LOCUS AH003215 3614 bp DNA linear HUM 01-AUG-2016
DEFINITION Homo sapiens CD8 antigen (CD8A) gene, complete cds, alternatively
spliced.
ACCESSION AH003215 M26313 M26314 M26315
VERSION AH003215.2
KEYWORDS CD8 antigen; T cell surface glycoprotein CD8-alpha; alternative
splicing.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3614)
AUTHORS Norment,A.M., Lonberg,N., Lacy,E. and Littman,D.R.
TITLE Alternatively spliced mRNA encodes a secreted form of human CD8
alpha. Characterization of the human CD8 alpha gene
JOURNAL J. Immunol. 142 (9), 3312-3319 (1989)
PUBMED 2496167
COMMENT On or before Aug 1, 2016 this sequence version replaced M26313.1,
M26314.1, M26315.1, AH003215.1.
FEATURES Location/Qualifiers
source 1..3614
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="2p12"
gene 92..3516
/gene="CD8A"
exon 92..261
/gene="CD8A"
/note="G00-120-581"
/number=1
exon 129..261
/gene="CD8A"
/note="G00-120-581"
/number=1
CDS join(213..261,356..709,1247..1357,1564..1674,1987..2017,
2189..2240)
/gene="CD8A"
/codon_start=1
/product="CD8 antigen"
/protein_id="AAA79217.1"
/db_xref="GDB:G00-120-581"
/translation="MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQ
VLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTL
SDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLR
PEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCP
RPVVKSGDKPSLSARYV"
CDS join(213..261,356..709,1247..1357,1987..2017,2189..2240)
/gene="CD8A"
/note="alternatively spliced"
/codon_start=1
/product="CD8 antigen"
/protein_id="AAA79218.1"
/db_xref="GDB:G00-120-581"
/translation="MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQ
VLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTL
SDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLR
PEACRPAAGGAGNRRRVCKCPRPVVKSGDKPSLSARYV"
intron 262..355
/gene="CD8A"
/note="G00-120-581"
/number=1
exon 356..709
/gene="CD8A"
/note="G00-120-581"
/number=2
intron order(710..>922,<1023..1246)
/gene="CD8A"
/note="G00-120-581"
/number=2
gap 923..1022
/estimated_length=unknown
exon 1247..1357
/gene="CD8A"
/note="G00-120-581"
/number=3
intron 1358..1563
/gene="CD8A"
/note="G00-120-581"
/number=3
exon 1564..1674
/gene="CD8A"
/note="G00-120-581"
/number=4
intron order(1675..>1785,<1886..1986)
/gene="CD8A"
/note="0.61 kb gap; G00-120-581"
/number=4
gap 1786..1885
/estimated_length=unknown
exon 1987..2017
/gene="CD8A"
/note="G00-120-581"
/number=5
intron 2018..2188
/gene="CD8A"
/note="G00-120-581"
/number=5
exon 2189..>3516
/gene="CD8A"
/note="G00-120-581"
/number=6
exon 2189..>2919
/gene="CD8A"
/note="G00-120-581"
/number=6
regulatory 2914..2919
/regulatory_class="polyA_signal_sequence"
/gene="CD8A"
/note="G00-120-581"
regulatory 3511..3516
/regulatory_class="polyA_signal_sequence"
/gene="CD8A"
/note="G00-120-581"
BASE COUNT 713 a 957 c 964 g 780 t
ORIGIN
1 agcctcctcg ccgggctgga aggcgacaac cgcgaaaaag gagggtgact ctcctcggcg
61 ggggcttcgg gtgacatcac atcctccaaa tgcgaaatca ggctccgggc cggccgaagg
121 gcgcaacttt cccccctcgg cgccccaccg gctcccgcgc gcctcccctc gcgcccgagc
181 ttcgagccaa gcagcgtcct ggggagcgcg tcatggcctt accagtgacc gccttgctcc
241 tgccgctggc cttgctgctc cgtgagtttg agacgcccgg gaaggcaggg gatggggcgg
301 gcggggggcg ggggcgcggg actgcgggct cagcctcgct gcttgccgcc tgcagacgcc
361 gccaggccga gccagttccg ggtgtcgccg ctggatcgga cctggaacct gggcgagaca
421 gtggagctga agtgccaggt gctgctgtcc aacccgacgt cgggctgctc gtggctcttc
481 cagccgcgcg gcgccgccgc cagtcccacc ttcctcctat acctctccca aaacaagccc
541 aaggcggccg aggggctgga cacccagcgg ttctcgggca agaggttggg ggacaccttc
