LOCUS MUSDHFR 1499 bp mRNA linear ROD 24-SEP-2001 DEFINITION Mus musculus dihydrofolate reductase (dhfr) mRNA, complete cds. ACCESSION L26316 VERSION L26316.1 KEYWORDS dihydrofolate reductase. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 91 to 217; 228 to 240; 318 to 343; 346 to 517) AUTHORS Nunberg,J.H., Kaufman,R.J., Chang,A.C., Cohen,S.N. and Schimke,R.T. TITLE Structure and genomic organization of the mouse dihydrofolate reductase gene JOURNAL Cell 19 (2), 355-364 (1980) PUBMED 6244105 REFERENCE 2 (bases 28 to 986) AUTHORS Setzer,D.R., McGrogan,M. and Schimke,R.T. TITLE Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene JOURNAL J. Biol. Chem. 257 (9), 5143-5147 (1982) PUBMED 6121807 REFERENCE 3 (bases 1 to 670) AUTHORS Crouse,G.F., Simonsen,C.C., McEwan,R.N. and Schimke,R.T. TITLE Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells JOURNAL J. Biol. Chem. 257 (13), 7887-7897 (1982) PUBMED 6282858 REFERENCE 4 (bases 71 to 528) AUTHORS Simonsen,C.C. and Levinson,A.D. TITLE Isolation and expression of an altered mouse dihydrofolate reductase cDNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (9), 2495-2499 (1983) PUBMED 6573667 REFERENCE 5 (bases 1 to 1499) AUTHORS Schilling,L.J. and Farnham,P.J. TITLE Transcriptional regulation of the dihydrofolate reductase/rep-3 locus JOURNAL Crit. Rev. Eukaryot. Gene Expr. 4 (1), 19-53 (1994) PUBMED 7987046 FEATURES Location/Qualifiers source 1..1499 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /cell_line="sarcoma cell line s180" gene 1..1499 /gene="dhfr" 5'UTR 1..55 /gene="dhfr" CDS 56..619 /gene="dhfr" /codon_start=1 /product="dihydrofolate reductase" /protein_id="AAA37523.1" /translation="MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSV EGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIE QPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLL PEYPGVLSEVQEEKGIKYKFEVYEKKD" 3'UTR 620..1499 /gene="dhfr" regulatory 1130..1140 /regulatory_class="polyA_signal_sequence" /gene="dhfr" regulatory 1478..1483 /regulatory_class="polyA_signal_sequence" /gene="dhfr" polyA_site 1495 /gene="dhfr" BASE COUNT 498 a 300 c 336 g 365 t ORIGIN 1 aacttgacgg caatcctagc gtgaaggctg gtaggatttt atccccgctg ccatcatggt 61 tcgaccattg aactgcatcg tcgccgtgtc ccaaaatatg gggattggca agaacggaga 121 cctaccctgg cctccgctca ggaacgagtt caagtacttc caaagaatga ccacaacctc 181 ttcagtggaa ggtaaacaga atctggtgat tatgggtagg aaaacctggt tctccattcc 241 tgagaagaat cgacctttaa aggacagaat taatatagtt ctcagtagag aactcaaaga 301 accaccacga ggagctcatt ttcttgccaa aagtttggat gatgccttaa gacttattga 361 acaaccggaa ttggcaagta aagtagacat ggtttggata gtcggaggca gttctgttta 421 ccaggaagcc atgaatcaac caggccacct tagactcttt gtgacaagga tcatgcagga 481 atttgaaagt gacacgtttt tcccagaaat tgatttgggg aaatataaac ttctcccaga 541 atacccaggc gtcctctctg aggtccagga ggaaaaaggc atcaagtata agtttgaagt 601 ctacgagaag aaagactaac aggaagatgc tttcaagttc tctgctcccc tcctaaagct 661 atgcattttt ataagaccat gggacttttg ctggctttag atctatgagt aattatttct 721 ttagggaggg gtagttggaa gaagtgtccg tcccgtgacc ctggggatgg aacctaagac 781 ccagtgcgtg ctgagcaaat gctatactgc tgagccaccc caaccctagt cccctatata 841 attctaaaca atatgttgtc attttcccag taattcaaca aggtatagta aaagtgtcca 901 agttatgtca tctgcataag gtctcagtgt cccctcccat gaggaacctc aagtggctcc 961 ccagcatatg cacagggtac tgtgtgtaca gagaccccag tgatgtagag cccctagagc 1021 atgagcagat gtgtgggctc ataaaagtgg agctaggcag gtaagccaaa gggcagaaac 1081 aggtatacaa gcagagctgg aactcagact ataaagaaaa ttccatcaaa agtagagact 1141 ggattattgt atgcacatca acaacttgca gcaaagctct gctcactcag acagaaaatc 1201 agtaaatgga gaactccatt gtgttccatg gagacgagag caggtggaag attatgtaag 1261 atctgaaaca ctgaaattgt ctgcttctca tcttcagtga gattccaaag gatagtacag 1321 tgacagaaca agaataggca ctctctacaa aaaaaagaaa gaaaaaacta agtaatagca 1381 agcataatag ctatcgttaa gaactcagag ataatgaatt gagaatggat actgcttgaa 1441 atgaaaattt aataagttag aaactaaact ttataaaaat aaaaaaatga gcattaaaa //