LOCUS HUMATCT4 1742 bp mRNA linear HUM 27-APR-1993
DEFINITION Human T-cell surface glycoprotein T4 mRNA, complete cds.
ACCESSION M12807
VERSION M12807.1
KEYWORDS glycoprotein; immunoglobulin super gene family; recognition
antigen; surface antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1742)
AUTHORS Maddon,P.J., Littman,D.R., Godfrey,M., Maddon,D.E., Chess,L. and
Axel,R.
TITLE The isolation and nucleotide sequence of a cDNA encoding the T cell
surface protein T4: a new member of the immunoglobulin gene family
JOURNAL Cell 42 (1), 93-104 (1985)
PUBMED 2990730
REFERENCE 2 (bases 153 to 153)
AUTHORS Littman,D.R.
JOURNAL Unpublished
COMMENT Original source text: Human peripheral T lymphocyte, cDNA to mRNA,
clone pT4B.
T4 is a member of the immunoglobulin supergene family. The T4 mRNA
encodes contiguous V- and J-like elements without the requirement
for DNA recombination events. The V-like domain can be found at
positions 145 to 426 and the J-like domain from 427 to 471. The T4
protein may serve as the specific surface receptor for the AIDS
virus [1].
With the revision of the nucleotide at position 153, the amino acid
encoded by 151-153 becomes lysine. This is now regarded to be the
first residue in the mature protein [2].
FEATURES Location/Qualifiers
source 1..1742
/db_xref="H-InvDB:HIT000194180"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 76..1452
/note="T4 surface glycoprotein precursor"
/codon_start=1
/protein_id="AAA35572.1"
/translation="MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTAS
QKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIE
DSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRG
KNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQ
VEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGK
KLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPT
SPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWST
PVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHR
FQKTCSPI"
sig_peptide 76..150
/note="T4 surface glycoprotein signal peptide"
mat_peptide 151..1449
/product="T4 surface glycoprotein mature peptide"
BASE COUNT 405 a 492 c 466 g 379 t
ORIGIN 198 bp upstream of RsaI site.
1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc
61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa
121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat
181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac
241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag
301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc
361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag
421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag
481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt
541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag
601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc
661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag
721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt
781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac
841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc
901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga
961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg
1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc
1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag
1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg
1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag
1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc
1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc
1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt
1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc
1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt
1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag
1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct
1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat
1741 cc
//