc gaggcccctg tctcagggtg aggtgcttga
6061 gtctccaacg gcaagggaac aagtacttct tgatacctgg gatactgtgc ccagagcctc
6121 gaggaggtaa tgaattaaag aagagaactg cctttggcag agttctataa tgtaaacaat
6181 atcagacttt ttttttttta taatcaagcc taaaattgta tagacctaaa ataaaatgaa
6241 gtggtgagct taaccctgga aaatgaancc ctctatctct aaagaaaatc tctgtgaaac
6301 ccctacgtgg aggcggaatt gctctcccag cccttgcatt gcagaggggc ccatgaaaga
6361 ggacaggcta cccctttaca aatagaattt gagcatcagt gaggttaaac taaggccctc
6421 ttgaatctct gaatttgaga tacaaacatg ttcctgggat cactgatgac tttttatact
6481 ttgtaaagac aattgttgga gagaaaatca cacagccctg gcctccgctc aactagcaga
6541 tacagggatg aggcagacct gactctctta aggaggctga gagcccaaac tgctgtccca
6601 aacatgcact tccttgctta aggtatggta caagcaatgc ctgcccattg gagagaaaaa
6661 acttaagtag ataaggaaat aagaaccact cataattctt caccttagga ataatctcct
6721 gttaatatgg tgtacattct tcctgattat tttctacaca tacatgtaaa atatgtcttt
6781 cttttttaaa tagggttgta ctatgctgtt atgagtggct ttaatgaata aacatttgta
6841 gcatcctctt taatgggtaa acagcatccg attttggttg tgccatcatt tatttaacta
6901 ttacctgata tttagttgtt tccaaccttt tcctactata acactcttaa aatgttgcat
6961 atatttttgt ttctttagga taaagaccta aaagtaaaat tattgaatca gtccccacct
7021 tcacctgagc ctgccatttt cacatcaatc aaaacagatt agcttcatcc tgcattaccc
7081 ttcttccttt tgttctttct tggtaacaga ggagacgatg ctcctttcat gataaatcac
7141 taagtcatct tgttgttgag gtaaaatatt cgtactgaaa attgcttaag tcgtaaatgt
7201 acagctcgat gacatcataa agcaaacaca cccatgtaat cagccctcca gaagtctgtc
7261 gttagtttta aaaccaagat acttttagag aatggaaagc aagagtggct ttctgttct
//