601 gtcctcaccc tgagcgactt ccgccgagag aacgagggct actatttctg ctcggccctg
661 agcaactcca tcatgtactt cagccacttc gtgccggtct tcctgccagg tccgacgcgc
721 cgggttgcgg cacctctccg cgtggggctt ggggttcacc tcaacctgtt ttccacacct
781 gggccctgct ttcaagcctc ttagcgcacc tggaagcgac ttagatactg ttcccatttc
841 acagacacag caaactgagg ctaacgcgag gctgagtagg gactggggat ggctttttac
901 gtccggccga tctggactcg agnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1021 nnctggatcc tgcgctccgg ctctgggcgc cgggtgcgtg ggctgagccg aggcccgagc
1081 acaggggtcc gcgcgcatcc cggggtcccc atcctgtctc ctctgctatc ccttctccca
1141 ggaaaaccgg ggggaggcgt cccgtgggga aaggtgcgcg aggccggggc tggggcgcct
1201 ccataacccc agcctggccc ccaaccacgc tctgttgctc ttgcagcgaa gcccaccacg
1261 acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg
1321 cgcccagagg cgtgccggcc agcggcgggg ggcgcaggtg aggcgtgcgg gggcccgggg
1381 cgggggcggc acgcaccgcg gggagagccc atgccaggga cagccctgat actgtaggta
1441 gagtcaaggg ctgtccaagt ggtgggaaac cgagatctga ggcggagaga cgttcccggg
1501 acggtggggc ggttgggagg tcccgggccc tctcctaaat gtcggcgtct ttggtgtcgt
1561 cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg
1621 ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaac cacagtaagt
1681 cccgaggaat cgcggcggga aggagtcggc ccccgctcct gcccttggct ctgctagctc
1741 caggcggacc ttgcgagggg ggagcttggg gttgagtttt ctgggnnnnn nnnnnnnnnn
1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1861 nnnnnnnnnn nnnnnnnnnn nnnnnaaaac agcagcaaca acaacagcaa caacaaaaaa
1921 tacactgtct ttgggactat tgatggatag gggcactcac tttttccctt ctttttcctt
1981 atccagggaa ccgaagacgt gtttgcaaat gtccccggtg agtctctttt gaactctcag
2041 cctgctcacc ttggccagcc ctggggtggg gtcctggttg gttctcagac ctttcaaagg
2101 ctgggggatt gggaggctgg acgtggctgg atggatgctg cactggcggg gttctggcta
2161 caatgatggt cgctttcctc tctttcaggc ctgtggtcaa atcgggagac aagcccagcc
2221 tttcggcgag atacgtctaa ccctgtgcaa cagccactac attacttcaa actgagatcc
2281 ttccttttga gggagcaagt ccttcccttt cattttttcc agtcttcctc cctgtgtatt
2341 cattctcatg attattattt tagtgggggc ggggtgggaa agattacttt ttctttatgt
2401 gtttgacggg aaacaaaact aggtaaaatc tacagtacac cacaagggtc acaatactgt
2461 tgtgcgcaca tcgcggtagg gcgtggaaag gggcaggcca gagctacccg cagagttctc
2521 agaatcatgc tgagagagct ggaggcaccc atgccatctc aacctcttcc ccgcccgttt
2581 tacaaagggg gaggctaaag cccagagaca gcttgatcaa aggcacacag caagtcaggg
2641 ttggagcagt agctggaggg accttgtctc ccagctcagg gctctttcct ccacaccatt
2701 caggtctttc tttccgaggc ccctgtctca gggtgaggtg cttgagtctc caacggcaag
2761 ggaacaagta cttcttgata cctgggatac tgtgcccaga gcctcgagga ggtaatgaat
2821 taaagaagag aactgccttt ggcgaagttc tataatgtaa acaatatcag actttttttt
2881 tttataatca agcctaaaat tgtatagacc taaaataaaa tgaagtggtg agcttaaccc
2941 tggaaaatga atccctctat ctctaaagaa aatctctgtg aaacccctat gtggaggcgg
3001 aattgctctc ccagcccttg cattgcagag gggcccatga aagaggacag gctacccctt
3061 tacaaataga atttgagcat cagtgaggtt aaactaaggc cctcttgaat ctctgaattt
3121 gagatacaaa catgttcctg ggatcactga tgacttttta tactttgtaa agacaattgt
3181 tggagagccc ctcacacagc cctggcctct gctcaactag cagatacagg gatgaggcag
3241 acctgactct cttaaggagg ctgagagccc aaactgctgt cccaaacatg cacttccttg
3301 cttaaggtat ggtacaagca atgcctgccc attggagaga aaaaacttaa gtagataagg
3361 aaataagaac cactcataat tcttcacctt aggaataatc tcctgttaat atggtgtaca
3421 ttcttcctga ttattttcta cacatacatg taaaatatgt ctttcttttt taaatagggt
3481 tgtactatgc tgttatgagt ggctttaatg aataaacatt tgtagcatcc tctttaatgg
3541 gtaaacagca tccgattttg gttgtgccat gcatttattt aactattacc tgatatttag
3601 ttgtttccaa cctt
//