LOCUS HUMATCT4 1742 bp mRNA linear HUM 27-APR-1993 DEFINITION Human T-cell surface glycoprotein T4 mRNA, complete cds. ACCESSION M12807 VERSION M12807.1 KEYWORDS glycoprotein; immunoglobulin super gene family; recognition antigen; surface antigen. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1742) AUTHORS Maddon,P.J., Littman,D.R., Godfrey,M., Maddon,D.E., Chess,L. and Axel,R. TITLE The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family JOURNAL Cell 42 (1), 93-104 (1985) PUBMED 2990730 REFERENCE 2 (bases 153 to 153) AUTHORS Littman,D.R. JOURNAL Unpublished COMMENT Original source text: Human peripheral T lymphocyte, cDNA to mRNA, clone pT4B. T4 is a member of the immunoglobulin supergene family. The T4 mRNA encodes contiguous V- and J-like elements without the requirement for DNA recombination events. The V-like domain can be found at positions 145 to 426 and the J-like domain from 427 to 471. The T4 protein may serve as the specific surface receptor for the AIDS virus [1]. With the revision of the nucleotide at position 153, the amino acid encoded by 151-153 becomes lysine. This is now regarded to be the first residue in the mature protein [2]. FEATURES Location/Qualifiers source 1..1742 /db_xref="H-InvDB:HIT000194180" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 76..1452 /note="T4 surface glycoprotein precursor" /codon_start=1 /protein_id="AAA35572.1" /translation="MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTAS QKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIE DSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRG KNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQ VEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGK KLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPT SPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWST PVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHR FQKTCSPI" sig_peptide 76..150 /note="T4 surface glycoprotein signal peptide" mat_peptide 151..1449 /product="T4 surface glycoprotein mature peptide" BASE COUNT 405 a 492 c 466 g 379 t ORIGIN 198 bp upstream of RsaI site. 1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc 61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa 121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat 181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac 241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag 301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc 361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag 421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag 481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt 541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag 601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc 661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag 721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt 781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac 841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc 901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga 961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg 1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc 1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag 1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg 1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag 1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc 1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc 1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt 1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc 1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt 1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag 1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct 1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat 1741 cc //